Gang Li, Han Zhang, Yao Yang, Yang Liu, Aijun Liu, Xiangming Fan, Pei Cheng, Junwu Su^*

Congenital Heart Disease, Vol.15, No.6, pp. 431-439, 2020, DOI:10.32604/CHD.2020.012249

Abstract Background: Pseudoaneurysm complicating right ventricular outflow tract (RVOT) with conduit placement was an infrequent complication but with potential for significant morbidity and mortality, and a more unusual pseudoaneurysm after RVOT patching was investigated here. Methods: Patients diagnosed as pseudoaneurysms at our institution from 2010 to 2019 were reviewed and their clinical characteristics were analyzed. Results: A total of seven patients developed pseudoaneurysm in RVOT were identified. One pseudoaneurysm arose after placement of a conduit between the right ventricle and the pulmonary artery, and the other six formed after RVOT patching. One patient presented with arrhythmia, one patient had the pseudoaneurysm… More >

Mingjie Zhang¹, Wenyi Luo¹, Liping Wang¹, Xi Chen¹, Nan Bao^2,*, Zhuoming Xu^1,*

Congenital Heart Disease, Vol.15, No.5, pp. 377-386, 2020, DOI:10.32604/CHD.2020.011983

Abstract Background: This retrospective cohort study aimed to explore the causes of death in children with congenital heart disease (CHD) after cardiac surgery in one of the biggest cardiac centers for children with CHD in China. Methods: A total of 26,856 children undergoing cardiac surgery from January 1, 2012 to December 31, 2019 were included. Based on the clinical data, the causes of death were divided into ten categories and further compared among different periods, types of CHD and surgical procedures. Results: Of all patients, 513 (1.9%) died (median age 162 d, median weight 5.6 kg). The mortality in 2016–2019 was… More >

Shengwen Guo, Yuanyuan Tong, Liting Bai, Peiyao Zhang, Xin Duan^*, Jinping Liu^*

Congenital Heart Disease, Vol.15, No.5, pp. 275-285, 2020, DOI:10.32604/CHD.2020.011894

Abstract Objective: Serum ferritin has been identified as a prognostic marker in patients with a variety of diseases. In the present study we aim to determine the prevalence of risk factors and outcomes for hyperferritinemia in children undergoing cardiac surgery with cardiopulmonary bypass for congenital heart defects. Methods: The serum ferritin levels of 457 children between the ages of twentyeight days and three years undergoing cardiopulmonary bypass surgery between June 1, 2017 and June 1, 2018 were analyzed. The prevalence of early postoperative hyperferritinemia was investigated; hyperferritinemia was defined as a ferritin level ≥250 ng/ml. Multivariable regression models including candidate risk… More >

Or Bercovich¹, Tal Tirosh-Wagner², Lior Goldberg¹, Amir Vardi³, David Mishali⁴, Gideon Paret^1,#, Yael Nevo-Caspi^1,*,#

Congenital Heart Disease, Vol.15, No.4, pp. 239-249, 2020, DOI:10.32604/CHD.2020.011576

Abstract Objective: To test the hypothesis that circulating miRNAs-146a, -146b, -155, and -21 reflect the inflammatory state of children following heart surgery, and that they may, therefore, correlate with postoperative parameters. We aimed to quantify miRNAs in blood samples from pediatric patients before and 6, 12, and 24 hours after surgery and to evaluate correlations between the miRNA levels and the postoperative course. Setting: PICU. Patients: Forty-two pediatric patients with CHD who underwent cardiac surgery at Safra Children’s Hospital between 2012–2016. Interventions: none. Outcome Measures: The primary outcomes were the postoperative cardiac complications and the secondary outcomes were the length of… More >

Xiaorui Zhang^1,2,*, Xuefeng Yu¹, Wei Sun², Aiguo Song³

CMES-Computer Modeling in Engineering & Sciences, Vol.124, No.3, pp. 1131-1147, 2020, DOI:10.32604/cmes.2020.09735

Abstract In order to solve the problem of high computing cost and low simulation accuracy caused by discontinuity of incision in traditional meshless model, this paper proposes a soft tissue deformation model based on the Marquardt algorithm and enrichment function. The model is based on the element-free Galerkin method, in which Kelvin viscoelastic model and adjustment function are integrated. Marquardt algorithm is applied to fit the relation between force and displacement caused by surface deformation, and the enrichment function is applied to deal with the discontinuity in the meshless method. To verify the validity of the model, the Sensable Phantom Omni… More >

Hui Zhang, Zhan Wang, Lin Liu, Fuqiang Zhang, Yuxin Song, Yaowen Qian^*

Oncologie, Vol.22, No.1, pp. 23-33, 2020, DOI:10.32604/oncologie.2020.012493

Abstract The expression changes of miR-625-3p and miR-449a in osteosarcoma patients after surgery is the critical study in this paper. Analysis of their prognosis and risk factors can be helpful in understanding the prognostic value for clinical purposes. Fifty-eight patients with osteosarcoma diagnosed in our hospital were considered as the research group (RG), and 52 health subjects at the same time were collected as the control group (CG). Fluorescence quantitative PCR (RTPCR) was employed to test the expression levels of miR-625-3p and miR-449a in the serum of subjects in both groups before surgery and patients in the RG after surgery. The… More >

Alvise Guariento^1,2, Ilias P. Doulamis³, David Blitzer⁴, Claudia Cattapan², Massimo A. Padalino², Vladimiro L. Vida^2,*

Congenital Heart Disease, Vol.15, No.3, pp. 127-139, 2020, DOI:10.32604/CHD.2020.012197

Abstract Background: In an effort to reduce postoperative trauma and achieve more cosmetic results, minimally invasive approaches to correct congenital heart anomalies have been recently proposed and increasingly adopted. Here we describe our experience for the past 23 years. Methods: Patients who underwent a surgical procedure between February 1996 and March 2019 with a minimally invasive approach for the correction of congenital heart disease in our center were included in this study. A statistical analysis was carried out to compare the results of the different minimally invasive techniques. A meta-analysis was conducted to compare our results in patients undergoing atrial septal… More >

Michela Palma, Giancarlo Scognamiglio^*, Flavia Fusco, Assunta Merola, Anna Correra, Diego Colonna, Emanuele Romeo, Berardo Sarubbi

Congenital Heart Disease, Vol.15, No.1, pp. 33-49, 2020, DOI:10.32604/CHD.2020.011523

Abstract Adults with congenital heart disease (ACHD) constitute a growing population with complex cardiac physiopathology and frequent extra-cardiac involvement. The recent dramatic improvement of their life expectancy has resulted in an increasing proportion of ACHD patients requiring non-cardiac surgery. While a large body of evidence demonstrated the importance of an accurate risk assessment in patients with acquired heart disease before noncardiac surgery in order to reduce perioperative morbidity and mortality and detailed algorithms have been released by international societies, no specific guidelines are available for the perioperative management in this population. Nonetheless, understanding the complex anatomy and unusual physiology of both… More >

Richard D. Mainwaring, Frank L. Hanley

Congenital Heart Disease, Vol.14, No.4, pp. 504-510, 2019, DOI:10.1111/chd.12826

Abstract Objective: Anomalous left main coronary artery (LMCA) with an intraconal course is a relatively rare form of anomalous aortic origin of a coronary artery (AAOCA) from the wrong sinus of Valsalva. There is currently a paucity of information regarding this entity. The purpose of this article is to review our surgical experience with repair of anomalous LMCA with an intraconal course.
Methods: This was a retrospective review of 12 patients with an anomalous LMCA and an intraconal course who underwent surgical repair. The median age at surgery was 15 years (range 2‐47). The seven oldest patients all had preoperative symptoms… More >

Jenny Alenius Dahlqvist¹, Jan Sunnegårdh², Katarina Hanséus³, Eva Strömvall Larsson², Anders Nygren², Magnus Dalén^4,5, Håkan Berggren⁶, Jens Johansson Ramgren⁷, Urban Wiklund⁸, Annika Rydberg¹

Congenital Heart Disease, Vol.14, No.4, pp. 582-589, 2019, DOI:10.1111/chd.12766

Abstract Objective: Fontan surgery is performed in children with univentricular heart defects. Previous data regarding permanent pacemaker implantation frequency and indica‐ tions in Fontan patients are limited and conflicting. We examined the prevalence of and risk factors for pacemaker treatment in a consecutive national cohort of patients after Fontan surgery in Sweden.
Methods: We retrospectively reviewed all Swedish patients who underwent Fontan surgery from 1982 to 2017 (n = 599).
Results: After a mean follow‐up of 12.2 years, 13% (78/599) of the patients with Fontan circulation had received pacemakers. Patients operated with the extracardiac conduit (EC) type of total cavopulmonary connection… More >