YANYAN LI¹, SHAHANAVAJ KHAN^2,3,4, ANIS AHMAD CHAUDHARY⁵, HASSAN AHMED RUDAYNI⁵, ABDUL MALIK², ASHWAG SHAMI⁶

BIOCELL, Vol.46, No.1, pp. 87-95, 2022, DOI:10.32604/biocell.2022.016509

Abstract Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth. These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the… More >

MUBASHIR HUSSAIN¹, ZEESHAN ALI¹, BIN LIU², JIANGUO DAI¹, XIAOLONG LIU¹, JUNCHEN ZHU¹, YONGJUN TANG¹

BIOCELL, Vol.46, No.1, pp. 61-74, 2022, DOI:10.32604/biocell.2022.016392

Abstract Dengue virus infections are increasing worldwide generally and in Asia, Central and South America and Africa, particularly. It poses a serious threat to the children population. The rapid and accurate diagnostic systems are essentially required due to lack of effective vaccine against dengue virus and the progressive spread of the dengue virus infection. The recent progress in developing micro- and nano-fabrication techniques has led to low cost and scale down the biomedical point-of-care devices. Starting from the conventional and modern available methods for the diagnosis of dengue infection, this review examines several emerging rapid and point-of-care diagnostic devices that hold… More >

AJIT C. DHADVE^1,2, PRITHA RAY^1,2

BIOCELL, Vol.46, No.1, pp. 75-86, 2022, DOI:10.32604/biocell.2022.016346

Abstract Progression, relapse, and therapy resistance are the most challenging features of cancer therapy that have been postulated to be driven by Cancer Stem Cell (CSC) population. This enigmatic subpopulation of cancer cells has therefore emerged as promising therapeutic candidate. We earlier reported enrichment of CSC-like side population (SP) with increasing resistance towards Cisplatin and Paclitaxel either alone or in combination in epithelial ovarian cancer (EOC) cells. This SP population is a small proportion of the total population of cancer cells characterised with high expression of drug transporters, a unique feature of stem cells and thereby can be isolated through their… More >

LINGJIAO FAN¹, DAN SONG¹, YINGWEI KHOO², MENGMENG WU¹, TENGFEI XU¹, XIAOLI ZHAO¹, HONGQING WANG¹

BIOCELL, Vol.46, No.1, pp. 263-273, 2022, DOI:10.32604/biocell.2022.016306

Abstract

Strawberry mottle virus (SMoV) and strawberry vein banding virus (SVBV) cause diseases on strawberry plants, but the effect of coinfection of SMoV and SVBV on the growth, development, and defense system of strawberry (Fragaria × ananassa Duchesne) remains unknown. We investigated the effect of SMoV and SVBV co-infection on strawberry cultivar ‘Benihope’. The results showed that stem diameter, leaf size, leaf number, relative chlorophyll content, total chlorophyll content, photosynthetic parameters, and stomatal aperture of SMoV and SVBV co-infected strawberry (VIS) plants were in a weaker level than uninfected control plants, indicating that viruses inhibited the growth and photosynthesis of strawberry… More >

ILGIZ GAREEV¹, OZAL BEYLERLI¹, CHUNLEI WANG^2,3, ANDREI SOKHATSKII^2,3, YANCHAO LIANG^2,3, HUAN XIANG^2,3, CHUNYANG LIU^2,3, XUN XU^2,3, YANG GUANG^2,3

BIOCELL, Vol.46, No.1, pp. 27-35, 2022, DOI:10.32604/biocell.2022.016288

Abstract Brain arteriovenous malformations (AVMs) are abnormal vessels that are prone to rupture, causing life-threatening intracerebral hemorrhage (ICH). Understanding the molecular basis of pathogenesis, timely diagnosis, and treatment of brain AVMs are some of the urgent problems in neurosurgery. MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNAs are involved in almost all biological processes, including cell proliferation, apoptosis, and cell differentiation. Recent studies have shown that miRNAs can be involved in brain AVMs formation and rupture. There are also extracellular forms of miRNAs. Circulating miRNAs have been detected in the blood circulation and other body fluids. Owing to… More >

JELAN MOFEED^1,2, MOHAMED DEYAB³, ABDELNASER MOHAMED³, MAHMOUD MOUSTAFA^4,5, SALLY NEGM^6,7, EMAD EL-BILAWY¹

BIOCELL, Vol.46, No.1, pp. 247-261, 2022, DOI:10.32604/biocell.2022.015966

Abstract

Microbial infections cause complicated health influences along with bad economic impacts. In the present investigation, three dominant seaweeds namely, Amphiroa anceps, Corallina officinalis and Sargassum filipendula were collected from different Egyptian sites at the Red Sea and Mediterranean Sea during autumn 2019. Organic extracts of the three algae were screened for their antibacterial activity against three pathogenic bacteria Salmonella typhiimurium, Staphylococcus aureus and Escherichia coli, in addition to in vitro antiviral activity against Rotavirus (RV), and Coxsackie virus B3 (CVB3) that cause severe diseases in human. Organic extract of A. anceps, C. officinalis and S. filipendula inhibit E. coli cells… More >

RONGXUE WEI¹, CHUNCHUN HAN^1,*, FENGJIANG YE¹, SHOUHAI WEI², FANG HE¹, HEHE LIU¹, LIANG LI¹, HONGYONG XU¹, SHENQIANG HU¹, XIANYIN ZENG²

BIOCELL, Vol.46, No.1, pp. 171-183, 2022, DOI:10.32604/biocell.2022.015409

Abstract In order to explore the role of forkhead box protein O1 (FoxO1) in the lipid metabolism and cell proliferation, goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVP-BEZ235, and then transfected with FoxO1 interference plasmid. The related parameters of lipid metabolism and cell proliferation were measured. The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration (P < 0.05); and increased the proliferative index (PI), cell DNA synthesis, protein expression of Cyclin D1 in goose primary hepatocytes (P < 0.05). Secondly, the co-treatment of insulin and FoxO1 interference increased the… More >

LUPING YANG^1,#, YIJING JIANG^2,#, XIAOQIAN YE^3,#, YONGMEI YOU², LING LIN², JING LIAN², JUAN LI¹, SHANLI YANG², XIEHUA XUE²

BIOCELL, Vol.46, No.1, pp. 235-245, 2022, DOI:10.32604/biocell.2022.014997

Abstract ATP depletion is one of the pathological bases in cerebral ischemia. Electro-acupuncture (EA) is widely used in clinical practice for ischemia. However, the mechanism of EA remains unclear. The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and, consequently, increase the preservation of ATP in rats with ischemia. In this study, 48 rats were randomly divided into four groups as a sham-operation control group (sham group), a middle cerebral artery occlusion group (MCAO group), an EA group, and an EA group blocked by the AMPK inhibitor compound C (EA + CC group) (N… More >

José Vulfrano González-Fernández^1,*, Diego David Pinzón-Moreno¹, Antony Alexander Neciosup-Puican², María Verónica Carranza-Oropeza¹

Journal of Renewable Materials, Vol.10, No.3, pp. 833-847, 2022, DOI:10.32604/jrm.2021.017377

Abstract ZnO nanoparticles (ZnO-NP) present innovative optical, electrical, and magnetic properties that depend on specific characteristics, e.g., size, distribution, and morphology. Thus, these properties are essential to address various applications in areas such as electronics, medicine, energy, and others. In addition, the performance of this ZnONP depends of their preparation which can be done by chemical, physical, and biological methods. Meanwhile, nowadays, the main interest in developing ZnO-NP synthesis through biological methods bases on the decrease of use of toxic chemicals or energy applied to the procedures, making the process more cost-effective and environmentally friendly. However, the large-scale production of nanoparticles… More >

Chen Chen^1,2, Haitao Li^1,2,*, Assima Dauletbek^1,2, Feng Shen³, David Hui⁴, Milan Gaff⁵, Rodolfo Lorenzo⁶, Ileana Corbi⁷, Ottavia Corbi⁷, Mahmud Ashraf⁸

Journal of Renewable Materials, Vol.10, No.3, pp. 605-624, 2022, DOI:10.32604/jrm.2022.018685

Abstract Fibers are used in many forms in engineering applications–one of the most common being used as reinforcement. Due to its renewable short natural growth cycle and abundance of bamboo resources, bamboo fiber has attracted attention over other natural fibers. Bamboo fiber has a complex natural structure but offers excellent mechanical properties, which are utilized in the textile, papermaking, construction, and composites industry. However, bamboo fibers can easily absorb moisture and are prone to corrosion limiting their use in engineering applications. Therefore, a better understanding of bamboo fiber is particularly important. This paper reviews all existing research on the mechanical characterization… More >