SHAN OU^#, YUN XU^#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI^*, JIE YAO^*

BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178

Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a series of experiments, including the… More > Graphic Abstract

PEI QIN^#, MIAO LIU^#, XIN WANG, JIANHUA MA^*

BIOCELL, Vol.48, No.3, pp. 513-523, 2024, DOI:10.32604/biocell.2023.045640

Abstract Background: L-dopa (Levodopa) is well known for managing PD (Parkinson’s disease); however, its prolonged use caused dyskinesia (LID). Due to the varied presentation of LID, effective treatment options are scarce. Flavonoids reported their neuroprotective activity by ameliorating acetylcholinesterase, monoamine oxidase, and neuroinflammation. Kaempferol is another flavonoid bearing these potentials. Aim: To evaluate neuroprotective activity of kaempferol in dyskinetic rats. Methods: PD was developed in Sprague-Dawley rats by injecting combination of L-ascorbic acid (10 µL) + 6-OHDA (12 µg) in medial forebrain bundle to induce neuronal damage in substantial nigra (SNr). LID was induced by administrating combination of L-dopa (20 mg/kg)… More > Graphic Abstract

SHAHID HUSSAIN^1,*, HABIB BOKHARI¹, XINGXING FAN², SHAUKAT IQBAL MALIK³, SUNDAS IJAZ¹, MUHAMMAD ADNAN SHEREEN⁴, AIMAN FATIMA³

BIOCELL, Vol.48, No.3, pp. 403-413, 2024, DOI:10.32604/biocell.2024.044801

Abstract The global incidence of lung cancer is marked by a considerably elevated mortality rate. MicroRNAs (miRNAs) exert pivotal influence in the intricate orchestration of gene regulation, and their dysregulation can precipitate dire consequences, notably cancer. Within this context, miRNAs encapsulated in exosomes manifest a diversified impact on the landscape of lung cancer, wherein their actions may either foster angiogenesis, cell proliferation, and metastasis, or counteract these processes. This comprehensive review article discerns potential targets for the prospective development of therapeutic agents tailored for lung cancer. Tumor-suppressive miRNAs, such as miR-204, miR-192, miR-30a, miR-34a, miR-34b, miR-203, and miR-212, exhibit heightened expression… More >

YAN LI¹, HUZHI CAI², XIAOLING PENG³, YOUHUI LIU⁴, QINGYANG CHEN⁴, XIANGDONG LIN⁵, XINYU CHEN^6,*

BIOCELL, Vol.48, No.3, pp. 501-511, 2024, DOI:10.32604/biocell.2023.030854

Abstract Background: Renal fibrosis is an important process in the development of chronic kidney disease. Understanding the pathogenesis and finding effective treatments for renal fibrosis is crucial. This study aims to investigate whether a newly discovered long non-coding RNA (lncRNA) called LOC103694972 could be a potential target for treating fibrosis of NRK-49F cells. Methods:: LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal cells. The dual-luciferase assay confirmed the binding between miR-29c-3p and signal transducer and activator of transcription (STAT3), as well as between miR-29c-3p and lncRNA LOC103694972. Si-LOC103694972 and miR-29c-3p mimic were then transfected… More > Graphic Abstract

FEI SHA¹, DAISHAN XIN², JUN XU³, ZHIWEI ZHENG¹, WENXIN LIN¹, XIAORUI CAI¹, FEI LIN³, MINGHAO ZHENG^1,*, JIAOLING CHEN^1,*

BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188

Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western blot, and immunofluorescence assays. Then… More > Graphic Abstract

P. K. Das^*, S. Chakraborty, S. Bhaduri

Frontiers in Heat and Mass Transfer, Vol.3, No.1, pp. 1-17, 2012, DOI:10.5098/hmt.v3.1.3008

Abstract A state of the art review of critical heat flux during flow boiling through mini and microchannels has been provided based on the open literature. This review mainly examines three aspects, namely the experimental investigations, the available correlations and the state of prediction using those correlations and finally the proposed physical mechanisms as well as the theoretical models. Before discussing the specific literature on microchannels, a brief overview of critical heat flux for pool and flow boiling is provided. The review has been concluded with a summary of the available information on this topic and the need for future research. More >

Sira Saisorn^a,b, Somchai Wongwises^b,c,∗

Frontiers in Heat and Mass Transfer, Vol.3, No.1, pp. 1-7, 2012, DOI:10.5098/hmt.v3.1.3007

Abstract Two-phase pressure drop during flow boiling has been studied for several decades. Obviously, the publications available on micro-channels are relatively small compared with those for ordinarily sized channels. Although the use of micro-channels yields several advantages, the pressure drop taking p lace in these extremely small channels is higher than that in the ordinarily sized channels because of the increased wall friction. The knowledge of the two-phase pressure drop characteristics in addition to heat transfer phenomena is essential to the design and evaluation of the micro-systems. In this paper, recent research on the flow boiling pressure drop in micro-scale channels… More >

Sira Saisorn^a,b, Somchai Wongwises^b,c,*

Frontiers in Heat and Mass Transfer, Vol.3, No.1, pp. 1-15, 2012, DOI:10.5098/hmt.v3.1.3006

Abstract A summary of recent research on flow boiling in micro-channels is provided in this article. This review aims to survey and identify new findings arising in this important area, which may contribute to optimum design and process control of high performance miniature devices comprising extremely small channels. Several criteria for defining a micro-channel are presented at first and the recent works on micro-scale flow boiling are subsequently described into two parts including flow visualization and two-phase heat transfer. The results obtained from a number of p revious studies show that the flow behaviours and heat transfer mechanisms in micro-channels deviate… More >

Bijon Mallik¹, Md Abdur Rahim¹, Abu Saleh Musa Miah², Keun Soo Yun^3,*, Jungpil Shin²

Computer Systems Science and Engineering, Vol.48, No.2, pp. 555-570, 2024, DOI:10.32604/csse.2023.045981

Abstract In the digital age, non-touch communication technologies are reshaping human-device interactions and raising security concerns. A major challenge in current technology is the misinterpretation of gestures by sensors and cameras, often caused by environmental factors. This issue has spurred the need for advanced data processing methods to achieve more accurate gesture recognition and predictions. Our study presents a novel virtual keyboard allowing character input via distinct hand gestures, focusing on two key aspects: hand gesture recognition and character input mechanisms. We developed a novel model with LSTM and fully connected layers for enhanced sequential data processing and hand gesture recognition.… More >

Zhonghao Guo^*, Xinyue Xu, Xiangxian Chen

Computer Systems Science and Engineering, Vol.48, No.2, pp. 479-509, 2024, DOI:10.32604/csse.2023.043932

Abstract In software testing, the quality of test cases is crucial, but manual generation is time-consuming. Various automatic test case generation methods exist, requiring careful selection based on program features. Current evaluation methods compare a limited set of metrics, which does not support a larger number of metrics or consider the relative importance of each metric to the final assessment. To address this, we propose an evaluation tool, the Test Case Generation Evaluator (TCGE), based on the learning to rank (L2R) algorithm. Unlike previous approaches, our method comprehensively evaluates algorithms by considering multiple metrics, resulting in a more reasoned assessment. The… More >