Guest Editors
Dr. Ut Dong Thach
Email: thachutdong@tdtu.edu.vn
Affiliation: Faculty of Pharmacy, Ton Duc Thang University, 19 Nguyen Huu Tho, District 7, Ho Chi Minh City, Vietnam
Homepage:
Research Interests: material chemistry; organic chemistry; polymer chemistry
Summary
Gene delivery is a pivotal approach in treating genetic disorders, cancers, and infectious diseases by introducing therapeutic genes into cells. While viral vectors have been widely used, polymer-based non-viral carriers offer advantages such as reduced immunogenicity, scalability, and design flexibility. Advances in polymer science have led to the development of novel biodegradable, biocompatible, and targeted gene delivery systems, addressing key challenges like cellular uptake, endosomal escape, and controlled release.
This Special Issue highlights recent progress in polymer-based gene delivery, focusing on material synthesis, functionalization, and applications in gene therapy. Topics include:
· Biodegradable and targeted polymeric gene carriers
· Polymeric nanoparticles and dendrimers for nucleic acid transport
· Stimuli-responsive and hybrid polymeric systems
· Preclinical and clinical studies of polymer-mediated gene therapy
· Computational modeling of polymer-gene interactions
· Polymer design and modifications
· Polymeric nanocarriers for gene therapy
We welcome original research and reviews contributing to advancements in polymer-based gene therapy for clinical applications.
Keywords
gene delivery; polymeric carriers, non-viral vectors, biodegradable polymers , nanoparticles for gene therapy, stimuli-responsive polymers, endosomal escape, targeted gene delivery, polyplex formation, transfection efficiency
Login
Register
Submit a Paper
Propose a Special lssue