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Polymer Materials for Tissue Engineering and Cell Encapsulation

Submission Deadline: 30 August 2026 View: 899 Submit to Special Issue

Guest Editor(s)

Prof. Zhongliang Jiang

Email: jz82070@163.com

Affiliation: Chemical Engineering Department, University of Science and Technology Liaoning, China

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Research Interests: Droplet-microfluidics, Tissue Engineering, Cell Microencapsulation, Drug Release, Microgels

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Prof. Dr. John S. Oakey

Email: joakey@uwyo.edu

Affiliation: Chemical & Biomedical Engineering, University of Wyoming, USA

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Research Interests: Microfluidics, Transport Phenomenon, Tissue Engineering

Dr. Wei Yao

Email: yaowei@ustl.edu.cn

Affiliation: Chemical Engineering Department, University of Science and Technology Liaoning, China

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Research Interests: Polyoxometallate, MOFs, Coordination Chemistry, Fluorescence Detection, Electrochemistry

Summary

This special issue should cover research spanning from fundamental polymer design and synthesis, polymer analysis and characterization, polymer fabrication, and other related fields with a goal to promote the field of tissue engineering and stem cell-based therapies.

Research and review articles on using advanced fabrication techniques like microfluidic chips or 3D/bioprinting would be a plus for the special issue.

Characterization of cell-cell or cell-material interaction, influencing factors governing stem cell fate decision, and drug delivery schemes should be included in publications.

Keywords

Microfluidics, Tissue Engineering, Cell Encapsulation, Drug Delivery, Stem Cell Therapy

Published Papers

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Open Access

ARTICLE

Schisandra Lignans- and MSCs-Laden Microgels Attenuate Inflammation on LPS-Induced HepG2 Cells in a PEGNB Hydrogel Model
Xingdan Wang, Lei Yang, Renmeng Liu, Yuheng Du, Zhihuan Li, Xinyue Zhang, Linhao Zhu, Ni Ren
Journal of Polymer Materials, DOI:10.32604/jpm.2026.081663
（This article belongs to the Special Issue: Polymer Materials for Tissue Engineering and Cell Encapsulation)
Abstract Hepatitis has imposed a substantial burden on human health. Tumor necrosis factor-α (TNF-α) drives the inflammatory response by triggering downstream signaling, particularly the nuclear factor kappa B (NF-κB) pathway. Suppressing NF-κB activation represents a promising therapeutic strategy. PEGNB, a polymeric hydrogel, exhibits significant potential due to its superior cytocompatibility. We developed a controlled-delivery microgel platform by encapsulating Schisandra lignans (SLs) and mesenchymal stromal cells (MSCs) in polyethylene glycol-norbornene (PEGNB) microgels. To mimic an inflammatory hepatic microenvironment in vitro, Lipopolysaccharide (LPS)-induced HepG2 cells were encapsulated in bulk PEGNB hydrogel. The microgel–cell system enabled localized co-delivery of SLs… More >

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ARTICLE

A Fluorescent-Electrochemical Hydrogel Sensing for H₂O₂ and Tartrazine Analysis Based on methacrylamide composite hydrogel materials (MCHM)
Peiqi Zhang, Weifeng Chen, Xiaoliang Hao
Journal of Polymer Materials, DOI:10.32604/jpm.2026.084020
（This article belongs to the Special Issue: Polymer Materials for Tissue Engineering and Cell Encapsulation)
Abstract Health remains a persistent focus of research. Currently, many commonly used synthetic dyes are toxic to some extent. Tartrazine is a common synthetic dye used in the food, pharmaceutical, printing, and dyeing industries. Long-term exposure to this substance or its ingestion may pose significant health risks. In addition, oxidizing agents used in water treatment may threaten environmental and human health if they are not properly controlled. Hydrogen peroxide (H₂O₂) is one of the most widely used oxidants and therefore requires effective monitoring. Against this background, this study contributes to the efficient detection of environmentally harmful substances… More >

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ARTICLE

Co-Encapsulation of Silymarin and Mesenchymal Stromal Cells in PEG Norbornene Microgels Enhances HepG2 Cell Resistance to Inflammatory Damage
Zhihuan Li, Shiqi Lei, Yajuan Guo, Renmeng Liu, Lei Yang, Yuheng Du, Xingdan Wang, Yun Zou, Kun Jiang, Zhongliang Jiang
Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.081661
（This article belongs to the Special Issue: Polymer Materials for Tissue Engineering and Cell Encapsulation)
Abstract Inflammatory liver injury represents a significant clinical challenge, characterized by a hostile immune microenvironment and extensive tissue damage. Although silymarin and mesenchymal stromal cells (MSCs) show promise in treating inflammatory liver injury, their efficacy is restricted by the drug’s poor bioavailability while MSC therapy is hampered by low cellular viability under inflammatory stress. To overcome these challenges, we engineered a droplet-microfluidic-assisted platform to co-encapsulate silymarin and MSCs within uniform, biocompatible polyethylene glycol-norbornene (PEGNB) hydrogel microspheres. This design establishes a dual-functional scaffold that supports MSC survival by shielding them from the harsh milieu while enabling the… More >

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Open Access

REVIEW

The Design, Fabrication and Miniaturization of Polymeric Hydrogels for Therapeutic Actions
Xingdan Wang, Yuheng Du, Xinyue Zhang, Yifei Li, Renmeng Liu, Lei Yang, Edward Ramsey, Zhongliang Jiang
Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.080578
（This article belongs to the Special Issue: Polymer Materials for Tissue Engineering and Cell Encapsulation)
Abstract Polymeric hydrogels are three-dimensional hydrophilic macromolecular networks capable of retaining varying amounts of water, similar to the extracellular matrix (ECM). To effectively translate these materials into therapeutic actions, it is of importance to control their molecular design, structural architecture, and physical dimensions, ensuring that these factors are strictly optimized to meet the demands of therapeutic applications. Existing reviews mainly focus on specific hydrogel aspects, but there is a gap in translating hydrogel miniaturization into therapeutic potential. This review highlights developments in hydrogel miniaturization, focusing on microfluidic strategies for precise microgel control. Miniaturized hydrogels improve cell-material More >

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ARTICLE

Development of Calopogonium mucunoides PEGylated Solidified Reverse Micellar Suspensions: Polymer-Matrix Design for Sustainable Wound Application
Edith O. Diovu, Calister E. Ugwu, Eunice N. Anaele, Samuel WisdomofGod Uzondu, Ogochukwu N. Umeh, Iheanacho O. Enyum, Kingsley C. Eze, Godswill C. Onunkwo, Anthony A. Attama
Journal of Polymer Materials, Vol.43, No.2, 2026, DOI:10.32604/jpm.2026.077511
（This article belongs to the Special Issue: Polymer Materials for Tissue Engineering and Cell Encapsulation)
Abstract Polymer-lipid hybrid-based solidified reverse micellar suspensions (SRMs) have gained increasing interest for topical drug delivery due to their ability to enhance solubility, stabilize bioactive compounds, and achieve sustained skin permeation. In this study, PEGylated SRMs were developed using a beeswax: Phospholipon 90H lipid matrix to enhance the solubility, stability, bioavailability, and wound-healing properties of a lipophilic extract of Calopogonium mucunoides (CM). PEG: lipid matrix ratios (1:0, 0:1, 1:1, 1:2, 1:3) were formulated and designated as CM1–CM5, with an unloaded matrix (CM6) as control. Physicochemical characterization included encapsulation efficiency (EE%), spreadability, pH, viscosity, Fourier transform infrared spectroscopy… More >

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Polymer Materials for Tissue Engineering and Cell Encapsulation

Guest Editor(s)

Summary

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