JIATENG ZHONG^1,2, JINGYU GUO¹, XINYU ZHANG¹, SHUANG FENG¹, WENYU DI², YANLING WANG^3,*, HUIFANG ZHU^1,*

Oncology Research, Vol.30, No.5, pp. 231-242, 2022, DOI:10.32604/or.2022.027900 - 03 February 2023

Abstract Lipid is a key component of plasma membrane, which plays an important role in the regulation of various cell biological behaviors, including cell proliferation, growth, differentiation and intracellular signal transduction. Studies have shown that abnormal lipid metabolism is involved in many malignant processes, including colorectal cancer (CRC). Lipid metabolism in CRC cells can be regulated not only by intracellular signals, but also by various components in the tumor microenvironment, including various cells, cytokines, DNA, RNA, and nutrients including lipids. In contrast, abnormal lipid metabolism provides energy and nutrition support for abnormal malignant growth and distal More >

YUNG-SUNG YEH^1,2,3, HSIANG-LIN TSAI^4,5, YEN-CHENG CHEN^4,6, WEI-CHIH SU^4,6, PO-JUNG CHEN^4,6, TSUNG-KUN CHANG^4,6,7, CHING-CHUN LI⁴, CHING-WEN HUANG^4,5, JAW-YUAN WANG^{4,5,6,8,9,10,*}

Oncology Research, Vol.30, No.2, pp. 65-76, 2022, DOI:10.32604/or.2022.026659 - 05 January 2023

Abstract The controversial outcomes in patients with metastatic colorectal cancer (mCRC) highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical results. The optimal treatment cycles in patients with mCRC for metastasectomy remain undefined. This retrospective study compared the efficacy, safety, and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such patients. Sixty-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April 2022. Twenty-eight patients received 6 cycles of chemotherapy/targeted therapy, whereas 36 patients received ≥7 cycles (median, 13; range, 7–20). Clinical outcomes, including response,… More >

Shengzhe Ma^1,#, Xiaoming Zhu^1,#, Cheng Xin^1,#, Fuao Cao¹, Mengnan Xu¹, Xiangling Han¹, Jinke Sui^3,*, Wenjun Chang^2,*, Wei Zhang^1,*

Oncologie, Vol.24, No.4, pp. 823-833, 2022, DOI:10.32604/oncologie.2022.025411 - 31 December 2022

Abstract Background: Reticulocalbin 3 (RCN3) has been associated with several malignancies. However, its role in colorectal cancer (CRC) remains controversial. Thus, this study aimed to investigate the role of RCN3 in CRC prognosis. Methods: The clinical significance of RCN3 expression in CRC was evaluated in a large cohort of 483 patients. Normal tissues, carcinoma, para-carcinoma, adenoma, and metastatic tissues were evaluated by immunohistochemistry. We investigated the association between RCN3 expression and CRC occurrence in tumors and other tissues. Prognostic factors were also evaluated by Kaplan-Meier survival analysis and the Cox regression model. Results: RCN3 was significantly overexpressed in CRC… More >

SANHUA LI^1,2,#, QINGHONG KONG^1,2,#, XIAOKE ZHANG^1,2, XINTING ZHU^1,3, CHUNBO YU³, CHANGYAN YU^1,2, NIAN JIANG^1,2, JING HUI^1,2, LINGJIE MENG^1,2,*, YUN LIU^1,2,3,*

BIOCELL, Vol.46, No.11, pp. 2425-2432, 2022, DOI:10.32604/biocell.2022.019916 - 07 July 2022

Abstract Traditional Chinese medicine (TCM) has been increasingly employed in the last decades in China for both preventing and treating a variety of cancers. 3-epi-bufotalin is an active ingredient of TCM “Chanpi” with anti-tumor potential. However, the effect and mechanism of 3-epi-bufotalin on colorectal cancers were not well disclosed. The present study demonstrated that 3-epi-bufotalin could reduce viability, trigger apoptosis, and block the cell cycle at the G₂/M stage in colorectal cancer cell lines HT29, RKO, and COLO205 in vitro. Moreover, 3-epi-bufotalin inhibited the JAK1/STAT3 signaling pathway. These results indicated the anti-proliferation ability of 3-epi-bufotalin in colorectal cancer cells. More >

ZHIYONG ZHANG^1,#, YAN PAN^2,#, YAN ZHAO¹, MUDAN REN¹, YARUI LI¹, YUN FENG¹, GUIFANG LU^1,*, SHUIXIANG HE^1,*

BIOCELL, Vol.46, No.8, pp. 1917-1924, 2022, DOI:10.32604/biocell.2022.018847 - 22 April 2022

Abstract Colorectal cancer (CRC) is a heterogeneous cancer, and many risk factors for colorectal cancer have been established. For CRC metastasis, tumor cell migration, adhesion as well as invasion are important processes. WiskottAldrich syndrome protein family member 3 (WASF3) is necessary for metastasis of various types of cancers. However, its role in CRC progression has not been fully elucidated. This study examined the in vitro functional roles of WASF3 in the CRC and explored the underlying molecular mechanisms. We used siRNA-WASF3 to gene silence WASF3 in colon cancer cell (HCT116) in vitro. The effects of WASF3… More >

Mahmoud Ragab^1,2,3,*, Ashwag Albukhari^2,4

CMC-Computers, Materials & Continua, Vol.72, No.3, pp. 5577-5591, 2022, DOI:10.32604/cmc.2022.026715 - 21 April 2022

Abstract Colorectal cancer is one of the most commonly diagnosed cancers and it develops in the colon region of large intestine. The histopathologist generally investigates the colon biopsy at the time of colonoscopy or surgery. Early detection of colorectal cancer is helpful to maintain the concept of accumulating cancer cells. In medical practices, histopathological investigation of tissue specimens generally takes place in a conventional way, whereas automated tools that use Artificial Intelligence (AI) techniques can produce effective results in disease detection performance. In this background, the current study presents an Automated AI-empowered Colorectal Cancer Detection and… More >

Mahmoud Ragab^1,2,3,*, Khalid Eljaaly⁴, Maha Farouk S. Sabir⁵, Ehab Bahaudien Ashary⁶, S. M. Abo-Dahab^7,8, E. M. Khalil^3,9

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 5751-5764, 2022, DOI:10.32604/cmc.2022.024658 - 14 January 2022

Abstract The recent developments in biological and information technologies have resulted in the generation of massive quantities of data it speeds up the process of knowledge discovery from biological systems. Due to the advancements of medical imaging in healthcare decision making, significant attention has been paid by the computer vision and deep learning (DL) models. At the same time, the detection and classification of colorectal cancer (CC) become essential to reduce the severity of the disease at an earlier stage. The existing methods are commonly based on the combination of textual features to examine the classifier… More >

XUE MEI LUO¹, SHAHANAVAJ KHAN^2,3,4,*, ABDUL MALIK², FAHAD M. ALDAKHEEL⁵, ANIS AHMAD CHAUDHARY⁶, SHOUKI BAZARBASHI⁷, FATEMEH TABATABAIE⁸

BIOCELL, Vol.46, No.3, pp. 759-767, 2022, DOI:10.32604/biocell.2022.016586 - 18 November 2021

Abstract Despite the multiple systematic reviews and meta-analyses accumulating evidence on the preventive effect of calcium supplementation for colorectal cancer, most of the associated adverse effects are not systematically analyzed. The aim of the study is evaluating adverse events associated with calcium supplementation for colorectal cancer prevention through a systematic meta-analysis. We searched Medline, PubMed Central, EMBASE (Excerpta Medica database), Scopus, Cochrane Central Register of Controlled Trials, and Web of Science published in English from database inception up to 31 July 2019. In the current systematic meta-analysis, we included human studies (including cohort studies, clinical trials,… More >

HAIZHENG LIU¹, SHAOFEI CHANG^2,*

BIOCELL, Vol.46, No.2, pp. 453-462, 2022, DOI:10.32604/biocell.2021.015340 - 20 October 2021

Abstract Lysophosphatidylcholine acyltransferase 1 (LPCAT1) is a phospholipid acyltransferase that promotes phospholipid synthesis and plasma membrane reconstruction. Exosomes play an important role in tumor metastasis. The release and uptake of exosomes are key steps of their functions and depend on plasma membrane fusion and plasma membrane receptors, respectively. The purpose of this study was to explore whether LPCAT1-induced plasma membrane remodeling would change the secretion and uptake behavior of exosomes in tumor cells. We first confirmed the abnormally high expression of LPCAT1 in colorectal cancer cells by quantitative real-time PCR (qPCR) and Western blot analysis. Then,… More >

XIANGCAI YANG^1,2,*, YA XU³, SHUTING MEI¹, JIEJING LI^3,*

BIOCELL, Vol.46, No.2, pp. 463-470, 2022, DOI:10.32604/biocell.2021.014834 - 20 October 2021

Abstract Cell migration is a finely tuned biological process that often involves epithelial-mesenchymal transition (EMT). EMT is typically characterized by the upregulation of mesenchymal markers such as Snail1. This process has been shown to be of critical importance to normal developmental processes, including neural crest migration and invasion. Interestingly, similar mechanisms are utilized in disease processes, such as tumor metastasis and migration. Notably, EMT and EMT-like processes confer tumor cells with the ability to migrate, invade, and adopt stem cell-like properties that largely account for immunosuppression and tumor recurrence. Therefore, identifying sensitive EMT markers may… More >