MENG FANG¹, JING GUO¹, HAIPING WANG¹, ZICHANG YANG², HAN ZHAO^1,*, QINGJIA CHI²

BIOCELL, Vol.46, No.2, pp. 401-415, 2022, DOI:10.32604/biocell.2022.016989

Abstract Hepatocellular carcinoma (HCC) is a common immunogenic malignant tumor. Although the new strategies of immunotherapy and targeted therapy have made considerable progress in the treatment of HCC, the 5-year survival rate of patients is still very low. The identification of new prognostic signatures and the exploration of the immune microenvironment are crucial to the optimization and improvement of molecular therapy strategies. We studied the potential clinical benefits of the inflammation regulator miR-93-3p and mined its target genes. Weighted gene co-expression network analysis (WGCNA), univariate and multivariate COX regression and the LASSO COX algorithm are employed to identify prognostic-related genes and… More >

Junding Sun^1,3,#, Xiang Li^1,#, Chaosheng Tang^1,*, Shixin Chen^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.2, pp. 729-753, 2021, DOI:10.32604/cmes.2021.016416

Abstract Purpose: As to January 11, 2021, coronavirus disease (COVID-19) has caused more than 2 million deaths worldwide. Mainly diagnostic methods of COVID-19 are: (i) nucleic acid testing. This method requires high requirements on the sample testing environment. When collecting samples, staff are in a susceptible environment, which increases the risk of infection. (ii) chest computed tomography. The cost of it is high and some radiation in the scan process. (iii) chest X-ray images. It has the advantages of fast imaging, higher spatial recognition than chest computed tomography. Therefore, our team chose the chest X-ray images as the experimental dataset in… More >

LUPING YANG^1,#, YIJING JIANG^2,#, XIAOQIAN YE^3,#, YONGMEI YOU², LING LIN², JING LIAN², JUAN LI¹, SHANLI YANG², XIEHUA XUE²

BIOCELL, Vol.46, No.1, pp. 235-245, 2022, DOI:10.32604/biocell.2022.014997

Abstract ATP depletion is one of the pathological bases in cerebral ischemia. Electro-acupuncture (EA) is widely used in clinical practice for ischemia. However, the mechanism of EA remains unclear. The purpose of this study was to investigate whether EA could activate the AMPK/PGC-1α/TFAM signaling pathway and, consequently, increase the preservation of ATP in rats with ischemia. In this study, 48 rats were randomly divided into four groups as a sham-operation control group (sham group), a middle cerebral artery occlusion group (MCAO group), an EA group, and an EA group blocked by the AMPK inhibitor compound C (EA + CC group) (N… More >

CHUAN TIAN¹, MUBALAKE ABUDOUREYIMU¹, XINRONG LIN¹, HAO ZHOU², XIAOYUAN CHU¹, RUI WANG^1,*

BIOCELL, Vol.45, No.6, pp. 1527-1541, 2021, DOI:10.32604/biocell.2021.016203

Abstract PSMD14 played a vital role in initiation and progression of hepatocellular carcinoma (HCC). However, PSMD14 and its-related genes for the immune prognostic implications of HCC patients have rarely been analyzed. Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) database-Liver Hepatocellular Carcinoma (LIHC). Additionally, we used multi-dimensional bioinformatics analysis to construct and validate a PSMD14-based immune prognostic signature (including RBM45, PSMD1, OLA1, CCT6A, LCAT and IVD) for HCC prognosis prediction. Patients in the high-risk group shown significantly poorer survival than patients in the low-risk group. Calibration curves confirmed… More >

Khalid Mahmood Aamir¹, Muhammad Bilal², Muhammad Ramzan^1,3, Muhammad Attique Khan⁴, Yunyoung Nam^5,*, Seifedine Kadry⁶

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3829-3844, 2021, DOI:10.32604/cmc.2021.017835

Abstract Retroviruses are a large group of infectious agents with similar virion structures and replication mechanisms. AIDS, cancer, neurologic disorders, and other clinical conditions can all be fatal due to retrovirus infections. Detection of retroviruses by genome sequence is a biological problem that benefits from computational methods. The National Center for Biotechnology Information (NCBI) promotes science and health by making biomedical and genomic data available to the public. This research aims to classify the different types of rotavirus genome sequences available at the NCBI. First, nucleotide pattern occurrences are counted in the given genome sequences at the preprocessing stage. Based on… More >

Sk Sarif Hassan¹, Ranjeet Kumar Rout², Kshira Sagar Sahoo³, Nz Jhanjhi⁴, Saiyed Umer⁵, Thamer A. Tabbakh^6,*, Zahrah A. Almusaylim⁷

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3477-3493, 2021, DOI:10.32604/cmc.2021.017206

Abstract Coronaviruses are responsible for various diseases ranging from the common cold to severe infections like the Middle East syndromes and the severe acute respiratory syndrome. However, a new coronavirus strain known as COVID-19 developed into a pandemic resulting in an ongoing global public health crisis. Therefore, there is a need to understand the genomic transformations that occur within this family of viruses in order to limit disease spread and develop new therapeutic targets. The nucleotide sequences of SARS-CoV-2 are consist of several bases. These bases can be classified into purines and pyrimidines according to their chemical composition. Purines include adenine… More >

Naglaa F. Soliman^1,2, Abeer D. Algarni^1,*, Walid El-Shafai³, Fathi E. Abd El-Samie^1,3, Ghada M. El Banby⁴

CMC-Computers, Materials & Continua, Vol.69, No.2, pp. 1571-1595, 2021, DOI:10.32604/cmc.2021.016980

Abstract Cancelable biometrics are required in most remote access applications that need an authentication stage such as the cloud and Internet of Things (IoT) networks. The objective of using cancelable biometrics is to save the original ones from hacking attempts. A generalized algorithm to generate cancelable templates that is applicable on both single and multiple biometrics is proposed in this paper to be considered for cloud and IoT applications. The original biometric is blurred with two co-prime operators. Hence, it can be recovered as the Greatest Common Divisor (GCD) between its two blurred versions. Minimal changes if induced in the biometric… More >

GAGANJOT GUPTA¹, DEEPAK BANSAL², ANSHULA SHARMA¹, TAWSEEF AHMAD¹, ATUL SACHDEV², AJAZ AHMAD³, HAMED A. EL-SEREHY⁴, BALJINDER KAUR^1,*

BIOCELL, Vol.45, No.5, pp. 1299-1311, 2021, DOI:10.32604/biocell.2021.015411

Abstract Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer. Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H. pylori-induced pathogenicity. The rationale of the study is to explore the underlying distinct metabolic mechanisms of H. pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry. GC/MS-based analytical method was used to compare metabolic profiles of healthy controls (N = 20) and peptic ulcer patients (N = 45). Acquired metabolomic data were analyzed by constructing a diagnostic model using principal… More >

José María Esbrí^*, Alba Martinez-Coronado, Sofía Rivera Jurado, Eva García-Noguero, Pablo Higueras

Energy Engineering, Vol.118, No.4, pp. 1223-1235, 2021, DOI:10.32604/EE.2021.015781

Abstract Mercury (Hg) is a global pollutant that is subject to strict regulations to reduce anthropogenic emissions. The production of energy represents an important activity that leads to Hg emissions into the atmosphere. Of all the systems used, IGCC plants are the most promising for reducing Hg emissions, since it is possible to remove Hg from syngas prior to combustion. The aim of the present work was to evaluate the presence of Hg in the main streams of an experimental IGCC plant (ELCOGAS, Puertollano) in order to quantify Hg emissions and investigate the possibility of reducing them. The main streams of… More >

MENGYI TANG^1,2,3,4,#, BOWEN YANG^1,2,3,4,#, CHUANG ZHANG^1,2,3,4, CHAOXU ZHANG^1,2,3,4, DAN ZANG^1,2,3,4, LIBAO GONG^1,2,3,4, YUNPENG LIU^1,2,3,4, ZHI LI^1,2,3,4,*, XIUJUAN QU^1,2,3,4,*

BIOCELL, Vol.45, No.4, pp. 911-921, 2021, DOI:10.32604/biocell.2021.010119

Abstract Distal gastric cancer (DGC) is a subgroup of gastric cancer (GC), which has different molecular characteristics from proximal gastric cancer (PGC). These differences result in different overall survival (OS) rates; however, data pertaining to the survival rate in PGC or DGC are contradictory. This suggests that the location of GC is not the unique cause of the different survival rates, while the molecular characteristics might be more important factors determining the prognosis of DGC. Therefore, the aim of this study was to discover key prognostic factors in DGC using bioinformatic methods and to explore the potential molecular mechanism. The Cancer… More >