Saher Manzoor¹, Muhammad Waseem Ashraf^1,*, Shahzadi Tayyaba², Muhammad Imran Tariq^3,*, M. Khalid Hossain⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.2, pp. 1007-1052, 2023, DOI:10.32604/cmes.2022.022093

Abstract The progress of membrane technology with the development of membranes with controlled parameters led to porous membranes. These membranes can be formed using different methods and have numerous applications in science and technology. Anodization of aluminum in this aspect is an electro-synthetic process that changes the surface of the metal through oxidation to deliver an anodic oxide layer. This process results in a self-coordinated, exceptional cluster of round and hollow formed pores with controllable pore widths, periodicity, and thickness. Categorization in barrier type and porous type films, and different methods for the preparation of membranes, have been discussed. After the… More > Graphic Abstract

KAI WANG^2,#, FENGTIAN ZHANG^1,3,4,#, CHANGLONG WEN⁵, ZHIHUA HUANG⁶, ZHIHAO HU¹, YUWEN ZHANG¹, FUQIANG HU^2,*, LIJUAN WEN^1,6,*

Oncology Research, Vol.29, No.5, pp. 351-363, 2021, DOI:10.32604/or.2022.025696

Abstract The blood-brain barrier (BBB) is an essential component in regulating and maintaining the homeostatic microenvironment of the central nervous system (CNS). During the occurrence and development of glioblastoma (GBM), BBB is pathologically destroyed with a marked increase in permeability. Due to the obstruction of the BBB, current strategies for GBM therapeutics still obtain a meager success rate and may lead to systemic toxicity. Moreover, chemotherapy could promote pathological BBB functional restoration, which results in significantly reduced intracerebral transport of therapeutic agents during multiple administrations of GBM and the eventual failure of GBM chemotherapy. The effective delivery of intracerebral drugs still… More >

Fazal Muhammad^1,*, Bilal Khan², Rashid Naseem³, Abdullah A Asiri⁴, Hassan A Alshamrani⁴, Khalaf A Alshamrani⁴, Samar M Alqhtani⁵, Muhammad Irfan⁶, Khlood M Mehdar⁷, Hanan Talal Halawani⁸

CMC-Computers, Materials & Continua, Vol.74, No.1, pp. 1049-1067, 2023, DOI:10.32604/cmc.2023.032698

Abstract Today, liver disease, or any deterioration in one’s ability to survive, is extremely common all around the world. Previous research has indicated that liver disease is more frequent in younger people than in older ones. When the liver’s capability begins to deteriorate, life can be shortened to one or two days, and early prediction of such diseases is difficult. Using several machine learning (ML) approaches, researchers analyzed a variety of models for predicting liver disorders in their early stages. As a result, this research looks at using the Random Forest (RF) classifier to diagnose the liver disease early on. The… More >

Shengjin Yu, Huiming Lv, Jinhui Zhang, He Zhang, Weiwei Ju, Yu Jiang^*, Lijuan Lin^*

Oncologie, Vol.24, No.3, pp. 539-551, 2022, DOI:10.32604/oncologie.2022.024882

Abstract Background: Although heparanase/syndecan-1 axis is involved in malignant progression of many cancers, its significance in liver cancer is not well understood. In this study, we explored the value of heparanase/syndecan-1 axis expression in liver cancer and the intervention mechanisms that target this axis by inhibiting the proliferation of hepatocellular carcinoma cells. Materials and Methods: We conducted tissue microarray analysis that included 90 primary liver cancer and their corresponding adjacent samples to evaluate the expression of heparanase and syndecan-1 and their correlation with clinicopathologic characteristics. RNA interference and western blot assays were performed to analyze the effect of heparanase on syndecan-1… More >

Mahmoud Ragab^1,2,3,*, Jaber Alyami^4,5

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2309-2322, 2023, DOI:10.32604/csse.2023.026877

Abstract Liver cancer is one of the major diseases with increased mortality in recent years, across the globe. Manual detection of liver cancer is a tedious and laborious task due to which Computer Aided Diagnosis (CAD) models have been developed to detect the presence of liver cancer accurately and classify its stages. Besides, liver cancer segmentation outcome, using medical images, is employed in the assessment of tumor volume, further treatment plans, and response monitoring. Hence, there is a need exists to develop automated tools for liver cancer detection in a precise manner. With this motivation, the current study introduces an Intelligent… More >

Srilekha Muthukaruppankaruppiah^1,*, Shanker Rajendiran Nagalingam², Priya Murugasen³, Rajesh Nandaamarnath⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2309-2323, 2023, DOI:10.32604/iasc.2023.029598

Abstract Malfunction of human liver happens due to non-alcoholic fatty liver. Fatty liver measurement is used for grading hepatic steatosis, fibrosis and cirrhosis. The various imaging techniques for measuring fatty liver are Magnetic Resonance Imaging, Ultrasound and Computed Tomography. Imaging modalities lead to the exposure of harmful radiation of electromagnetic waves because of frequent measurement. The continuous monitoring of fatty liver is never achieved through imaging techniques. In this paper, the human fatty liver measured through a Fatty Liver Sensor (FLS). The continuous monitoring of the fatty liver is achieved through the FLS. FLS is fabricated through the screen-printing with materials… More >

Genglong Zhu^*, Xialei Liu^*, Yonghui Su^†, Fangen Kong^‡, Xiaopeng Hong^*, Zhidong Lin^†

Oncology Research, Vol.27, No.1, pp. 55-64, 2019, DOI:10.3727/096504018X15201143705855

Abstract Liver cancer is one of the most common malignancies in the world and a leading cause of cancer-related mortality. Accumulating evidence has highlighted the critical role of long noncoding RNAs (lncRNAs) in various cancers. The present study aimed to explore the role of lncRNA urothelial carcinoma-associated 1 (UCA1) in cell growth and migration in MHCC97 cells and its underlying mechanism. First, we assessed the expression of UCA1 in MHCC97 and three other cell lines by RT-qPCR. Then the expression of UCA1, miR-301a, and CXCR4 in MHCC97 cells was altered by transient transfection. The effects of UCA1 and miR-301 on cell… More >

Yaohong Liu, Wensou Huang, Mingji He, Hui Lian, Yongjian Guo, Jingjun Huang, Jingwen Zhou, Kangshun Zhu

Oncology Research, Vol.27, No.5, pp. 565-573, 2019, DOI:10.3727/096504018X15313896322888

Abstract This study aimed to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Barcelona Clinic Liver Cancer (BCLC) stage C liver cancer patients. In 39 patients with BCLC stage C liver cancer, after the first cycle of DEB-TACE, 2 (5.1%) and 24 (61.5%) patients achieved complete response (CR) and partial response (PR) to give an overall objective response rate (ORR) of 66.7%. With respect to the second cycle of therapy, the ORR was higher in patients receiving DEB-TACE compared with those receiving cTACE (57.1% vs. 11.1%). After the first cycle of DEB-TACE treatment, the percentages of… More >

Junhui Sun^*1, Guanhui Zhou^*1, Xiaoxi Xie^†, Wenjiang Gu^‡, Jing Huang^§, Dedong Zhu^¶, Wenhao Hu^#, Qinming Hou^**, Changsheng Shi^††, Tiefeng Li^‡‡ , Xin Zhang^§§, Wenbin Ji^¶¶, Shihong Ying^§§, Zhiyi Peng^§§, Jian Zhou^##, Zhihai Yu^***, Jiansong Ji^†††, Haijun Du^‡‡‡, Xiaohua Guo^§§§, Jian Fang^¶¶¶, Jun Han^###, Huanhai Xu^****, Zhichao Sun^††††, Wenqiang Yu^‡‡‡‡, Guoliang Shao^§§§§, Xia Wu^¶¶¶¶ ,Hongjie Hu^¶¶¶¶ , Ling Li^#, Jiaping Zheng^§§§§, Jun Luo^§§§§, Yutang Chen^§§§§, Guohong Cao^####, Tingyang Hu^‡‡‡‡

Oncology Research, Vol.28, No.1, pp. 75-94, 2020, DOI:10.3727/096504019X15662966719585

Abstract The purpose of this study was to investigate the efficacy and safety of drug-eluting beads transarterial chemoembolization (DEB-TACE) treatment in Chinese hepatocellular carcinoma (HCC) patients and the prognostic factors for treatment response as well as survival. A total of 275 HCC patients were included in this prospective study. Treatment response was assessed by modified Response Evaluation Criteria in Solid Tumors (mRECIST), and progression-free survival (PFS) as well as overall survival (OS) were determined. Liver function and adverse events (AEs) were assessed before and after DEB-TACE operation. Complete response (CR), partial response (PR), and objective response rate (ORR) were 22.9%, 60.7%,… More >

Zhiyi Peng^*1, Guohong Cao^†1, Qinming Hou^‡, Ling Li^§, Shihong Ying^*, Junhui Sun^¶, Guanhui Zhou^¶, Jian Zhou^#, Xin Zhang^*, Wenbin Ji^**, Zhihai Yu^††, Tiefeng Li^‡‡, Dedong Zhu^§, Wenhao Hu^§§, Jiansong Ji^¶¶, Haijun Du^##, Changsheng Shi^***, Xiaohua Guo^†††, Jian Fang^‡‡‡, Jun Han^§§§, Wenjiang Gu^¶¶¶, Xiaoxi Xie^###, Zhichao Sun^****, Huanhai Xu^††††, Xia Wu^‡‡‡‡, Tingyang Hu^§§§§, Jing Huang^¶¶¶¶, Hongjie Hu^‡‡‡‡, Jiaping Zheng^####, Jun Luo^####, Yutang Chen^####, Wenqiang Yu^§§§§, Guoliang Shao^####

Oncology Research, Vol.28, No.3, pp. 249-271, 2020, DOI:10.3727/096504019X15766663541105

Abstract This study aimed to investigate the efficacy, safety, and prognostic factors of drug-eluting beads transarterial chemoembolization (DEB-TACE) in treating Chinese patients with liver cancer. A total of 367 liver cancer patients from 24 medical centers were consecutively enrolled in this multiple-center, prospective cohort study, including 275 hepatocellular carcinoma (HCC) cases, 37 intrahepatic cholangiocarcinoma (ICC) cases, and 55 secondary liver cancer cases. All the patients received CalliSpheres^® DEB-TACE treatment. Treatment response, overall survival (OS), change of liver function, and adverse events (AEs) were assessed. DEB-TACE treatment achieved 19.9% complete response (CR) and 79.6% objective response rate (ORR), with mean OS of… More >