Yasmeen Al-Saeed^1,2, Wael A. Gab-Allah¹, Hassan Soliman¹, Maysoon F. Abulkhair³, Wafaa M. Shalash⁴, Mohammed Elmogy^1,*

CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 4871-4894, 2022, DOI:10.32604/cmc.2022.023638

Abstract One of the leading causes of mortality worldwide is liver cancer. The earlier the detection of hepatic tumors, the lower the mortality rate. This paper introduces a computer-aided diagnosis system to extract hepatic tumors from computed tomography scans and classify them into malignant or benign tumors. Segmenting hepatic tumors from computed tomography scans is considered a challenging task due to the fuzziness in the liver pixel range, intensity values overlap between the liver and neighboring organs, high noise from computed tomography scanner, and large variance in tumors shapes. The proposed method consists of three main stages; liver segmentation using Fast… More >

AMANDA BARACHO TRINDADE HILL^1,2,*, JONATHAN EDWIN BARACHO TRINDADE HILL²

BIOCELL, Vol.46, No.5, pp. 1173-1176, 2022, DOI:10.32604/biocell.2022.018637

Abstract Mesenchymal stem cells (MSCs) represent an important tool in veterinary regenerative medicine due to their ability to home to injury sites and secrete molecules that regulate niches into regenerative microenvironments. Successful cell therapy depends on many factors, including choice of administration route and application of understanding of cell potency and their therapeutic mechanisms. In this point of view, the authors leverage the tumultuous history of the field to demonstrate the need for clinicians to continually update themselves as new discoveries are made in order to avoid misalignments in the future, especially regarding administration routes and dose frequency, as well as… More >

Mengdan Ma^1,2, Yuchen Liu^1,*, Weiren Huang^1,*

Oncologie, Vol.23, No.4, pp. 463-492, 2021, DOI:10.32604/oncologie.2022.019415

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas system, which is an RNA-guided nuclease system, plays an important role in the adaptive immune response of bacteria, and it is a rapidly developing gene editing technology. It has been widely used in a variety of cells, microorganisms, plants, and animals. This technique has helped to overcome the limitations of previous gene editing methods, and it has promoted the development of synthetic biology, genetics, and proteomics. The ability of the CRISPR-Cas system to modify the genetic components of a system has led to various practical applications, such as base editing, transcription regulation,… More >

Zhengyi Li^1,2,3, Lihua Qiu^1,2,3,*

Oncologie, Vol.23, No.4, pp. 515-531, 2021, DOI:10.32604/oncologie.2021.019856

Abstract Improving the effectiveness of cancer treatment has become a central concern for the public. In recent years, in order to maximize the efficiency of cancer treatment, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have received widespread attention. Chlorin e6 (Ce6) is a fluorescent dye with strong optical properties and excellent photoconversion efficiency under near-infrared light irradiation, which has been widely used in PDT in recent decades due to its superior antitumor ability. Of note, Ce6 can be used as a sonosensitizer for SDT, which generates large amounts of reactive oxygen species (ROS) for tumor treatment after ultrasound activation. These strategies… More >

KENJI TSUJI^*, SHINJI KITAMURA, JUN WADA

BIOCELL, Vol.46, No.4, pp. 899-902, 2022, DOI:10.32604/biocell.2022.018594

Abstract Mesenchymal stem cells (MSCs) have abilities to mediate tissue protection through mechanisms of anti-apoptosis, anti-oxidative stress and anti-fibrosis as well as tissue regeneration through mechanisms of cell proliferation, differentiation and angiogenesis. These effects by MSCs are mediated by a variety of factors, including growth factors, cytokines and extracellular vesicles (EVs). Among these factors, EVs, containing proteins, mRNA and microRNAs (miRNA), may carry their contents into distant tissues with high stability. Therefore, the treatment with MSC-derived EVs may be promising as ‘natural’ drug delivery systems (DDS). Especially, the treatment of MSC-derived EVs with the manipulation of specific miRNAs expression has been… More >

MENGTING LI^*, YI-ER QIU, KAIFENG ZHENG

BIOCELL, Vol.46, No.4, pp. 1089-1096, 2022, DOI:10.32604/biocell.2022.013432

Abstract The effect of the baicalin, a bio-active flavonoid extracted from Scutellaria baicalensis Georgi, on the carbon tetrachloride (CCl₄) induced liver fibrosis was investigated. To compare the effect of baicalin on the liver fibrosis, five different groups of rats treated by 100, 200, and 400 mg/kg baicalin were studied. Upon CCl₄ treatment, the levels of procollagen type III, aspartate aminotransferase, aminotransferase, hyaluronic acid, and hydroxyproline were significantly increased, whereas the superoxide dismutase and glutathione peroxidase content were decreased. These changes in the biochemical parameters, which are associated with liver function, were significantly attenuated by the baicalin treatment, suggesting that baicalin can… More >

Muhammad Zafar^1,#,*, Muhammad Saif Ullah^1,#, Tareq Manzoor², Muddassir Ali³, Kashif Nazar⁴, Shaukat Iqbal⁵, Habib Ullah Manzoor⁶, Rizwan Haider¹, Woo Young Kim^7,*

CMES-Computer Modeling in Engineering & Sciences, Vol.130, No.2, pp. 723-749, 2022, DOI:10.32604/cmes.2022.017257

Abstract In recent years, the emergence of nanotechnology experienced incredible development in the field of medical sciences. During the past decade, investigating the characteristics of nanoparticles during fluid flow has been one of the intriguing issues. Nanoparticle distribution and uniformity have emerged as substantial criteria in both medical and engineering applications. Adverse effects of chemotherapy on healthy tissues are known to be a significant concern during cancer therapy. A novel treatment method of magnetic drug targeting (MDT) has emerged as a promising topical cancer treatment along with some attractive advantages of improving efficacy, fewer side effects, and reduce drug dose. During… More >

Ali Alkhalifah^*, Fadwa Alorini, Reef Alturki

Computer Systems Science and Engineering, Vol.42, No.1, pp. 49-67, 2022, DOI:10.32604/csse.2022.021326

Abstract The revolution of technology and the rapid evolution of the digital world had a significant effect on the development and expansion of e-commerce. Last mile delivery, for which different app-based delivery services have recently emerged, is a new area of research that is not thoroughly addressed. Delivery service is one of the supporting platforms of e-commerce. One of the delivery issues is that many customers experience difficulties in communicating and coordinating with the logistics companies responsible for the delivery service. This challenge is emphasized in this study which introduces a new system to facilitate communication and coordination between customers and… More >

Baili Zhang¹, Keke Ling^1,*, Pei Zhang^2,3, Zhao Zhang^2,3, Mingjun Zhong⁴

Computer Systems Science and Engineering, Vol.41, No.2, pp. 699-715, 2022, DOI:10.32604/csse.2022.020193

Abstract Calculating the most reliable maximum flow (MRMF) from the edge cache node to the requesting node can provide an important reference for selecting the best edge cache node in a content delivery network (CDN). However, SDBA, as the current state-of-the-art MRMF algorithm, is too complex to meet real-time computing needs. This paper proposes a set of MRMF algorithms: NWCD (Negative Weight Community Deletion), SCPDAT (Single-Cycle Preference Deletion Approximation algorithm with Time constraint) and SCPDAP (Single-Cycle Preference Deletion Approximation algorithm with Probability constraint). NWCD draws on the “flow-shifting” algorithm of minimum cost and maximum flow, and further defines the concept of… More >

FUJI YANG¹, YAN HUANG¹, YOUWEN TAN^2,*, YONGMIN YAN^1,*

BIOCELL, Vol.46, No.2, pp. 389-400, 2022, DOI:10.32604/biocell.2021.015899

Abstract Nonalcoholic fatty liver disease (NAFLD) is a long-lasting condition that affects the liver, destroying its function. Liver injury can cause steatosis and inflammation, and further activation of hepatic stellate cells (HSCs) often leads to the development of nonalcoholic liver fibrosis. The patient with NAFLD is at risk of developing advanced liver disease and complications, such as liver failure, hepatocellular carcinoma (HCC), and portal hypertension. Although our understanding of the cellular and molecular mechanisms of NAFLD has greatly improved in recent years, treatment remains limited. Analysis and characterization of protein posttranslational modifications (PTMs) could improve our understanding of NAFLD pathology and… More >