AASTHA MITTAL¹, NEELAM MAHALA¹, KOWTHAVARAPU VENKATA KRISHNA², UMA S. DUBEY^1,*, SUNIL KUMAR DUBEY^2,3,*

BIOCELL, Vol.46, No.1, pp. 127-136, 2022, DOI:10.32604/biocell.2021.015932

Abstract Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles as a drug delivery system. Camel milk casein is not only biocompatible on oral administration but is actually a dietary protein of pharmaceutical relevance. Casein is used because of its amphiphilic nature, self-assembling property, ability to show sustained release, and capability of encapsulating both hydrophilic and hydrophobic drugs. In this study, camel milk casein nanoparticles loaded with sorafenib were developed and characterized. Characterization of casein nanoparticles was done by dynamic… More >

Mehdi Hassan^1,*, Safdar Ali², Muhammad Sanaullah³, Khuram Shahzad⁴, Sadaf Mushtaq^5,6, Rashda Abbasi⁶, Zulqurnain Ali⁴, Hani Alquhayz⁷

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 2743-2760, 2022, DOI:10.32604/cmc.2022.020055

Abstract Cancer is the second deadliest human disease worldwide with high mortality rate. Rehabilitation and treatment of this disease requires precise and automatic assessment of effective drug response and control system. Prediction of treated and untreated cancerous cell line is one of the most challenging problems for precise and targeted drug delivery and response. A novel approach is proposed for prediction of drug treated and untreated cancer cell line automatically by employing modified Deep neural networks. Human hepatocellular carcinoma (HepG2) cells are exposed to anticancer drug functionalized CFO@BTO nanoparticles developed by our lab. Prediction models are developed by modifying ResNet101 and… More >

K. Venkatachalam¹, P. Prabu², B. Saravana Balaji³, Byeong-Gwon Kang⁴, Yunyoung Nam^4,*, Mohamed Abouhawwash^5,6

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 3685-3700, 2022, DOI:10.32604/cmc.2022.019502

Abstract Ad hoc mobile cloud computing networks are affected by various issues, like delay, energy consumption, flexibility, infrastructure, network lifetime, security, stability, data transition, and link accomplishment. Given the issues above, route failure is prevalent in ad hoc mobile cloud computing networks, which increases energy consumption and delay and reduces stability. These issues may affect several interconnected nodes in an ad hoc mobile cloud computing network. To address these weaknesses, which raise many concerns about privacy and security, this study formulated clustering-based storage and search optimization approaches using cross-layer analysis. The proposed approaches were formed by cross-layer analysis based on intrusion… More >

Manoj Sindhwani¹, Charanjeet Singh^1,*, Rajeshwar Singh²

Computer Systems Science and Engineering, Vol.40, No.2, pp. 455-467, 2022, DOI:10.32604/csse.2022.018498

Abstract With the growth of Vehicular Ad-hoc Networks, many services delivery is gaining more attention from the intelligent transportation system. However, mobility characteristics of vehicular networks cause frequent disconnection of routes, especially during the delivery of data. In both developed and developing countries, a lot of time is consumed due to traffic congestion. This has significant negative consequences, including driver stress due to increased time demand, decreased productivity for various personalized and commercial vehicles, and increased emissions of hazardous gases especially air polluting gases are impacting public health in highly populated areas. Clustering is one of the most powerful strategies for… More >

R. Kanthavel^1,*, R. Dhaya²

Intelligent Automation & Soft Computing, Vol.31, No.1, pp. 649-659, 2022, DOI:10.32604/iasc.2022.019779

Abstract Wireless Underground Sensor Networks (WUSNs) refer to a group of nodes working underneath the earth plane that has been predicted to render concurrent observation capability in the hostile subversive and underwater surroundings. The accurate monitoring in places like underground earth, water, lubricates so on called non-conventional media need high accuracy of tiny sized sensors with antennas at a similar size. Therefore, an investigation is needed to study the opportunities and drawbacks of utilizing WUSNs without compromising the effectiveness of real-time monitoring procedures. With this, the major confrontation is to institute a trustworthy underground communication regardless of the complex environment that… More >

P. Naga Srinivasu¹, Shakeel Ahmed^2,*, Abdulaziz Alhumam², Akash Bhoi Kumar³, Muhammad Fazal Ijaz⁴

CMC-Computers, Materials & Continua, Vol.69, No.3, pp. 3303-3319, 2021, DOI:10.32604/cmc.2021.018472

Abstract In the digestion of amino acids, carbohydrates, and lipids, as well as protein synthesis from the consumed food, the liver has many diverse responsibilities and functions that are to be performed. Liver disease may impact the hormonal and nutritional balance in the human body. The earlier diagnosis of such critical conditions may help to treat the patient effectively. A computationally efficient AW-HARIS algorithm is used in this paper to perform automated segmentation of CT scan images to identify abnormalities in the human liver. The proposed approach can recognize the abnormalities with better accuracy without training, unlike in supervisory procedures requiring… More >

Mounita Ghosh¹, Md. Mohsin Sarker Raihan¹, M. Raihan², Laboni Akter¹, Anupam Kumar Bairagi³, Sultan S. Alshamrani⁴, Mehedi Masud^5,*

Intelligent Automation & Soft Computing, Vol.30, No.3, pp. 917-928, 2021, DOI:10.32604/iasc.2021.017989

Abstract The liver is considered an essential organ in the human body. Liver disorders have risen globally at an unprecedented pace due to unhealthy lifestyles and excessive alcohol consumption. Chronic liver disease is one of the principal causes of death affecting large portions of the global population. An accumulation of liver-damaging factors deteriorates this condition. Obesity, an undiagnosed hepatitis infection, alcohol abuse, coughing or vomiting blood, kidney or hepatic failure, jaundice, liver encephalopathy, and many more disorders are responsible for it. Thus, immediate intervention is needed to diagnose the ailment before it is too late. Therefore, this work aims to evaluate… More >

Aihong Yu¹, Zhe Liu^1,*, Victor S. Sheng², Yuqing Song¹, Xuesheng Liu³, Chongya Ma⁴, Wenqiang Wang¹, Cong Ma¹

Intelligent Automation & Soft Computing, Vol.30, No.2, pp. 589-599, 2021, DOI:10.32604/iasc.2021.019513

Abstract Liver cancer is one of frequent causes of death from malignancy in the world. Owing to the outstanding advantages of computer-aided diagnosis and deep learning, fully automatic segmentation of computed tomography (CT) images turned into a research hotspot over the years. The liver has quite low contrast with the surrounding tissues, together with its lesion areas are thoroughly complex. To deal with these problems, we proposed effective methods for enhancing features and processed public datasets from Liver Tumor Segmentation Challenge (LITS) for the verification. In this experiment, data pre-processing based on the image enhancement and noise reduction. This study redesigned… More >

Osama S. Faragallah^1,*, Abdullah N. Muhammed², Taha S. Taha³, Gamal G. N. Geweid^4,5

Intelligent Automation & Soft Computing, Vol.30, No.1, pp. 215-225, 2021, DOI:10.32604/iasc.2021.019058

Abstract Medical image fusion is designed to help physicians in their decisions by providing them with a preclinical image with enough information. Accurate assessment and effective treatment of the disease reduce the time it takes to relieve the symptoms of the disease. This article utilizes an effective data fusion approach to work on two different imaging modalities; computed tomography (CT) and magnetic resonance imaging (MRI). The data fusion approach is based on the combination of singular value decomposition (SVD) and the Fast Discrete Curvelet Transform (FDCT) techniques to reduce processing time during the fusion process. The SVD-FDCT data fusion approach is… More >

Salome Kiparoidze^1,*, Nino Karumidze², Ekaterine Bakuradze¹, Irina Modebadze¹, Levan Rusishvili¹, Dimitri Kordzaia², Diana Dzidziguri¹

Molecular & Cellular Biomechanics, Vol.18, No.3, pp. 131-138, 2021, DOI:10.32604/mcb.2021.015596

Abstract According to the literature, different mechanisms and kinetics proceeding of regenerative growth has been established using the basic models of liver regeneration (after resection or chemically induced). Hence, in order to determine general regularities of the adaptive-compensatory processes in various pathological conditions, the processes taking place in the cholestatic liver of adult white rats during the first four days after common bile duct ligation have been studied. It has been shown that in cholestatic liver, compensatory-adaptive processes take place with different kinetics compared to those after resection. In particular, in response to the increased functional load caused by destructive processes… More >