Francisco Raúl Borzone^1,2,*, María Belén Giorello¹, Agustina Freire³, Leandro Marcelo Martinez⁴, Leonardo Feldman⁵, Federico Dimase⁶, Pablo Evelson³, Irene Larripa⁷, Emilio Batagelj⁸, Marcela Beatriz González Cid⁹, Norma Alejandra Chasseing^1,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074321 - 23 March 2026

Abstract Backgrounds: Breast cancer metastasis remains the leading cause of mortality and frequently targets the bone. Breast cancer cells release soluble factors and extracellular vesicles that disrupt bone marrow (BM)/bone homeostasis, promoting osteoclastogenesis and the accumulation of senescent cells. In line with updated cancer hallmarks, senescent mesenchymal stem/ stromal cells (MSCs), osteoblasts, and osteocytes contribute to remodeling of the BM microenvironment, thereby favoring pre-metastatic niche (PMN) formation and subsequent bone metastasis. We previously demonstrated that untreated stage III-B breast cancer patients (BCPs) exhibit increased oxidative stress and elevated reactive oxygen species (ROS) levels, accompanied by senescent… More > Graphic Abstract

Candela Cives-Losada^1,2, Cristiana Soldani², Michela Anna Polidoro², Barbara Franceschini², Ana Lleo^3,4, Marcello Di Martino^1,5, Matteo Donadon^1,5,*

Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2025.074093 - 23 March 2026

Abstract Colorectal cancer (CRC) is the second deadliest cancer worldwide, being the presence of metastasis, mainly in the liver, a major contributor to high mortality rates in affected patients. The tumor microenvironment (TME)—comprised of interacting endothelial, stromal, and immune cells—plays a critical role in creating a supportive niche for tumor cell colonization and immune evasion and, thus, the establishment of metastases. The liver’s intrinsic nature further facilitates the development of immune tolerance, mediated by regulatory T cells, myeloid-derived suppressor cells, and soluble factors such as anti-inflammatory cytokines, which together dampen antitumor immune responses. This immunosuppressive milieu More > Graphic Abstract

Kursad Donmez^1,*, Enis Mert Yorulmaz², Enes Candemir², Serkan Ozcan², Osman Kose², Sacit Nuri Gorgel², Yigit Akin²

Canadian Journal of Urology, Vol.33, No.1, pp. 211-219, 2026, DOI:10.32604/cju.2025.068294 - 28 February 2026

Abstract Background: Urologic cancers typically metastasize to common organs, while spread to sites such as the heart, hand, cranial bones, penis, or tonsil is exceedingly rare. The clinical relevance and prognostic impact of these unusual metastases remain unclear. This case series highlights six exceptional cases, providing unique insights to support awareness and management. Case Description: We retrospectively analyzed six cases of patients diagnosed with urologic cancers who developed metastases at uncommon sites. Each case was evaluated based on clinical presentation, imaging findings, histopathological confirmation, treatment course, and outcomes. Relevant literature was reviewed to contextualize findings. Among the… More >

Bo Yin^1,#, Xingyu Long^2,#, Zhi Wang¹, Feng Ning¹, Kan Wang², Jun He^1,*

Canadian Journal of Urology, Vol.33, No.1, pp. 201-210, 2026, DOI:10.32604/cju.2025.067189 - 28 February 2026

Abstract Background: Clear cell sarcoma of the kidney (CCSK) is a rare and highly aggressive pediatric renal malignancy with a marked propensity for metastatic spread. Cases of CCSK associated with inferior vena cava (IVC) tumor thrombus (IVCTT) are exceptionally uncommon in the literature. We report a case of CCSK with IVCTT in a 15-month-old male infant. Case Description: We reported a case admitted in May 2020 for a 3-day history of fever and hematuria. Abdominal CT revealed an unevenly enhanced mass and low-density shadows within the IVC. The diagnosis of CCSK was confirmed via needle biopsy. The… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.080056 - 24 February 2026

Abstract This article has no abstract. More >

Frank Traub^1,#, Muhammad A. Panezai^1,#, Michaela Moisch¹, Julia Melke¹, Leonard Schöbel¹, Tilmann Busse¹, Fei Xing², Jiachen Sun², Ulrike Ritz^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.071919 - 24 February 2026

Abstract Objectives: Photodynamic therapy (PDT) is a minimally invasive method used in the treatment of various cancers and skin diseases, but it is not widely used in bone cancer, where the current therapy is often not effective and accompanied by side effects. Alternative and more effective therapies like PDT are needed. In this in-vitro study, the effect of the photosensitizer (PS) chlorin e6 (Ce6) on cancerous bone tumor cells using PDT was examined. Methods: A total of 27 tissue specimens from patients with primary bone cancers or bone metastases of different origins were genetically characterized and treated… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.078459 - 19 January 2026

Abstract This article has no abstract. More >

Huan Zhang^1,#, Zhangwendi Xu^1,#, Yien Xu^1,#, Mao Li², Lingrui Liu¹, Caiyun He^1,*, Wenhuan Zhong^1,*, Jiliang Qiu^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.073079 - 19 January 2026

Abstract Objective: Ring finger protein 145 (RNF145), an E3 ubiquitin ligase, is significantly upregulated in hepatocellular carcinoma (HCC). However, its role in HCC remains unknown. The study aimed to investigate the functions and underlying mechanisms of RNF145 in HCC. Methods: The role of RNF145 in HCC was investigated using data from The Cancer Genome Atlas (TCGA) and in vitro experimental assays. Its oncogenic functions were assessed using the transwell migration assay and the wound-healing assay. The molecular mechanism was explored through protein immunoprecipitation and western blot analyses. Data from public databases were analyzed to correlate RNF145 expression… More >

Jiayu Zou^1,2,3, Yajie Lu³, Jiaqi Li³, Zhaokai Zhou^4,5, Fu Peng³, Pu Qiu^2,*, Hailin Tang⁶, Cheng Peng^1,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071940 - 19 January 2026

Abstract Lung cancer is the most common but fatal malignant tumor worldwide. Patients with lung cancer experienced a relatively low 5-year overall survival rate, and issues such as metastasis and drug resistance remain prominent challenges in its clinical management. Neddylation, a novel type of post-translational modification, was overactivated in lung cancer and was closely associated with its occurrence, development, metastasis, and drug resistance. This review systematically summarizes the biological process of neddylation and deeply explores the latest research progress on how neddylation affects lung cancer cell proliferation, metastasis, and drug resistance mechanisms, with a focus on More >

Min Hee Kim¹, Boyoon Huh¹, Joo-Won Park^1,*, Woo-Jae Park^2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071523 - 19 January 2026

Abstract Breast cancer is one of the most prevalent malignancies among women and comprises a heterogeneous spectrum of molecular subtypes with distinct biological behaviors. Among various regulatory molecules, sphingolipids play pivotal roles in dynamically modulating fundamental cellular processes such as proliferation, apoptosis, and metastasis through metabolic interconversions, including phosphorylation, glycosylation, and the generation of sphingosine-1-phosphate. This review aims to elucidate the mechanisms through which sphingolipid metabolism orchestrates cancer cell fate and drives breast cancer progression. Particular emphasis is placed on the balance between proapoptotic ceramides and pro-survival metabolites, such as sphingosine-1-phosphate, which collectively influence tumor growth More >