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Search Results (118)
  • Open Access

    ARTICLE

    The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway

    SHUIZHONG CEN1,#, XIAOJIE PENG2,#, JIANWEN DENG3,#, HAIYUN JIN4, ZHINAN DENG5, XIAOHUA LIN3, DI ZHU3, MING JIN6, YANWEN ZHU3, PUSHENG ZHANG3, YUNFENG LUO3, HONGYAN HUANG3,*

    Oncology Research, Vol.31, No.3, pp. 375-388, 2023, DOI:10.32604/or.2023.028256 - 22 May 2023

    Abstract Triple-negative breast cancer (TNBC) is characterized by fast growth, high metastasis, high invasion, and a lack of therapeutic targets. Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression. It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors, but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown. In this study, we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1 (PLK1) activation and participating in mitosis of TNBC cells. We detected the expression of AFAP1-AS1 in the TNBC… More > Graphic Abstract

    The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway

  • Open Access

    ARTICLE

    Senescent mesenchymal stem/stromal cells in pre-metastatic bone marrow of untreated advanced breast cancer patients

    FRANCISCO RAÚL BORZONE1,*, MARÍA BELÉN GIORELLO1, LEANDRO MARCELO MARTINEZ2, MARÍA CECILIA SANMARTIN1,3, LEONARDO FELDMAN4, FEDERICO DIMASE5, EMILIO BATAGELJ6, GUSTAVO YANNARELLI3, NORMA ALEJANDRA CHASSEING1,*

    Oncology Research, Vol.31, No.3, pp. 361-374, 2023, DOI:10.32604/or.2023.028104 - 22 May 2023

    Abstract Breast cancer is the predominant form of carcinoma among women worldwide, with 70% of advanced patients developing bone metastases, with a high mortality rate. In this sense, the bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are critical for BM/bone homeostasis, and failures in their functionality, transform the BM into a pre-metastatic niche (PMN). We previously found that BM-MSCs from advanced breast cancer patients (BCPs, infiltrative ductal carcinoma, stage III-B) have an abnormal profile. This work aims to study some of the metabolic and molecular mechanisms underlying MSCs shift from a normal to an abnormal profile… More >

  • Open Access

    REVIEW

    The role of LIN28B in tumor progression and metastasis in solid tumor entities

    TABEA GEWALT1,2, KA-WON NOH3, LYDIA MEDER1,2,4,*

    Oncology Research, Vol.31, No.2, pp. 101-115, 2023, DOI:10.32604/or.2023.028105 - 10 April 2023

    Abstract LIN28B is an RNA-binding protein that targets a broad range of microRNAs and modulates their maturation and activity. Under normal conditions, LIN28B is exclusively expressed in embryogenic stem cells, blocking differentiation and promoting proliferation. In addition, it can play a role in epithelial-to-mesenchymal transition by repressing the biogenesis of let-7 microRNAs. In malignancies, LIN28B is frequently overexpressed, which is associated with increased tumor aggressiveness and metastatic properties. In this review, we discuss the molecular mechanisms of LIN28B in promoting tumor progression and metastasis in solid tumor entities and its potential use as a clinical therapeutic More >

  • Open Access

    ARTICLE

    Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

    XUELIANG WU1,#, SHAOYU GUAN2,#, YONGGANG LU3, JUN XUE4, XIANGYANG YU1, QI ZHANG5,*, XIMO WANG1,5,*, TIAN LI6

    Oncology Research, Vol.31, No.2, pp. 125-139, 2023, DOI:10.32604/or.2023.028657 - 10 April 2023

    Abstract This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase (SHP- 2) on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2 (Tie2)-expressing monocyte/macrophages (TEMs) and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) (Ang/Tie2-PI3K/Akt/mTOR) signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment. In vivo, SHP-2- deficient mice were used to construct colorectal cancer (CRC) liver metastasis models. SHP-2-deficient mice had significantly more metastatic cancer and inhibited nodules on the liver surface than wild-type mice, and the high-level expression… More > Graphic Abstract

    Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

  • Open Access

    VIEWPOINT

    Galectins dysregulation: A way for cancer cells to invade and pervade

    MAHMOUD M. ABDELFATTAH1, REHAM HELWA1,2,*

    Oncology Research, Vol.30, No.3, pp. 129-135, 2022, DOI:10.32604/or.2022.026838 - 12 January 2023

    Abstract Galectins are sticky molecules that bind to β-galactoside. Their interactions render them essential players in many cellular processes. The imbalance of galectin expression was reported in many diseases. In cancer, galectins interact with the extracellular matrix, evade the immune system, and potentially have broad interactions with blood components. In the last ten years, since 2010, we did focus on galectin research in different cancer types. Our findings showed an interaction between cancer cells and erythrocytes via galectin-4. Moreover, we found that upregulation of galectins was associated with lymph node metastasis in ovarian cancers. Hence, with More >

  • Open Access

    CASE REPORT

    Multiple Recurrence of Primary Orbital Synovial Sarcoma: Report of Two Cases and Literature Review

    Yi Wu, Yujiao Wang, Weimin He*

    Oncologie, Vol.24, No.4, pp. 927-935, 2022, DOI:10.32604/oncologie.2022.026720 - 31 December 2022

    Abstract Synovial sarcoma (SS) is typically an aggressive malignant soft tissue tumor that mostly affects adolescents and young adults. It is extremely rare in orbit and carries a high risk of recurrence and metastasis, posing a challenge to ophthalmologists in diagnosing and managing. We present two primary orbital synovial sarcoma cases with unilateral exophthalmos and limited motility. Both male patients underwent reoperation in our hospital since tumor recurrence; the pathologic diagnoses were biphasic type and occult type, respectively. Both cases were positive for EMA and CK, and SOX-9 and INI-1 were newly discovered immune markers. Fluorescence in More >

  • Open Access

    ARTICLE

    Integrative multiomics analysis identifies a metastasis-related gene signature and the potential oncogenic role of EZR in breast cancer

    GUODONG XIAO1,#, FENG CHENG1,#, JING YUAN1, WEIPING LU1, PEILI WANG2, HUIJIE FAN1,*

    Oncology Research, Vol.30, No.1, pp. 35-51, 2022, DOI:10.32604/or.2022.026616 - 06 December 2022

    Abstract Distant metastasis is a major cause of increased mortality in breast cancer patients, but the mechanisms underlying breast cancer metastasis remain poorly understood. In this study, we aimed to identify a metastasis-related gene (MRG) signature for predicting progression in breast cancer. By screening using three regression analysis methods, a 9-gene signature (NOTCH1, PTP4A3, MMP13, MACC1, EZR, NEDD9, PIK3CA, F2RL1 and CCR7) was constructed based on an MRG set in the BRCA cohort from TCGA. This signature exhibited strong robustness, and its generalizability was verified in the Metabric and GEO cohorts. Of the nine MRGs, EZR… More >

  • Open Access

    VIEWPOINT

    A Novel Biological Nano Confinement Inhibits Cancer Metastasis

    Sen Lu1,3, Zunqiang Zhao2,4, Zhongwei Lv2, Jianshe Yang2,3,*

    Oncologie, Vol.24, No.3, pp. 591-597, 2022, DOI:10.32604/oncologie.2022.025144 - 19 September 2022

    Abstract Cancer is a complex genetic disease hallmarked with a strong competitive capacity in energy and utilization of substances compared to normal cells, which is partially due to the ability to adjust their metabolism in response to environmental changes. During the lifespan of cancer cells, either during carcinogenesis, progress, or metastasis, massive energy and other substances are essential prerequisites, however, the underlying mechanisms are controversial and still remain unclear. Understanding how cancer cells seize much of the energy and other substances than normal cells is of utmost importance for next-generation cancer therapy, along with the finding… More >

  • Open Access

    CASE REPORT

    Gastric Cancer with Bone Marrow Invasion and Disseminated Intravascular Coagulation: A Case Report

    Lilan Chen, Lu Lu, Xinlei Gong, Yichen Xu, Xiaoyuan Chu*, Guichun Huang*

    Oncologie, Vol.24, No.3, pp. 599-604, 2022, DOI:10.32604/oncologie.2022.023310 - 19 September 2022

    Abstract Gastric cancer is the fifth most commonly diagnosed cancer and the fourth leading cause of cancer death worldwide in 2020. Gastric cancer usually undergoes lymph node metastasis and implantation metastasis, but bone metastasis and bone marrow invasion are rare. However, gastric cancer patients with bone marrow invasion usually have cancer emergency, so special attention should be paid in clinical practice. Herein, we analyzed the clinical characteristics of an asian gastric cancer patient with bone marrow invasion and disseminated intravascular coagulation (DIC) in our hospital and summarized the diagnosis and treatment experience to provide a reference More >

  • Open Access

    ARTICLE

    Paclitaxel Combined with Ticagrelor Inhibits B16F10 and Lewis Lung Carcinoma Cell Metastasis

    Xingjun Meng1,#, Zhihui Cao2,#, Renfeng Liu3,#, Kai Zheng4, Shuai Ding5, Yuefan Gu4, Yonghua Chen6, Jun Lv7, Ping Li8, Li Zhou9, Wenbo Wang10, Shiliang Ji11, Hui He12,*, Hui Yang9,*

    Oncologie, Vol.24, No.2, pp. 283-294, 2022, DOI:10.32604/oncologie.2022.021259 - 29 June 2022

    Abstract It is widely accepted that tumor metastasis is the dominant factor leading to cancer-related death. Tumor metastasis is mediated by cell invasion, blood circulation and lymphatic circulation. Paclitaxel, as a common anti-tumor drug and a mitotic inhibitor, promotes microtubule assembly and inhibits microtubule depolymerization. In addition, ticagrelor, an anti-platelet drug, is used to treat acute coronary syndrome. Increasing numbers of studies have reported that platelets can facilitate tumor metastasis. Therefore, inhibiting the effects of platelets can serve as a novel therapeutic strategy for cancer. To explore the effect of anti-tumor and anti-platelet drugs on tumor More >

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