Sangho Kim^∗,†, Peng Kai Ong^*, Paul C. Johnson^‡

Molecular & Cellular Biomechanics, Vol.6, No.2, pp. 83-92, 2009, DOI:10.3970/mcb.2009.006.083

Abstract Recently, we reported that collision efficiency (fraction of total collisions that result in the formation of aggregates) between red blood cells was an important factor in the formation of aggregates in postcapillary venules. In the present study, we focus on how high molecular weight dextran influences the overall radial migration trend of red blood cells in the postcapillary venule along a longitudinal distance of 50 μm from the bifurcation which would in turn affect collision behavior of these cells. A radial migration index, which defines the extent of radial migration of individual cells relative to the vessel center, was found… More >

Judith Su^∗, Ricardo R. Brau^†, Xingyu Jiang^‡, George M. Whitesides^§, Matthew J. Lang^¶, Peter T. C. So^||

Molecular & Cellular Biomechanics, Vol.4, No.2, pp. 105-118, 2007, DOI:10.3970/mcb.2007.004.105

Abstract During migration, asymmetrically polarized cells achieve motion by coordinating the protrusion and retraction of their leading and trailing edges, respectively. Although it is well known that local changes in the dynamics of actin cytoskeleton remodeling drive these processes, neither the cytoskeletal rheological properties of these migrating cells are well quantified nor is it understand how these rheological properties are regulated by underlying molecular processes. In this report, we have used soft lithography to create morphologically polarized cells in order to examine rheological differences between the front and rear zone of an NIH 3T3 cell posed for migration. In addition, we… More >

Cheng Dong^1,2,3, Margaret J. Slattery^2,3, Shile Liang³, Hsin-Hsin Peng²

Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 145-160, 2005, DOI:10.3970/mcb.2005.002.145

Abstract Attachment of tumor cells to the endothelium (EC) under flow conditions is critical for the migration of tumor cells out of the vascular system to establish metastases. Innate immune system processes can potentially promote tumor progression through inflammation dependant mechanisms.\nobreakspace {} White blood cells, neutrophils (PMN) in particular, are being studied to better understand how the host immune system affects cancer cell adhesion and subsequent migration and metastasis. Melanoma cell interaction with the EC is distinct from PMN-EC adhesion in the circulation. We found PMN increased melanoma cell extravasation, which involved initial PMN tethering on the EC, subsequent PMN capture… More >

S.-C. Hsiao¹, M.S. Ingber²

CMC-Computers, Materials & Continua, Vol.1, No.1, pp. 51-58, 2004, DOI:10.3970/cmc.2004.001.051

Abstract The lateral migration of nonneutrally-buoyant spherical particles in Poiseuille flow is investigated numerically using the boundary element method. In particular, the steady, Navier-Stokes equations are solved using a classical domain integration method treating the nonlinear terms as pseudo-body forces. The numerical results for the lateral migration velocity are compared with experimental data. The numerical results indicate that the lateral migration velocity does not scale linearly with the Reynolds number. The methodology is extended to include non-Newtonian power-law fluids. The migration velocity is significantly affected for particles suspended in this class of fluids and can actually change direction for large values… More >

Seon Doo Jo¹, Chan Kyu Park², Jae Hong Jeong², Seung Hoon Lee², Seung Hee Kwon³

CMC-Computers, Materials & Continua, Vol.27, No.3, pp. 189-210, 2012, DOI:10.3970/cmc.2011.027.189

Abstract When concrete is being pumped, a lubricating layer forms at the interface of the inner concrete and the wall of the pipe. The lubricating layer is one of the most dominant factors in determining the pumping capability, yet no study has endeavored to quantitatively estimate the thickness and rheological properties of the layer. Recently, there has been a growing demand for large-scale construction under extreme conditions, such as high-rise buildings and super-long span bridges. This demand has heightened the need for more accurate predictions of pumpability.
A possible mechanism that contributes to the formation of the lubricating layer is shear-induced… More >

W.H. Chen¹, H.C. Cheng^2,3, C.F. Yu^1,3

CMES-Computer Modeling in Engineering & Sciences, Vol.109-110, No.1, pp. 1-13, 2015, DOI:10.3970/cmes.2015.109.001

Abstract This study aims at exploring the interfacial adhesion strength between solder bump and four typical under bump metallurgies (UBMs), i.e., Cu/Ni, Cu/TiW, Cu/Ni/Cr and /Cu/V/Cr, at atomistic scale. The average bond length and interfacial adhesion stress of the Sn-3.5Ag/Cu/Ni, Sn-3.5Ag/Cu/TiW, Sn-3.5Ag/Cu/Ni/Cr and Sn-3.5Ag/Cu/V/Cr micro-bump interconnects are calculated through the firstprinciples density functional theory (DFT) calculation to estimate the interfacial adhesion strength between the solder bump and UBMs. In addition, by investigating the electric field effect on the average bond length and adhesive stress, the combination of solder bump and UBM with better interfacial adhesion strength and electromigration resistance ability can… More >

Wen-Hwa Chen^1,2, Ching-Feng Yu¹, Hsien-Chie Cheng^2,3

CMES-Computer Modeling in Engineering & Sciences, Vol.100, No.2, pp. 119-131, 2014, DOI:10.3970/cmes.2014.100.119

Abstract The aim of the study is to investigate the interactions between Sn adatoms in a solder bump and three typical Sn-based intermetallic compounds (IMCs) surface, i.e., Cu₃Sn, Cu₆Sn₅, and Ni₃Sn₄, at the atomistic scale. The adsorption energy, average bond length, and bond population of the Sn/Cu₃Sn, Sn/Cu₆Sn₅,and Sn/Ni₃Sn₄ systems are calculated through the first-principles density functional theory (DFT) calculation to investigate how the Sn adatoms influence the IMC surface. The calculated results show that the Sn atoms on the Cu₃Sn (0 0 1) surface hold the largest adsorption energy, average bond length and bond population, implying that the Cu₃Sn (0… More >

Banghua Yao^1,2, Jianping Wei¹, Dengke Wang¹, Dan Ma^2,3, Zhanqing Chen²

CMES-Computer Modeling in Engineering & Sciences, Vol.91, No.2, pp. 81-100, 2013, DOI:10.3970/cmes.2013.091.081

Abstract Presently, there is an increasing number of water outburst accidents in China as mining activity continues to develop to deeper ground. In these accidents, water outburst caused by karst collapse columns often results in serious damage, involving both the loss of lives and significant economic loss. Therefore, it is of utmost importance to study the seepage property and water outburst mechanism of karst collapse columns. In this paper, based on the seepage theory and the groundwater dynamic theory of porous media, a fluid-solid coupling model for karst collapse columns was built and then imported into COMSOL Multiphysics to be solved,… More >

A. Sellier¹

CMES-Computer Modeling in Engineering & Sciences, Vol.21, No.2, pp. 105-132, 2007, DOI:10.3970/cmes.2007.021.105

Abstract We examine the low-Reynolds-number migration of a conducting and arbitrarily-shaped solid particle freely immersed in a metal liquid of different conductivity when subject to uniform ambient electric and magnetic fields. The boundary formulation established elsewhere for an insulating particle is extended and the incurred particle's rigid-body motion is then obtained by determinating a very few surface quantities on the particle's surface. The behavior of either oblate or prolate conducting spheroids is analytically investigated and the poposed procedure for the challenging case of other non-trivial geometries is implemented and benchmarked against those solutions. The numerical implementation makes it possible to obtain… More >

T. Iwasaki¹ and H. Miura¹

CMES-Computer Modeling in Engineering & Sciences, Vol.4, No.5, pp. 551-558, 2003, DOI:10.3970/cmes.2003.004.551

Abstract We have developed a molecular-dynamics technique for investigating migration-induced failures in interconnect films for ULSIs. This technique was used to simulate grain-boundary grooving in Al and Cu films. The simulations showed that the grain-boundary grooves are formed by atomic diffusion at the grain boundary. To clarify what kind of underlay material is effective in suppressing this diffusion, we calculated the dependence of groove depth on the kind of underlay material. The calculation showed that the groove depth of the Al film decreases in the order: Al/Ta, Al/W, and Al/TiN while that of the Cu film decreases in the order: Cu/TiN,… More >