G. Oldrini, P. Henrot, F. Marchal

Oncologie, Vol.21, No.1, pp. 17-21, 2019, DOI:10.3166/onco-2019-0033

Abstract Breast cancer is the first female cancer in France and its early detection is essential. Breast MRI is an element of choice in its diagnosis but it has high direct and indirect costs because of its duration which slows down its wider use. Given its elements, the use of an abbreviated protocol develops to overcome these disadvantages. Early literature data suggests that this faster examination also allows for a shorter interpretation time. In addition, the sensitivity and specificity of the examination are not inferior to that of the complete protocol. This article explains the new concept and its interest, compares… More >

Kunkun Wang^1,2, Xianda Liu^2,3,4,*

Journal on Artificial Intelligence, Vol.3, No.1, pp. 9-19, 2021, DOI:10.32604/jai.2021.016706

Abstract With the development of Internet technology, the computing power of data has increased, and the development of machine learning has become faster and faster. In the industrial production of industrial control systems, quality inspection and safety production of process products have always been our concern. Aiming at the low accuracy of anomaly detection in process data in industrial control system, this paper proposes an anomaly detection method based on stacking integration using the machine learning algorithm. Data are collected from the industrial site and processed by feature engineering. Principal component analysis (PCA) and integrated rule tree method are adopted to… More >

Elio Caruso¹, Silvia Farruggio^1,*, Davide Calvaruso¹, Corrado Di Mambro¹, David Angel Ortiz Ruiz¹, Salvatore Agati¹, Rafie Khoargami²

Congenital Heart Disease, Vol.16, No.4, pp. 417-425, 2021, DOI:10.32604/CHD.2021.015808

Abstract We show a brief report of two common arterial trunk cases (CAT) with different arrhythmias and discuss anatomy, clinical and diagnostic management. The burden of volume and pressure overload of this cardiac malformation may predispose to different types of arrhythmia before and after surgical repair. Because of labile hemodynamic state in this group of patients, prompt diagnosis of any arrhythmia is mandatory as the devastating factor on prognosis. The first patient with a diagnosis of CAT Type II Collett and Edwards (CE) had a particular history with HIV seropositive mother assuming antiretroviral therapy during pregnancy, who presented hyperbilirubinemia and liver… More >

Pierre-Guillaume Poureau^1,2,*, Jean-Philippe Metges²

Oncologie, Vol.23, No.1, pp. 47-59, 2021, DOI:10.32604/Oncologie.2021.15525

Abstract Immunotherapy for digestive cancers is booming and for the first time an immune checkpoint inhibitor has been granted marketing authorization for the treatment of digestive cancer. In order to better understand the mecanism of action of these treatments, their adverse events and the escape mecansim, it is necessary to know the fundamentals of cancer immunology. The innate and adaptive immune system allows the elimination of cancer cells by direct non-specific cytotoxicity (Natural Killer cells), by the development of an adaptive cell-mediated response (dendritic cells becoming antigen presenting cells, allowing the differentiation of lymphocytes naive in CD4 and CD8 T lymphocytes)… More >

R. Thamizhamuthu^*, D. Manjula

CMC-Computers, Materials & Continua, Vol.68, No.1, pp. 1147-1160, 2021, DOI:10.32604/cmc.2021.015503

Abstract The deadliest type of skin cancer is malignant melanoma. The diagnosis requires at the earliest to reduce the mortality rate. In this study, an efficient Skin Melanoma Classification (SMC) system is presented using dermoscopic images as a non-invasive procedure. The SMC system consists of four modules; segmentation, feature extraction, feature reduction and finally classification. In the first module, k-means clustering is applied to cluster the colour information of dermoscopic images. The second module extracts meaningful and useful descriptors based on the statistics of local property, parameters of Generalized Autoregressive Conditional Heteroscedasticity (GARCH) model of wavelet and spatial patterns by Dominant… More >

Xingran Kou^1,2, Qixuan Zhao², Wenwen Xu², Zuobing Xiao², Yunwei Niu², Kai Wang^3,*

Journal of Renewable Materials, Vol.9, No.7, pp. 1189-1211, 2021, DOI:10.32604/jrm.2021.015268

Abstract Several important drugs and nutritional supplements are limited by their lack of bioavailability. Nanomaterials display unique beneficial properties that might help improve the bioavailability of drugs and nutritional supplements. Unfortunately, nanomaterials produced from synthetic polymers and metals may have similar difficulties with bioavailability and toxicity. Naturally occurring biopolymers are biodegradable and non-toxic and are adaptable to the synthesis of nanoparticles. Drugs and other substances can be encapsulated or embedded in such particles with an increase in bioavailability. The search for biodegradable nanomaterials is an active research field. This review summarizes the research on nanocrystalline cellulose, starch, lignin, and other biological… More >

BENJIANG QIAN¹, XIAOYAN YING², GUANG YANG¹, HUIZHANG LI³, JIANMING TAN^1,*

BIOCELL, Vol.45, No.3, pp. 577-588, 2021, DOI:10.32604/biocell.2021.014972

Abstract This work aimed to discover new therapeutic targets in renal clear cell carcinoma by bioinformatics and detect the effect of candidate gene TRIP13 in renal cell carcinoma (RCC) cell proliferation, migration, and invasion. Differentially expressed mRNAs were screened based on The Cancer Genome Atlas (TCGA)-Kidney Renal Clear Cell Carcinoma (KIRC) databases, and functional enrichments, survival analysis, receiver operating characteristic curve (ROC), and Protein–Protein Interaction (PPI) protein interaction analysis were performed by R software to screen the candidate gene TRIP13. Then, the expression of candidate gene TRIP13 in 92 pairs of cancer and adjacent normal tissues of renal clear cell carcinoma… More >

MENGDAN WU¹, MENGYAO SUN¹, QINHUAI LAI¹, YIN LU¹, YUYIN FU¹, YUJIA PENG¹, WEIRONG LAI¹, LISHI ZENG¹, SHENGYAN ZHAO¹, YUYAN LI¹, ZHIXIONG ZHANG¹, XIAOFENG CHEN¹, FAN QIAO¹, YIWEN ZHANG^1,*, SHIJIE ZHOU^1,2,*, LANTU GOU¹, JINLIANG YANG^1,2

BIOCELL, Vol.45, No.3, pp. 589-597, 2021, DOI:10.32604/biocell.2021.013882

Abstract The chemokine ligand 13-chemokine receptor 5 (CXCL13-CXCR5) axis has been characterized as a critical tumor-promoting signaling pathway in the tumor microenvironment (TME) in multiple types of solid tumors. In this study, we analyzed the expression profile of CXCL13 in kidney clear cell carcinoma (KIRC) and its correlation with tumor-infiltrating immune cells (TIICs). A monoclonal antibody against CXCL13 with high affinity and purity was generated in our lab for western blot and immunohistochemistry (IHC). Bioinformatic analysis was performed based on bulk-seq data from the Cancer Genome Atlas (TCGA)-KIRC and single-cell RNA-seq data from scRNASeqDB and PanglaoDB. Results showed that high CXCL13… More >

LITING YOU^1,#, FEIFEI NA^2,#, JUAN ZHOU³, LIN JIAO³, YI ZHOU^3,*, BINWU YING^3,*

BIOCELL, Vol.45, No.3, pp. 649-663, 2021, DOI:10.32604/biocell.2021.013978

Abstract Reviews The Dectin-1 cluster comprises seven members: CLEC-12A, CLEC-12B, CLEC-1A, CLEC-7A, CLEC- 2, CLEC-9A and OLR1. These members have been demonstrated to be involved in the tumorigenesis, progression, and metastasis of several cancers. However, little is known about their roles in human lung adenocarcinoma (LUAD). The expression patterns of the Dectin-1 cluster were analyzed via the ONCOMINE and GEPIA databases. We evaluated the prognostic value of the Dectin-1 cluster in patients with LUAD using the Kaplan-Meier plotter and GEPIA. Differential expression was validated with the EMBL-EBI database, and protein expression was analyzed with the HPA database. In addition, protein-protein interaction… More >

RUCHI SHAH^1,*, SONALI VERMA¹, AMRITA BHAT¹, GH RASOOL BHAT¹, VARUN SHARMA¹, INDU SHARMA¹, HEMENDER SINGH¹, SANDEEP KAUL², EKTA RAI¹, SWARKAR SHARMA^1,*

BIOCELL, Vol.45, No.3, pp. 665-670, 2021, DOI:10.32604/biocell.2021.09629

Abstract Esophageal cancer is the second most common type of cancer after lung carcinoma in the state of Jammu and Kashmir (J&K). The understanding of genetics in Esophageal cancer development is poor in the state. Genome wide association studies (GWAS) has proved to be unsurpassed tool in identification of new loci associated with different cancers. GWAS in Chinese population has identified SNP rs2294693 present in UNC5CL (UNC-5 Family C-Terminal like) to be associated with non-cardia gastric cancer. We performed a case control association study and genotyped the SNP rs2294693 using Taqman allele discrimination assay in 566 individuals (166 esophageal cancer patients… More >