Peng Wang, Haiyang Zhang, Zilian Cui, Xunbo Jin^*, Dong Zhang^*

Oncologie, Vol.23, No.2, pp. 259-268, 2021, DOI:10.32604/Oncologie.2021.015503

Abstract Urothelial carcinoma of bladder (UCB) is a common urological malignancy in the world, but its progression mechanism remains unclear. MiR-612 was found as an anti-tumor factor in multiple types of cancer, while few studies have revealed its functions in UCB cells. Based on this, UCB cells such as HTB-9 and HTB-4, and normal urothelial of bladder cells such as SV-Huc1, were used as subjects in this study. Western blot, qRTPCR, CCK-8 assay and transwell assay were used to assess functions of miR-612 in UCB cells. The database, miRWalk, was used to search for potential targets of miR-612, and dual-luciferase reporter… More >

Xiaofan Deng^1,2, Yamei Yang^2,3, Xianfeng Gan^2,3, Gang Wu^2,3,*

Oncologie, Vol.23, No.2, pp. 251-258, 2021, DOI:10.32604/Oncologie.2021.016900

Abstract microRNA-422a (miR-422a) is downregulated in many hematopoietic tumors and solid tumors including hepatocellular carcinoma. We previously demonstrated that hepatitis B virus X protein (HBx) downregulated expression of miR-422a in HCC cell line HepG2 in vitro. However, we explore the mechanisms underlying this action. Forkhead box proteins (FOX) G1/Q1/E1 are known to negatively regulate miR-422a expression, and this prompted us to determine whether HBx suppresses miR-422a expression via activation of FOXG1/Q1/E1. The relationship between FOXG1/Q1/E1 and miR-422a in HepG2 cells stably expressing HBx was assessed with qRT-PCR. The correlation between HBx and FOXG1/Q1/E1 was determined with qRT-PCR and western blot in… More >

Yu Xiao¹, Peng Zhou², Yizi Zheng¹, Chang Zheng¹, Guowen Liu¹, Weixiang Liu^3,*

Oncologie, Vol.23, No.2, pp. 219-228, 2021, DOI:10.32604/Oncologie.2021.016480

Abstract The elevation for lateral lymph node metastasis (LLNM) plays an important role in therapeutic decision-making for thyroid carcinoma. A reliable forecasting model for LLNM in patients with papillary thyroid micro-carcinoma (PTMC) is needed, using clinicopathological characteristics. A total of 576 PTMC patients with suspicious lateral cervical lymph node (II, III, IV or V region) metastasis and known clinicopathological variables were randomly collected at Shenzhen Second People’s Hospital. Cervical lymph node status of every patient was assessed by ultrasonography (US). The patients in this cohort study underwent thyroidectomy and lateral neck lymph node dissection. Univariate analysis and logistic regression analysis were… More >

Mohammed Abd-Elnaby^*

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 521-537, 2021, DOI:10.32604/cmc.2021.018351

Abstract Non-orthogonal multiple access (NOMA) is one of the leading technologies for 5G communication. User pairing (UP) and power allocation (PA) are the key controlling mechanisms for the optimization of the performance of NOMA systems. This paper presents a novel UP and PA (UPPA) technique for capacity and fairness maximization in NOMA called (CFM-UPPA). The impact of the power allocation coefficient and the ratio between the channel gains of the paired users on the sum-rate capacity and the fairness in NOMA is firstly investigated. Then, based on this investigation, the PA and UP algorithms of the CFM-UPPA technique are proposed. The… More >

Mohit Kumar Sharma, Arun Kumar^*

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 1391-1406, 2021, DOI:10.32604/cmc.2021.017666

Abstract Non-orthogonal multiple access (NOMA) is gaining considerable attention due to its features, such as low out-of-band radiation, signal detection capability, high spectrum gain, fast data rate, and massive D2D connectivity. It may be considered for 5G networks. However, the high peak-to-average power ratio (PAPR) is viewed as a significant disadvantage of a NOMA waveform, and it weakens the quality of signals and the throughput of the scheme. In this article, we introduce a modified NOMA system by employing a block of wavelet transform, an alternative to FFT (Fast Fourier transform). The modified system combines the details of fractional frequency and… More >

Xiajiong Shen^1,3, Shuaimin Jiang^2,3, Lei Zhang^1,2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.3, pp. 1069-1085, 2021, DOI:10.32604/cmes.2021.015736

Abstract The emergence of smart contracts has increased the attention of industry and academia to blockchain technology, which is tamper-proofing, decentralized, autonomous, and enables decentralized applications to operate in untrustworthy environments. However, these features of this technology are also easily exploited by unscrupulous individuals, a typical example of which is the Ponzi scheme in Ethereum. The negative effect of unscrupulous individuals writing Ponzi scheme-type smart contracts in Ethereum and then using these contracts to scam large amounts of money has been significant. To solve this problem, we propose a detection model for detecting Ponzi schemes in smart contracts using bytecode. In… More >

ALFONSO BLÁZQUEZ-CASTRO^1,2,*, JUAN CARLOS STOCKERT^2,3

BIOCELL, Vol.45, No.4, pp. 849-862, 2021, DOI:10.32604/biocell.2021.015900

Abstract Melanins (eumelanin, pheomelanin, and allomelanin) represent a very, if not the most, important group of biological pigments. Their biological roles are multiple, from photoprotection to antioxidant activity, heavy metal disposal or the myriad uses of color in organisms across all Phyla. In the first part of this review, eumelanin biology and some chemical aspects will be presented, as well as key physico-chemical features that make this biological pigment so interesting. The principal characteristics of the melanocyte, the melanin-synthesizing cell in mammals, will also be introduced. Transformed melanocytes are the cause of one of the most devastating known cancers: the malignant… More >

XI YANG¹, KE MA^1,*, RUI CHEN¹, NAIYI ZHANG², YITING MENG³, JIA WEN¹, QINPING LIAO¹

BIOCELL, Vol.45, No.4, pp. 923-932, 2021, DOI: 10.32604/biocell.2021.013625

Abstract The current study is designed to evaluate certain immunocytochemical (ICC) biomarkers to gain a better cytodiagnosis. For this purpose, 85 patients from March 2016 to March 2019 who planned to get a hysteroscopy assay were recruited. Cytological sampling was conducted by scratching the uterus cavity using SAP-1, and the samples were processed as liquid-based smears, using SurePath technology. 36 patients diagnosed with EC or atypical endometrial hyperplasia were recruited in this study. 33 cases were diagnosed with EC, and 3 cases were diagnosed with atypical endometrial hyperplasia, allocated with EC or precancerous lesions group. 26 cases were diagnosed with benign… More >

Yanlong Zhang¹, Yanhui Zhou², Jiming Wu^3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.127, No.2, pp. 487-514, 2021, DOI:10.32604/cmes.2021.014950

Abstract In this article, we study a 2D nonlinear time-fractional Rayleigh-Stokes problem, which has an anomalous sub-diffusion term, on triangular meshes by quadratic finite volume element schemes. Time-fractional derivative, defined by Caputo fractional derivative, is discretized through formula, and a two step scheme is used to approximate the time first-order derivative at time , where the nonlinear term is approximated by using a matching linearized difference scheme. A family of quadratic finite volume element schemes with two parameters are proposed for the spatial discretization, where the range of values for two parameters are , . For testing the precision of numerical… More >

Weiwu Ren^1,*, Xiaoqiang Di¹, Zhanwei Du², Jianping Zhao¹

CMC-Computers, Materials & Continua, Vol.68, No.2, pp. 2057-2073, 2021, DOI:10.32604/cmc.2021.016678

Abstract CFSFDP (Clustering by fast search and find of density peak) is a simple and crisp density clustering algorithm. It does not only have the advantages of density clustering algorithm, but also can find the peak of cluster automatically. However, the lack of adaptability makes it difficult to apply in intrusion detection. The new input cannot be updated in time to the existing profiles, and rebuilding profiles would waste a lot of time and computation. Therefore, an adaptive anomaly detection algorithm based on CFSFDP is proposed in this paper. By analyzing the influence of new input on center, edge and discrete… More >