Sheeba Naaz^1,2, Nadeem Ahmad², Asma A. Al-Huqail³, Mohammad Irfan⁴, Faheema Khan³, Mohammad Irfan Qureshi^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1725-1742, 2023, DOI:10.32604/phyton.2023.026100

Abstract Cadmium (Cd) and Mercury (Hg) is among the heavy metals most hazardous for plant and human health. Known to induce oxidative stress in plants and disbalance equilibrium in the antioxidant defence system, these metals alter plant growth and cause damage at the cellular and molecular levels. Soybean is an important oilseed crop that is raised in soils often contaminated by Cd and Hg. The comparative studies on the deleterious effect of Cd and Hg and the defence system of antioxidants were not studied earlier in soybean plant. In this study, soybean plants were exposed to Cd (100 µM CdCl₂) and… More >

PAULA MARIELA GONZÁLEZ^1,2, JOAQUIN CABRERA^1,2, SUSANA PUNTARULO^1,2,*

BIOCELL, Vol.47, No.5, pp. 1177-1189, 2023, DOI:10.32604/biocell.2023.027107

Abstract

The purpose of this review is to briefly summarize the central role of iron (Fe) in terms of cellular alterations of the oxidative/protective balance with special emphasis on its possible involvement in ferroptosis-dependent disruption in aquatic organisms. In ferroptotic cells or tissues, the intracellular Fe level increases; meanwhile the treatment with Fe chelators limits ferroptosis. Eukaryotic algae can assimilate Fe from the environment through several mechanisms, and aquatic animals incorporate dissolved Fe and Fe bound to both inorganic particles and organic matter. The central role of lipid peroxidation mediating ferroptosis was demonstrated in some algae where both low and high… More >

SITONG QIAN^1,2,#, YING FANG^1,#, CHENGYUN YAO^1,#, YONGSHENG WANG^3,#, ZHI ZHANG¹, XIAOHUA WANG¹, JIN GAO¹, YONG FENG¹, LEI SUN¹, RUNYUE ZOU², GUOREN ZHOU^1,*, JINJUN YE^1,*, RUIXUE XIA^4,*, HONGPING XIA^5,6,*

Oncology Research, Vol.30, No.2, pp. 53-64, 2022, DOI:10.32604/or.2022.026302

Abstract Previous studies have shown that PRDX5 and Nrf2 are antioxidant proteins related to abnormal reactive oxidative species (ROS). PRDX5 and Nrf2 play a critical role in the progression of inflammations and tumors. The combination of PRDX5 and Nrf2 was examined by Co-immunoprecipitation, western blotting and Immunohistochemistry. H₂O₂ was applied to affect the production of ROS and induced multi-resistant protein 1 (MRP1) expression in NSCLC cells. The zebrafish models mainly investigated the synergistic effects of PRDX5 and Nrf2 on lung cancer drug resistance under oxidative stress. We showed that PRDX5 and Nrf2 form a complex and significantly increase the NSCLC tissues… More >

Savita Bhardwaj¹, Tunisha Verma¹, Ali Raza^2,*, Dhriti Kapoor^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 763-782, 2023, DOI:10.32604/phyton.2023.025672

Abstract

Arsenic (As) contaminated food chains have emerged as a serious public concern for humans and animals and are known to affect the cultivation of edible crops throughout the world. Therefore, the present study was designed to investigate the individual as well as the combined effects of exogenous silicon (Si) and sodium nitroprusside (SNP), a nitric oxide (NO) donor, on plant growth, metabolites, and antioxidant defense systems of radish (Raphanus sativus L.) plants under three different concentrations of As stress, i.e., 0.3, 0.5, and 0.7 mM in a pot experiment. The results showed that As stress reduced the growth parameters of… More >

Iva Šutevski^1,#, Klara Krmpotić^1,#, Sandra Vitko¹, Nataša Bauer¹, Eva Fancev², Mario Cifrek², Željka Vidaković-Cifrek^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 901-920, 2023, DOI:10.32604/phyton.2023.025165

Abstract Mechanical stimulation of plants can be caused by various abiotic and biotic environmental factors. Apart from the negative consequences, it can also cause positive changes, such as acclimatization of plants to stress conditions. Therefore, it is necessary to study the physiological and biochemical mechanisms underlying the response of plants to mechanical stimulation. Our aim was to evaluate the response of model plant Arabidopsis thaliana to a moderate force of 5 N (newton) for 20 s, which could be compared with the pressure caused by animal movement and weather conditions such as heavy rain. Mechanically stimulated leaves were sampled 1 h… More >

Liang Chai^1,2, Cheng Cui¹, Benchuan Zheng¹, Jinfang Zhang¹, Jun Jiang¹, Haojie Li^1,2,*, Liangcai Jiang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 645-663, 2023, DOI:10.32604/phyton.2023.024717

Abstract Nitrogen (N) is one of the basic nutrients and signals for plant development and deficiency of it would always limit the productions of crops in the field. Quantitative research on expression of N-stress responsive proteins on a proteome level remains elusive. In order to gain a deep insight into the proteins responding to nitrogen stress in rapeseed (Brassica napus L.), comparative proteomic analysis was performed to investigate changes of protein expression profiles from the root, stem and leaf under different N concentrations, respectively. More than 200 differential abundance proteins (DAPs) were detected and categorized into groups according to annotations, including… More >

LINSHEN XIE¹, QIAOLAN WANG¹, JINGXUAN MA¹, YE ZENG^2,*

BIOCELL, Vol.47, No.2, pp. 261-267, 2023, DOI:10.32604/biocell.2023.024738

Abstract Fibrosis is the end-stage change of damaged tissues in various human diseases, which can lead to permanent scarring or organ malfunction. Hypoxia leads to oxidative stress, mitochondrial dysfunction, and inflammation in dysfunctional organs and tissues. Oxidative stress resulting from the overproduction of reactive oxygen species plays a central role in the fibrosis of injured organs. This review addresses the updated knowledge of the relationship between hypoxia and tissue fibrosis mediated by the reactive oxygen species pathway. Moreover, novel anti-fibrotic strategies are discussed, which may suppress reactive oxygen species and organ fibrosis. More >

Munir Ozturk^1,*, Mert Metin², Volkan Altay³, Tomonori Kawano², Alvina Gul⁴, Bengu Turkyilmaz Unal^5,*, Dilek Unal⁶, Rouf Ahmad Bhat⁷, Moonisa Aslam Dervash⁸, Kristina Toderich⁹, Esra Koc¹⁰, Pedro Garcia Caparros¹¹, Andleeb Shahzadi¹²

Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 165-192, 2023, DOI:10.32604/phyton.2022.022038

Abstract Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic environments. Many plants are affected by the presence of aluminum at the whole plant level, at the organ level, and at the cellular level. Tobacco as a cash crop (Nicotiana tabacum L.) is a widely cultivated plant worldwide and is also a good model organism for research. Although there are many articles on Al-phytotoxicity in the literature, reviews on a single species that are economically and scientifically important are limited. In this article, we not only provide the biology associated with tobacco Al-toxicity,… More >

EKHLAQUE A. KHAN^1,2,*, HAMDINO M. I. AHMED³, MEENA MISRA¹, PALLAVI SHARMA^1,4, AMARENDRA N. MISRA^1,5, MIRZA HASANUZZAMAN^6,*

BIOCELL, Vol.46, No.12, pp. 2583-2593, 2022, DOI:10.32604/biocell.2022.021732

Abstract

Cadmium (Cd) causes oxidative stress, which leads to the oxidation of various biomolecules by the production of reactive oxygen species (ROS) to facilitate programmed cell death (PCD). The antioxidant defense system fails to detoxify ROS when it is produced in excess. Nitric oxide (NO), a gaseous free radical and a phytohormone, regulates various physiological processes of plants. Therefore, this work was undertaken to study the effects of the application of exogenous sodium nitroprusside (SNP, a NO donor) on growth parameters, oxidative stress, accumulation of secondary metabolites, and activities of antioxidant enzymes under Cd stress. Mild (50 µM) and severe (200… More >

Jinfeng Qu^*, Lei Zhang^†, Lanyu Li^*, Yujie Su^*

Oncology Research, Vol.27, No.1, pp. 81-88, 2019, DOI:10.3727/096504018X15202988139874

Abstract This study investigated the tumor-suppressive role of miR-148b in regulating endoplasmic reticulum metalloprotease 1 (ERMP1) expression and the oxidative stress response in endometrial cancer cells. Human endometrial cancer RL95-2 cells were used and transfected with miR-148b mimic, miR-148b inhibitor, or their scrambled negative control. Thereafter, the transfection efficiency was determined by RT-qPCR, and cell proliferation was assessed by MTT assay. The dual-luciferase reporter assay, Western blot, and RT-qPCR were conducted to determine the target gene of miR-148b. ERMP1 is a putative target of miR-148b, and thereby the overexpression and downregulation of ERMP1 on the proliferation of RL95-2 cells were assessed.… More >