Meryam Manzoor¹, Konstantin Korolev², Maryam³, Riaz Ahmad^4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1401-1418, 2025, DOI:10.32604/phyton.2025.063930 - 29 May 2025

Abstract The productivity of fruit crops is badly affected by abrupt changes in climatic conditions. It is a matter of concern for fruit tree researchers to feed the huge population within the available resources. The adverse effects of abiotic stresses are increasing due to fluctuations in climate change. Several abiotic stresses (salinity, drought, water logging, minerals deficiency, temperature extremities and heavy metals) are reducing the overall productivity of crops. Therefore, the application of different management approaches, i.e., phytohormones, nanoparticles, organic amendments, microbes and molecular aspects are effective for the mitigation of abiotic stresses in fruit crops.… More >

Ammar Attar^*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1225-1237, 2025, DOI:10.32604/phyton.2025.063207 - 30 April 2025

Abstract Artemisia dracunculus L., or tarragon, is a perennial herb from the Asteraceae family that is extensively cultivated for its aromatic leaves, which are valued for its preventative and therapeutic properties in both cookery and traditional medicine. This study aims to investigate the antibacterial, antioxidant, and anti-inflammatory properties of A. dracunculus (tarragon) essential oil (ADEO), with estragole (57.23%) identified as the major compound through gas chromatography-mass spectrometry (GC-MS) analysis. ADEO exhibited varying degrees of antibacterial activity, with Escherichia coli showing higher resistance (inhibition zone (IZ) = 14.7 ± 0.58 mm, minimum inhibitory concentration (MIC) = 2% and minimum bactericidal… More >

Alena A. Semenova^1,*, Anastasia D. Igoshkina¹, Alena A. Cherepanova¹, Natalia V. Mikina¹, Anastasia E. Stepanova¹, Оlga E. Krasnoshchekova¹, Vyacheslav A. Sharapov¹, Rimma G. Savchenko², Lyudmila V. Parfenova², Mikhail V. Dubinin¹

BIOCELL, Vol.49, No.3, pp. 437-450, 2025, DOI:10.32604/biocell.2025.061798 - 31 March 2025

Abstract Objectives: Skeletal muscle ischemia/reperfusion injury (IRI) occurs as a result of a marked reduction in arterial perfusion to a limb and can lead to tissue death and threaten limb viability. This work assessed the effects of 20-hydroxyecdysone (20E) on hindlimb skeletal tissue following tourniquet-induced ischemia/reperfusion injury. Methods: Animals were divided into 4 groups—control group (Control), Control + 20E (C + 20E), mice with IRI (IRI), and mice with IRI + 20E (IRI + 20E). IRI was modeled by applying a tourniquet to the hind limb for 2 h with reperfusion for 1 h. 5 mg/kg… More >

Nathan Isaac Dibal^1,*, Martha Orendu Oche Attah^1,2

BIOCELL, Vol.49, No.3, pp. 419-435, 2025, DOI:10.32604/biocell.2025.060565 - 31 March 2025

Abstract Oxidative stress is characterized by elevated intracellular reactive oxygen species (ROS) levels. At physiological levels, ROS work as signaling molecules, helping cells go through the cell cycle normally and keeping their balance. They also balance several physiological processes. However, a shift in the delicate balance between antioxidants and ROS results in aberrant cell death and deleterious effects. Elevated ROS is implicated in many diseases and disorders like diabetes, autoimmune diseases, infertility, and cardiovascular disorders. The imbalance disrupts normal cellular functions, including cell division. ROS are important regulators of the cell cycle, exerting both favorable and More >

Juan Yang^1,2,#, Jiahui Zhang^3,#, Le Zhang^1,2,*, Zhenshan Yang^4,*

BIOCELL, Vol.49, No.3, pp. 399-417, 2025, DOI:10.32604/biocell.2025.059908 - 31 March 2025

Abstract With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to More >

Samiah Hamad Al-Mijalli¹, Hanae Naceiri Mrabti², Amine Elbouzidi^3,*, Naglaa S. Ashmawy^4,5, Amine Batbat⁶, Emad M. Abdallah⁷, Wafa Laaboudi⁸, Mohammed Aladhadh⁹, Fahad M. Alshabrmi¹⁰, Sulaiman Mohammed Alnasser¹¹, Mohamed Addi³, Naoufal El Hachlafi¹²

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 209-227, 2025, DOI:10.32604/phyton.2025.060438 - 24 January 2025

Abstract Thymus serpyllum L., often known as wild thyme, has been used since ancient times due to its multifaceted culinary and medicinal attributes. It is usually utilized in folk medicine to manage different health issues. This work aimed to investigate the chemical composition and biological characteristics of T. serpyllum essential oil (EO), including its antimicrobial, antioxidant, and anti-inflammatory capabilities. Moreover, we have prompted an in-silico simulation to reveal the underlying mode of action of these properties. The chemical characterization of T. serpyllum (EO) by Gas Chromatography-Mass Spectrometry (GC-MS) indicated sabinene (17.33%), terpinen-4-ol (11.73%), phellandral (13.18%), and thymol (10.54%) as main… More >

Marwa Rezgui^1,#,*, Wided Ben Ammar¹, Muhammad Nazim^2,3,#, Walid Soufan⁴, Chiraz Chaffei Haouari¹

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 137-155, 2025, DOI:10.32604/phyton.2025.058851 - 24 January 2025

Abstract Nickel (Ni) toxicity significantly impairs plant growth, photosynthesis, and metabolism by inducing oxidative stress. This study evaluates the potential of exogenous Alpha-Ketoglutarate (AKG) in mitigating Ni-induced stress in Peganum harmala L. Seedlings were exposed to 0, 200, 500, and 750 μM NiCl₂, with or without AKG supplementation. Under 750 μM Ni stress, dry weight (DW) decreased by 33.7%, tissue water content (TWC) by 39.9%, and chlorophyll a and total chlorophyll levels were reduced by 17% and 15%, respectively. Ni exposure also significantly increased secondary metabolite production, with leaf anthocyanin content rising by 131%, and superoxide dismutase (SOD)… More >

TINGTING LIU^#, XIANGRUI KONG^#, JIANSHE WEI^*

BIOCELL, Vol.48, No.12, pp. 1735-1749, 2024, DOI:10.32604/biocell.2024.056272 - 30 December 2024

Abstract Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia. In recent times, an elevated risk of Parkinson’s disease (PD) development among individuals with T2DM has become evident. However, the molecular mechanisms that underpin the interplay between T2DM and the pathogenesis of PD remain to be elucidated. Nevertheless, recent epidemiological studies have underscored several shared molecular pathways that are crucial for normal cellular function and are also associated with the progression and etiology of both T2DM and PD. This review encapsulates some of the shared pathophysiological mechanisms, including genetic risk factors, More >

Md. Tahjib-Ul-Arif^1,2,*, Md Asaduzzaman³, Bir Jahangir Shirazy^2,4, Md. Shihab Uddine Khan⁵, A. M. Sajedur Rahman^2,6, Yoshiyuki Murata², Sozan Abdel Hamed⁷, Arafat Abdel Hamed Abdel Latef^8,9,*

Phyton-International Journal of Experimental Botany, Vol.93, No.11, pp. 3013-3027, 2024, DOI:10.32604/phyton.2024.058710 - 30 November 2024

Abstract Chilling is one of the major abiotic stresses for plants, especially for rice cultivation. Many essential metabolic processes for growth and development are temperature-dependent. In that case, reducing the negative effects of cold stress using exogenous chemicals is a possible option. Therefore, the current study examined the effects of pre-sowing seed treatment with different chemicals, viz. hydrogen peroxide (H₂O₂), salicylic acid (SA), calcium chloride (CaCl₂), thiourea (TU), and citric acid (CA) on the germination of rice seeds (cv. BRRI dhan28) under chilling environments. Rice seeds were soaked in distilled water (control), 10 mM CA, 2 mM SA,… More >

WENJUAN ZHU¹, ZHENGZHENG JU², FAN CUI^2,*

BIOCELL, Vol.48, No.9, pp. 1379-1388, 2024, DOI:10.32604/biocell.2024.052205 - 04 September 2024

Abstract Objective: Diabetic nephropathy (DN) is a deleterious microangiopathy of diabetes, constituting a critical determinant of fatality in diabetic patients. This work is purposed to disclose the effects and modulatory mechanism of BTG anti-proliferation factor 2 (BTG2) during the pathological process of DN. Methods: BTG2 expression in kidney tissues of diabetic mice and high glucose (HG)-exposed human proximal tubular cell line HK-2 was assessed with Western blot and RT-qPCR. The diabetic mice model was constructed by streptozotocin injection and confirmed by the blood glucose level beyond 16.7 mmol/L. Hematoxylin and eosin (H&E) staining and measurement of… More >