Nadeem Malik^1,*, Saud Altaf¹, Muhammad Usman Tariq², Ashir Ahmed³, Muhammad Babar⁴

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1599-1615, 2023, DOI:10.32604/cmc.2023.040455

Abstract The severity of traffic accidents is a serious global concern, particularly in developing nations. Knowing the main causes and contributing circumstances may reduce the severity of traffic accidents. There exist many machine learning models and decision support systems to predict road accidents by using datasets from different social media forums such as Twitter, blogs and Facebook. Although such approaches are popular, there exists an issue of data management and low prediction accuracy. This article presented a deep learning-based sentiment analytic model known as Extra-large Network Bi-directional long short term memory (XLNet-Bi-LSTM) to predict traffic collisions based on data collected from… More >

CONGCHEN BAI¹, QIHANG KONG², HAO TANG², SHUWEN ZHANG², JUNTENG ZHOU^3,*, XIAOJING LIU^2,4,*

BIOCELL, Vol.47, No.11, pp. 2517-2533, 2023, DOI:10.32604/biocell.2023.043864

Abstract Background: Various physiological mechanisms are linked to dilated cardiomyopathy (DCM) development, including oxidative stress, immune irregularities, inflammation, fibrosis, and genetic changes. However, precise molecular drivers of DCM, especially regarding abnormal immune responses, remain unclear. This study investigates immune-related long non-coding RNAs (lncRNAs) in DCM’s diagnostic and therapeutic potential. Methods: GSE141910, GSE135055, and GSE165303 datasets were acquired from the GEO database. LASSO, SVM-RFE, and random forest algorithms identified DCM-associated immune-related lncRNAs. Diagnostic capabilities were assessed by Nomogram and receiver operating characteristic (ROC) curves. Multivariate linear regression explored lncRNA correlations with ejection fraction. Single-sample gene set enrichment analysis (ssGSEA) gauged immune cell… More > Graphic Abstract

ZHONGXIANG TANG^1,2, LILI WANG^1,2, GUOJUN WU^1,2, LING QIN^1,2,*, YURONG TAN^1,2,*

BIOCELL, Vol.47, No.11, pp. 2503-2516, 2023, DOI:10.32604/biocell.2023.031565

Abstract Background: Non-small cell lung cancer (NSCLC) has a poor prognosis with a low 5-year survival rate. Lung adenocarcinoma (LUAD) accounts for 50%. Facio-genital dysplasia-5 (FGD5), a member of a subfamily of Rho GTP-GDP exchange factors, may be a good molecular biomarker for diagnosis and prognosis. Objective: To explore the clinical application of FGD5, the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients. Methods: Through the Wilcoxon signed-rank test and logistic regression, the correlation between clinical characteristics and FGD5 expression was analyzed. Kaplan–Meier plotter analysis, Cox regression, and a… More > Graphic Abstract

PRIYADHARSHINI THANJAVUR SRIRAMAMOORTHI^1,2, GAYATHRI GOPAL^1,2, SHIBI MURALIDAR^1,2, SAI RAMANAN ESWARAN^1,2, DANUSH NARAYAN PANNEERSELVAM^1,2, BHUVANESWARAN MEIYANATHAN^1,2, SRICHANDRASEKAR THUTHIKKADU INDHUPRAKASH^1,2, SENTHIL VISAGA AMBI^1,2,*

BIOCELL, Vol.47, No.11, pp. 2335-2350, 2023, DOI:10.32604/biocell.2023.029379

Abstract The novel coronavirus pneumonia (COVID-19) is spreading worldwide and threatening people greatly. The routes by which SARS-CoV-2 causes lung injury have grown to be a major concern in the scientific community since patients with new Coronavirus, severe acute respiratory syndrome coronavirus (SARS-CoV-2) have a high likelihood of developing acute respiratory distress syndrome (ARDS) in severe cases. The mortality rate of COVID-19 has increased over the period due to rapid spread, and it becomes crucial to understand the disease epidemiology, pathogenic mechanisms, and suitable treatment strategies. ARDS is a respiratory disorder and is one of the clinical manifestations observed in patients… More > Graphic Abstract

HEE JU SONG, TAEHEE KIM, HAN NA CHOI, SOO JIN KIM, SANG DO LEE^*

Oncology Research, Vol.32, No.1, pp. 151-161, 2024, DOI:10.32604/or.2023.030690

Abstract Lung cancer has the highest mortality rate among all cancers, in part because it readily metastasizes. The tumor microenvironment, comprising blood vessels, fibroblasts, immune cells, and macrophages [including tumor-associated macrophages (TAMs)], is closely related to cancer cell growth, migration, and invasion. TAMs secrete several cytokines, including interleukin (IL)-1β, which participate in cancer migration and invasion. p21-activated kinase 1 (PAK1), an important signaling molecule, induces cell migration and invasion in several carcinomas. Tonicity-responsive enhancer-binding protein (TonEBP) is also known to participate in cancer cell growth, migration, and invasion. However, the mechanisms by which it increases lung cancer migration remain unclear. Therefore,… More > Graphic Abstract

Jebran Khan¹, Kashif Ahmad², Kyung-Ah Sohn^1,3,*

Computer Systems Science and Engineering, Vol.47, No.3, pp. 2869-2894, 2023, DOI:10.32604/csse.2023.040159

Abstract In recent years, the growing popularity of social media platforms has led to several interesting natural language processing (NLP) applications. However, these social media-based NLP applications are subject to different types of adversarial attacks due to the vulnerabilities of machine learning (ML) and NLP techniques. This work presents a new low-level adversarial attack recipe inspired by textual variations in online social media communication. These variations are generated to convey the message using out-of-vocabulary words based on visual and phonetic similarities of characters and words in the shortest possible form. The intuition of the proposed scheme is to generate adversarial examples… More >

Sarah M. Alhammad¹, Doaa Sami Khafaga^1,*, Aya Y. Hamed², Osama El-Koumy³, Ehab R. Mohamed³, Khalid M. Hosny³

Computer Systems Science and Engineering, Vol.47, No.3, pp. 2939-2952, 2023, DOI:10.32604/csse.2023.041011

Abstract Face mask detection has several applications, including real-time surveillance, biometrics, etc. Identifying face masks is also helpful for crowd control and ensuring people wear them publicly. With monitoring personnel, it is impossible to ensure that people wear face masks; automated systems are a much superior option for face mask detection and monitoring. This paper introduces a simple and efficient approach for masked face detection. The architecture of the proposed approach is very straightforward; it combines deep learning and local binary patterns to extract features and classify them as masked or unmasked. The proposed system requires hardware with minimal power consumption… More >

Firas Abedi¹, Hayder M. A. Ghanimi², Abeer D. Algarni³, Naglaa F. Soliman^3,*, Walid El-Shafai^4,5, Ali Hashim Abbas⁶, Zahraa H. Kareem⁷, Hussein Muhi Hariz⁸, Ahmed Alkhayyat⁹

Computer Systems Science and Engineering, Vol.47, No.3, pp. 2791-2814, 2023, DOI:10.32604/csse.2023.038762

Abstract Data mining plays a crucial role in extracting meaningful knowledge from large-scale data repositories, such as data warehouses and databases. Association rule mining, a fundamental process in data mining, involves discovering correlations, patterns, and causal structures within datasets. In the healthcare domain, association rules offer valuable opportunities for building knowledge bases, enabling intelligent diagnoses, and extracting invaluable information rapidly. This paper presents a novel approach called the Machine Learning based Association Rule Mining and Classification for Healthcare Data Management System (MLARMC-HDMS). The MLARMC-HDMS technique integrates classification and association rule mining (ARM) processes. Initially, the chimp optimization algorithm-based feature selection (COAFS)… More >

MENGYING MAO^1,2,3,#, TING DONG^1,2,3,#, YANJING LIANG^3,4, KEYONG YUAN^1,2,3, QIAOQIAO JIN^1,2,3, PENGFEI ZHANG^1,2,3, ZHENGWEI HUANG^1,2,3,*

BIOCELL, Vol.47, No.10, pp. 2187-2193, 2023, DOI:10.32604/biocell.2023.042357

Abstract The oral microbiota is a vital part of the human microbiota that functions in various physiological processes and is highly relevant to cancers and other diseases. With the alterations of host immune competence, the homeostatic balance existing between the oral microbiota and host may be disturbed and result in the development of diseases. Numerous observations have suggested that small RNAs are key regulators of bacterial pathogenesis and bacteria-host interactions. Further, bacterial small RNAs are considered to be promising biomarkers for the development of novel, and efficacious therapies for oral dysbiosis. Mechanistic insights into how oral pathogens communicate with other bacteria… More > Graphic Abstract

ELYN AMIELA SALLEH¹, YEONG YEH LEE², ANDEE DZULKARNAEN ZAKARIA³, NUR ASYILLA CHE JALIL⁴, MARAHAINI MUSA^1,*

BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541

Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed to help in determining patient… More > Graphic Abstract