CARL RANDALL HARREL¹, VALENTIN DJONOV², ANA VOLAREVIC³, DRAGICA PAVLOVIC⁴, VLADISLAV VOLAREVIC^4,5,*

BIOCELL, Vol.47, No.8, pp. 1757-1769, 2023, DOI:10.32604/biocell.2023.028567 - 28 August 2023

Abstract Exosomes derived from mesenchymal stem cells (MSC-Exos) are nano-sized extracellular vesicles enriched with bioactive molecules, such as microRNAs, enzymes, cytokines, chemokines, immunomodulatory, trophic, and growth factors. These molecules regulate the survival, phenotype, and function of malignant and tumor-infiltrated immune cells. Due to their nano-size and bilayer lipid envelope, MSC-Exos can easily bypass biological barriers and may serve as drug carriers to deliver chemotherapeutics directly into the tumor cells. Here, we summarize current knowledge regarding molecular mechanisms responsible for MSC-Exos-dependent modulation of tumor progression and discuss insights regarding the therapeutic potential of MSC-Exos in the treatment More > Graphic Abstract

John Freddy Gelves-Díaz^1,*, Ludovic Dorkis², Richard Monroy-Sepúlveda¹, Sandra Rozo-Rincón¹, Yebrail Alexis Romero-Arcos¹

Journal of Renewable Materials, Vol.11, No.10, pp. 3769-3787, 2023, DOI:10.32604/jrm.2023.029270 - 10 August 2023

Abstract Secondary lignocellulosic biomass has proved to be useful as an energy source through its oxidation by means of combustion processes. In accordance with the above, in this paper, we wanted to study the ash from urban pruning residues that are generated in cities in the Neotropics. Species such as Licania tomentosa, Azadirachta indica, Ficus benjamina, Terminalia catappa, Leucaena leucocephala, Prosopis juliflora and Pithecellobium dulce were selected because they have been previously studied and showed potential for thermal energy generation. These materials were calcined in an oxidizing atmosphere and characterized by X-ray diffraction and fluorescence, scanning electron microscopy with microchemistry, BET surface area,… More > Graphic Abstract

Abida Kausar^1,*, Noreen Zahra^1,2, Humaira Kiran¹, Sadia Asim³, Abid Raza⁴, Ali Raza^5,*

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2245-2260, 2023, DOI:10.32604/phyton.2023.028264 - 25 June 2023

Abstract The study aimed to evaluate the ability of some terrestrial and aquatic plants for wastewater purification. Aquatic plants can remove pollutants from wastewater by consuming and accumulating various contaminants in different parts of plants. Different aquatic and terrestrial plants (Rosa sinensis, Typha latifolia, Ocimm bacilicum, Azolla pinnata, and Salvinia molesta) which have the ability to decrease water pollution were utilized in this study. The capability of five different species of plants was investigated by measuring chemical oxygen demand (COD), biological oxygen demand (BOD), electrical conductivity (EC), total dissolved solids (TDS), and pH of the medium. In this research, some aquatic… More >

Xuan Sun^1,2, Xue Wang¹, Bijaya Sharma Subedi³, Yin Jiang^1,2, Di Wang^1,2, Rongxin Gou^1,2, Guojun Zhang², Wenting Xu^4,*, Zunzheng Wei^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2413-2428, 2023, DOI:10.32604/phyton.2023.029667 - 25 June 2023

Abstract The calla lily (Zantedeschia spreng.) is a bulbous flower native to the tropical regions of Africa. Calla lily has gained significant popularity in the international market owing to its intricate morphology and prolonged flowering duration. Despite such advantages, for two sub-groups of calla lily, known as group Zantedeschia and group Aestivae, there are challenges in terms of hybrid production due to the ‘plastome-genome incompatibility’ therebetween. Tissue culture is a fundamental biotechnological tool used in gene editing research, with a focus on disease resistance and flower color in calla lily breeding programs. The present review provides a brief… More >

Esraa E. Shalan¹, Said S. Soliman¹, Ahmed A. Mahmoud¹, Jameel M. Al-Khayri^2,*, Salha M. ALshamrani³, Fatmah A. Safhi⁴, Areej S. Jalal⁴, Diaa Abd El-Moneim⁵, Abdallah A. Hassanin^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2183-2196, 2023, DOI:10.32604/phyton.2023.028537 - 29 May 2023

Abstract Determination of the somaclonal variation of in vitro-propagated plants is crucial to determine the appropriate micropropagation protocol and growth regulators for commercial scale multiplication. In this research, nine multiplication media (MM) augmented with different concentrations of 6-benzyl adenine (BA), Kinetin (Kin), and Thidiazuron (TDZ), Three rooting media (RM) supplemented with three levels of α-naphthalene acetic acid (NAA) and three types of soil mixtures (v/v); Coco peat/Vermiculite/Sand (CVS), Peat moss/Perlite/Sand (PPS) and Peat moss/Perlite (PP) were used in the micropropagation protocol of daylily plants. MM2 showed the maximum shoot length and the number of leaves, while MM9… More >

YU LU¹, TSUTOMU MIYAMOTO^1,*, HODAKA TAKEUCHI¹, FUMI TSUNODA¹, NAOKI TANAKA^2,3,4, TANRI SHIOZAWA¹

Oncology Research, Vol.31, No.3, pp. 239-253, 2023, DOI:10.32604/or.2023.026067 - 22 May 2023

Abstract Endometrial carcinoma (EMC) is associated with obesity; however, the underlying mechanisms have not yet been elucidated. Peroxisome proliferator-activated receptor alpha (PPARα) is a nuclear receptor that is involved in lipid, glucose, and energy metabolism. PPARα reportedly functions as a tumor suppressor through its effects on lipid metabolism; however, the involvement of PPARα in the development of EMC remains unclear. The present study demonstrated that the immunohistochemical expression of nuclear PPARα was lower in EMC than in normal endometrial tissues, suggesting the tumor suppressive nature of PPARα. A treatment with the PPARα activator, irbesartan, inhibited the More >

P. Chellamani^1,2,*, D. Ajay¹, Mohammed M. Al-Shamiri^3,4, Rashad Ismail^3,4

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 4935-4953, 2023, DOI:10.32604/cmc.2023.036321 - 29 April 2023

Abstract Graph theory has a significant impact and is crucial in the structure of many real-life situations. To simulate uncertainty and ambiguity, many extensions of graph theoretical notions were created. Planar graphs play a vital role in modelling which has the property of non-crossing edges. Although crossing edges benefit, they have some drawbacks, which paved the way for the introduction of planar graphs. The overall purpose of the study is to contribute to the conceptual development of the Pythagorean Neutrosophic graph. The basic methodology of our research is the incorporation of the analogous concepts of planar… More >

ADEM OZCELIK^1,*, OZGE CEVIK²

BIOCELL, Vol.47, No.5, pp. 959-964, 2023, DOI:10.32604/biocell.2023.028371 - 10 April 2023

Abstract Exosomes are important biomarkers for clinical diagnosis. It is critical to isolate secreted exosomes from bodily fluids such as blood, saliva, breast milk, and urine for liquid biopsy applications. The field of microfluidics provides numerous benefits for biosample processing, diagnostics, and prognostics. Several microfluidics-based methods have been employed for the isolation and purification of exosomes in the last ten years. These microfluidic methods can be grouped into two categories based on passive and active isolation mechanisms. In the first group, inertial and hydrodynamic forces are employed to separate exosomes based on their size differences. In More >

OMER ERDOGAN¹, GULEN MELIKE DEMIRBOLAT², OZGE CEVIK^1,*

BIOCELL, Vol.47, No.5, pp. 1051-1063, 2023, DOI:10.32604/biocell.2023.028129 - 10 April 2023

Abstract Background: Raloxifene, a selective estrogen receptor modulator, is also known to be a lysosomotropic agent. The bioavailability of raloxifene is around 2% due to extensive hepatic transport. Exosomes are nanosized vesicles that are naturally released from cells. Method: In this study, exosomes released from HeLa cervical cancer cells were loaded with raloxifene to increase its bioavailability, and an aptamer was attached to the exosome membrane for targeting only HeLa cells. Characterization of exosomes isolated from HeLa cells was performed by transmission electron microscopy, zeta sizer, and western blotting. In addition, the cytotoxic, apoptotic, autophagic, and lysosomotropic More >

YANGYI HE^1,2, DAVID SANCHEZ-LORENTE^3,4,5, MELISSA ACOSTA-PLASENCIA¹, MARC BOADA^3,4,5, ANGELA GUIRAO^3,4,5, RAMON M. MARRADES^4,5,6,7, LAUREANO MOLINS^3,4,5, ALFONS NAVARRO^1,4,5,*

BIOCELL, Vol.47, No.5, pp. 951-957, 2023, DOI:10.32604/biocell.2023.027718 - 10 April 2023

Abstract Tumor-secreted extracellular vesicles (EVs) participate in the metastasis process through different mechanisms, including the preparation of the pre-metastatic niche to grant circulating tumor cells (CTCs) implantation and growth. The study of the metastasis process through the analysis of CTCs and tumor-derived EVs is difficult because of the dilution grade of these elements in peripheral blood. In early-stage lung cancer patients, the tumor-secreted products are even more diluted. An attractive strategy in surgical lung cancer patients is to purify them from a pulmonary tumor-draining vein where they are enriched. The information obtained from the analysis of More >