Jian-Wei Wang, Xiao-Feng Wu, Xiao-Juan Gu, Xing-Hua Jiang

Oncology Research, Vol.27, No.9, pp. 979-986, 2019, DOI:10.3727/096504018X15336368805108

Abstract Cancer-associated fibroblasts (CAFs) play a predominant role in regulating tumor progression. Understanding how CAFs communicate with osteosarcoma is crucial for developing novel approaches for osteosarcoma therapy. Exosomes are able to transmit messages between cells. In this study, we demonstrated that CAFs transfer exosomes to osteosarcoma cells, which promotes osteosarcoma cell migration and invasion. Using a miRNA microarray analysis, we identified 13 miRNAs that are significantly increased in exosomes derived from cancer-associated fibroblasts (CAFs) and corresponding paracancer fibroblasts (PAFs). In vitro studies further validated that the levels of microRNA-1228 (miR-1228) were increased in CAFs, its secreted exosomes, and in recipient osteosarcoma… More >

Qing Wei¹, Rui Zhu¹, Junying Zhu, Rongping Zhao, Min Li

Oncology Research, Vol.27, No.7, pp. 827-834, 2019, DOI:10.3727/096504018X15462920753012

Abstract Emerging evidence suggests that 17β-estradiol (E2) and estrogen receptor (ER) signaling are protective against hepatocellular carcinoma (HCC). In our previous study, we showed that E2 suppressed the carcinogenesis and progression of HCC by targeting NLRP3 inflammasome activation, whereas the molecular mechanism by which the NLRP3 inflammasome initiated cancer cell death was not elucidated. The present study aimed to investigate the effect of NLRP3 inflammasome activation on cell death pathways and autophagy of HCC cells. First, we observed an increasing mortality in E2-treated HCC cells, and then apoptotic and pyroptotic cell death were both detected. The mortality of HCC cells was… More >

Yanhui Li^*†, Su Dong^*†, Arya Tamaskar^†, Heather Wang^†, Jing Zhao^†, Haichun Ma^*, Yutong Zhao^†

Oncology Research, Vol.28, No.5, pp. 497-507, 2020, DOI:10.3727/096504020X15929939001042

Abstract Non-small cell lung cancer (NSCLC) is the most common type of lung cancer and accounts for 85% of all lung carcinomas. The hepatocyte growth factor receptor (c-Met) has been considered as a potential therapeutic target for NSCLC. Proteasome inhibition induces cell apoptosis and has been used as a novel therapeutic approach for treating diseases including NSCLC; however, the effects of different proteasome inhibitors on NSCLC have not been fully investigated. The aim of this study is to determine a precise strategy for treating NSCLC by targeting c-Met using different proteasome inhibitors. Three proteasome inhibitors, bortezomib, MG132, and ONX 0914, were… More >

Farag Azzedin^*, Husam Suwad, Md Mahfuzur Rahman

CMC-Computers, Materials & Continua, Vol.73, No.2, pp. 3003-3020, 2022, DOI:10.32604/cmc.2022.028646

Abstract This article presents an asset-based security system where security practitioners build their systems based on information they own and not solicited by observing attackers’ behavior. Current security solutions rely on information coming from attackers. Examples are current monitoring and detection security solutions such as intrusion prevention/detection systems and firewalls. This article envisions creating an imbalance between attackers and defenders in favor of defenders. As such, we are proposing to flip the security game such that it will be led by defenders and not attackers. We are proposing a security system that does not observe the behavior of the attack. On… More >

Yixin Liu^*

Molecular & Cellular Biomechanics, Vol.19, No.3, pp. 131-139, 2022, DOI:10.32604/mcb.2022.019342

Abstract When basketball players play against each other in a game, better coordinated balance can give them a better advantage. This paper briefly introduces the coordination balance and core strength of basketball players. Twenty basketball varsity members were selected from Chengdu College of University of Electronic Science and Technology of China as subjects for the test. The athletes were randomly divided into a control group and an experimental group. The control group received regular strength training, and the experimental group received core strength training in addition to regular training. Both groups underwent isometric muscle strength test, coordination and balance test and… More >

ISABELLA PANFOLI^1,*, MAURIZIO BRUSCHI², GIOVANNI CANDIANO²

BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154

Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the rest of the body, promoting… More >

CARL RANDALL HARRELL^1,#, ANA VOLAREVIC^2,#,*, DRAGICA PAVLOVIC³, VALENTIN DJONOV⁴, VLADISLAV VOLAREVIC^4,5,*

BIOCELL, Vol.46, No.10, pp. 2195-2200, 2022, DOI:10.32604/biocell.2022.020175

Abstract Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases. Inflammatory mediators and proteolytic enzymes released by activated immune cells induce serious injury of corneal epithelial cells and retinal ganglion cell which may result in the vision loss. Mesenchymal stem cells (MSCs) are regulatory cells which produce various immunosuppressive factors that modulate phenotype and function of inflammatory immune cells. However, several safety issues, including undesired differentiation and emboli formation, limit clinical use of MSCs. MSC-derived exosomes (MSC-Exos) are nano-sized extracellular vesicles which contain all MSC-derived immunoregulatory factors. Intraocular administration of MSC-Exos efficiently attenuated… More >

G. Ravikumar¹, K. Venkatachalam², Mohammed A. AlZain³, Mehedi Masud⁴, Mohamed Abouhawwash^5,6,*

Computer Systems Science and Engineering, Vol.44, No.1, pp. 945-959, 2023, DOI:10.32604/csse.2023.024605

Abstract Sleep apnea syndrome (SAS) is a breathing disorder while a person is asleep. The traditional method for examining SAS is Polysomnography (PSG). The standard procedure of PSG requires complete overnight observation in a laboratory. PSG typically provides accurate results, but it is expensive and time consuming. However, for people with Sleep apnea (SA), available beds and laboratories are limited. Resultantly, it may produce inaccurate diagnosis. Thus, this paper proposes the Internet of Medical Things (IoMT) framework with a machine learning concept of fully connected neural network (FCNN) with k-nearest neighbor (k-NN) classifier. This paper describes smart monitoring of a patient’s… More >

Soliman Abdalla^1,2,*, Sherif Kandil², Waleed El-Shirbeeny¹, Fatma Bahabri^1,3

Journal of Renewable Materials, Vol.10, No.9, pp. 2335-2354, 2022, DOI:10.32604/jrm.2022.021211

Abstract Diabetes disorder turns smoothly to be a global epidemic disorder and the glycated hemoglobin (HbA1c) starts to be an efficient marker of it. The dielectric spectroscopy on different human normal- and diabetic-blood samples is used to characterize and to estimate the HbA1c concentration. “dc-” and ac-measurement of the complex conductivity in the temperature range from 280 K up to 320 K, and in the frequency range from one Hz up to 32 MHz have been performed. The thermal activation energy, ΔE_σ, of dc-electric conductivity lies in the range 95 meV < ΔE_σ < 115 meV; while the thermal activation energy,… More >

Thongchai Botmart¹, Wajaree Weera^1,*, Muhammad Asif Zahoor Raja², Zulqurnain Sabir³, Qusain Hiader⁴, Gilder Cieza Altamirano⁵, Plinio Junior Muro Solano⁶, Alfonso Tesen Arroyo⁶

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 981-999, 2022, DOI:10.32604/cmc.2022.028921

Abstract In the present study, a design of a fractional order mathematical model is presented based on the schistosomiasis disease. To observe more accurate performances of the results, the use of fractional order derivatives in the mathematical model is introduce based on the schistosomiasis disease is executed. The preliminary design of the fractional order mathematical model focused on schistosomiasis disease is classified as follows: uninfected with schistosomiasis, infected with schistosomiasis, recovered from infection, susceptible snail unafflicted with schistosomiasis disease and susceptible snail afflicted with this disease. The solutions to the proposed system of the fractional order mathematical model will be presented… More >