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  • Open Access

    ARTICLE

    AdVance sling use decreasing relative to artifcial urinary sphincters

    Chad R. Pusateri, Jack M. Zuckerman

    Canadian Journal of Urology, Vol.24, No.6, pp. 9121-9125, 2017

    Abstract Introduction: To evaluate the percent of AdVance male slingusagerelativetoartifcialurinarysphincters(AUS) overa9yearperiodsinceitsintroductioninordertoassess trends across the United States.
    Materials and methods: As a surrogate for procedures performed, we reviewed device utilization trends of the AdVance sling and AUS broken down by American Urological Association (AUA) section. ANOVA testing between years was used to determine purchasing trends withpvaluesof<0.05consideredstatisticallysignifcant.
    Results: Relative to AUS, AdVance sling percentage signifcantly increased from 36% in 2007 to 48% in 2008 (p = 0.032). Sling percentage then remained stable over the next 3 years from 2008-2011 with no signifcant percent change between years (p = NS). Compared with More >

  • Open Access

    ARTICLE

    Long Noncoding RNA MEG3 Suppresses Glioma Cell Proliferation, Migration, and Invasion by Acting as a Competing Endogenous RNA of miR-19a

    Nan Qin*1, Gui-Feng Tong†1, Li-Wei Sun, Xiao-Lin Xu

    Oncology Research, Vol.25, No.9, pp. 1471-1478, 2017, DOI:10.3727/096504017X14886689179993

    Abstract Glioma, with varying malignancy grades and histological subtypes, is the most common primary brain tumor in adults. Long noncoding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play an important role in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA maternally expressed gene 3 (MEG3) and microRNA-19a (miR-19a) in human glioma U87 and U251 cell lines. Real-time PCR revealed that MEG3 was downregulated and miR-19a was upregulated in malignant glioma tissues and cell lines. Bioinformatics analyses (TargetScan, miRanda, and starBase V2.0) showed that phosphatase and tensin homolog (PTEN) is a… More >

  • Open Access

    ARTICLE

    3-Phosphoinositide Dependent Protein Kinase-1 (PDK-1) Promotes Migration and Invasion in Gastric Cancer Cells Through Activating the NF-κB Pathway

    Ning Wu*, Changyu He, Bohui Zhu*, Jinling Jiang, Yiwen Chen*, Tao Ma

    Oncology Research, Vol.25, No.7, pp. 1153-1159, 2017, DOI:10.3727/096504017X14845839228545

    Abstract Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Many factors have been reported regarding the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase-1 (PDK-1) with cell viability, migration, and invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of nuclear factor-kB (NF-kB) pyrrolidine dithiocarbamate (PDTC). We… More >

  • Open Access

    ARTICLE

    Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated According to Uridine Diphosphate Glucuronosyltransferase 1A1 Genotyping in Patients With Metastatic Colorectal Cancer

    Cheng-Jen Ma*†‡, Ching-Wen Huang*‡§, Yung-Sung Yeh*†¶, Hsiang-Lin Tsai*§#**, Huang-Ming Hu††‡‡, I-Chen Wu††‡‡, Tian-Lu Cheng§§¶¶, Jaw-Yuan Wang*†‡§**¶¶

    Oncology Research, Vol.25, No.5, pp. 673-679, 2017, DOI:10.3727/97818823455816X14786040691928

    Abstract We analyzed the results of previously treated patients with metastatic colorectal cancer (mCRC) who received regorafenib plus FOLFIRI with the irinotecan dose escalation on the basis of uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) genotyping. Thirteen patients with previously treated mCRC were subjected to UGT1A1 genotyping between October 2013 and June 2015 and were administered regorafenib plus FOLFIRI with irinotecan dose escalation. Patients with UGT1A1*1/*1 and *1/*28 genotypes were administered 180 mg/m2 of irinotecan, whereas those with the UGT1A1*28/*28 genotype were administered 120 mg/m2 of irinotecan. For all patients, the irinotecan dose was increased by 30 mg/m2 every… More >

  • Open Access

    RETRACTION

    [ARTICLE WITHDRAWN] Upregulation of MicroRNA-935 Promotes the Malignant Behaviors of Pancreatic Carcinoma PANC-1 Cells via Targeting Inositol Polyphosphate 4-Phosphatase Type I Gene (INPP4A)

    Wang Cuiyue1, Feng Zhen2, Jiang Kaitong3, Zuo Xiuli1

    Oncology Research, Vol.25, No.4, pp. 559-569, 2017, DOI:10.3727/096504016X14759554689565

    Abstract THIS ARTICLE WAS WITHDRAWN BY THE PUBLISHER IN NOVEMBER 2020 More >

  • Open Access

    ARTICLE

    MATHEMATICAL STUDY OF NON-NEWTONIAN NANOFLUID TRANSPORT PHENOMENA FROM AN ISOTHERMAL SPHERE

    CH. Amanullaa,b , N. Nagendraa,1 , M. Surya Narayana Reddyb , A. Subba Raoa , O. Anwar Bégc

    Frontiers in Heat and Mass Transfer, Vol.8, pp. 1-13, 2017, DOI:10.5098/hmt.8.29

    Abstract In this article, the heat, momentum and mass (species) transfer in external boundary layer flow of Casson nanofluid from an isothermal sphere surface is studied theoretically. The effects of Brownian motion and thermophoresis are incorporated in the model in the presence of both heat and nanoparticle mass transfer. The governing partial differential equations (PDEs) are transformed into highly nonlinear, coupled, multi-degree non-similar partial differential equations consisting of the momentum, energy and concentration equations via appropriate non-similarity transformations. These transformed conservation equations are solved subject to appropriate boundary conditions with a second order accurate finite difference More >

  • Open Access

    ARTICLE

    STEADY-STATE TRANSPORT PHENOMENA ON INDUCED MAGNETIC FIELD MODELLING FOR NON-NEWTONIAN TANGENT HYPERBOLIC FLUID FROM AN ISOTHERMAL SPHERE WITH SORET AND DUFOUR EFFECTS

    A. Subba Raoa,*, L. Nagarajaa,b, M. Sudhakar Reddya , M. Surya Narayana Reddyb

    Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-11, 2017, DOI:10.5098/hmt.9.17

    Abstract This article investigates the theoretical steady magneto hydrodynamic heat flow of incompressible non-Newtonian Tangent Hyperbolic fluid flow over a sphere with Soret and Dufour effects. The governing coupled non-linear partial differential equations are reduced to non-similarity boundary layer equations using appropriate transformation and then solved using the finite difference Keller-Box method. The effect of various flow parameters on the velocity, temperature and concentration are analyzed and presented graphically. More >

  • Open Access

    ARTICLE

    Dysphagia in infants with single ventricle anatomy following stage 1 palliation: Physiologic correlates and response to treatment

    Katlyn Elizabeth McGrattan1,2,3,4, Heather McGhee2,3, Allan DeToma5, Elizabeth G. Hill5, Sinai C. Zyblewski6, Maureen Lefton-Greif7,8,9, Lucinda Halstead1,2, Scott M. Bradley10, Bonnie Martin-Harris1,2,3,4

    Congenital Heart Disease, Vol.12, No.3, pp. 382-388, 2017, DOI:10.1111/chd.12456

    Abstract Background: Deficits in swallowing physiology are a leading morbidity for infants with functional single ventricles and systemic outflow tract obstruction following stage 1 palliation. Despite the high prevalence of this condition, the underlying deficits that cause this post-operative impairment remain poorly understood.
    Objective: Identify the physiologic correlates of dysphagia in infants with functional single ventricles and systemic outflow tract obstruction following stage 1 palliative surgery.
    Methods: Postoperative fiberoptic laryngoscopies and videofluoroscopic swallow studies (VFSS) were conducted sequentially on infants with functional single ventricles following stage 1 palliative surgery. Infants were dichotomized as having normal or impaired laryngeal function… More >

  • Open Access

    Solubilization of Renewable Phosphorus Sources with Organic Acids Produced by Bacillus megaterium

    Małgorzata Wyciszkiewicz, Agnieszka Saeid*, Katarzyna Chojnacka

    Journal of Renewable Materials, Vol.5, Suppl.1, pp. 39-52, 2017, DOI:10.7569/JRM.2017.634132

    Abstract The aim of this work was to evaluate the effects of using B. megaterium in solubilization of phosphates from different secondary raw materials, such as fish bones, poultry bones, ashes and phosphorite, by identification of the effect of different doses of phosphorus-bearing materials on the growth of microbial cells and the effectiveness of the solubilization process. Both FTIR as well as SEM-EDX techniques were used to compare the effect of the acids on renewable phosphorus source. Two doses of mentioned materials were used: 2 and 30 g/L. The effect of solubilization was expressed as the solubilization More >

  • Open Access

    ARTICLE

    In vitro antifungal/fungistatic activity of manganese phosphite against soybean soil-borne pathogens

    Carmona MA1, E Simonetti2,3, ME Ravotti1, MM Sc,iani4, AG Luque4, NA Formento5, FJ Sautua1

    Phyton-International Journal of Experimental Botany, Vol.86, pp. 265-269, 2017, DOI:10.32604/phyton.2017.86.265

    Abstract Soybean root and stem rots caused by soil-borne pathogens are diseases commonly found in soybean fields, and one of the most important causes of crop losses. In the present study, the mycelial sensitivity of Fusarium virguliforme, F. tucumaniae, Sclerotinia sclerotiorum and Macrophomina phaseolina was evaluated on potato dextrose agar media (25 mL) supplemented with different concentrations of manganese phosphite (MnPhi) diluted in water (0, 25, 37.5, 50, 100, 200, 300, 400, 500, 800 and 1000 μg/mL). Mycelial growth sensitivity was analyzed using logarithmic linear regression analysis. The MnPhi concentration needed to inhibit 50% of the mycelial growth (IC50) More >

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