Xinyue Wang^1,#, Jing Xu^1,#, Qihong Gu¹, Dingxuan Tang¹, Huoyan Ji², Shaoqing Ju², Feng Wang^2,*, Lin Chen³, Ruoyu Yuan^2,*

Oncologie, Vol.24, No.3, pp. 513-526, 2022, DOI:10.32604/oncologie.2022.024373

Abstract Background: MicroRNAs (miRNAs) have been identified as promising novel biomarkers for cancer diagnosis and prognosis, especially for hepatocellular carcinoma (HCC). Nowadays, the expression level of miR-21 in serum samples is a diagnostic indicator for HCC diagnosis. Thus, the quantitative determination of miRNA concentration is of significance in clinical practice. It is particularly important to establish an analytical detection method for miR-21 in patient serum. Methods: The signal readout for miR-21 was based on the mass response of a reporter peptide using an isotope dilution mass spectrometry (MS) method in this work. To be more specific, miR-21 was biotinylated before being… More >

S. Siamala Devi¹, Chandrakala Kuruba², Yunyoung Nam^3,*, Mohamed Abouhawwash^4,5

Computer Systems Science and Engineering, Vol.44, No.3, pp. 2209-2223, 2023, DOI:10.32604/csse.2023.025514

Abstract Health care visualization through Internet of Things (IoT) over wireless sensor network (WSN) becomes a current research attention due to medical sensor evolution of devices. The digital technology-based communication system is widely used in all application. Internet of medical thing (IoMT) assisted healthcare application ensures the continuous health monitoring of a patient and provides the early awareness of the one who is suffered without human participation. These smart medical devices may consume with limited resources and also the data generated by these devices are large in size. These IoMT based applications suffer from the issues such as security, anonymity, privacy,… More >

Saravanan Manikandan¹, Mosiur Rahaman¹, Yu-Lin Song^1,2,*

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5789-5808, 2022, DOI:10.32604/cmc.2022.031490

Abstract The Internet of Vehicles (IoV) has evolved as an advancement over the conventional Vehicular Ad-hoc Networks (VANETs) in pursuing a more optimal intelligent transportation system that can provide various intelligent solutions and enable a variety of applications for vehicular traffic. Massive volumes of data are produced and communicated wirelessly among the different relayed entities in these vehicular networks, which might entice adversaries and endanger the system with a wide range of security attacks. To ensure the security of such a sensitive network, we proposed a distributed authentication mechanism for IoV based on blockchain technology as a distributed ledger with an… More >

S. Sathish Kumar^1,*, G. Ravi²

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2367-2382, 2023, DOI:10.32604/iasc.2023.030054

Abstract Due to the scattered nature of the network, data transmission in a distributed Mobile Ad-hoc Network (MANET) consumes more energy resources (ER) than in a centralized network, resulting in a shorter network lifespan (NL). As a result, we build an Enhanced Opportunistic Routing (EORP) protocol architecture in order to address the issues raised before. This proposed routing protocol goal is to manage the routing cost by employing power, load, and delay to manage the routing energy consumption based on the flooding of control packets from the target node. According to the goal of the proposed protocol technique, it is possible… More >

Weixing Zhang, Chunxia He^*

Journal of Renewable Materials, Vol.10, No.12, pp. 3263-3283, 2022, DOI:10.32604/jrm.2022.020516

Abstract With the exponential growth of the computing power, machine learning techniques have been successfully used in various applications. This paper intended to predict and optimize the shear strength of single lap cassava starchbased adhesive joints for comparison with the application of artificial intelligence (AI) methods. The shear strength was firstly determined by the experiment with three independent experimental variables (starch content, NaOH concentration and reaction temperature). The analysis of range (ANORA) and analysis of variance (ANOVA) were applied to investigate the optimal combination and the significance of each factor for the shear strength based on the orthogonal experiment. The performance… More >

Minxi Rong¹, Yong Li^1,*, Xiaoli Guo^1,*, Tao Zong², Zhiyuan Ma², Penglei Li²

Oncologie, Vol.24, No.2, pp. 309-327, 2022, DOI:10.32604/oncologie.2022.021256

Abstract Objectives: The ERα biological activity prediction model is constructed by the compound molecular data of the anti-breast cancer therapeutic target ERα and its biological activity data, which improves the screening efficiency of anti-breast cancer drug candidates and saves the time and cost of drug development. Methods: In this paper, Ridge model is used to screen out molecular descriptors with a high degree of influence on the biological activity of Erα and divide datasets with different numbers of the molecular descriptors by screening results. Random Forest (RF) is trained by Root Mean Square Error (RMSE) and Coefficient of determination (R²) to… More >

Xianling Fu^#, Hongliang Ding^#, Xin Wang^*, Lei Song, Yuan Hu^*

Journal of Renewable Materials, Vol.10, No.9, pp. 2303-2317, 2022, DOI:10.32604/jrm.2022.020759

Abstract Although epoxy resin has been widely used in various fields, it still suffers from some problems including brittleness and flammability. In this study, a new phosphonic acid, N, N-bis(phosphomethyl) glycine (GDMP), was prepared by Mannich reaction with bio-based glycine and then a novel layered zirconium phosphonate (ZrGDMP) was synthesized using GDMP and zirconyl chloride hydrate as reactants. The chemical structure of ZrGDMP was well characterized by ¹H and ³¹P NMR, SEM, XRD and XPS. The effect of ZrGDMP on the flame retardancy, smoke suppression, strengthening and toughening performances of the epoxy matrix was investigated and evaluated. TGA results indicated that… More > Graphic Abstract

Chenxi Yu, Xin Li^*

Intelligent Automation & Soft Computing, Vol.34, No.3, pp. 2023-2034, 2022, DOI:10.32604/iasc.2022.029447

Abstract Machine reading comprehension (MRC) is a task in natural language comprehension. It assesses machine reading comprehension based on text reading and answering questions. Traditional attention methods typically focus on one of syntax or semantics, or integrate syntax and semantics through a manual method, leaving the model unable to fully utilize syntax and semantics for MRC tasks. In order to better understand syntactic and semantic information and improve machine reading comprehension, our study uses syntactic and semantic attention to conduct text modeling for tasks. Based on the BERT model of Transformer encoder, we separate a text into two branches: syntax part… More >

Najla Bagais^*, Etimad Fadel, Amal Al-Mansour

CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1237-1267, 2022, DOI:10.32604/cmc.2022.026070

Abstract Wireless sensor networks (WSNs) are considered the backbone of the Internet of Things (IoT), which enables sensor nodes (SNs) to achieve applications similarly to human intelligence. However, integrating a WSN with the IoT is challenging and causes issues that require careful exploration. Prolonging the lifetime of a network through appropriately utilising energy consumption is among the essential challenges due to the limited resources of SNs. Thus, recent research has examined mobile sinks (MSs), which have been introduced to improve the overall efficiency of WSNs. MSs bear the burden of data collection instead of consuming energy at the routeing by SNs.… More >

JULIANA SOARES^1,2,#, DOUGLAS G. FREITAS^1,3,#, PEDRO S. LOURENÇO^1,4, JEFTE FARIAS^1,5, BRUNO PONTES^1,2,3,4,5,*

BIOCELL, Vol.46, No.9, pp. 2009-2013, 2022, DOI:10.32604/biocell.2022.019969

Abstract Mammalian cell surfaces consist of the plasma membrane supported by an underneath cortical cytoskeleton. Together, these structures can control not only the shape of cells but also a series of cellular functions ranging from migration and division to exocytosis, endocytosis and differentiation. Furthermore, the cell surface is capable of exerting and reacting to mechanical forces. Its viscoelastic properties, especially membrane tension and bending modulus, are fundamental parameters involved in these responses. This viewpoint summarizes our current knowledge on how to measure the viscoelastic properties of cell surfaces employing optical tweezers-based tether assays, paving the way for a better understanding of… More >