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  • Open Access


    Drosophila melanogaster as an indispensable model to decipher the mode of action of neurotoxic compounds


    BIOCELL, Vol.47, No.1, pp. 51-69, 2023, DOI:10.32604/biocell.2022.023392

    Abstract Exposure to some toxic compounds causes structural and behavioral anomalies associated with the neurons in the later stage of life. Those toxic compounds are termed as a neurotoxicant, which can be a physical factor, a toxin, an infection, radiation, or maybe a drug. The incongruities caused due to a neurotoxicant further depend on the toxicity of the compound. More importantly, the neurotoxicity of the compound is associated with the concentration and the time point of exposure. The neurodevelopmental defect appears depending on the toxicity of the compound. A neurodevelopmental defect may be associated with a More >

  • Open Access


    A UHPLC/MS/MS Assay Based on an Isotope-Labeled Peptide for Sensitive miR-21 Detection in HCC Serum

    Xinyue Wang1,#, Jing Xu1,#, Qihong Gu1, Dingxuan Tang1, Huoyan Ji2, Shaoqing Ju2, Feng Wang2,*, Lin Chen3, Ruoyu Yuan2,*

    Oncologie, Vol.24, No.3, pp. 513-526, 2022, DOI:10.32604/oncologie.2022.024373

    Abstract Background: MicroRNAs (miRNAs) have been identified as promising novel biomarkers for cancer diagnosis and prognosis, especially for hepatocellular carcinoma (HCC). Nowadays, the expression level of miR-21 in serum samples is a diagnostic indicator for HCC diagnosis. Thus, the quantitative determination of miRNA concentration is of significance in clinical practice. It is particularly important to establish an analytical detection method for miR-21 in patient serum. Methods: The signal readout for miR-21 was based on the mass response of a reporter peptide using an isotope dilution mass spectrometry (MS) method in this work. To be more specific, miR-21… More >

  • Open Access


    Paillier Cryptography Based Message Authentication Code for IoMT Security

    S. Siamala Devi1, Chandrakala Kuruba2, Yunyoung Nam3,*, Mohamed Abouhawwash4,5

    Computer Systems Science and Engineering, Vol.44, No.3, pp. 2209-2223, 2023, DOI:10.32604/csse.2023.025514

    Abstract Health care visualization through Internet of Things (IoT) over wireless sensor network (WSN) becomes a current research attention due to medical sensor evolution of devices. The digital technology-based communication system is widely used in all application. Internet of medical thing (IoMT) assisted healthcare application ensures the continuous health monitoring of a patient and provides the early awareness of the one who is suffered without human participation. These smart medical devices may consume with limited resources and also the data generated by these devices are large in size. These IoMT based applications suffer from the issues… More >

  • Open Access


    Active Authentication Protocol for IoV Environment with Distributed Servers

    Saravanan Manikandan1, Mosiur Rahaman1, Yu-Lin Song1,2,*

    CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5789-5808, 2022, DOI:10.32604/cmc.2022.031490

    Abstract The Internet of Vehicles (IoV) has evolved as an advancement over the conventional Vehicular Ad-hoc Networks (VANETs) in pursuing a more optimal intelligent transportation system that can provide various intelligent solutions and enable a variety of applications for vehicular traffic. Massive volumes of data are produced and communicated wirelessly among the different relayed entities in these vehicular networks, which might entice adversaries and endanger the system with a wide range of security attacks. To ensure the security of such a sensitive network, we proposed a distributed authentication mechanism for IoV based on blockchain technology as… More >

  • Open Access


    Opportunistic Routing with Multi-Channel Cooperative Neighbour Discovery

    S. Sathish Kumar1,*, G. Ravi2

    Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2367-2382, 2023, DOI:10.32604/iasc.2023.030054

    Abstract Due to the scattered nature of the network, data transmission in a distributed Mobile Ad-hoc Network (MANET) consumes more energy resources (ER) than in a centralized network, resulting in a shorter network lifespan (NL). As a result, we build an Enhanced Opportunistic Routing (EORP) protocol architecture in order to address the issues raised before. This proposed routing protocol goal is to manage the routing cost by employing power, load, and delay to manage the routing energy consumption based on the flooding of control packets from the target node. According to the goal of the proposed… More >

  • Open Access


    Modeling and Optimization of the Shear Strength of Cassava Starch-Based Adhesives Using Artificial Intelligence Methods

    Weixing Zhang, Chunxia He*

    Journal of Renewable Materials, Vol.10, No.12, pp. 3263-3283, 2022, DOI:10.32604/jrm.2022.020516

    Abstract With the exponential growth of the computing power, machine learning techniques have been successfully used in various applications. This paper intended to predict and optimize the shear strength of single lap cassava starchbased adhesive joints for comparison with the application of artificial intelligence (AI) methods. The shear strength was firstly determined by the experiment with three independent experimental variables (starch content, NaOH concentration and reaction temperature). The analysis of range (ANORA) and analysis of variance (ANOVA) were applied to investigate the optimal combination and the significance of each factor for the shear strength based on… More >

  • Open Access


    An ISSA-RF Algorithm for Prediction Model of Drug Compound Molecules Antagonizing ERα Gene Activity

    Minxi Rong1, Yong Li1,*, Xiaoli Guo1,*, Tao Zong2, Zhiyuan Ma2, Penglei Li2

    Oncologie, Vol.24, No.2, pp. 309-327, 2022, DOI:10.32604/oncologie.2022.021256

    Abstract Objectives: The ERα biological activity prediction model is constructed by the compound molecular data of the anti-breast cancer therapeutic target ERα and its biological activity data, which improves the screening efficiency of anti-breast cancer drug candidates and saves the time and cost of drug development. Methods: In this paper, Ridge model is used to screen out molecular descriptors with a high degree of influence on the biological activity of Erα and divide datasets with different numbers of the molecular descriptors by screening results. Random Forest (RF) is trained by Root Mean Square Error (RMSE) and Coefficient of… More >

  • Open Access


    A Novel Bio-Based Zirconium Phosphonate as a Flame Retardant and Smoke Suppressant for Epoxy Resin

    Xianling Fu#, Hongliang Ding#, Xin Wang*, Lei Song, Yuan Hu*

    Journal of Renewable Materials, Vol.10, No.9, pp. 2303-2317, 2022, DOI:10.32604/jrm.2022.020759

    Abstract Although epoxy resin has been widely used in various fields, it still suffers from some problems including brittleness and flammability. In this study, a new phosphonic acid, N, N-bis(phosphomethyl) glycine (GDMP), was prepared by Mannich reaction with bio-based glycine and then a novel layered zirconium phosphonate (ZrGDMP) was synthesized using GDMP and zirconyl chloride hydrate as reactants. The chemical structure of ZrGDMP was well characterized by 1H and 31P NMR, SEM, XRD and XPS. The effect of ZrGDMP on the flame retardancy, smoke suppression, strengthening and toughening performances of the epoxy matrix was investigated and evaluated.… More > Graphic Abstract

    A Novel Bio-Based Zirconium Phosphonate as a Flame Retardant and Smoke Suppressant for Epoxy Resin

  • Open Access


    SSAG-Net: Syntactic and Semantic Attention-Guided Machine Reading Comprehension

    Chenxi Yu, Xin Li*

    Intelligent Automation & Soft Computing, Vol.34, No.3, pp. 2023-2034, 2022, DOI:10.32604/iasc.2022.029447

    Abstract Machine reading comprehension (MRC) is a task in natural language comprehension. It assesses machine reading comprehension based on text reading and answering questions. Traditional attention methods typically focus on one of syntax or semantics, or integrate syntax and semantics through a manual method, leaving the model unable to fully utilize syntax and semantics for MRC tasks. In order to better understand syntactic and semantic information and improve machine reading comprehension, our study uses syntactic and semantic attention to conduct text modeling for tasks. Based on the BERT model of Transformer encoder, we separate a text… More >

  • Open Access


    An Efficient Path Planning Strategy in Mobile Sink Wireless Sensor Networks

    Najla Bagais*, Etimad Fadel, Amal Al-Mansour

    CMC-Computers, Materials & Continua, Vol.73, No.1, pp. 1237-1267, 2022, DOI:10.32604/cmc.2022.026070

    Abstract Wireless sensor networks (WSNs) are considered the backbone of the Internet of Things (IoT), which enables sensor nodes (SNs) to achieve applications similarly to human intelligence. However, integrating a WSN with the IoT is challenging and causes issues that require careful exploration. Prolonging the lifetime of a network through appropriately utilising energy consumption is among the essential challenges due to the limited resources of SNs. Thus, recent research has examined mobile sinks (MSs), which have been introduced to improve the overall efficiency of WSNs. MSs bear the burden of data collection instead of consuming energy… More >

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