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  • Open Access

    ARTICLE

    Inhibitory Effect of Ponkan (Citrus reticulata ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway

    Lili Liu1, Can Hu4, Huilin Cheng1, Chuangju Ma1, Jiancheng Sun1, Yunyi Chen2, Manxi Wu2, Han Yang2, Cui Sun2,3, Jinping Cao2,3, Dengliang Wang1,*, Yue Wang2,*, Chongde Sun2,3

    Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2499-2518, 2024, DOI:10.32604/phyton.2024.054449 - 30 September 2024

    Abstract Oral ulcers, a common mucosal affliction, severely diminish patients’ quality of life due to pain and discomfort. Despite existing treatments, the frequent recurrence of oral ulcers underscores the need for more effective therapeutic options. This study aimed to investigate the inhibitory effects of Ponkan (Citrus reticulata ‘Ponkan’) extracts and their flavonoid components on oral ulcers, exploring their potential as a natural therapy. Twenty different Ponkan cultivars were selected for flavonoid extraction and analysis. Ultra-performance liquid chromatography (UPLC) and high-resolution mass spectrometry (HRMS) were utilized for substance identification, leading to the discovery of 16 flavonoid compounds. Using… More > Graphic Abstract

    Inhibitory Effect of Ponkan (<i>Citrus reticulata</i> ‘Ponkan’) Flavonoids on Oral Ulcers through Jak2-Stat3 Signaling Pathway

  • Open Access

    ARTICLE

    Lovastatin modulation of YAP/TAZ signaling on cardiomyocyte autophagy and mitochondrial damage in myocardial I/R injury

    KAITIAN ZHANG1,#, MINGZHU LI2,#,*, JIANPING ZHANG3, JINFENG LI2, KUNLANG LI2, HUANQIAN LU2, JINYAN LV2

    BIOCELL, Vol.48, No.10, pp. 1489-1501, 2024, DOI:10.32604/biocell.2024.053930 - 02 October 2024

    Abstract Objective: Studies have demonstrated that administering statins promptly following myocardial ischemia/reperfusion (MI/R) can confer cardioprotective benefits. This study investigates whether Lovastatin can modulate the Yes-associated protein/Transcriptional co-activator with PDZ-binding motif (YAP/TAZ) signaling pathway to mitigate cardiomyocyte injury caused by hypoxia/reoxygenation (H/R). Methods: The in vitro MI/R model was established by H/R in rat myocardial H9c2 cells, and the cells were pretreated with varying doses of Lovastatin before reoxygenation. The extent of cellular injury was evaluated by measuring the myocardial enzyme content and cell viability. The levels of oxidative stress and inflammatory factors were quantified by enzyme-linked… More > Graphic Abstract

    Lovastatin modulation of YAP/TAZ signaling on cardiomyocyte autophagy and mitochondrial damage in myocardial I/R injury

  • Open Access

    RETRACTION

    Retraction: YEATS domain containing 4 promotes gastric cancer cell proliferation and mediates tumor progression via activating the Wnt/β-Catenin signaling pathway

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.10, pp. 1697-1698, 2024, DOI:10.32604/or.2024.056918 - 18 September 2024

    Abstract This article has no abstract. More >

  • Open Access

    RETRACTION

    Retraction: LINC00052 promotes gastric cancer cell proliferation and metastasis via activating the Wnt/β-Catenin signaling pathway

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.10, pp. 1677-1678, 2024, DOI:10.32604/or.2024.056891 - 18 September 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Apatinib reduces liver cancer cell multidrug resistance by modulating NF-κB signaling pathway

    XIAOXIAO HE1, XUEQING ZHOU2, JINPENG ZHANG2, MINGFEI ZHANG2, DANHONG ZENG2, HENG ZHANG1, SHUCAI YANG2,*

    BIOCELL, Vol.48, No.9, pp. 1331-1341, 2024, DOI:10.32604/biocell.2024.052625 - 04 September 2024

    Abstract Objectives: This investigation aimed to elucidate the inhibitory impact of apatinib on the multidrug resistance of liver cancer both in vivo and in vitro. Methods: To establish a Hep3B/5-Fu resistant cell line, 5-Fu concentrations were gradually increased in the culture media. Hep3B/5-Fu cells drug resistance and its alleviation by apatinib were confirmed via flow cytometry and Cell Counting Kit 8 (CCK8) test. Further, Nuclear factor kappa B (NF-κB) siRNA was transfected into Hep3B/5-Fu cells to assess alterations in the expression of multidrug resistance (MDR)-related genes and proteins. Nude mice were injected with Hep3B/5-Fu cells to establish subcutaneous… More >

  • Open Access

    RETRACTION

    Retraction: miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.9, pp. 1523-1523, 2024, DOI:10.32604/or.2024.056118 - 23 August 2024

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    IL13RA2 promotes progression of infantile haemangioma by activating glycolysis and the Wnt/β-catenin signaling pathway

    ZIYONG LIU1,#, TAO MA1,#, JINFANG LI2, WEI REN1,*, ZHIXIN ZHANG1,*

    Oncology Research, Vol.32, No.9, pp. 1453-1465, 2024, DOI:10.32604/or.2024.048315 - 23 August 2024

    Abstract Background: Interleukin 13 receptor subunit alpha 2 (IL13RA2) plays an essential role in the progression of many cancers. However, the role of IL13RA2 in infantile haemangioma (IH) is still unknown. Materials and Methods: IL13RA2 expression in IH tissues was analyzed using western blot, qRT-PCR, and immunofluorescence. The role of IL13RA2 in haemangioma-derived endothelial cells (HemECs) was determined following knockdown or overexpression of IL13RA2 using CCK-8, colony formation, apoptosis, wound healing, tubule formation, Transwell, and western blot. Results: IL13RA2 expression was upregulated in IH tissues. IL13RA2 overexpression promoted proliferation, migration, and invasion of HemECs and induced glycolysis, More >

  • Open Access

    ARTICLE

    Oleanolic acid inhibits colon cancer cell stemness and reverses chemoresistance by suppressing JAK2/STAT3 signaling pathway

    RUOYU CHEN1, YIMAN WU1, FENG WANG1, JUNTAO ZHOU1, HUAZHANG ZHUANG1, WEI LI2,*

    BIOCELL, Vol.48, No.7, pp. 1037-1046, 2024, DOI:10.32604/biocell.2024.051074 - 03 July 2024

    Abstract Background: Oleanolic acid (OA), a pentacyclic triterpenoid exhibiting specific anti-cancer properties and highly effective antioxidant activity, was isolated from traditional Chinese medicinal herbs. Conversely, the OA that impacts colon cancer (CC) cells and its underlying mechanisms remain poorly understood. Methods: The cytotoxic effect of OA alone or OA-5-Fluorouracil (5-FU) combination on normal and CC cells was analyzed by methyl thiazolyl diphenyl-tetrazolium bromide (MTT). Then, the impact of OA on CC cell lines (LoVo and HT-29) proliferation and stemness were measured using colon formation and tumorsphere formation assays. Octamer-binding transcription factor 4 (Oct4), Prominin-1 (CD133), Nanog,… More >

  • Open Access

    ARTICLE

    Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

    YAN-NAN LI1,#, YUN-HONG XIU2,#, YAN-JUN TANG3, JING-LONG CAO1, WEN-SHUANG HOU1, AN-QI WANG1, TIAN-ZHU LI4,*, CHENG-HAO JIN1,3,5,*

    BIOCELL, Vol.48, No.7, pp. 1055-1069, 2024, DOI:10.32604/biocell.2024.050515 - 03 July 2024

    Abstract Objectives: Sciadopitysin (SP) is a flavonoid in Ginkgo biloba that exhibits various pharmacological activities. This study aimed to investigate its antitumor effects and the underlying molecular mechanism of SP in hepatocellular carcinoma (HCC) cells. Methods: Network pharmacology was used for target prediction analysis. Cell Counting Kit-8 (CCK-8) assay was used to test the cell viability. Flow cytometry was used to test the cell cycle distribution, apoptosis status, and reactive oxygen species (ROS) levels. Transwell and wound-healing assay was used to test the migration effect of SP on HepG2 cells. Western Blot assay was used to… More > Graphic Abstract

    Sciadopitysin exerts anticancer effects on HepG2 hepatocellular carcinoma cells by regulating reactive oxygen species-mediated signaling pathways

  • Open Access

    ARTICLE

    Cholic acid mitigates osteoarthritis by inhibiting the NF-κB/PERK/SIRT1 signaling pathway

    JIAOE SHENG1, ZUMIN YI2, SANSHAN HE1, QINGCHAO WU1, XIA HUANG1, GUOQING YAN1, YUFANG DAI1,*, LINCHONG SU1,*

    BIOCELL, Vol.48, No.7, pp. 1095-1104, 2024, DOI:10.32604/biocell.2024.028421 - 03 July 2024

    Abstract Introduction: Cholic acid (CA) is a natural steroid useful in treating chronic bronchitis and cholecystitis. On the other hand, its potential impact on osteoarthritis (OA) is unknown. Objective: Using an in vitro and in vivo osteoarthritis model, we sought to assess the chondroprotective properties of CA. Methods: We employed the Cell Counting Kit-8 to measure the impact of CA on chondrocyte activity to assess the toxicity of the cells. Multiple molecular biology experimental techniques were used to investigate potential signaling pathways that CA may use to prevent inflammation and give chondrocytes protection. Furthermore, how CA affects the OA… More >

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