Shaomin Liang, Lu Liu, Shunying Ji^*

CMES-Computer Modeling in Engineering & Sciences, Vol.128, No.1, pp. 145-160, 2021, DOI:10.32604/cmes.2021.016403

Abstract Based on the discrete element method and hydrostatics theory, an improved Archimedes principle is proposed to study the rules pertaining to resistance changes during the penetration process of an intruder into the particulate materials. The results illustrate the fact that the lateral contribution to the resistance is very small, while the tangential force of the lateral resistance originates from friction effects. Conversely, the resistance of particulate materials on the intruder mainly occurs at the bottom part of the intruding object. Correspondingly, the factors that determine the resistance of the bottom part of the intruding object and the rules pertaining to… More >

Keiichi Kontani^1,*, Kana Kuraishi¹, Shin-ichiro Hashimoto¹, Shoko Norimura², Nozomi Hashimoto¹, Masahiro Ohtani³, Naomi Fujiwara-Honjo⁴, Manabu Date⁵, Koji Teramoto⁶, Hiroyasu Yokomise¹

Oncologie, Vol.23, No.2, pp. 229-239, 2021, DOI:10.32604/Oncologie.2021.016277

Abstract The prognosis of patients with human epidermal growth factor receptor-2 (HER2)-overexpressed metastatic breast cancer (MBC) has improved drastically following the development of anti-HER2 therapies. We question what factors are involved in the improved outcome by the treatment. One hundred and two MBC patients who received chemotherapy were classified into groups according to breast cancer subtype: luminal/HER2-negative (n = 50), HER2 (n = 26), and triple-negative subtypes (n = 26). Clinicopathologic features and clinical outcomes of the groups were compared. Disease-free intervals in the triple-negative group were significantly shorter than those in the other two groups. Age, tumor grade, the number… More >

Pierre-Guillaume Poureau^1,2,*, Estelle Dhamelincourt², Jessica Nguyen², Hélène Babey², Emmanuelle Renaud², Margaux Geier², Michèle Boisdron-Celle³, Jean-Philippe Metges²

Oncologie, Vol.23, No.2, pp. 195-202, 2021, DOI:10.32604/Oncologie.2021.015929

Abstract Introduction: Regorafenib is a multi tyrosin-kinase inhibitor prescribed in metastatic refractory colorectal cancer treatment. Its toxicity is significant but inconstant. The metabolism of regorafenib includes oxydation via cytochrome P3A4, then glucuroconjugation. A pharmacogenetical approach of mutational status of Uridine-Diphospho-Glucuronosyltransfersase (UDP-glucuronosyl-transferase, UGT) could be a strategy to optimise the use of regorafenib. Patients and Method: This is a restrospective, unicentric study. All adult patients treated with regorafenib for a metastatic colorectal cancer in our center between 2013 and 2017 were analysed. UGT1A1 polypmorphism was previously researched in the laboratory after written informed consent. Results: Thirty-five patients received regorafenib during the study… More >

Zele Li¹, Mohammad Noori², Wael A. Altabey^1,3,*

Structural Durability & Health Monitoring, Vol.15, No.2, pp. 103-123, 2021, DOI:10.32604/sdhm.2021.011193

Abstract Earth buildings are common types of structures in most rural areas in all developing countries. Catastrophic failure and destruction of these structures under seismic loads always result in loss of human lives and economic losses. Wall is an important load-bearing component of raw soil buildings. In this paper, a novel approach is proposed to improve the strength and ductility of adobe walls. Three types of analyses, material properties, mechanical properties, and dynamic properties, are carried out for the seismic performance assessment of the adobe walls. These performed studies include that, material properties of the earth cylinder block, mechanical properties of… More >

Osamah Ibrahim Khalaf¹, Munsif Sokiyna^2,*, Youseef Alotaibi³, Abdulmajeed Alsufyani⁴, Saleh Alghamdi⁵

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 3167-3184, 2021, DOI:10.32604/cmc.2021.016099

Abstract A major issue while building web applications is proper input validation and sanitization. Attackers can quickly exploit errors and vulnerabilities that lead to malicious behavior in web application validation operations. Attackers are rapidly improving their capabilities and technologies and now focus on exploiting vulnerabilities in web applications and compromising confidentiality. Cross-site scripting (XSS) and SQL injection attack (SQLIA) are attacks in which a hacker sends malicious inputs (cheat codes) to confuse a web application, to access or disable the application’s back-end without user awareness. In this paper, we explore the problem of detecting and removing bugs from both client-side and… More >

Man Yuan, Lu Hong, Zehui Ju, Wenli Gu, Biqing Shu, Jianxin Cui, Xiaoning Lu^*, Zhiqiang Wang^*

Journal of Renewable Materials, Vol.9, No.8, pp. 1433-1445, 2021, DOI:10.32604/jrm.2021.015040

Abstract In this study, the effects of three different particle sizes of wood wastes (A = –8 + 12 mesh; B = –12 + 20 mesh; C = –20 + 30 mesh) and factory shavings (D) on the properties of particleboard were investigated. According to the test results, three-layer particleboard was designed. Particleboard face layers made with mixture of A, B, and C. The core layer made with D. The ratio of core layer to face layers is 50:50. Three-layer particleboard were fabricated with 12% urea-formaldehyde (UF) resins and three different high voltage electrostatic field intensities (0 kv, 30 kv, 60… More >

SUSHMITHA SRIRAMULU¹, SARUBALA MALAYAPERUMAL¹, SUMAN K. NANDY², ANTARA BANERJEE¹, MUSTHAFA MOHAMED ESSA^3,4, SARAVANABABU CHIDAMBARAM⁵, M. WALID QORONFLEH^6,7, SURAJIT PATHAK^1,*

BIOCELL, Vol.45, No.3, pp. 563-576, 2021, DOI:10.32604/biocell.2021.014756

Abstract Colon cancer is the third major cause of cancer deaths, accounting for about 8% in terms of mortality globally. The present study aims to explore the effect of silencing Astrocyte Elevated Gene-1 (AEG-1), a metastasis mediating factor, and how it interacts with Exostosin-1 (EXT-1) protein to inhibit the proliferative and invasive potential in colon cancer cells. Forward siRNA transfection was performed using AEG-1 siRNA in SW480 and SW620 colon cancer cell lines, and the expression levels of mRNA and protein were analyzed by Real-time PCR and Immunofluorescence. A simple bioinformatics approach was carried out to identify the possible interactions between… More >

Zhiguo Chen^1,*, Xiaorui Zhang^1,2, Sungryul Kim³

Intelligent Automation & Soft Computing, Vol.27, No.3, pp. 891-908, 2021, DOI:10.32604/iasc.2021.016933

Abstract The rapid growth of malware poses a significant threat to the security of computer systems. Analysts now need to examine thousands of malware samples daily. It has become a challenging task to determine whether a program is a benign program or malware. Making accurate decisions about the program is crucial for anti-malware products. Precise malware detection techniques have become a popular issue in computer security. Traditional malware detection uses signature-based strategies, which are the most widespread method used in commercial anti-malware software. This method works well against known malware but cannot detect new malware. To overcome the deficiency of the… More >

Yun Zhao, Shi Yan^*, Jiale Jia

CMES-Computer Modeling in Engineering & Sciences, Vol.126, No.3, pp. 1251-1274, 2021, DOI:10.32604/cmes.2021.013478

Abstract In this study, the pyramidal lattice stitched foam sandwich composite materials were manufactured by integrating top and bottom panels with pyramidal lattice core to overcome the weak interface between the core and the skins of the sandwich structure. The influence of the reinforcing core rods on the mechanical properties including compressive, shear, and three-point bending performances of the foam sandwich composite materials were revealed through theoretical analysis and comparative experiments. The theoretical predictions were consistent with the experimental results. Compressive test, shear test and three-point bending test were performed. The experimental results show that the core rods can significantly improve… More >

Senchun Miao^1,2,*, Hongbiao Zhang¹, Fengxia Shi¹, Xiaohui Wang¹, Xijin Ma¹

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.1, pp. 201-214, 2021, DOI:10.32604/fdmp.2021.012950

Abstract A volute is a curved funnel with cross-sectional area increasing towards the discharge port. The volute of a centrifugal pump is the casing hosting the fluid being pumped by the impeller. In Pump-as-turbine devices (PAT), vice versa the volute plays the role of energy conversion element. In the present analysis, this process is analyzed using CFD. The results show that in the contraction section of volute the conversion between dynamic pressure energy and static pressure energy essentially depends on the reduction of flow area, while in the spiral section, frictional losses also play a significant role. From the throat to… More >