Tingting Wu¹, Yunwei Dong^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.121, No.3, pp. 909-928, 2019, DOI:10.32604/cmes.2019.07809

Abstract The application of metamorphic testing (MT) on automatic program repair (APR-MT) is used to generate a patch without test oracles by examining whether the input metamorphic relation (MR) is satisfied or not. However, the delivered patch is plausible since it may satisfy the input MR but violate other MRs. This inspires us to propose an improved approach to enhance the effectiveness of APR-MT with metamorphic relation group. Our approach involves three major steps. First, we formally define the repair process of APR-MT by building the model of automatic program repair and metamorphic testing separately. Then, More >

Juan Isidro Sánchez-Duarte¹, David Guadalupe Reta-Sánchez^1,*, José Antonio Cueto-Wong¹, Arturo Reyes-González¹, Esmeralda Ochoa-Martínez¹

Phyton-International Journal of Experimental Botany, Vol.88, No.4, pp. 435-448, 2019, DOI:10.32604/phyton.2019.07512

Abstract Canola and oat forage potential may be affected by climatic conditions when sown early. The objective of this study was to evaluate the forage canola and oat potential in four early sowing dates (September 11 and 25; October 9 and 23) during the 2012-2013 and 2013-2014 cycles in Matamoros, Coahuila, Mexico. Growth cycle duration, chemical composition, dry matter (DM), crude protein (CP), and net energy for lactation (NE_L) yields were determined. High temperatures and long photoperiods affected crops seeded on September 11, accelerating growth and reducing canola (26.6%-31.7%) and oat (15.8%) DM yields. As of September… More >

Bengu Turkyilmaz Unal^1,*, Mustafa Bayram²

Phyton-International Journal of Experimental Botany, Vol.88, No.4, pp. 413-423, 2019, DOI:10.32604/phyton.2019.08244

Abstract In this study, we aimed to investigate the allelopathic effects of sunflower and wheat root exudates on the common weeds such as wild mustard and white mustard in our region. The root exudates which were obtained by soaking 8 weeks old sunflower and wheat seedlings (20 or 40 seedlings) in 100 mL of distilled water for 3 days were applied to the leaves of wild mustard and white mustard. In order to compare the allelopathic effect, the recommended dose (1 g.da^-1 ) and twice the recommended dose (2 g.da^-1 ) of Gromstor (Tribenuron-methyl), a herbicide preferred… More >

Narsimha Pandi¹, Shirish H. Sonawane^1,*, Sarang P. Gumfekar², Anand Kishore Kola¹, Pramod H. Borse³, Swapnil B. Ambade⁴, Sripadh Guptha¹, Muthupandian Ashokkumar⁵

Journal of Renewable Materials, Vol.7, No.12, pp. 1279-1293, 2019, DOI:10.32604/jrm.2019.07609

Abstract The present study deals with the intensified synthesis of starchpolyaniline (starch-PANI) nanocomposite using an ultrasound-assisted method. Starch is a key component in this nanocomposite, which acts as a backbone of the nucleation of PANI. The Electrochemical property of the nanocomposite arises due to the addition of PANI. This is one of green approach for the synthesis of bio nanocomposite using ultrasound. The crystallinity of the composite is evaluated using the Scherrer Formula. The starch-PANI nanocomposite was characterized by XRD, FT-IR, Raman, XPS and TEM. The composite nanoparticles show spherical morphology. The elemental composition of starch-PANI More >

Samsul Rizal¹, Fizree, H. M.², Chaturbhuj K. Saurabh³, Deepu A. Gopakumar², N. A. Sri Aprilia⁴, D. Hermawan⁵, A. Banerjee⁶, Fazita M. R. M², Haafiz M. K. M.², Abdul Khalil H. P. S.^2,*

Journal of Renewable Materials, Vol.7, No.12, pp. 1269-1278, 2019, DOI:10.32604/jrm.2019.07227

Abstract Oil palm ash (OPA) is an agro-industry waste and it has disposable problems. In the present study, an effort was made for value addition to OPA by incorporating it as a micro-filler in different concentration (0, 10, 20, 30, 40, and 50%) and sizes (100, 200, and 300 mesh size particles) in the epoxy matrix. Prepared micro OPA was having a crystallinity index of 65.4%, high inorganic elements, and smooth surface morphology. Fabricated composites had higher void content as compared to neat epoxy matrix. Mechanical properties of fabricated composites had a maximum value at 30%… More >

Viviane Timmermann¹, Kevin Vincent², Joakim Sundnes¹, Andrew D. McCulloch^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 133-133, 2019, DOI:10.32604/mcb.2019.07311

Abstract Heterogeneous mechanical dyskinesis has been implicated in arrhythmogenic phenotypes. Strain-induced perturbations to cardiomyocyte electrophysiology (EP) may trigger arrhythmias via a variety of mechano-electric feedback (MEF) mechanisms. While the role of stretch-activated ionic currents (SACs) has been investigated intensively using computational models, experimental studies have shown that mechanical strain can also trigger intra- and inter-cellular calcium waves. To investigate whether the inherent strain dependence of myofilament calcium affinity may promote arrhythmogenic intra- and inter-cellular calcium waves under conditions of pathologic mechanical heterogeneity, we coupled a mathematical model of excitation-contraction coupling (ECC) in rabbit ventricular myocytes to… More >

Fan Feng¹, Tingting Xia¹, Runze Zhao¹, Mengyue Wang¹, Li Yang^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 131-131, 2019, DOI:10.32604/mcb.2019.07211

Abstract Objective: To study the effects of different substrate stiffness on human hepatocytes using RNA sequencing (RNA-Seq) technology. The stiffness was corresponding to physiology and pathology stiffness of liver tissues.
Results: With the aid of RNA-Seq technology, our study characterizes the transcriptome of hepatocytes cultured on soft, moderate, stiff and plastic substrates. Compared to soft substrate, our RNA-Seq results revealed 1131 genes that were up-regulated and 2534 that were down-regulated on moderate substrate, 1370 genes that were up-regulated and 2677 down-regulated genes on stiff substrate. Functional enrichment analysis indicated that differentially expressed genes were associated with More >

Qiuping Liu¹, Guanbin Song^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 127-127, 2019, DOI:10.32604/mcb.2019.07105

Abstract Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Increased matrix stiffness of extracellular matrix (ECM) is commonly associated with HCC. During tumour formation and expansion, increasing glucose metabolism is necessary for unrestricted growth of tumour cells. Yet, the correlation between matrix stiffness and glucose metabolism in the development of HCC remains unknown. In this study, we aim to investigate the effect of matrix stiffness on glucose metabolism and migration of MHCC97L and HepG2 hepatoma cells, and explore the mechanotransduction involved in this process. Polyacrylamide hydrogels with stiffness gradients of 6,… More >

Lianhong Pan¹, Li Yang^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 118-118, 2019, DOI:10.32604/mcb.2019.07133

Abstract Osteoarthritis (OA) is a chronic joint bone disease which always leads to the dysfunction and disability of arthritis. Synovial inflammation plays an important role in the pathogenesis and progress of OA which can secrete large amounts of inflammatory cytokines. There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Icariin, a traditional Chinese herbal medicine, is the major pharmacological active component of herb Epimedium. This study we investigated the influence of icariin on the main cells in synovium-osteoarthritis fibroblast-like synoviocytes… More >

Lining Arnold Ju^{1,2,3,4,6,†,*}, James McFadyen^4,†, Saheb Al-Daher^4,†, Imala Alwis^1,2,3,4, Yunfeng Chen^6,7,8, Mark E. Cooper⁹, Cheng Zhu^1,2,3,5,6,7, Shaun P. Jackson^1,2,3,4,8

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 96-96, 2019, DOI:10.32604/mcb.2019.06979

Abstract Thrombotic diseases where platelets form clots and obstruct blood vessels remains the leading cause of death and disability in the world. Despite intense investigation over the last 40 years into the discovery and development of more effective drugs, less than 1 in 6 patients taking anti-thrombotic therapies avoid a fatal event. This situation is likely to worsen in younger generations due to the rapidly growing incidence of diabetes, which makes people more prone to thrombosis and resistant to existing anti-thrombotics with unknown reasons.
To investigate this, I have developed the ‘Biomembrane Force Probe’ as the… More >