Yongguo Li, Yuanrong Wang, Jia Xie^*, Caiyin Xu, Kun Zhang

CMC-Computers, Materials & Continua, Vol.80, No.1, pp. 467-486, 2024, DOI:10.32604/cmc.2024.051426 - 18 July 2024

Abstract To address the challenges of missed detections in water surface target detection using solely visual algorithms in unmanned surface vehicle (USV) perception, this paper proposes a method based on the fusion of visual and LiDAR point-cloud projection for water surface target detection. Firstly, the visual recognition component employs an improved YOLOv7 algorithm based on a self-built dataset for the detection of water surface targets. This algorithm modifies the original YOLOv7 architecture to a Slim-Neck structure, addressing the problem of excessive redundant information during feature extraction in the original YOLOv7 network model. Simultaneously, this modification simplifies… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1379-1379, 2024, DOI:10.32604/or.2024.055034 - 17 July 2024

Abstract This article has no abstract. More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.8, pp. 1371-1371, 2024, DOI:10.32604/or.2024.055030 - 17 July 2024

Abstract This article has no abstract. More >

HUI SUN, MASANORI KAWANO^*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

Oncology Research, Vol.32, No.8, pp. 1369-1370, 2024, DOI:10.32604/or.2024.052652 - 17 July 2024

Abstract This article has no abstract. More >

GERHARD HAMILTON^*, MARIE-THERESE EGGERSTORFER, SANDRA STICKLER

Oncology Research, Vol.32, No.8, pp. 1257-1264, 2024, DOI:10.32604/or.2024.051653 - 17 July 2024

Abstract The Kirsten rat sarcoma virus—son of sevenless 1 (KRAS-SOS1) axis drives tumor growth preferentially in pancreatic, colon, and lung cancer. Now, KRAS G12C mutated tumors can be successfully treated with inhibitors that covalently block the cysteine of the switch II binding pocket of KRAS. However, the range of other KRAS mutations is not amenable to treatment and the G12C-directed agents Sotorasib and Adragrasib show a response rate of only approximately 40%, lasting for a mean period of 8 months. One approach to increase the efficacy of inhibitors is their inclusion into proteolysis-targeting chimeras (PROTACs), which… More > Graphic Abstract

SNJEŽANA KAŠTELAN^1,2, ANA DIDOVIĆ PAVIČIĆ³, DARIA PAŠALIĆ⁴, TAMARA NIKUŠEVA-MARTIĆ⁵, SAMIR ČANOVIĆ^3,7, PETRA KOVAČEVIĆ^1,6,*, SUZANA KONJEVODA^3,7

Oncology Research, Vol.32, No.8, pp. 1265-1285, 2024, DOI:10.32604/or.2024.048437 - 17 July 2024

Abstract Uveal and conjunctival melanomas are relatively rare tumors; nonetheless, they pose a significant risk of mortality for a large number of affected individuals. The pathogenesis of melanoma at different sites is very similar, however, the prognosis for patients with ocular melanoma remains unfavourable, primarily due to its distinctive genetic profile and tumor microenvironment. Regardless of considerable advances in understanding the genetic characteristics and biological behaviour, the treatment of uveal and conjunctival melanoma remains a formidable challenge. To enhance the prospect of success, collaborative efforts involving medical professionals and researchers in the fields of ocular biology… More > Graphic Abstract

HAIQING HU^1,#,*, HAO YANG^2,#, SHUAISHUAI FAN³, XUE JIA³, YING ZHAO³, HONGRUI LI³

Oncology Research, Vol.32, No.8, pp. 1335-1346, 2024, DOI:10.32604/or.2024.044174 - 17 July 2024

Abstract Long non-coding RNAs (lncRNAs) have been implicated in cancer progression and drug resistance development. Moreover, there is evidence that lncRNA HOX transcript antisense intergenic RNA (HOTAIR) is involved in colorectal cancer (CRC) progression. The present study aimed to examine the functional role of lncRNA HOTAIR in conferring radiotherapy resistance in CRC cells, as well as the underlying mechanism. The relative expression levels of HOTAIR were examined in 70 pairs of CRC tumor and para-cancerous tissues, as well as in radiosensitive and radioresistant samples. The correlations between HOTAIR expression levels and clinical features of patients with… More >

Isaac Asare Boateng^1,2,*, Lord Amoah², Isogun Toluwalase Adewale³

Journal of Information Hiding and Privacy Protection, Vol.6, pp. 1-19, 2024, DOI:10.32604/jihpp.2024.051354 - 24 June 2024

Abstract Contrast enhancement in medical images has been vital since the prevalence of image representations in healthcare. In this research, the PRDHMCE (pairwise reversible data hiding for medical images with contrast enhancement) algorithm is proposed as an automatic contrast enhancement (CE) method for medical images based on region of interest (ROI) and non-region of interest (NROI). The PRDHMCE algorithm strategically enhances the ROI after segmentation using histogram stretching and data embedding. An initial histogram evaluation compares histogram bins with their neighbours to select the bin with the maximum pixel count. The selected bin is set as More >

LINGLI ZHANG^1,2,#, YAN LI^1,#, JINGXIN MAO^1,*

BIOCELL, Vol.48, No.6, pp. 905-922, 2024, DOI:10.32604/biocell.2024.050396 - 10 June 2024

Abstract Hepatocellular carcinoma (HCC) remains a prevalent and challenging malignancy globally, characterized by its numerous causal factors and generally unfavorable prognosis. In the relentless pursuit of effective treatment modalities, natural products have emerged as a promising and relatively non-toxic alternative, garnering significant interest. The integration of natural products with contemporary medical research has yielded encouraging therapeutic outcomes in the management of HCC. This review offers a comprehensive overview of the causal factors underlying HCC, and the diverse treatment options available, and highlights the advancements made by natural products in anti-HCC research. Particularly, we provide an outline More >

BINGJIE LI^1,#, WENBO CAO^1,2,3,#, JINJING XIAO¹, YIXIAO CHEN¹, QIYING WEI¹, MINGJIN YUE⁴, SAIJUN MO^1,2,3,*

BIOCELL, Vol.48, No.6, pp. 923-934, 2024, DOI:10.32604/biocell.2024.049160 - 10 June 2024

Abstract Perineural invasion (PNI), a particularly insidious form of tumor metastasis distinct from hematogenous or lymphatic spread, has the capacity to extend well beyond the primary tumor site, infiltrating distant regions devoid of lymphatic or vascular structures. PNI often heralds a decrease in patient survival rates and is recognized as an indicator of an unfavorable prognosis across a variety of cancers. Despite its clinical significance, the underlying molecular mechanisms of PNI remain elusive, complicating the development of specific and efficacious diagnostic and therapeutic strategies. In the realm of cancer research, non-coding RNAs (ncRNAs) have attracted considerable… More >