ZHIZHENG ZHANG^1,#, TAO LI^2,#, YUAN LI³, XI WANG⁴, HAO LIU⁵, XINYU SHEN⁵, ANN XU⁶, TIANSONG XIA^1,*, BO XU^7,*

Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >

Oncology Research Editorial Office

Oncology Research, Vol.33, No.3, pp. 735-735, 2025, DOI:10.32604/or.2024.056907 - 28 February 2025

Abstract This article has no abstract. More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >

ARMAND N. YAZDANI¹, MICHAELA PLETSCH¹, ABRAHAM CHORBAJIAN¹, DAVID ZITSER¹, VIKRANT RAI^1,2,*

BIOCELL, Vol.48, No.12, pp. 1683-1702, 2024, DOI:10.32604/biocell.2024.056252 - 30 December 2024

Abstract Mixed cholangiocarcinoma is a rare and aggressive neoplastic proliferation of biliary tract epithelial cells, accounting for up to 20% of primary liver cancers. It is the second most common primary liver malignancy with a 5-year survivability of less than 10% at diagnosis and is associated with various inflammatory diseases. Current management involves systemic chemotherapy, targeted radiation, and surgical resection, but long-term survival remains low, especially for surgically unresectable cases. Novel discoveries and understandings of the tumor microenvironment reveal new opportunities for targeted therapies for cholangiocarcinoma. Specifically, new pharmaceuticals including cell-based vaccines, tumor-associated neutrophils, and hepatic… More >

Sanxia Shi, Yinglei Song^*

CMC-Computers, Materials & Continua, Vol.81, No.2, pp. 2911-2934, 2024, DOI:10.32604/cmc.2024.055363 - 18 November 2024

Abstract Infrared small target detection technology plays a pivotal role in critical military applications, including early warning systems and precision guidance for missiles and other defense mechanisms. Nevertheless, existing traditional methods face several significant challenges, including low background suppression ability, low detection rates, and high false alarm rates when identifying infrared small targets in complex environments. This paper proposes a novel infrared small target detection method based on a transformed Gaussian filter kernel and clustering approach. The method provides improved background suppression and detection accuracy compared to traditional techniques while maintaining simplicity and lower computational costs.… More >

Suya Li¹, Ying Cao^1,*, Hengyi Ren², Dongsheng Zhu³, Xin Xie¹

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1449-1470, 2024, DOI:10.32604/cmc.2024.056824 - 15 October 2024

Abstract Multi-object tracking (MOT) has seen rapid improvements in recent years. However, frequent occlusion remains a significant challenge in MOT, as it can cause targets to become smaller or disappear entirely, resulting in low-quality targets, leading to trajectory interruptions and reduced tracking performance. Different from some existing methods, which discarded the low-quality targets or ignored low-quality target attributes. LQTTrack, with a low-quality association strategy (LQA), is proposed to pay more attention to low-quality targets. In the association scheme of LQTTrack, firstly, multi-scale feature fusion of FPN (MSFF-FPN) is utilized to enrich the feature information and assist… More >

Tongan Yu¹, Yali Xue^1,*, Yiming He¹, Shan Cui², Jun Hong²

CMC-Computers, Materials & Continua, Vol.81, No.1, pp. 1235-1250, 2024, DOI:10.32604/cmc.2024.056075 - 15 October 2024

Abstract With the rapid development of deep learning-based detection algorithms, deep learning is widely used in the field of infrared small target detection. However, well-designed adversarial samples can fool human visual perception, directly causing a serious decline in the detection quality of the recognition model. In this paper, an adversarial defense technology for small infrared targets is proposed to improve model robustness. The adversarial samples with strong migration can not only improve the generalization of defense technology, but also save the training cost. Therefore, this study adopts the concept of maximizing multidimensional feature distortion, applying noise… More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.10, pp. 1693-1694, 2024, DOI:10.32604/or.2024.056909 - 18 September 2024

Abstract This article has no abstract. More >

FEI CHU¹, KAI TONG¹, XIANG GU¹, MEI BAO¹, YANFEN CHEN¹, BIN WANG², YANHUA SHAO¹, LING WEI^1,*

Oncology Research, Vol.32, No.10, pp. 1661-1671, 2024, DOI:10.32604/or.2024.048287 - 18 September 2024

Abstract Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human body. Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters. Targeted inhibition of glutamine transporters effectively inhibits cell growth and proliferation in tumors. Among all cancers, digestive system malignant tumors (DSMTs) have the highest incidence and mortality rates, and the current therapeutic strategies for DSMTs are mainly surgical resection and chemotherapy. Due to the relatively More > Graphic Abstract

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1537-1537, 2024, DOI:10.32604/or.2024.056125 - 23 August 2024

Abstract This article has no abstract. More >