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  • Open Access

    REVIEW

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

    NILAM BHUSARE, MAUSHMI KUMAR*

    Oncology Research, Vol.32, No.5, pp. 849-875, 2024, DOI:10.32604/or.2024.047042

    Abstract Glioblastoma, the most aggressive form of brain tumor, poses significant challenges in terms of treatment success and patient survival. Current treatment modalities for glioblastoma include radiation therapy, surgical intervention, and chemotherapy. Unfortunately, the median survival rate remains dishearteningly low at 12–15 months. One of the major obstacles in treating glioblastoma is the recurrence of tumors, making chemotherapy the primary approach for secondary glioma patients. However, the efficacy of drugs is hampered by the presence of the blood-brain barrier and multidrug resistance mechanisms. Consequently, considerable research efforts have been directed toward understanding the underlying signaling pathways involved in glioma and developing… More > Graphic Abstract

    A review on potential heterocycles for the treatment of glioblastoma targeting receptor tyrosine kinases

  • Open Access

    ARTICLE

    Effect of Alkali Treatment on Saharan aloe vera cactus Fibre Properties and Optimization of Process by Response Surface Methodology

    GOBI NALLATHAMBI, BHARGAVI RAM THIMMIAH*

    Journal of Polymer Materials, Vol.37, No.3-4, pp. 189-200, 2020, DOI:10.32381/JPM.2020.37.3-4.6

    Abstract The aim of this study is to optimize the process parameters of alkali treated Saharan aloe vera cactus fibres using of Box-behnken experimental design. The Saharan aloe vera cactus fibres were treated with different concentration of NaOH, soaking time and temperature which affect the properties of fibres and plays main role in removal of lignin, hemicellulose, pectin and wax content. The chemical composition of untreated and treated fibres was analyzed by standard methods. XRD result shows the improvement in the crystallinity index of fibres due to alkali treatment. ATR-FTIR analysis shows that hemicellulose and lignin were decreased in all alkali… More >

  • Open Access

    ARTICLE

    Durable Aroma Finishing of Wool Fabric with Microencapsulated Vetiver Essential Oil and Assessment of its Properties

    SHALINI RUKHAYA*, NEELAM M. ROSE, SAROJ YADAV

    Journal of Polymer Materials, Vol.38, No.3-4, pp. 179-190, 2021, DOI:10.32381/JPM.2021.38.3-4.1

    Abstract The present study was conducted to develop aroma wool fabric using microencapsulated vetiver essential oil without deteriorating the fabric properties. SEM analysis of the treated wool fabric depicted adhesion of numerous microcapsules of spherical shape and FTIR analysis indicated presence of different functional groups on the fabric. The aroma treatment improved most of the tested physical properties of wool fabric. Aroma treated fabric displayed good antimoth efficacy in terms of weight reduction (7.57%) and moth mortality (40%). Treated wool fabric also exhibited antibacterial activity with 63.45 and 61.37 percent reduction in bacterial growth against S. aureus and E.coli, respectively. The… More >

  • Open Access

    ARTICLE

    Effect of Tetramethylurea (TMU) on Polysulfone Membrane Performance for Atrazine-containing Wastewater Treatment

    NIKITA GUPTA, SARITA KALLA, Z.V.P. MURTHY*

    Journal of Polymer Materials, Vol.40, No.3-4, pp. 317-328, 2023, DOI:10.32381/JPM.2023.40.3-4.12

    Abstract Tetramethylurea (TMU) is a good solvent for organic substances and has received little attention as compared to other solvents. The TMU is a polar solution and is one of the molecules with an amphiphilic character. In the present work, an attempt has been made to use TMU as an additive in the preparation of nanofiltration membranes to improve the hydrophilicity of the membrane. The polysulfone membrane has been modified by incorporating different concentrations of TMU (0, 0.5, and 1 wt.%) in order to check the rejection of atrazine in water. This study aim is to optimize the conditions to enhance… More >

  • Open Access

    ARTICLE

    Preparation of Polysulfone Capillary Ultrafiltration Membranes for Pre-treatment of Sea Water Reverse Osmosis and Studies on its Fouling behavior after Turbidity Removal from Sea Water

    V. S. MAMTANI, A. K. GHOSH*, R. C. BINDAL

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 137-149, 2022, DOI:10.32381/JPM.2022.39.1-2.9

    Abstract In this study, polysulfone based capillary ultrafiltration membranes with desired characteristics were indigenously developed and their performance was evaluated with respect to turbidity removal from raw sea water. Capillary membranes were spun with in-house fabricated spinneret using polymer casting solution (dope solution) of different compositions having different viscosity using polyvinyl pyrrolidone (PVP) as pore-forming agent. Different experimental conditions namely dope pressure, bore fluid flow rate and air gap distance are optimized to get membranes of desired properties. Test results of individual capillaries in terms of pure water permeability (PWP), separation of single uncharged solutes like polyethylene glycol (PEG) and mechanical… More >

  • Open Access

    ARTICLE

    ASSESSMENT OF TURBULENCE MODELS IN THE PREDICTION OF FLOW FIELD AND THERMAL CHARACTERISTICS OF WALL JET

    Arvind Pattamattaa,*, Ghanshyam Singhb

    Frontiers in Heat and Mass Transfer, Vol.3, No.2, pp. 1-11, 2012, DOI:10.5098/hmt.v3.2.3005

    Abstract The present study deals with the assessment of different turbulence models for heated wall jet flow. The velocity field and thermal characteristics for isothermal and uniform heat flux surfaces in the presence of wall jet flow have been predicted using different turbulence models and the results are compared against the experimental data of Wygnanski et al. (1992), Schneider and Goldstein (1994), and AbdulNour et al. (2000). Thirteen different turbulence models are considered for validation, which include the Standard k-ε (SKE), Realizable k-ε (RKE), shear stress transport (SST), Sarkar & So (SSA), v 2 -f, Reynolds stress Model (RSM), and Spalart… More >

  • Open Access

    ARTICLE

    Research on the Intervention Effect of Vibroacoustic Therapy in the Treatment of Patients with Depression

    Xiaodan Wang1,*, Zheng Xie2, Guiping Du3

    International Journal of Mental Health Promotion, Vol.26, No.2, pp. 149-160, 2024, DOI:10.32604/ijmhp.2023.030755

    Abstract Research purpose: This study implemented somatosensory music therapy on patients with depressive disorders, and explored the effects of somatosensory music therapy on the degree of depression, positive and negative emotions, intuitive stress and autonomic nervous function of patients. Research method: We collected 66 patients diagnosed with depression from the Department of Psychological Medicine of Henan Provincial People’s Hospital, and divided them into a control group and an intervention group according to the random number table, with 33 people in each group. The control group received routine psychiatric treatment and nursing. On the basis of the control group, the intervention group… More >

  • Open Access

    REVIEW

    Farnesol as a multifunctional candidate for treatment development

    ANWAR ALI1,#, SREEKANTH REDDY OBIREDDY2,#, WING-FU LAI3,*

    BIOCELL, Vol.48, No.2, pp. 163-171, 2024, DOI:10.32604/biocell.2023.043839

    Abstract Farnesol is a C15 isoprenyl alcohol generated from the hydrolysis of farnesyl diphosphate under the action of farnesol synthase in plants. Although this sesquiterpenoid alcohol has been exploited in a wide variety of industrial applications, serious discussions on the possible use of this agent in disease treatment have been scant until now. In this article, we review the current understanding of the physiological properties of farnesol and the potential use of the agent as a candidate for treatment development. In fact, since the turn of the last century, farnesol has been found not only to trigger apoptosis in tumor cells… More >

  • Open Access

    ARTICLE

    Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia

    MONA S. ABDELLATEIF1,*, NAGLAA M. HASSAN2, MAHMOUD M. KAMEL2, YOMNA M. EL-MELIGUI2

    Oncology Research, Vol.32, No.3, pp. 577-584, 2024, DOI:10.32604/or.2023.043026

    Abstract Background: microRNA-34a (miR-34a) had been reported to have a diagnostic role in acute myeloid leukemia (AML). However, its value in the bone marrow (BM) of AML patients, in addition to its role in response to therapy is still unclear. The current study was designed to assess the diagnostic, prognostic, and predictive significance of miR-34a in the BM of AML patients. Methods: The miR-34a was assessed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR. The data were assessed for correlation with the relevant clinical criteria, response to therapy, disease-free survival (DFS), and overall… More >

  • Open Access

    ARTICLE

    Repair of Second-Generation Recycled Fine Aggregate of Waste Concrete from Freeze-Thaw Environment by Carbonation Treatment

    Jie Huang*, Rongbin Jiang, Xiaobo Sun, Yingyong Shuai

    Journal of Renewable Materials, Vol.12, No.1, pp. 187-201, 2024, DOI:10.32604/jrm.2023.044232

    Abstract The reuse of waste recycled concrete from harsh environments has become a research hotspot in the field of construction. This study investigated the repair effect of carbonation treatment on second-generation recycled fine aggregate (SRFA) obtained from recycled fine aggregate concrete (RFAC) subjected to freeze-thaw (FT) cycles. Before and after carbonation, the properties of SRFA were evaluated. Carbonated second-generation recycled fine aggregate (CSRFA) at five substitution rates (0%, 25%, 50%, 75%, 100%) to replace SRFA was used to prepare carbonated second-generation recycled fine aggregate concrete (CSRFAC). The water absorption, porosity and mechanical properties of CSRFAC were tested, and its frost-resisting durability… More >

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