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  • Open Access

    ARTICLE

    Effect of Green Lipid Treatments on the Morphological, Physical, Hygroscopic, and Mechanical Properties of Pineapple Leaf Fibres

    Achille Désiré Betené Omgba1,2,*, Cheryle Manfouo Tchoupmene1, Benoit Ndiwe1,2,*, Antonios N. Papadopoulos3, Remy Legrand Ndoumou Belinga1, Julien Clerc Obam1, Christel Cedrig Laris Nsi Ongo1, Ioanna A. Papadopoulou4, Armel Brice Mvogo1,2, Fabien Betené Ebanda1,2, Atangana Ateba1,2, Antonio Pizzi5

    Journal of Renewable Materials, Vol.14, No.3, 2026, DOI:10.32604/jrm.2026.02025-0201 - 25 March 2026

    Abstract The high hydrophilicity of pineapple leaf fibres (PALF) limits their use in cement- and gypsum-based composites exposed to moisture. This study evaluates, for the first time, the combined effect of palm kernel oil and beeswax on the hygroscopic resistance and mechanical stability of PALF. The fibres were functionalised with three formulations (oil, wax, and a 1:2 oil/wax blend) applied at different mass ratios (CR = 0.5–2). Treatments increased the average bundle diameter by up to +46% (238 μm) and reduced density down to 1.06 g/cm3. Hygroscopically, water absorption decreased from 202.4% (raw fibres) to 76.3% (CR… More > Graphic Abstract

    Effect of Green Lipid Treatments on the Morphological, Physical, Hygroscopic, and Mechanical Properties of Pineapple Leaf Fibres

  • Open Access

    REVIEW

    Enhancements in Oil Palm Fiber for Composite Material Development

    H. A. Aisyah1,*, I. Nur Azreena2, E. Hishamuddin1, A.W. Noorshamsiana1, N. M. Nurazzi2

    Journal of Renewable Materials, Vol.14, No.3, 2026, DOI:10.32604/jrm.2025.02025-0141 - 25 March 2026

    Abstract Oil palm fiber is a natural fiber derived from agricultural biomass and has gained significant attention as an alternative reinforcement material in composite materials due to its abundance, renewability, and environmental benefits. This review explores the various enhancement techniques applied to oil palm fiber to improve its properties for composite material development. Key areas of focus include chemical treatments, physical modifications, and hybridization with other fibers to improve fiber-matrix bonding, mechanical strength, and thermal stability. Integration of nanomaterials and bio-based resins to enhance the performance and sustainability of oil palm fiber composites is also discussed. More > Graphic Abstract

    Enhancements in Oil Palm Fiber for Composite Material Development

  • Open Access

    ARTICLE

    Exploring Machine Learning Approaches for Decision Support in Neoadjuvant Therapy of Locally Advanced Rectal Cancer

    Eshita Dhar1,2, Muhammad Ashad Kabir3, Divyabharathy Ramesh Nadar4, Li-Jen Kuo5, Jitendra Jonnagaddala6,7, Yaoru Huang1, Mohy Uddin8,*, Shabbir Syed-Abdul1,2,9,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074385 - 23 March 2026

    Abstract Objectives: Decisions regarding CT after nCCRT for locally advanced rectal cancer (LARC) are challenging due to limited evidence guiding treatment. This study aimed to (i) evaluate the predictive performance of machine learning (ML) models in patients treated with neoadjuvant concurrent chemoradiotherapy (nCCRT) alone vs. those receiving nCCRT plus chemotherapy (CT), (ii) identify features associated with treatment improvement, and (iii) derive ML-based thresholds for treatment response. Methods: This retrospective study included 409 patients with LARC treated at three affiliated hospitals of Taipei Medical University. Patients were categorised into two groups: nCCRT alone followed by surgery (n =… More >

  • Open Access

    REVIEW

    Next-Generation Hydrogel Platforms for Effective Localized Cancer Therapy: Advances in Biologics, Immunotherapeutics, and Gene Delivery

    Vincenzo Montanarella1, Marcelo Guerrero2,3, David Filho2,3, Júlia German-Cortés1, Giacomoluciano Vitelli1, Magalí Sureda1, Carlos Pavón Regaña1, Roser Ferrer1,4, Simó Schwartz1,4, Esteban Durán-Lara2,3, Fernanda Andrade1,5,*, Diana Rafael1,6,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.074061 - 23 March 2026

    Abstract Despite remarkable advances in nanomedicine, localized delivery of advanced cancer therapeutics remains underexploited. Advanced therapies based on biopharmaceuticals, immunotherapy, or gene therapy have revolutionized oncology. Yet, their systemic administration is often associated with limitations such as poor site-specific accumulation, instability, and systemic toxicity. Hydrogels/macrogels offer the ability to encapsulate, protect, and release biomolecules in situ with sustained and stimulus-responsive profiles, addressing key translational gaps. This review provides a focused synthesis of the last five years of hydrogel-based research for cancer therapy, with emphasis on peptides, antibodies, immunotherapeutic agents, and gene delivery systems. We discuss design principles,… More > Graphic Abstract

    Next-Generation Hydrogel Platforms for Effective Localized Cancer Therapy: Advances in Biologics, Immunotherapeutics, and Gene Delivery

  • Open Access

    REVIEW

    Efficacy and Mechanisms of CDK4/6 Inhibitors in Breast Cancer: Advancing Targeted Therapeutic Strategies

    Mohsina Patwekar1,2, Faheem Patwekar3, Zulhisyam Abdul Kari1,4,*, Muhammad Rajaei Ahmad Mohd Zain5,*, Arifullah Mohammed6, Rohit Sharma7,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073601 - 23 March 2026

    Abstract Breast cancer remains the primary cause of cancer-related mortality for women globally; therefore, further breakthroughs in treatment approaches are crucial. Palbociclib, ribociclib, and abemaciclib are among the Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors that have become an innovative family of targeted therapy for hormone receptor-positive, Human Epidermal Growth factor receptor 2 (HR+/HER2−) breast cancer. These inhibitors work by preventing the action of CDK4/6, which are crucial in the regulation of the cell cycle. Leading cancer cells to cell cycle arrest and undergo apoptosis. When these inhibitors are used with endocrine medicines like letrozole and… More > Graphic Abstract

    Efficacy and Mechanisms of CDK4/6 Inhibitors in Breast Cancer: Advancing Targeted Therapeutic Strategies

  • Open Access

    REVIEW

    Surgery Alone Treatment vs. Surgery with Adjuvant Therapy for Laryngeal Mucoepidermoid Cancer: A Systematic Review

    Francesco Chiari1,*, Giovanni Motta2, Daria Maria Filippini3, Claudio Donadio Caporale1, Pierre Guarino1

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073086 - 23 March 2026

    Abstract Objective: Mucoepidermoid carcinoma (MEC) of the larynx is an extremely rare malignancy, accounting for less than 1% of primary laryngeal tumors. The optimal role of adjuvant therapy, particularly radiotherapy (RT), remains unclear due to limited evidence. This systematic review aimed to evaluate oncologic outcomes and the impact of adjuvant treatment in patients with early- and advanced-stage laryngeal MEC. Methods: A systematic literature search was performed according to PRISMA 2020 guidelines in PubMed/Embase, Scopus, and Cochrane for studies published up to 31 July 2025. Results: Twenty-two studies, encompassing 55 patients, were included. Early-stage (T1–T2) patients (n =… More >

  • Open Access

    ARTICLE

    The Effect of Metformin on Atezolizumab/Bevacizumab Treatment in Patients with Hepatocellular Carcinoma and Diabetes

    Andrea Dalbeni1,2, Marco Vicardi1,2,*, Leonardo A. Natola1,2, Alessandra Auriemma3, Bernardo Stefanini4, Caterina Vivaldi5, Piera Federico6, Andrea Polloni7, Caterina Soldà8, Lorenzo Lani4, Ingrid Garajová9, Stefano Tamberi10, Stefania De Lorenzo11, Fabio Piscaglia4,12, Vincenzo Di Maria1, Gianluca Masi5, Sara Lonardi8, Giovanni Brandi4,7, Bruno Daniele6, Franco Trevisani4,13, Gianluca Svegliati-Baroni14, Laura Schiada14, Fabio Marra15, Claudia Campani15, Ciro Celsa16, Giuseppe Cabibbo16, Mariangela Bruccoleri17, Massimo Iavarone17,18, Leonardo Stella19, Francesca R. Ponziani19, Tiziana Pressiani20, Lorenza Rimassa20,21, Francesco Tovoli4, David Sacerdoti2

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.073063 - 23 March 2026

    Abstract Objectives: The combination of atezolizumab plus bevacizumab (A+B) represents one of the standards first-line treatments for unresectable hepatocellular carcinoma (HCC). Metformin has garnered attention for its potential antitumour and immunomodulatory properties beyond glycaemic control. This study aimed to assess metformin’s impact in patients with type 2 diabetes mellitus (T2DM) receiving A+B therapy. Methods: This retrospective analysis of a prospectively-maintained multicentre database included 523 patients with HCC treated with A+B from the ARTE (Atezolizumab-bevacizumab Real-life Experience for Treatment of Hepatocellular Carcinoma) dataset across 18 Italian centres (May 2020–January 2024). We evaluated objective response rate (ORR), disease… More >

  • Open Access

    VIEWPOINT

    Lorlatinib and Amivantamab: A Paradigm Shift in EGFR and ALK Positive NSCLC, with More Effective but More Toxic Treatments Requiring a Well-Structured Shared Decision Making

    Paolo Maione1,*, Valentina Palma1,2, Cesare Gridelli1

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.072992 - 23 March 2026

    Abstract After about 20 years of exciting improvements in treatment efficacy outcomes of advanced epidermal growth factor receptor (EGFR) mutant and anaplastic lymphoma kinase (ALK) rearranged non-small cell lung cancer (NSCLC), also combined with a progressively better safety profile, from chemotherapy to new generation tyrosine kinase inhibitors (TKIs) (osimertinib, alectinib, brigatinib), the recent MARIPOSA and CROWN trials have changed this trend. For the first time in the history of EGFR and ALK treatments, we must face the issue of being a step behind in terms of toxicity profile. The combination of amivantamab plus lazertinib in EGFR mutant NSCLC, and… More >

  • Open Access

    ARTICLE

    Pre-Treatment BOC Expression as an Indicator of Lymphovascular Invasion and In Vitro Chemotherapeutic Response in Upper Tract Urothelial Carcinoma

    Yin-Lun Chang1,2, Hao-Lun Luo1, Jei-Ming Peng3,*, Chang-Chun Hsiao2,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.070837 - 23 March 2026

    Abstract Background: Upper tract urothelial carcinoma (UTUC) is an aggressive malignancy with high recurrence rates. Lymphovascular invasion (LVI) predicts a poor prognosis, yet its molecular drivers remain unclear. BOC cell adhesion-associated, oncogene-regulated (BOC, also known as Brother of CDO [Cell adhesion molecule-Related/Down-regulated by Oncogenes]), a hedgehog-related cell surface receptor, may serve as a biomarker for tumor progression and chemotherapy response. The study aimed to investigate the role of BOC in UTUC and its potential to predict LVI and chemotherapy response. Methods: Sequencing (RNA-seq) of 10 stage III UTUC, treatment-naïve, fresh tissue samples identified BOC as a… More >

  • Open Access

    ARTICLE

    Single-Cell and Multi-Omics-Based Characterization of Gastric Cancer Identifies TPP1 as a Potential Target for Gastric Cancer Progression and Treatment

    Yingying Zhao1,2, Jiakang Ma1,3, Rujin Huang1,2, Shuxian Pan1,*

    Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.070208 - 23 March 2026

    Abstract Background: Cancer-associated fibroblasts (CAFs) play critical roles in tumor progression and immunosuppression; however, their contribution to the functional classification and personalized treatment of gastric cancer remains poorly defined. This study aimed to identify effective therapeutic targets to facilitate individualized treatment strategies for patients with gastric cancer. Methods: Single-cell and bulk transcriptomic analyses were integrated to characterize gastric cancer fibroblasts. “Seurat”, “Slingshot”, and “CellChat” were used for dimensionality reduction, trajectory inference, and cell–cell communication analyses, respectively. Key metastasis-associated fibroblast modules were identified using High-dimensional weighted gene co-expression network analysis (hdWGCNA) to construct a prognostic model, which was further… More > Graphic Abstract

    Single-Cell and Multi-Omics-Based Characterization of Gastric Cancer Identifies TPP1 as a Potential Target for Gastric Cancer Progression and Treatment

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