JINGDAN QUAN¹, ZIXIN WAN¹, WEI WU², XINYUAN CAO², JIAYUAN QIU², XIAOYE LIU², ZHIWEI ZHANG^1,*

Oncology Research, Vol.33, No.5, pp. 1069-1089, 2025, DOI:10.32604/or.2025.063005 - 18 April 2025

Abstract One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%–35%, the prognosis is bad, the patients’ quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient… More >

Dan Li¹, Jiayu Chen¹, Biyu Jiang¹, Ce Sun^2,*, Huazhan Yin^1,*

International Journal of Mental Health Promotion, Vol.27, No.3, pp. 347-361, 2025, DOI:10.32604/ijmhp.2025.059151 - 31 March 2025

Abstract Objectives: The statistics from World Health Organization show a high incidence of childhood maltreatment which has a negative impact on the development of middle school students; for this reason, it is necessary to investigate the potential harms of childhood maltreatment. This study aimed to explore the direct negative consequences of childhood maltreatment on subjective well-being as well as the mediating roles of shyness and emotion regulation strategies. Methods: A random cluster sampling survey was conducted among 1021 Chinese middle school students (male 49.2%, female 50.8%). The Subjective Well-Being Scale (SWLS), The Positive affect and Negative… More >

Bingbing Zhang¹, Minghao Li¹, Xiaoli Huang¹, Siqi Zheng¹, Guorong Lai¹, Quan Yang^1,2,3,4,*, Xiaomin Tang^1,2,3,4,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 843-860, 2025, DOI:10.32604/phyton.2025.063062 - 31 March 2025

Abstract Fertilization is essential for high yield and quality in Chinese herbs. Grona styracifolia (Osbeck) H. Ohashi, a distinctive medicinal plant in the Lingnan region, currently encounters cultivation issues stemming from the overuse of chemical fertilizers. Adopting organic and microbial fertilizers presents a sustainable solution for its cultivation management. This study compared a no-fertilization control group with eight treatment groups using various concentrations of compound, organic, compound microbial, and Bacillus amyloliquefaciens fertilizers to evaluate their effects on G. styracifolia and soil microbial communities. The results demonstrated that the different fertilization treatments significantly enhanced plant growth and quality of G. styracifolia,… More > Graphic Abstract

Blanca Olivia Trejo-Paniagua¹, Nancy Ruiz-Lau^2,*, María Goretty Caamal-Chan³, Rosa Isela Cruz-Rodríguez¹, Anayancy Lam-Gutiérrez⁴, Víctor Manuel Ruíz-Valdiviezo¹

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 861-873, 2025, DOI:10.32604/phyton.2025.062410 - 31 March 2025

Abstract Exogenous proline is an effective agent for increasing plant tolerance to abiotic stress in plants. In this study, we evaluated its effect on seedlings of Siete Caldos chili pepper (Capsicum frutescens), a semi-domesticated variety. The Capsicum genus is known for its sensitivity to water stress. We pretreated the seedlings’ roots by immersing them in proline solutions (0, 2.5, 5, 7.5, and 10 mM) for 48 h. Then, we exposed them to water stress using a Hoagland nutrient solution supplemented with 10% polyethylene glycol (PEG-8000) for nine days. We analyzed key physiological and biochemical parameters, including relative… More >

Jianying Li^1,2,*, Donglai Li^1,2, Tiefeng Li^1,2

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.3, pp. 445-470, 2025, DOI:10.32604/fdmp.2025.062337 - 01 April 2025

Abstract Hydrodynamic cavitation, as an efficient technique applied in many physical and chemical treatment methods, has been widely used by various industries and in several technological fields. Relevant generators, designed with specific structures and parameters, can produce cavitation effects, thereby enabling effective treatment and reasonable transformation of substances. This paper reviews the design principles, performance, and practical applications associated with different types of cavitation generators, aiming to provide theoretical support for the optimization of these systems. It systematically analyzes the underpinning mechanisms and the various factors influencing the cavitation phenomena, also conducting a comparative analysis of More > Graphic Abstract

Olga Koval^1,2,*, Maria Zhilnikova¹, Maria Balantaeva^1,2, Mikhail Biryukov^1,2, Vasiliy Atamanov^1,3

BIOCELL, Vol.49, No.3, pp. 355-379, 2025, DOI:10.32604/biocell.2025.059987 - 31 March 2025

Abstract Melanomas are aggressive cancers, with a high rate of metastatic disease. Cutaneous (CM) and uveal (UM) melanomas are intrinsically different diseases, and most cell death inducers effective for CM do not function for UM. This is primarily due to the fact the eye is an immunologically privileged organ, and it fails to achieve the efficacy of immune checkpoint inhibitors (ICIs) comparable to that for CM. However, approaches utilizing specific melanoma-associated antigens are being developed for metastatic forms of CM and UM. The most promising to date are gp100 and tyrosinase related protein 1 (TYRP1), primarily… More >

Mohamad Firdaus Omar¹, Fathilah Ali^1,*, Mohammed Saedi Jami¹, Azlin Suhaida Azmi¹, Farah Ahmad¹, Mohd Zahid Marzuki², Shantha Kumari Muniyandi³, Zuraidah Zainudin⁴, Minsoo P. Kim⁵

Journal of Renewable Materials, Vol.13, No.3, pp. 497-538, 2025, DOI:10.32604/jrm.2024.057248 - 20 March 2025

Abstract This review provides a comprehensive overview of natural rubber (NR) composites, focusing on their properties, compounding aspects, and renewable practices involving natural fibre reinforcement. The properties of NR are influenced by the compounding process, which incorporates ingredients such as elastomers, vulcanizing agents, accelerators, activators, and fillers like carbon black and silica. While effective in enhancing properties, these fillers lack biodegradability, prompting the exploration of sustainable alternatives. The potential of natural fibres as renewable reinforcements in NR composites is thoroughly covered in this review, highlighting both their advantages, such as improved sustainability, and the challenges they More > Graphic Abstract

GIULIANO BERNAL^*, GISELA AQUEA, SEBASTIÁN RAMÍREZ-RIVERA

Oncology Research, Vol.33, No.4, pp. 759-779, 2025, DOI:10.32604/or.2024.057019 - 19 March 2025

Abstract Cancer remains one of the leading causes of death in the world, with more than 9 million deaths in 2022, a number that continues to rise. This highlights the urgent need for the development of new drugs, with enhanced antitumor capabilities and fewer side effects. Metal-based drugs have been used in clinical practice since the late 1970s, beginning with the introduction of cisplatin. Later, two additional platinum-based molecules, carboplatin, and oxaliplatin, were introduced, and all three continue to be widely used in the treatment of various cancers. However, despite their significant anticancer activity, the undesirable… More > Graphic Abstract

ZHIZHENG ZHANG^1,#, TAO LI^2,#, YUAN LI³, XI WANG⁴, HAO LIU⁵, XINYU SHEN⁵, ANN XU⁶, TIANSONG XIA^1,*, BO XU^7,*

Oncology Research, Vol.33, No.4, pp. 811-819, 2025, DOI:10.32604/or.2024.050505 - 19 March 2025

Abstract Background: Breast cancer is a prevalent malignant tumor affecting females, with treatment options including surgery, radiotherapy, chemotherapy, and endocrine therapy. Methods: This review synthesizes existing literature on breast cancer stem cells and their applications in breast cancer treatment. PubMed, Web of Science, and other relevant databases were systematically searched using keywords such as “breast cancer stem cells,” “immunotherapy,” “gene therapy,” and “cell therapy.” Studies published in English were included, and their findings were analyzed to provide insights into the characteristics and therapeutic potential of breast cancer stem cells. Results: Breast cancer stem cells exhibit unique properties More >

LI SUN^1,#, SHICHAO ZHUO^2,#, XIAOXIN LI², HUSHENG KONG³, WEIWEI DU³, CHONG ZHOU⁴, JUNXING HUANG^1,*

Oncology Research, Vol.33, No.3, pp. 641-651, 2025, DOI:10.32604/or.2024.050057 - 28 February 2025

Abstract Background: Cisplatin (DDP) has been used in the treatment of various human cancers. However, DDP alone lacks efficacy in treating triple-negative breast cancer (TNBC), and its clinical application is often hampered by side effects. Astragalus polysaccharide (APS) is one of the active components extracted from Astragalus membranaceus and has gained attention for its various biological properties. This research is aimed to evaluate the effectiveness of a combination of APS and DDP on TNBC and explore the potential mechanisms. Methods: The efficacy and mechanisms of single or combined treatment were evaluated using Cell Counting Kit-8 (CCK8) assay, Annexin… More >