Marie-Lou Letouche^1,2,*, Aideen Madden^2,3, Mariela Corralles^2,3, Steeve Doizi^2,3, Olivier Traxer^2,3

Canadian Journal of Urology, Vol.33, No.1, pp. 227-232, 2026, DOI:10.32604/cju.2025.067253 - 28 February 2026

Abstract Background: We present a case of two major complications following insertion of a nephrostomy managed in a minimally invasive way. Our case is the first in the literature to describe this minimally invasive treatment technique for colon perforation in a completely asymptomatic patient. Case Description: A 75-year-old female patient with a history of bilateral obstructive uropathy secondary to bilateral radiation-induced ureteric strictures attended for bilateral nephrostomy placement. The patient had a history of endometrial cancer, treated previously by total hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemo-radiotherapy and brachytherapy. Her recovery had been further complicated by the… More >

Hikaru Kobori¹, Emilia-Adela Manea Salca^2,*, Tetsuya Inagaki³, Shigehiko Suzuki⁴, Sahriyanti Saad⁵, Aujchariya Chotikhun⁶

Journal of Renewable Materials, Vol.14, No.2, 2026, DOI:10.32604/jrm.2025.02025-0152 - 25 February 2026

Abstract Heat treatment is applied to wood to improve various properties of the material. The present study focuses on the colour changes of wood veneer samples due to heat treatment. Native wood species from Japan and Europe, such as Japanese oak (Quercus mongolica var. crispula), field maple (Acer campestre) and Scots pine (Pinus sylvestris) were used in the experiments. A laboratory-type oven was used to apply the heat at a temperature of 190°C, in the presence of oxygen, for different periods, gradually increasing from 5 to 40 min. The CIELab system (a colour space defined by the International Commission… More >

Amal F. Gharib¹, Ohud Alsalmi¹, Hayaa M. Alhuthali¹, Afaf Alharthi¹, Saud Ayed Alharthi², Shaimaa A. Alharthi³, Rasha L. Etewa⁴, Wael H. Elsawy^5,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.073051 - 24 February 2026

Abstract Background: Locally advanced laryngeal squamous cell carcinoma (LA-LSCC) presents clinical challenges due to the lack of reliable non-invasive biomarkers. This study aimed to evaluate miR-449a as a diagnostic and prognostic biomarker in LA-LSCC. Methods: miR-449a expression was analyzed in tumor tissues, adjacent normal tissues, and serum from 81 LA-LSCC patients and 50 controls using quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR). We assessed the diagnostic accuracy by Receiver Operating Characteristic curve (ROC curves), clinicopathological associations, survival outcomes (Kaplan-Meier), and treatment response dynamics. Results: miR-449a was significantly downregulated in LA-LSCC tissues (p < 0.0001) and serum (p <… More >

Liang Zhou, Jia Zhou, Zhengyi Wang^*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.069317 - 24 February 2026

Abstract A clear goal in cold tumor research is to identify strategies for converting them into immunologically ‘hot’ tumors with enhanced immune cell infiltration and activity, thereby improving their responsiveness to immunotherapy. The genesis of cold tumors is exceedingly intricate. In recent times, as the analysis of this phenomenon has been pursued with greater depth, a suite of advanced diagnostic and therapeutic technologies has surfaced. These novel approaches and tactics are anticipated to modulate the tumor immune microenvironment across various dimensions, thereby facilitating the advancement of personalized and precise treatment modalities for cold tumors. The present… More >

George Anderson^*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.073221 - 14 February 2026

Abstract As natural killer (NK) cells eliminate cancer cells and virus-infected cells, as well as modulate various other medical conditions, including aging-associated conditions such as neurodegenerative disorders, understanding NK cell regulation is of considerable clinical importance. This article reviews the role of circadian processes (melatonin and the cortisol system), aryl hydrocarbon receptor, and vagal nerve in the modulation of NK cell function, highlighting the importance of the endogenous mitochondrial melatonergic pathway in NK cells. As circadian and exogenous melatonin increase NK cell cytotoxicity, the presence of the endogenous melatonergic pathway may be of some importance not… More >

Stefano Dore¹, Matteo Sacchi¹, Antonio Pinna¹, Giuseppe Palmieri^2,3, Panagiotis Paliogiannis^4,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071831 - 19 January 2026

Abstract Uveal melanoma (UM) is the most common intraocular cancer, with approximately 5.2 individuals per million affected annually in the United States. It represents approximately 3% of the global malignant melanoma cases, accounting for 80% of the overall noncutaneous melanomas. Clinically, it remains silent in about 30% of the cases; when symptomatic, it generally causes metamorphopsia (painless loss or distortion of vision) and/or photopsia (flashing or flickering of light in the visual field). Discoloration of the iris, astigmatism, glaucoma, and even blindness are other, less common clinical manifestations. Several pathophysiological mechanisms underlie the development of UM.… More >

Kamila Mozga¹, Olga Synowiecka¹, Igor Rydzyk¹, Anna Marek¹, Ewelina Wieczorek¹, Alicja Petniak^2,*, Paulina Gil-Kulik²

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.070505 - 19 January 2026

Abstract Objectives: Immunotherapy based on immune checkpoint blockade (ICB) has become a key treatment for melanoma. However, the increasing number of cases of melanoma resistant to immunotherapy highlights the need to develop methods to overcome this resistance. This study aims to collect the most recent information on melanoma immunotherapy, discuss potential strategies to overcome resistance to immunotherapy, and identify areas that require further analysis. Methods: To achieve this goal, scientific publications from 2021–2024 available in PubMed and Google Scholar databases were analyzed. The databases were searched using the following terms: “melanoma”, “immunotherapy”, “Immune Checkpoint Blockade”, and More >

Urszula Częścik^1,2,#, Martyna Gryglas³, Arkadiusz Szterk⁴, Sylwia Flis^3,#,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.067449 - 19 January 2026

Abstract Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer-related deaths, accounting for approximately 10% of all cancer cases. By 2050, CRC incidence is expected to rise substantially, driven by population aging and greater exposure to risk factors in developing countries. Despite advances in medicine and pharmacy, the effectiveness of available treatments remains limited, underscoring the urgent need for innovative therapeutic strategies. This review summarizes and critically evaluates currently available CRC therapies and explores new emerging directions. Particular attention is given to the role of immunotherapy, targeted therapies,… More >

Zhengwei Li^1,#, Xin Li^2,#, Dong Luo¹, Meijun Liu¹, Luxi Guan¹, Haibo Hu^1,*

Congenital Heart Disease, Vol.20, No.6, pp. 673-682, 2025, DOI:10.32604/chd.2026.069714 - 10 February 2026

Abstract Background: During the surgical repair of complex congenital heart disease (CCHD), a subset of patients is unable to tolerate abrupt postoperative hemodynamic shifts, which can lead to significant complications. To mitigate this risk, certain abnormal venous channels are deliberately left open at the conclusion of surgery to provide a decompressive route, thereby reducing the likelihood of pulmonary hypertensive crises. Nevertheless, the continued patency of these vessels may induce chronic hemodynamic disturbances, often requiring subsequent treatment. This study was designed to assess the safety and efficacy of transcatheter intervention for such persistent anomalous systemic veins in CCHD… More >

Anushka Ghosh, Maria J. D’Amico, Yash B. Shah, Whitney R. Smith, Mihir S. Shah, Costas D. Lallas, Alana M. Murphy^*

Canadian Journal of Urology, Vol.32, No.6, pp. 627-632, 2025, DOI:10.32604/cju.2025.067575 - 30 December 2025

Abstract Background: Genitourinary syndrome of menopause (GSM) is a highly prevalent, underdiagnosed condition that can significantly impair quality of life (QoL). This study evaluates real-world treatment trends for GSM to better understand current management practices and highlight ongoing gaps in care. The background is in a different font than the rest of the abstract. Methods: We queried the TriNetX database for patients with a diagnosis of postmenopausal atrophic vaginitis (ICD N95.2) and treatment information from 2004–2024. A combination of RxNorm and International Classification of Diseases-10 (ICD) codes was used to classify disease and treatment type, including… More >