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  • Open Access

    PROCEEDINGS

    Treatments of Fractures Intersection in the Enriched-Embedded Discrete Fracture Model (nEDFM) for Porous Flow

    Kaituo Jiao1, Dongxu Han2,*, Bo Yu2

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.30, No.1, pp. 1-3, 2024, DOI:10.32604/icces.2024.011520

    Abstract Motivated by the fractures being very thin compared to the size of rock matrix, utilizing the non-conforming grid is an efficient approach to simulate fluid flow in fractured porous media. The embedded discrete fracture model (EDFM) is the typical one that using the conforming grid and modelled based on the finite volume method (FVM) framework. The EDFM maintains advantages of mass conservation and low computational complexity, but it cannot characterize blocking fractures and has a low accuracy on the mass exchange between fractures and matrix [1]. In our previous work [2], we developed the enriched-EDFM… More >

  • Open Access

    ARTICLE

    Mechanical Behavior of Panels Reinforced with Orthogonal Plant Fabrics: Experimental and Numerical Assessment

    Martha L. Sánchez1,*, G. Capote2

    Journal of Renewable Materials, Vol.12, No.10, pp. 1791-1810, 2024, DOI:10.32604/jrm.2024.055122 - 23 October 2024

    Abstract The construction sector is one of the main sources of pollution, due to high energy consumption and the toxic substances generated during the processing and use of traditional materials. The production of cement, steel, and other conventional materials impacts both ecosystems and human health, increasing the demand for ecological and biodegradable alternatives. In this paper, we analyze the properties of panels made from a combination of plant fibers and castor oil resin, analyzing the viability of their use as construction material. For the research, orthogonal fabrics made with waste plant fibers supplied by a company… More >

  • Open Access

    ARTICLE

    Piperlongumine in combination with EGFR tyrosine kinase inhibitors for the treatment of lung cancer cells

    SHAIL RAKESH MODI, TERRICK ANDEY*

    Oncology Research, Vol.32, No.11, pp. 1709-1721, 2024, DOI:10.32604/or.2024.053972 - 16 October 2024

    Abstract Objectives: EGFR tyrosine kinase inhibitor (EGFR-TKI) therapies such as erlotinib and gefitinib are approved for the treatment of non-small cell lung cancer (NSCLC). However, the high incidence of acquired resistance to these EGFR-TKIs may preclude their effectiveness. Piperlongumine (PPL), an extract from the long pepper fruit (Piper longum), has been shown to possess anticancer properties. The purpose of the study was to investigate piperlongumine as an anticancer agent and to study a combination treatment approach with EGFR-TKIs against lung cancer cells. Methods: Anticancer efficacy of PPL, erlotinib (ERL), gefitinib (GEF), and cisplatin (CIS) were investigated in… More >

  • Open Access

    ARTICLE

    Is ypTNM staging a comparable predictor as pTNM staging for survival in non-metastatic rectal cancer after preoperative chemoradiation therapy?

    JEN-PIN CHUANG1,2,3, HSIANG-LIN TSAI4,5, WEI-CHIH SU4,6,7, PO-JUNG CHEN4,6, CHING-WEN HUANG4,5, TSUNG-KUN CHANG4,6,7, YEN-CHENG CHEN4,6, CHING-CHUN LI4,8, YUNG-SUNG YEH4,9,10, TZU-CHIEH YIN4,5,11, JAW-YUAN WANG4,5,6,12,13,*

    Oncology Research, Vol.32, No.11, pp. 1723-1732, 2024, DOI:10.32604/or.2024.052098 - 16 October 2024

    Abstract Background: The pTNM staging system is widely recognized as the most effective prognostic indicator for cancer. The latest update of this staging system introduced a new pathological staging system (ypTNM) for patients receiving neoadjuvant chemoradiotherapy (NACRT). However, whether the prognostic value of the ypTNM staging system for rectal cancer is similar to that of the pTNM staging system remains unclear. This study was conducted to compare the ypTNM and pTNM staging systems in terms of their prognostic value for patients with nonmetastatic rectal cancer undergoing proctectomy. Material and Methods: This study was conducted at a large teaching… More >

  • Open Access

    PROCEEDINGS

    Simple but Effective Heat Treatment on Hot Isostatic Press Diffusion Bonded Ni60A Hardfacing Layer

    Lei Yu1,2, Yingjie Yan1,2, Hao Dong3,4, Suk-Chun Moon5,*, Zhengyi Jiang5,*, Rui Cao1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.4, pp. 1-2, 2024, DOI:10.32604/icces.2024.011941

    Abstract Ni60A hardfacing alloy, as one of the highest-alloy grades and hardest alloy of Ni-Cr-B-Si alloys, is expected to be used as hardfacing alloy for thrust discs in nuclear main pumps to reduce friction, corrosion and erosion. Since mechanical properties of Ni-Cr-B-Si alloys are very sensitive to their defects and microstructures, heat treatment/remelting methods have been used to eliminate porosity and to modify microstructural heterogeneity. In our previous research, Ni60A hardfacing layer with high micro-hardness and excellent bonding strength has been fabricated onto 0Cr18Ni10Ti austenitic stainless steel using hot isostatic press diffusion bonding technique. However, some… More >

  • Open Access

    ARTICLE

    Modeling the Dynamics of Tuberculosis with Vaccination, Treatment, and Environmental Impact: Fractional Order Modeling

    Muhammad Altaf Khan1,*, Mahmoud H. DarAssi2, Irfan Ahmad3, Noha Mohammad Seyam4, Ebraheem Alzahrani5

    CMES-Computer Modeling in Engineering & Sciences, Vol.141, No.2, pp. 1365-1394, 2024, DOI:10.32604/cmes.2024.053681 - 27 September 2024

    Abstract A mathematical model is designed to investigate Tuberculosis (TB) disease under the vaccination, treatment, and environmental impact with real cases. First, we introduce the model formulation in non-integer order derivative and then, extend the model into fractional order derivative. The fractional system’s existence, uniqueness, and other relevant properties are shown. Then, we study the stability analysis of the equilibrium points. The disease-free equilibrium (DFE) is locally asymptotically stable (LAS) when . Further, we show the global asymptotical stability (GAS) of the endemic equilibrium (EE) for and for . The existence of bifurcation analysis in the More >

  • Open Access

    ARTICLE

    Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

    Samar El-Mekkawi1, Wafaa Abou-Elseoud2, Shaimaa Fadel2, Enas Hassan2, Mohammad Hassan2,*

    Journal of Renewable Materials, Vol.12, No.9, pp. 1573-1591, 2024, DOI:10.32604/jrm.2024.053589 - 25 September 2024

    Abstract Recycling of paper sludge waste is crucial for establishing a sustainable green industry. This waste contains valuable sugars that can be converted into important chemicals such as ethanol, poly hydroxybutyrate, and lactic acid. However, the main challenge in obtaining sugars in high yield from paper sludge is the high crystallinity of cellulose, which hinders hydrolysis. To address this, pretreatment using phosphoric acid was optimized using response surface methodology to facilitate cellulose hydrolysis with minimal energy and chemicals. The created prediction model using the response surface method considered factors such as acid concentration (ranging from 60%… More > Graphic Abstract

    Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

  • Open Access

    ARTICLE

    Net Effect of Short-Term Smoking Cessation on Mental Health Changes: Inverse Probability of Treatment Weighting and Difference-in-Differences Method

    Ji-Su Park1, Tae-Hyeon Lee2, Il-Su Park3,*

    International Journal of Mental Health Promotion, Vol.26, No.9, pp. 745-755, 2024, DOI:10.32604/ijmhp.2024.054630 - 20 September 2024

    Abstract Background: In response to the need for research clearly demonstrating the net effect of smoking cessation on mental health status, considering the causal relationship between smoking cessation and changes in mental health status, this study was undertaken. Thus, this study aimed to examine the net effect of short-term smoking cessation on five specific mental health metrics and the overall mental health status score. Methods: We used data from the first wave of the Korean Health Panel (KHP) Survey (2011–2013, 2016–2018) and focused on men aged 19 years and older, to explore the effects of smoking… More >

  • Open Access

    REVIEW

    Glutamine transporters as effective targets in digestive system malignant tumor treatment

    FEI CHU1, KAI TONG1, XIANG GU1, MEI BAO1, YANFEN CHEN1, BIN WANG2, YANHUA SHAO1, LING WEI1,*

    Oncology Research, Vol.32, No.10, pp. 1661-1671, 2024, DOI:10.32604/or.2024.048287 - 18 September 2024

    Abstract Glutamine is one of the most abundant non-essential amino acids in human plasma and plays a crucial role in many biological processes of the human body. Tumor cells take up a large amount of glutamine to meet their rapid proliferation requirements, which is supported by the upregulation of glutamine transporters. Targeted inhibition of glutamine transporters effectively inhibits cell growth and proliferation in tumors. Among all cancers, digestive system malignant tumors (DSMTs) have the highest incidence and mortality rates, and the current therapeutic strategies for DSMTs are mainly surgical resection and chemotherapy. Due to the relatively More > Graphic Abstract

    Glutamine transporters as effective targets in digestive system malignant tumor treatment

  • Open Access

    ARTICLE

    Fuzzy Multi-Criteria Decision Support System for the Best Anti-Aging Treatment Selection Process through Normal Wiggly Hesitant Fuzzy Sets

    Daekook Kang1, Ramya Lakshmanaraj2, Samayan Narayanamoorthy2, Navaneethakrishnan Suganthi Keerthana Devi2, Samayan Kalaiselvan3, Ranganathan Saraswathy4, Dragan Pamucar5,6,7,*, Vladimir Simic8,9

    CMC-Computers, Materials & Continua, Vol.80, No.3, pp. 4947-4972, 2024, DOI:10.32604/cmc.2024.055260 - 12 September 2024

    Abstract This socialized environment among educated and developed people causes them to focus more on their appearance and health, which turns them towards medical-related treatments, leading us to discuss anti-aging treatment methods for each age group, particularly for urban people who are interested in this. Some anti-aging therapies are used to address the alterations brought on by aging in human life without the need for surgery or negative effects. Five anti-aging therapies such as microdermabrasion or dermabrasion, laser resurfacing anti-aging skin treatments, chemical peels, dermal fillers for aged skin, and botox injections are considered in this… More >

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