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  • Open Access

    REVIEW

    A Review on Sources, Extractions and Analysis Methods of a Sustainable Biomaterial: Tannins

    Antonio Pizzi1,*, Marie-Pierre Laborie2,3, Zeki Candan4

    Journal of Renewable Materials, Vol.12, No.3, pp. 397-425, 2024, DOI:10.32604/jrm.2023.046074 - 11 April 2024

    Abstract Condensed and hydrolysable tannins are non-toxic natural polyphenols that are a commercial commodity industrialized for tanning hides to obtain leather and for a growing number of other industrial applications mainly to substitute petroleum-based products. They are a definite class of sustainable materials of the forestry industry. They have been in operation for hundreds of years to manufacture leather and now for a growing number of applications in a variety of other industries, such as wood adhesives, metal coating, pharmaceutical/medical applications and several others. This review presents the main sources, either already or potentially commercial of More > Graphic Abstract

    A Review on Sources, Extractions and Analysis Methods of a Sustainable Biomaterial: Tannins

  • Open Access

    REVIEW

    Development of micro/nanostructured‒based biomaterials with biomedical applications

    AFAF ALHARTHI*

    BIOCELL, Vol.47, No.8, pp. 1743-1755, 2023, DOI:10.32604/biocell.2023.027154 - 28 August 2023

    Abstract Natural biomaterials are now frequently used to build biocarrier systems, which can carry medications and biomolecules to a target region and achieve a desired therapeutic effect. Biomaterials and polymers are of great importance in the synthesis of nanomaterials. The recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi, algae, bacteria, and medicinal plants. They are also biodegradable, compatible with neighborhoods, and non-toxic. Natural biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds, matrices, composites, More >

  • Open Access

    ARTICLE

    Novel Pectin/Chia-Mucilage Membranes: Human Serum Albumin Adsorption, Biocompatibility, and Physical-Chemical Properties

    S. E. Burruel-Ibarra1, R. A. Esquer-Osuna2, R. G. Valdez-Melchor2, D. A. Cuevas-Acuña2, L. QuihuiCota3, J. Juárez4, J. C. Campos-García2, E. Valbuena-Gregorio2, M. A. López-Mata2,*

    Journal of Renewable Materials, Vol.11, No.6, pp. 2647-2663, 2023, DOI:10.32604/jrm.2023.027372 - 27 April 2023

    Abstract This study aimed to characterize the physical-chemical and biological properties of pectin (PC)/chia seed mucilage (CM) membranes. PC/CM [100/0 (control), 80/20%, 60/40%, and 40/60% w/w] membranes were prepared using the casting method. The membranes (PC/CM) were thin, yellow, lightly opaque (≈10%) and capable of blocking light UVB (between 66 at 52%). SEM analysis showed the presence of aggregates in the shape of a sphere (≈13 µm) and ovoid (≈25 µm). The proportion of 80/20 showed an increase in tensile strength (29%) and elastic modulus (19%) when compared to the control. FTIR analysis exhibited intermolecular interactions More > Graphic Abstract

    Novel Pectin/Chia-Mucilage Membranes: Human Serum Albumin Adsorption, Biocompatibility, and Physical-Chemical Properties

  • Open Access

    ARTICLE

    Green Synthesis of Reduced Graphene Oxide Nanosheet by using L-ascorbic Acid and Study of its Cytotoxicity on Human Cervical Cancer Cell Line

    PRABHAT KUMAR, ANJANA SARKAR, PURNIMA JAIN*

    Journal of Polymer Materials, Vol.39, No.1-2, pp. 121-135, 2022, DOI:10.32381/JPM.2022.39.1-2.8

    Abstract Biocompatible graphene derivative materials (GBMs) to harness the maximum potential of pristine graphene biologically, is the most important strategy for its advanced applications in pharmaceutical and other biomedical fields. Currently, scientists are trying to find this by using biopolymer nanocomposites or anchored materials. Nevertheless, tuning the bare GBMs towards biocompatibility is a beautiful approach to exploit the fundamental potential of pristine graphene vis-à-vis suppressing the effects of incorporated biopolymers or anchored materials. Herein, a large-scale, cost-effective, facile, and environment-friendly green synthetic strategy is used for the synthesis of reduced graphene oxide (rGO) nanosheet using L-ascorbic… More >

  • Open Access

    VIEWPOINT

    Mesenchymal stem cells, the secretome and biomaterials: Regenerative medicine application

    KI-TAEK LIM#,*, TEJAL V. PATIL#, DINESH K. PATEL, SAYAN DEB DUTTA, KEYA GANGULY, AAYUSHI RANDHAWA

    BIOCELL, Vol.46, No.10, pp. 2201-2208, 2022, DOI:10.32604/biocell.2022.020013 - 13 June 2022

    Abstract Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their application in regenerative medicine and COVID-19 treatment. Different approaches to evaluate the future of biomaterials and stem cell properties have been developed. However, misconceptions and ethical issues still exist, such as MSCs being non-angiogenic, anti-apoptotic, and immunoregulatory competencies. Embryonic stem cells isolation primarily requires the consent… More >

  • Open Access

    VIEWPOINT

    Mesenchymal stem cells, secretome and biomaterials in in-vivo animal models: Regenerative medicine application in cutaneous wound healing

    MASSIMO CONESE1,*, AURELIO PORTINCASA2

    BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448 - 22 April 2022

    Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound More >

  • Open Access

    VIEWPOINT

    New paradigms in regenerative engineering: Emerging role of extracellular vesicles paired with instructive biomaterials

    W. BENTON SWANSON, YUJI MISHINA*

    BIOCELL, Vol.46, No.6, pp. 1445-1451, 2022, DOI:10.32604/biocell.2022.018781 - 07 February 2022

    Abstract Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve More >

  • Open Access

    VIEWPOINT

    Implant surface features as key role on cell behavior

    RAFAEL SCAF DE MOLON1,2, MARTA MARIA ALVES PEREIRA2, ERICA DORIGATTI DE AVILA2

    BIOCELL, Vol.46, No.5, pp. 1151-1156, 2022, DOI:10.32604/biocell.2022.018026 - 06 January 2022

    Abstract It has been recognized that physical and chemical properties of biomaterial surfaces mediate the quality of extracellular matrix (ECM) that may affect cell behaviors. In nature, ECM is a heterogeneous three-dimensional superstructure formed by three major components, glycosaminoglycan, glycoconjugate, and protein, that anchors cellular compartments in tissues and regulates the function and the behavior of cells. Changes in the biointerface alter the quality of ECM and morphology through cell surface receptors, which, in turn, enable it to trigger specific cell signaling and different cellular responses. In fact, a number of strategies have been used to More >

  • Open Access

    VIEWPOINT

    Dental-derived stem cells and biowaste biomaterials: What’s next in bone regenerative medicine applications

    MICHELE DI COSOLA1,§; STEFANIA CANTORE2,§,*; MARIO GIOSUÈ BALZANELLI3; CIRO GARGIULO ISACCO2,3; KIEU CAO DIEM NGUYEN2,3; RAJIV SAINI2; ANNARITA MALCANGI4; MARGHERITA TUMEDEI5; MARIATERESA AMBROSINO1; ANTONIO MANCINI2; SALVATORE SCACCO6; RICCARDO NOCINI7; LUIGI SANTACROCE2; ANDREA BALLINI8,9,#,*; EDOARDO BRAUNER10,#

    BIOCELL, Vol.46, No.4, pp. 923-929, 2022, DOI:10.32604/biocell.2022.018409 - 15 December 2021

    Abstract The human teeth and oral cavity harbor various populations of mesenchymal stem cells (MSCs), so called dental-derived stem cells (D-dSCs) with self-renewing and multilineage differentiation capabilities. D-dSCs properties involves a strong paracrine component resulting from the high levels of bioactive molecules they secrete in response to the local microenvironment. Altogether, this viewpoint develops a general picture of current innovative strategies to employ D-dSCs combined with biomaterials and bioactive factors for regenerative medicine purposes, and offers information regarding the available scientific data and possible applications. More >

  • Open Access

    VIEWPOINT

    The versatility of mesenchymal stem cells: From regenerative medicine to COVID, what is next?

    THAÍS CASAGRANDE PAIM, MÁRCIA ROSÂNGELA WINK*

    BIOCELL, Vol.46, No.4, pp. 913-922, 2022, DOI:10.32604/biocell.2022.018498 - 15 December 2021

    Abstract Mesenchymal stem cells (MSCs) play key roles in regenerative medicine by promoting tissue healing. MSCs can be isolated from different adult tissues and they are able to differentiate into several lineages. Due to their anti-inflammatory, angiogenic and immune-modulatory properties, MSCs are suitable for tissue engineering applications and, when associated with biomaterials, their benefits can be improved. Moreover, recently, MSCs have been studied for new clinical applications, such as in the treatment of patients with COVID-19. MSCs regenerative potential has been attributed to their secretome, which comprises extracellular matrix, soluble proteins and several elements, including the More >

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