Norbert Nass^1,2,*, Atanas Ignatov³, Thomas Kalinski¹

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072793 - 24 February 2026

Abstract Objectives: Vascular endothelial growth factor (VEGF) regulates tumor vascularization in response to hypoxia and inflammatory signals. The polyphenol curcumin is supposed to interfere with inflammation-induced VEGF secretion and might therefore support anti-VEGF-based treatments. We aimed to investigate the interaction between curcumin and the inflammatory cytokine Interleukin-1β (IL-1β) for VEGF secretion in breast cancer cell lines representing major breast cancer subtypes. Methods: VEGF in cell cultures was detected by Western blot and enzyme-linked immunosorbent assay (ELISA). Kinase phosphorylation was investigated by Western blotting. Gene expressions were analyzed by correlation tests. VEGF was evaluated in a retrospective… More > Graphic Abstract

Myeong Ryeo Kim^1,*, Jae Rim Lee¹, Xiaohan Zhang², Kwang Won Jeong^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072592 - 24 February 2026

Abstract Objectives: Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor (ER) α-positive breast cancer; however, resistance remains a significant clinical challenge. This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer, with particular focus on the role of SET Domain Containing 1A (SETD1A)-driven forkhead box A2 (FOXA2) as a key regulator of this resistance. Methods: FOXA2 expression and its regulation by SETD1A were assessed via (quantitative polymerase chain reaction), western blotting, transcriptome profiling, and chromatin immunoprecipitation analyses. The effects of FOXA2 on cell proliferation, migration, invasion, and cancer… More >

Ina Shehaj^1,2,*, Slavomir Krajnak¹, Katrin Almstedt¹, Yaman Degirmenci¹, Roxana Schwab¹, Kathrin Stewen¹, Walburgis Brenner¹, Annette Hasenburg¹, Marcus Schmidt^1,#, Anne-Sophie Heimes^1,#

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072222 - 24 February 2026

Abstract This article has no abstract. More >

Marcia Eduarda Viana Luna^1,2, Gustavo Jacob Lourenço², Juliana Carron^2,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072133 - 24 February 2026

Abstract This literature review explores the complex interaction between p53 and microRNAs (miRNAs) in the occurrence and progression of breast cancer (BC), the most common and lethal tumor type among women. BC is a multifactorial disease resulting from a combination of genetic and epigenetic alterations in cell DNA, influencing proliferation, differentiation, and migration. TP53 gene, which codifies p53 protein, is a known tumor suppressor, and it plays an important role in cell maintenance as DNA repair, cell proliferation control, and apoptosis activation. TP53 expression can be modulated by several miRNAs, as miR-30c, miR-34a, and the miR-200 family, More >

Weiping Yang^1,#, Wei Xiao^2,#, Wenhao Xu^3,#, Lijun Ren¹, Xian Li¹, Junhua Yu¹, Ronghua Wang^4,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.071122 - 24 February 2026

Abstract Background: Tertiary lymphoid structures (TLSs) promote antitumor immunity and predict favorable immunotherapy outcomes in breast cancer. The study aimed to investigate how Tryptophan 2,3-dioxygenase (TDO2)-associated tryptophan metabolism influences TLS maturation and B cell class switching in breast cancer. Methods: Bulk transcriptomic data from The Cancer Genome Atlas-Breast Invasive Carcinoma (TCGA-BRCA, n = 1055) were analyzed using Gene Set Variation Analysis (GSVA)–based metabolic scoring, immune deconvolution, and TLS quantification. Single-cell RNA sequencing (scRNA-seq, n = 26) and spatial transcriptomics (n = 1) were applied to map TDO2 expression and TLS spatial organization. Validation was performed by immunohistochemistry (n… More >

Chang-Eui Hong^1,2,3, Su-Yun Lyu^1,2,3,*

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.075574 - 14 February 2026

Abstract Objective: Tumor-associated macrophages (TAMs) contribute to chemoresistance in triple-negative breast cancer (TNBC), yet strategies to reprogram TAMs while enhancing chemotherapy efficacy remain limited. This study investigated whether Viscum album L. var. coloratum agglutinin (VCA) could sensitize TNBC cells to doxorubicin (DOX) and modulate TAM-mediated chemoresistance in three-dimensional (3D) co-culture models. Methods: MDA-MB-231 TNBC cells were co-cultured with RAW264.7 macrophages in collagen-embedded 3D spheroids. Spheroid viability was assessed using an ATP-based luminescent assay. Cytokine secretion and epithelial-mesenchymal transition (EMT) markers were measured using ELISA and Western blotting. Drug synergy was evaluated using combination index (CI) calculations. Results: VCA-DOX More >

Xiaoqing Jiang^1,2,#, Pengchong Li^1,2,#, Hongchuang Liu^1,2, Wenjie Dong^1,2, Wenjing Liu^1,2, Di Wu^1,2, Jianping Xue^1,2, Fenglan Zhao^1,2,*, Yongbo Duan^1,2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074434 - 30 January 2026

Abstract As its tuberous alkaloids induce valuable pharmacological effects, Pinellia ternata has considerable clinical value. However, its production currently fails to meet its demand. In vitro microtuber culture, combined with salicylic acid (SA) elicitation, may provide an effective alternative to traditional field production. In this study, an in vitro P. ternata microtuber induction system was developed and used to evaluate SA-induced elicitation of alkaloid accumulation. The quality of in vitro microtubers was assessed by total alkaloid measurement, a cytotoxicity assay, and transcriptomic analysis. With or without SA treatment, P. ternata microtuber induction was achieved within 60 d using petiole-derived explants, with… More >

Nuh Azginoglu^*

CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2026.075834 - 29 January 2026

Abstract Breast cancer screening programs rely heavily on mammography for early detection; however, diagnostic performance is strongly affected by inter-reader variability, breast density, and the limitations of conventional computer-aided detection systems. Recent advances in deep learning have enabled more robust and scalable solutions for large-scale screening, yet a systematic comparison of modern object detection architectures on nationally representative datasets remains limited. This study presents a comprehensive quantitative comparison of prominent deep learning–based object detection architectures for Artificial Intelligence-assisted mammography analysis using the MammosighTR dataset, developed within the Turkish National Breast Cancer Screening Program. The dataset comprises… More >

Oncology Research Editorial Office

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.078459 - 19 January 2026

Abstract This article has no abstract. More >

Min Hee Kim¹, Boyoon Huh¹, Joo-Won Park^1,*, Woo-Jae Park^2,*

Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071523 - 19 January 2026

Abstract Breast cancer is one of the most prevalent malignancies among women and comprises a heterogeneous spectrum of molecular subtypes with distinct biological behaviors. Among various regulatory molecules, sphingolipids play pivotal roles in dynamically modulating fundamental cellular processes such as proliferation, apoptosis, and metastasis through metabolic interconversions, including phosphorylation, glycosylation, and the generation of sphingosine-1-phosphate. This review aims to elucidate the mechanisms through which sphingolipid metabolism orchestrates cancer cell fate and drives breast cancer progression. Particular emphasis is placed on the balance between proapoptotic ceramides and pro-survival metabolites, such as sphingosine-1-phosphate, which collectively influence tumor growth More >