JINGLONG CAO^1,#, SHUMEI LI^2,#, TONG ZHANG^1,#, JIAN LIU¹, WENSHUANG HOU¹, ANQI WANG¹, CHANG WANG^3,4,*, CHENGHAO JIN^1,3,5,*

BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474 - 23 February 2024

Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated… More > Graphic Abstract

QI XIA¹, XING CHEN², QINGHUA MA³, XIANXIU WEN^2,*

BIOCELL, Vol.48, No.2, pp. 217-228, 2024, DOI:10.32604/biocell.2023.027414 - 23 February 2024

Abstract Background: Breast cancer (BC) is the most common cancer and the leading cause of cancer death in women. Immune features play an important role in improving the prognosis prediction of BC. However, while previous immune signatures consisted mainly of immune genes, immune cell-based signatures have been rarely reported. Methods: In this study, we report that a novel immune cell signature is effective in improving prognostic prediction by combining M2 macrophages. We identified 17 differentially infiltrating immune cells between cancer and normal groups. Prognostic features of the four immune cells identified by LASSO COX analysis showed… More >

JINSONG WU^1,2, ZHENG ZHI¹, WENZHONG XU¹, DIANCGENG LI¹, QIUBO LI¹, YAN HAN¹, JIANMING HE^1,3,*, XI LIANG^1,*

BIOCELL, Vol.47, No.12, pp. 2671-2680, 2023, DOI:10.32604/biocell.2023.043494 - 27 December 2023

Abstract Introduction: Collective cancer cell migration (CCCM) and epithelial-to-mesenchymal transition (EMT) play key roles in metastasis. This study reports that the colorectal carcinoma cell line LIM1863 is useful for the study of CCCM and EMT. Methods: Hematoxylin and eosin staining, scanning electron microscopy, transmission electron microscopy, and western blot analysis were performed. Results: LIM1863 automatically grew as spheroids in suspension and had important typical epithelial properties, including several layers of cells arranged around a central lumen, apical-basal polarity, and types of cell-cell junctions. Treatment with a combination of both TGF beta 1 and TNF alpha induced definite and… More >

IVANA PAJIC-LIJAKOVIC^*, MILAN MILIVOJEVIC

BIOCELL, Vol.47, No.11, pp. 2321-2334, 2023, DOI:10.32604/biocell.2023.043796 - 27 November 2023

Abstract The biointerface dynamics influence any cancer spreading through the epithelium since it is documented in the early stages some malignancies (like epithelial cancer). The altered rearrangement of epithelial cells has an impact on the development of cancer. Therefore, it is necessary to comprehend the underlying biological and physical mechanisms of this biointerface dynamics for early suppression of cancer. While the biological mechanisms include cell signaling and gene expression, the physical mechanisms are several physical parameters such as the epithelial-cancer interfacial tension, epithelial surface tension, and compressive stress accumulated within the epithelium. Although the segregation of… More > Graphic Abstract

JINGYAO XU^1,#, SHUANGLI HAO^1,#, KAIYUE HAN^1,#, WANXI YANG^1,*, HONG DENG^2,*

BIOCELL, Vol.47, No.4, pp. 773-788, 2023, DOI:10.32604/biocell.2023.026618 - 08 March 2023

Abstract As a pathway that plays a role in nutrient absorption, anabolic response, cell growth and survival, the important role of AKT/mTOR in tumorigenesis has also come to light. For cancer patients, most deaths are caused by the growth of metastatic tumors outside the primary focus. Therefore, migration and invasion in the late stage of tumor progression are the main unresolved issues in the study of tumor pathogenesis, and AKT/mTOR has been found to participate in the migration and invasion of cancer cells, which means that the study of this pathway may contribute to a solution… More >

IVANA PAJIC-LIJAKOVIC^*, MILAN MILIVOJEVIC

BIOCELL, Vol.47, No.1, pp. 15-25, 2023, DOI:10.32604/biocell.2023.023469 - 26 September 2022

Abstract A key feature that distinguishes cancer cells from all other cells is their capability to spread throughout the body. Although how cancer cells collectively migrate by following molecular rules which influence the state of cell-cell adhesion contacts has been comprehensively formulated, the impact of physical interactions on cell spreading remains less understood. Cumulative effects of physical interactions exist as the interplay between various physical parameters such as (1) tissue surface tension, (2) viscoelasticity caused by collective cell migration, and (3) solid stress accumulated in the cell aggregate core region. This review aims to point out… More >

HUOGEN LIU^#, YUNDI SHI^#, XIN WAN, YING LIU, HAILIN SHU, FENGMING HUANG, ZHENBIN GONG, LING GU^*

BIOCELL, Vol.46, No.12, pp. 2671-2680, 2022, DOI:10.32604/biocell.2022.018054 - 10 August 2022

Abstract Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the effect of PRDX1 on the EMT of airway epithelial cells stimulated with lipopolysaccharide (LPS) and transforming growth factor-beta 1 (TGF-β1). PRDX1 overexpression significantly increased the proliferation and migration of human bronchial epithelial (BEAS-2B) cells, reduced cell apoptosis (p < 0.01), and induced EMT and collagen deposition by upregulating the expression of the matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin and twist proteins and inhibiting E-cadherin expression (p < 0.05). PRDX1 overexpression More >

SHELDON R. GORDON^*

BIOCELL, Vol.46, No.9, pp. 2059-2063, 2022, DOI:10.32604/biocell.2022.019873 - 18 May 2022

Abstract Much of our understanding of the events which underlie cell migration has been derived from studies of cells in tissue culture. One of the components that mediates this process is the dynamic actin-based microfilament system that can reorganize itself into so-called stress fibers that are considered essential components for cell motility. In contrast, relatively few studies have investigated cell movement along an extracellular matrix (ECM) which is known to influence both cellular organization and behavior. This opinion/viewpoint article briefly reviews cell migration during corneal endothelial wound repair along the tissue’s natural basement membrane, Descemet’s membrane. More >

Jie Bai, Xiaowei Zeng^*

CMES-Computer Modeling in Engineering & Sciences, Vol.131, No.2, pp. 551-565, 2022, DOI:10.32604/cmes.2022.019376 - 14 March 2022

Abstract Cell migration plays a significant role in many biological activities, yet the physical mechanisms of cell migration are still not well understood. In this study, a continuum physics-based epithelial monolayer model including the intercellular interaction was employed to study the cell migration behavior in a confluent epithelial monolayer at constant cell density. The epithelial cell was modeled as isotropic elastic material. Through finite element simulation, the results revealed that the motile cell was subjected to higher stress than the other jammed cells during the migration process. Cell stiffness was implied to play a significant role More >

ANDREA FRACCHIA^1,2, GABI GERLITZ^1,*

BIOCELL, Vol.46, No.4, pp. 931-935, 2022, DOI:10.32604/biocell.2022.018179 - 15 December 2021

Abstract The link of the metazoan nucleus to the actin cytoskeleton is highly important for actin polymerization and migration of multiple cell types as well as for mechanotransduction and even affects the cellular transcriptome. Several mechanisms of organization of actin filaments next to the nuclear envelope have been identified. Among these mechanisms the most studied one is the Linker of nucleoskeleton and cytoskeleton (LINC) complex-dependent perinuclear actin organization. However, recently additional mechanisms have been identified: an Actin-related protein-2/3 (Arp2/3)-dependent perinuclear actin polymerization during migration of dendritic cells and a perinuclear actin rim that is formed in More >