Mujeebu Rehman¹, Qinghua Liu¹, Ali Ghulam², Tariq Ahmad³, Jawad Khan^4,*, Dildar Hussain^5,*, Yeong Hyeon Gu⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.1, pp. 779-805, 2025, DOI:10.32604/cmes.2025.067412 - 30 October 2025

Abstract Identifying druggable proteins, which are capable of binding therapeutic compounds, remains a critical and resource-intensive challenge in drug discovery. To address this, we propose CEL-IDP (Comparison of Ensemble Learning Methods for Identification of Druggable Proteins), a computational framework combining three feature extraction methods Dipeptide Deviation from Expected Mean (DDE), Enhanced Amino Acid Composition (EAAC), and Enhanced Grouped Amino Acid Composition (EGAAC) with ensemble learning strategies (Bagging, Boosting, Stacking) to classify druggable proteins from sequence data. DDE captures dipeptide frequency deviations, EAAC encodes positional amino acid information, and EGAAC groups residues by physicochemical properties to generate… More >

Yahya Alhaj Maz¹, Mohammed Anbar¹, Selvakumar Manickam^1,*, Mosleh M. Abualhaj², Sultan Ahmed Almalki³, Basim Ahmad Alabsi⁴

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5287-5307, 2025, DOI:10.32604/cmc.2025.068257 - 23 October 2025

Abstract The Internet of Things (IoT) is an innovation that combines imagined space with the actual world on a single platform. Because of the recent rapid rise of IoT devices, there has been a lack of standards, leading to a massive increase in unprotected devices connecting to networks. Consequently, cyberattacks on IoT are becoming more common, particularly keylogging attacks, which are often caused by security vulnerabilities on IoT networks. This research focuses on the role of transfer learning and ensemble classifiers in enhancing the detection of keylogging attacks within small, imbalanced IoT datasets. The authors propose… More >

Asif Nawaz^1,*, Rana Saud Shoukat², Mohammad Shehab¹, Khalil El Hindi³, Zohair Ahmed⁴

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 4777-4793, 2025, DOI:10.32604/cmc.2025.064088 - 23 October 2025

Abstract The kingdom Animalia encompasses multicellular, eukaryotic organisms known as animals. Currently, there are approximately 1.5 million identified species of living animals, including over 195 distinct breeds of dogs. Each breed possesses unique characteristics that can be challenging to distinguish. Each breed has its own characteristics that are difficult to identify. Various computer-based methods, including machine learning, deep learning, transfer learning, and robotics, are employed to identify dog breeds, focusing mainly on image or voice data. Voice-based techniques often face challenges such as noise, distortion, and changes in frequency or pitch, which can impair the model’s… More >

Xuezhi Wen^1,2, Eric Danso^1,2,*, Solomon Danso¹

Journal of Cyber Security, Vol.7, pp. 439-462, 2025, DOI:10.32604/jcs.2025.070587 - 17 October 2025

Abstract Cloud-based intrusion detection systems increasingly face sophisticated adversarial attacks such as evasion and poisoning that exploit vulnerabilities in traditional machine learning (ML) models. While deep learning (DL) offers superior detection accuracy for high-dimensional cloud logs, it remains vulnerable to adversarial perturbations and lacks interpretability. Conversely, Hidden Markov Models (HMMs) provide probabilistic reasoning but struggle with raw, sequential cloud data. To bridge this gap, we propose a Deep Learning-Enhanced Ensemble Hidden Markov Model (DL-HMM) framework that synergizes the strengths of Long Short-Term Memory (LSTM) networks and HMMs while incorporating adversarial training and ensemble learning. Our architecture… More >

Areeba Masood Siddiqui^1,2,*, Hyder Abbas^3,4, Muhammad Asim^5,6,*, Abdelhamied A. Ateya⁵, Hanaa A. Abdallah⁷

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3135-3168, 2025, DOI:10.32604/cmes.2025.069926 - 30 September 2025

Abstract Timely and accurate diagnosis of skin diseases is crucial as conventional methods are time-consuming and prone to errors. Traditional trial-and-error approaches often aggregate multiple models without optimization by resulting in suboptimal performance. To address these challenges, we propose a novel Squid Game Optimization-Dimension Reduction-based Ensemble (SGO-DRE) method for the precise diagnosis of skin diseases. Our approach begins by selecting pre-trained models named MobileNetV1, DenseNet201, and Xception for robust feature extraction. These models are enhanced with dimension reduction blocks to improve efficiency. To tackle the aggregation problem of various models, we leverage the Squid Game Optimization… More >

Lakshmi Alekhya Jandhyam^1,*, Ragupathy Rengaswamy¹, Narayana Satyala²

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.3, pp. 3679-3714, 2025, DOI:10.32604/cmes.2025.068941 - 30 September 2025

Abstract Human Activity Recognition (HAR) has become increasingly critical in civic surveillance, medical care monitoring, and institutional protection. Current deep learning-based approaches often suffer from excessive computational complexity, limited generalizability under varying conditions, and compromised real-time performance. To counter these, this paper introduces an Active Learning-aided Heuristic Deep Spatio-Textural Ensemble Learning (ALH-DSEL) framework. The model initially identifies keyframes from the surveillance videos with a Multi-Constraint Active Learning (MCAL) approach, with features extracted from DenseNet121. The frames are then segmented employing an optimized Fuzzy C-Means clustering algorithm with Firefly to identify areas of interest. A deep ensemble More >

Fatma S. Alrayes¹, Mohammed Zakariah^2,*, Mohammed K. Alzaylaee³, Syed Umar Amin⁴, Zafar Iqbal Khan⁴

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3457-3484, 2025, DOI:10.32604/cmc.2025.068599 - 23 September 2025

Abstract Healthcare networks prove to be an urgent issue in terms of intrusion detection due to the critical consequences of cyber threats and the extreme sensitivity of medical information. The proposed Auto-Stack ID in the study is a stacked ensemble of encoder-enhanced auctions that can be used to improve intrusion detection in healthcare networks. The WUSTL-EHMS 2020 dataset trains and evaluates the model, constituting an imbalanced class distribution (87.46% normal traffic and 12.53% intrusion attacks). To address this imbalance, the study balances the effect of training Bias through Stratified K-fold cross-validation (K = 5), so that… More >

Naif Almusallam^1,*, Junaid Qayyum^2,3

CMC-Computers, Materials & Continua, Vol.85, No.2, pp. 3653-3687, 2025, DOI:10.32604/cmc.2025.067220 - 23 September 2025

Abstract This paper proposes a novel hybrid fraud detection framework that integrates multi-stage feature selection, unsupervised clustering, and ensemble learning to improve classification performance in financial transaction monitoring systems. The framework is structured into three core layers: (1) feature selection using Recursive Feature Elimination (RFE), Principal Component Analysis (PCA), and Mutual Information (MI) to reduce dimensionality and enhance input relevance; (2) anomaly detection through unsupervised clustering using K-Means, Density-Based Spatial Clustering (DBSCAN), and Hierarchical Clustering to flag suspicious patterns in unlabeled data; and (3) final classification using a voting-based hybrid ensemble of Support Vector Machine (SVM),… More >

Yazeed Alkhrijah^1,2, Shehzad Khalid³, Syed Muhammad Usman^4,*, Amina Jameel³, Danish Hamid⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 1113-1141, 2025, DOI:10.32604/cmes.2025.068726 - 31 July 2025

Abstract Arabic Sign Language (ArSL) recognition plays a vital role in enhancing the communication for the Deaf and Hard of Hearing (DHH) community. Researchers have proposed multiple methods for automated recognition of ArSL; however, these methods face multiple challenges that include high gesture variability, occlusions, limited signer diversity, and the scarcity of large annotated datasets. Existing methods, often relying solely on either skeletal data or video-based features, struggle with generalization and robustness, especially in dynamic and real-world conditions. This paper proposes a novel multimodal ensemble classification framework that integrates geometric features derived from 3D skeletal joint… More >

Roseline Oluwaseun Ogundokun^*, Pius Adewale Owolawi, Chunling Tu

CMC-Computers, Materials & Continua, Vol.84, No.3, pp. 4869-4885, 2025, DOI:10.32604/cmc.2025.064944 - 30 July 2025

Abstract Breast cancer is among the leading causes of cancer mortality globally, and its diagnosis through histopathological image analysis is often prone to inter-observer variability and misclassification. Existing machine learning (ML) methods struggle with intra-class heterogeneity and inter-class similarity, necessitating more robust classification models. This study presents an ML classifier ensemble hybrid model for deep feature extraction with deep learning (DL) and Bat Swarm Optimization (BSO) hyperparameter optimization to improve breast cancer histopathology (BCH) image classification. A dataset of 804 Hematoxylin and Eosin (H&E) stained images classified as Benign, in situ, Invasive, and Normal categories (ICIAR2018_BACH_Challenge) has… More >