Moharam Habibnejad Korayem^1,*, Zahra Rastegar²

Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 109-122, 2019, DOI:10.32604/mcb.2019.04706

Abstract The mechanical properties of single cells have been recently identified as the basis of an emerging approach in medical applications since they are closely related to the biological processes of cells and human health conditions. The problem in hand is how to measure mechanical properties in order to obtain them more accurately and applicably. Some of the cell’s properties such as elasticity module and adhesion have been measured before using various methods; nevertheless, comprehensive tests for two healthy and cancerous cells have not been performed simultaneously. As a Nanoscale device, AFM has been used for some biological cells, however for… More >

Wenjia Wang^{1, 2}, Xiuqing Qian^{1, 2}, Qi Li^{1, 2}, Gong Zhang^{1, 2}, Huangxuan Zhao^{1, 2}, Tan Li^{1, 2}, Yang Yu^{1, 2}, Hongfang Song^{1, 2, *}, Zhicheng Liu^{1, 2, *}

Molecular & Cellular Biomechanics, Vol.16, No.1, pp. 59-74, 2019, DOI:10.32604/mcb.2019.06393

Abstract Pupillary block is considered as an important cause of primary angle-closure glaucoma (PACG). In order to investigate the effect of pupillary block on the hydrodynamics of aqueous humor (AH) in anterior chamber (AC) and potential risks, a 3D printed eye model was developed to mimic the AH flow driven by fluid generation, the differential pressure between AC and posterior chambers (PC) and pupillary block. Particle image velocimetry technology was applied to visualize flow distribution. The results demonstrated obvious differences in AH flow with and without pupillary block. Under the normal condition (without pupillary block), the flow filed of AH was… More >

Lilan Gao^1,2,*, Qingxian Yuan^1,2, Ruixin Li^3,*, Lei Chen^1,2, Chunqiu Zhang^1,2, Xizheng Zhang^1,2

Molecular & Cellular Biomechanics, Vol.15, No.2, pp. 85-98, 2018, DOI: 10.3970/mcb.2018.00329

Abstract Silk fibroin-typeⅡcollagen scaffold was made by 3D printing technique and freeze-drying method, and its mechanical properties were studied by experiments and theoretical prediction. The results show that the three-dimensional silk fibroin-typeⅡ collagen scaffold has good porosity and water absorption, which is (89.3%+3.26%) and (824.09%+93.05%), respectively. With the given strain value, the stress of scaffold decreases rapidly firstly and then tends to be stable during the stress relaxation. Both initial and instantaneous stresses increase with increase of applied strain value. The creep strains of scaffold with different stress levels show the two stages: the rapidly increasing stage and the second stable… More >

Yang Li¹, Xiuxian Liu², Zhiyong Li^2,*, Jiayi Tong¹, Yi Feng¹, Genshan Ma¹, Chengxing Shen³, Naifeng Liu¹

Molecular & Cellular Biomechanics, Vol.14, No.4, pp. 213-229, 2017, DOI:10.3970/mcb.2017.014.213

Abstract Coronary tortuosity is a common angiographic finding, but the hemodynamic significance of coronary tortuosity is largely unknown. The impact of coronary tortuosity on coronary pressure and wall shear stress is still unclear. We addressed this issue in the present experimental study. A distorted tube model connected to heart pumping machine was established to simulate the coronary circulation. The pressure of each point was measured with a coronary pressure guidewire. Influence of tortuosity angle and tortuosity number on local pressure was measured. Wall shear stress was calculated accordingly to the pressure of each point. Pressure distribution in this system was affected… More >

Chetan D. Kuthe^∗, R.V. Uddanwadiker^†, Alankar Ramteke^‡

Molecular & Cellular Biomechanics, Vol.11, No.2, pp. 113-128, 2014, DOI:10.3970/mcb.2014.011.113

Abstract Biomechanical researches are essential to develop new techniques to improve the clinical relevance. Skeletal muscle generates the force which results in the motion of human body, so it is essential to study the mechanical and structural properties of skeletal muscle. Many researchers have carried out mechanical study of skeletal muscle with in-vivo testing. This work aims to examine anisotropic mechanical behavior of skeletal muscle with in vitro test (tensile test). It is important to understand the mechanical and structural behavior of skeletal muscle when it is subjected to external loading; the research aims to determine the structural properties of skeletal… More >

Idalba A. Hidalgo A.^∗, Felipe Sojo^†, Francisco Arvelo^†, Marcos A. Sabino^∗,‡

Molecular & Cellular Biomechanics, Vol.10, No.2, pp. 85-105, 2013, DOI:10.3970/mcb.2013.010.085

Abstract The electrospinning technique is a method used to produce nano and microfibers using the influence of electrostatic forces. Porous three dimensional networks of continuous and interconnected fibers as scaffolds were obtained from a poly (lactic acid) solution. The concentration of the polymeric solution, 12.5% m/w, as well as the conditions of voltage (V=11kV) and tip-metallic collector distance (H=13cm) were established to develop these scaffolds through the electrospinning process. The characteristics of the scaffolds, such as fiber diameter, sintering and the biomimetics of the characteristics of a native extra cellular matrix were verified by Scanning Electron Microscopy (SEM). The orientation induced… More >

Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259

Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI human coronary plaque data to… More >

Chenxi Xiong^1,2, Xianghe Peng^1,2,3, Chunwei Zhao^1,2,4, Ning Hu^1,5,6

CMC-Computers, Materials & Continua, Vol.31, No.1, pp. 65-86, 2012, DOI:10.3970/cmc.2012.031.065

Abstract A method to reduce the sedimentation of the ferromagnetic particles in magnetorheological fluids (MRFs) is studied with numerical simulation and experiment. It shows that, making use of the magnetic field generated by a permanent magnet put simply above an MRF, the sedimentation of the particles in the MRF can be reduced remarkably. The magnetic force on a ferromagnetic particle and that on a particle chain are computed with the finite element (FE) code ANSYS. It reveals that the magnetic force on a particle-chain is much larger than the sum of the magnetic force on each individual particle in the chain… More >

D. A. Hu^1,2,3, C. Liang¹, X. Han¹, Y. Z. Chen⁴, W. F. Xu⁴

CMC-Computers, Materials & Continua, Vol.29, No.2, pp. 155-168, 2012, DOI:10.3970/cmc.2012.029.155

Abstract Penetration process of concrete plate is simulated by 3D FE-SPH adaptive coupling algorithm, which is based on experimental research of projectile with 25mm diameter penetrates concrete target. In experiment, a high speed camera is used to record dynamic deformation process of concrete plate. Acceleration responses of concrete are obtained by acceleration sensor, which is pre-embedded in target plate. This experiment is also simulated by 3D FE-SPH adaptive coupling algorithm to verify the numerical model. Numerical model is approximated initially by FEM, and distorted elements are automatically converted into meshless particles to simulate damage, splash of concrete by SPH method, when… More >

Jing Qian¹, Xuhong Miao², Yao Shen³

CMC-Computers, Materials & Continua, Vol.27, No.2, pp. 179-188, 2012, DOI:10.32604/cmc.2012.027.179

Abstract Based on experimental data, the research work on warp knitted spacer fabrics gives compression laws when structural parameters (such as diameter of spacer yarn, areal density, spacer yarn angle and the thickness of spacer fabrics ) of spacer fabric change. ANSYS calculation models were developed, and simulation results matched with experimental data well. The computer simulation on this area provides a fundamental tool which can help designer to decide structural parameters when working stresses are given. More >