XI YANG^1,5,#, HUIXIAN WU^2,3,#, CHAO XIONG^4,#, BO ZHAO¹, MEILIAN LIU¹, JIE QIN⁶, MEI DENG^1,2,3,*

BIOCELL, Vol.47, No.5, pp. 1021-1037, 2023, DOI:10.32604/biocell.2023.027103

Abstract Background: Cytochrome b561 (CYB561) plays a critical role in neuroendocrine function, cardiovascular regulation, and tumor growth; however, the prognostic value of CYB561 in patients with breast cancer and the relationship between CYB561 expression and immune infiltration in breast cancer remain unclear. Methods: The mRNA expression and clinical data of patients with breast cancer were obtained from The Cancer Genome Atlas database. Functional enrichment analysis was used to explore underlying biological functions associated with CYB561. The methylation status of CYB561 was analyzed using the MethSurv database. The enrichment score of immune cell infiltration for CYB561 in breast cancer was calculated using… More >

HAOTONG SUN^1,2, HEYING WANG^1,3, XIN LI^1,2, YANJIE HAO^1,2, JUN LING^1,2, HUAN WANG^1,2, FEIMIAO WANG^1,2, FANG XU^1,2,*

BIOCELL, Vol.47, No.3, pp. 607-618, 2023, DOI:10.32604/biocell.2023.026445

Abstract Background: Colon adenocarcinoma (COAD) is the second leading cause of cancer death worldwide thus, identification of COAD biomarkers is critical. Mitotic Arrest Deficient 2 Like 2 (MAD2L2) is a key factor in mammalian DNA damage repair and is highly expressed in many malignant tumors. This is a comprehensive study of MAD2L2 expression, its diagnostic value, prognostic analysis, potential biological function, and impact on the immune system of patients with COAD. Methods: Gene expression, clinical relevance, prognostic analysis, diagnostic value, GO/KEGG cluster analysis, data obtained from TCGA, and bioinformatics statistical analysis were performed using the R package. Immune responses to MAD2L2… More >

Xuelian Du^1,#, Hao Shi^2,#, Haiyan Liu¹, Linghua Zhou¹, Anqun Xie¹, Jufang Guo^1,*

Oncologie, Vol.24, No.4, pp. 769-787, 2022, DOI:10.32604/oncologie.2022.026248

Abstract Background: Gestational diabetes mellitus (GDM) affects the health of numerous women around the world. A recent study has shown that GDM is associated with an increased incidence of cancer. In this study, we aimed to explore the possible shared mechanisms and potential common therapeutic targets between GDM and cancer. Methods: The limma package was used to identify differentially expressed genes (DEGs) in GDM. The Cytoscape plugin cytoHubba was used to screen hub genes. The CIBERSORT algorithm was used to explore the correlation between hub genes and immunity. Cox regression analysis was used to assess the relationship between protein tyrosine kinase… More >

Shaojie Feng^*, Leipeng Liu, Chen Gao, Hang Hu

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.5, pp. 1189-1201, 2023, DOI:10.32604/fdmp.2023.023637

Abstract The present study considers the damage mechanisms and the rainfall infiltration process responsible for landslide phenomena which originate from accumulation slopes. Accordingly, a physical test model is developed for different slopes and different rainfall conditions. Moreover, a three-dimensional laser scanner and a camera are used to monitor the slope erosion and the landslide dynamic evolution. Using this approach, the time variation curves of volumetric water content, pore water pressure, soil pressure, slope deformation, and damage are determined. The results show that under similar conditions, similar trends of the pore water pressure are achieved for different slopes and rainfall intensities. More > Graphic Abstract

Bobo Luo^1,*, Yunbin Xiong¹, Zhuoyi Li², Zhanqing Qu³, Fenggang Liu¹, Tiankui Guo³, Zugui Yang¹, Yina Shi¹

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.4, pp. 911-928, 2023, DOI:10.32604/fdmp.2022.022761

Abstract Due to its long lifespan and high sand-removal efficiency, gravel packing is one of the most applied sand control methods during the recovery of reservoirs with sanding problems. The blockage and retention of injected sand in a gravel pack is a complex process affected by multiple mechanisms. The majority of existing studies based on the phenomenological deep bed filtration (DBF) theory focused on the gravel pack’s overall permeability damage and failed to obtain the inner-pore particle distribution pattern. In this work, experiments and simulations were carried out to reveal the particle distribution in a gravel pack during flooding. In particular,… More >

Saher Manzoor¹, Muhammad Waseem Ashraf^1,*, Shahzadi Tayyaba², Muhammad Imran Tariq^3,*, M. Khalid Hossain⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.135, No.2, pp. 1007-1052, 2023, DOI:10.32604/cmes.2022.022093

Abstract The progress of membrane technology with the development of membranes with controlled parameters led to porous membranes. These membranes can be formed using different methods and have numerous applications in science and technology. Anodization of aluminum in this aspect is an electro-synthetic process that changes the surface of the metal through oxidation to deliver an anodic oxide layer. This process results in a self-coordinated, exceptional cluster of round and hollow formed pores with controllable pore widths, periodicity, and thickness. Categorization in barrier type and porous type films, and different methods for the preparation of membranes, have been discussed. After the… More > Graphic Abstract

LIPING GONG¹, MING JIA^2,*

BIOCELL, Vol.47, No.1, pp. 109-123, 2023, DOI:10.32604/biocell.2023.024620

Abstract ATP binding cassette subfamily C member 8 (ABCC8) encodes a protein regulating the ATP-sensitive potassium channel. Whether the level of ABCC8 mRNA in lower grade glioma (LGG) correlates with immune cell infiltration and patient outcomes has not been evaluated until now. Comparisons of ABCC8 expression between different tumors and normal tissues were evaluated by exploring publicly available datasets. The association between ABCC8 and tumor immune cell infiltration, diverse gene mutation characteristics, tumor mutation burden (TMB), and survival in LGG was also investigated in several independent datasets. Pathway enrichment analysis was conducted to search for ABCC8-associated signaling pathways. Through an online… More >

Jiageng Zhang¹, Zhengfeng Wang², Jiguang Huang¹, Chao Cheng¹, Heng Zhang¹, Dan Gao^1,*

Energy Engineering, Vol.119, No.6, pp. 2277-2296, 2022, DOI:10.32604/ee.2022.020795

Abstract

Nowadays, the zero liquid discharge of flue gas desulfurization (FGD) wastewater from coal-fired units has attracted the attention of all countries in the world. The pretreatment methods generally have the problems of high operation cost, small treatment capacity, and poor flexibility. However, the membrane method can avoid the above problems. In the current research, it has not been found that someone directly uses submerged ultrafiltration to pretreat FGD wastewater. Therefore, this paper innovatively proposed to directly use ceramic ultrafiltration membrane to treat FGD wastewater, which can ensure effluent quality and improve the flexibility of the pretreatment system. In this paper,… More >

JIAMING ZHAN, WEIHUA WANG, YANLEI TANG, NING ZHOU, DAOWEN JIANG^*

BIOCELL, Vol.46, No.12, pp. 2601-2613, 2022, DOI:10.32604/biocell.2022.021300

Abstract Esophageal cancer (EC) was an aggressive malignant neoplasm characterized by high morbidity and poor prognosis. Identifying the changes in DNA damage repair genes helps to better understand the mechanisms of carcinoma progression. In this study, by comparing EC samples and normal samples, we found a total of 132 DDR expression with a significant difference. Moreover, we revealed higher expression of POLN, PALB2, ATM, PER1, TOP3B and lower expression of HMGB1, UBE2B were correlated to longer OS in EC. In addition, a prognostic risk score based on 7 DDR gene expression (POLN, HMGB1, TOP3B, PER1, UBE2B, ATM, PALB2) was constructed for… More >

WEI LIANG^1,2,*, QIANG LUO^1,2,#, ZONGWEI ZHANG^1,2,#, KEJU YANG^1,2,3, ANKANG YANG^1,2, QINGJIA CHI⁴, HUAN HU⁵

BIOCELL, Vol.46, No.8, pp. 1989-2002, 2022, DOI:10.32604/biocell.2022.019300

Abstract Diabetic nephropathy (DN) is a common microvascular complication that easily leads to end-stage renal disease. It is important to explore the key biomarkers and molecular mechanisms relevant to diabetic nephropathy (DN). We used highthroughput RNA sequencing to obtain the genes related to DN glomerular tissues and healthy glomerular tissues of mice. Then we used LIMMA to analyze differentially expressed genes (DEGs) between DN and non-diabetic glomerular samples. And we performed KEGG, gene ontology functional (GO) enrichment, and gene set enrichment analysis to reveal the signaling pathway of the disease. The CIBERSORT algorithm based on support vector machine was used to… More >