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  • Open Access

    CORRECTION

    Correction: LncRNA PCGEM1 facilitates cervical cancer progression via miR-642a-5p/KIF5B axis

    YUANLIN LIU1,3, YAN LIU2, YAN WANG2, QIANG WANG2, YAN YAN1, DANDAN ZHANG2,*, HUIQIN LIU2,*

    Oncology Research, Vol.33, No.6, pp. 1505-1505, 2025, DOI:10.32604/or.2024.056768 - 29 May 2025

    Abstract This article has no abstract. More >

  • Open Access

    ARTICLE

    Hypoxia-induced exosomal lncRNA-PVT1 as a biomarker and mediator of EMT in hepatocellular carcinoma

    LIBO LIANG1, XINYI WANG2,3,4, YUPING ZENG2,3,4, HAO CHEN2,3,4, WEN ZHOU1, HONGYING MU2,3,4, GA LIAO5,6,*

    Oncology Research, Vol.33, No.6, pp. 1405-1421, 2025, DOI:10.32604/or.2024.056708 - 29 May 2025

    Abstract Objectives: Exosomal long noncoding RNAs (lncRNAs) might facilitate epithelial–mesenchymal transition (EMT) in liver cancer after transarterial chemoembolization (TACE), thereby enhancing tumor cell invasiveness and migration. This study investigated the prognostic role of plasma exosomal long noncoding RNA-plasmacytoma variant translocation 1 (lncRNA-PVT1) in TACE treated hepatocellular carcinoma (HCC). Methods: Plasma exosomal lncRNA-PVT1 was evaluated via qPCR before and after TACE. Hepatoma cell behavior was investigated in different HCC cell lines. A lncRNA-PVT1 plasmid was synthesized and overexpressed, and si-lncRNA PVT1 was transfected into poorly invasive cells to reveal its influence on cell characteristics. The lncRNA-PVT1–FoxM1 interaction… More > Graphic Abstract

    Hypoxia-induced exosomal lncRNA-PVT1 as a biomarker and mediator of EMT in hepatocellular carcinoma

  • Open Access

    ARTICLE

    CFGANLDA: A Collaborative Filtering and Graph Attention Network-Based Method for Predicting Associations between lncRNAs and Diseases

    Dang Hung Tran, Van Tinh Nguyen*

    CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 4679-4698, 2025, DOI:10.32604/cmc.2025.063228 - 19 May 2025

    Abstract It is known that long non-coding RNAs (lncRNAs) play vital roles in biological processes and contribute to the progression, development, and treatment of various diseases. Obviously, understanding associations between diseases and lncRNAs significantly enhances our ability to interpret disease mechanisms. Nevertheless, the process of determining lncRNA-disease associations is costly, labor-intensive, and time-consuming. Hence, it is expected to foster computational strategies to uncover lncRNA-disease relationships for further verification to save time and resources. In this study, a collaborative filtering and graph attention network-based LncRNA-Disease Association (CFGANLDA) method was nominated to expose potential lncRNA-disease associations. First, it… More >

  • Open Access

    RETRACTION

    Retraction: lncRNA FEZF1-AS1 Is Associated with Prognosis in Lung Adenocarcinoma and Promotes Cell Proliferation, Migration, and Invasion

    Oncology Research Editorial Office

    Oncology Research, Vol.33, No.5, pp. 1251-1252, 2025, DOI:10.32604/or.2025.065346 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    REVIEW

    Classical biomarkers and non-coding RNAs associated with diagnosis and treatment in gastric cancer

    JINGDAN QUAN1, ZIXIN WAN1, WEI WU2, XINYUAN CAO2, JIAYUAN QIU2, XIAOYE LIU2, ZHIWEI ZHANG1,*

    Oncology Research, Vol.33, No.5, pp. 1069-1089, 2025, DOI:10.32604/or.2025.063005 - 18 April 2025

    Abstract One of the most prevalent malignant tumors worldwide, stomach cancer still has a high incidence and fatality rate in China, and the number of young people developing early-onset gastric cancer is steadily increasing. The 5-year survival rate of stomach cancer is typically 30%–35%, the prognosis is bad, the patients’ quality of life is low, and the progression of advanced gastric cancer cannot be effectively managed despite the use of surgical surgery, chemotherapy, and other medicines. We urgently need molecular biomarkers with high specificity and sensitivity to increase the early gastric cancer detection rate, extend patient… More >

  • Open Access

    REVIEW

    The regulatory role of lncRNA in tumor drug resistance: refracting light through a narrow aperture

    HENG ZHANG1,#, XIAO YANG2,#, YUJIN GUO3, HAIBO ZHAO4, PEI JIANG5,*, QING-QING YU3,*

    Oncology Research, Vol.33, No.4, pp. 837-849, 2025, DOI:10.32604/or.2024.053882 - 19 March 2025

    Abstract As living conditions improve and diagnostic capabilities advance, the incidence of tumors has increased, with cancer becoming a leading cause of death worldwide. Surgery, chemotherapy, and radiotherapy are the most common treatments. Despite advances in treatment options, chemotherapy remains a routine first-line treatment for most tumors. Due to the continuous and extensive use of chemotherapy drugs, tumor resistance often develops, becoming a significant cause of treatment failure and poor prognosis. Recent research has increasingly focused on how long stranded non-coding RNAs (LncRNAs) influence the development of malignant tumors and drug resistance by regulating gene expression More >

  • Open Access

    REVIEW

    The regulatory role of ZFAS1/miRNAs/mRNAs axis in cancer: a systematic review

    RAHUL KUMAR SINGH1,#, SUROJIT MANDAL1,#, ADRIJA MOHANTA1, RITU YADAV1, RAJIV RANJAN KUMAR1, RINKU KHATKAR1, VIVEK UTTAM1, UTTAM SHARMA1, MANJIT KAUR RANA2, MANJU JAIN3, HARDEEP SINGH TULI4, AKLANK JAIN1,*

    Oncology Research, Vol.33, No.3, pp. 591-604, 2025, DOI:10.32604/or.2024.050548 - 28 February 2025

    Abstract Objectives: Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 (ZFAS1) in cancer development. However, the intricate interplay of ZFAS1 with miRNAs and mRNAs remains to be fully understood. Materials and methods: We followed PRISMA guidelines to retrieve and assess the available literature on the topic “ZFAS1/miRNA/mRNA axis” and “Cancer” from databases such as PubMed, Google Scholar, and ScienceDirect. We also used bioinformatic webtools for analyzing the potential miRNA targets of ZFAS1 and its role in survival of cancer patients along with their role in various biological functions and pathways. Results: Our literature search… More >

  • Open Access

    ARTICLE

    lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis

    ZHOUYANG CHENG1,#, YUCHEN HUA2,#, YANG CAO3, JUN QIN1,*

    Oncology Research, Vol.33, No.1, pp. 185-198, 2025, DOI:10.32604/or.2024.042281 - 20 December 2024

    Abstract Objective: Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies. Studies have shown that the lncRNA small nucleolar RNA host gene 4 (SNHG4) serves as a tumor promoter in various malignancies, while its function in GC has yet to be characterized. Therefore, our study aimed to explore the role and underlying mechanism of… More >

  • Open Access

    ARTICLE

    LncRNA AFAP1-AS1 exhibits oncogenic characteristics and promotes gemcitabine-resistance of cervical cancer cells through miR-7-5p/EGFR axis

    CHAOQUN WANG1, TING ZHANG2, CHAOHE ZHANG3,*

    Oncology Research, Vol.32, No.12, pp. 1867-1879, 2024, DOI:10.32604/or.2024.044547 - 13 November 2024

    Abstract Background: Drug resistance is the main factor contributing to cancer recurrence and poor prognosis. Exploration of drug resistance-related mechanisms and effective therapeutic targets are the aim of molecular targeted therapy. In our study, the role of long non-coding RNA (lncRNA) AFAP1-AS1 in gemcitabine resistance and related mechanisms were explored in cervical cancer cells. Methods: Gemcitabine-resistant cervical cancer cell lines HT-3-Gem and SW756-Gem were constructed using the gemcitabine concentration gradient method. The overall survival rates and recurrence-free survival rates were evaluated by Kaplan-Meier analysis. The interaction was verified through a Dual-luciferase reporter gene assay and a… More > Graphic Abstract

    LncRNA AFAP1-AS1 exhibits oncogenic characteristics and promotes gemcitabine-resistance of cervical cancer cells through miR-7-5p/EGFR axis

  • Open Access

    RETRACTION

    Retraction: lncRNA C2dat1 promotes cell proliferation, migration, and invasion by targeting miR-34a-5p in osteosarcoma cells

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.11, pp. 1815-1815, 2024, DOI:10.32604/or.2024.056890 - 16 October 2024

    Abstract This article has no abstract. More >

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