Kai Luo¹, Yanbing Bai¹, Yan Jiang¹, Guiling Li¹, Min Jia¹, Yongguo He¹, Zhijun Yao¹, Ziwei Xiao¹, Xiaoqiong Liu¹, Wenjie Liu², Shanshan Yin^1,*, Zesheng Li^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 1975-1986, 2023, DOI:10.32604/phyton.2023.028232

Abstract Pollination biology studies of the endangered herbal medicines Dendrobium chrysotoxum were conducted in natural pollination conditions using flower observation, pollinator observation and artificial pollination experiments. Populations of D. chrysotoxum with fragrance and nectar were pollinated by Ctenoplectra davidi Valhalla (Hymenoptera: Apidae) species. The floral structure of D. chrysotoxum adapted precisely to its pollinators. Flowers had a low capsule setting (0.17%) under natural conditions. However, compared to open pollination, artificial pollination experiments showed a significant increase in capsule setting, and D. chrysotoxum was cross-compatible and self-compatible, but there was pollinator limitation also. This study will provide important information for the preservation… More >

Jia An^#, Xiang Wang^#, Yajiang Jing, Jianping Huang, Qilong Wang, Gang Zhang, Jing Gao, Liang Peng, Wenli Huang^*, Yonggang Yan^*

Phyton-International Journal of Experimental Botany, Vol.92, No.5, pp. 1405-1420, 2023, DOI:10.32604/phyton.2023.026525

Abstract Although Platycodon grandiflorum (Jacq.) A.DC. is a renowned medicine food homology plant, reports of excessive cadmium (Cd) levels are common, which affects its safety for clinical use and food consumption. To enable its Cd levels to be regulated or reduced, it is necessary to first elucidate the mechanism of Cd uptake and accumulation in the plant, in addition to its detoxification mechanisms. This present study used inductively couple plasma-mass-spectrometry to analyze the subcellular distribution and chemical forms of Cd in different tissues of P. grandiflorum. The experimental results showed that Cd was mainly accumulated in the roots [predominantly in the… More >

QIAO ZHOU^1,2,3, JIAN LIU^2,4, LING XIN⁴, YANYAN FANG^2,4, LEI WAN^2,4, DAN HUANG^2,4, JINCHEN GUO¹, JIANTING WEN^2,4

BIOCELL, Vol.47, No.4, pp. 761-772, 2023, DOI:10.32604/biocell.2023.026698

Abstract The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being obesity, age, environmental variables, and genetic predisposition. The available evidence suggests that genetic diversity does not adequately account for all clinical characteristics and heterogeneity of OA. Genetics has emerged as a nascent and crucial area of research in OA. The epigenetic module presents a potential link between genetic and environmental risk factors and the susceptibility and pathogenesis of OA. As a critical epigenetic alteration, DNA methylation has been shown to have an important role in the etiology of OA and is a viable biomarker for predicting disease… More >

LI YANG^1,2, KUN DENG³, ZHIQIANG MOU^1,2, PINGFU XIONG^1,2, JIAN WEN^1,2, JING LI^1,2,*

Oncology Research, Vol.30, No.5, pp. 243-258, 2022, DOI: 10.32604/or.2022.027958

Abstract Background: Considering the great heterogeneity of Hepatocellular carcinoma (HCC), more accurate prognostic models are urgently needed. This paper combined the advantages of genomics and pathomics to construct a prognostic model. Methods: First, we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database. Then, based on immune-related genes, we used random forest plots to screen prognosis-related genes and build prognostic models. Bioinformatics was used to identify biological pathways, evaluate the tumor microenvironment, and perform drug susceptibility testing. Finally, we divided the patients into different subgroups according to the gene model algorithm. Pathological… More >

Grégory Ninot^1,2,*, Estelle Guerdoux^1,2, François Carbonnel¹, Kerstin Faravel², Ludovic Ismael¹, Fanny Leenhardt², Béatrice Lognos¹, Caroline Perrier², Laurent Philibert², Boris Tronc¹, Marie Viala²

Oncologie, Vol.24, No.4, pp. 605-612, 2022, DOI:10.32604/oncologie.2022.024558

Abstract A retrospective observational study carried out in the United States showed a decrease in survival in patients treated for breast, prostate, lung and colorectal cancer with complementary medicines. We verified this result with a French population of consecutive 636 patients diagnosed with the same cancer and treated with oral chemotherapy in an hospital for three years. An interview by a pharmacist before the administration of oral chemotherapy was made to identify the complementary medicines used by the patients. We compared the overall survival using a log-rank test by stratifying the groups (number of cancers, number of comorbidities, age, sex). The… More >

M. Adjailia¹, H. Derbal Habak^2,*, Y. Hamaizi¹, H. Triki¹

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.3, pp. 831-844, 2023, DOI:10.32604/fdmp.2022.022162

Abstract Fiber Bragg grating (FBG) sensors are often used in monitoring activities and to ensure that environmental parameters satisfy industrial requirements. They offer crucial safety measures in the early detection of hazards due to their greatly reduced size, low weight, flexibility, and immunity to electromagnetic interference. These characteristics make FBGs suitable also for use in relation to the human body for in vivo measurements and long-term monitoring. In this study, recent developments are presented with regard to the utilization of these sensors to measure the so-called post-mortem interval (PMI). Such developments rely on numerical simulations based on the Matlab software and… More >

Natalia Roque^1,#, Diana Matias^2,#, Joana Balça-Silva³, Valéria Pereira Ferrer⁴, Luciana Santos Pessoa¹, Tania Cristina Leite de Sampaio e Spohr^1,5,*

Oncologie, Vol.24, No.3, pp. 371-411, 2022, DOI:10.32604/oncologie.2022.024035

Abstract Cancer is one of the deadliest diseases with a cure far from being found. Despite the extraordinary advances in the therapy approaches, only a few patients respond to treatments. The tumor microenvironment (TME) plays a crucial role in cancer progression by contributing to the chemoresistance. Thus, emerging efforts are being made in nanotechnology research focusing on nanoparticles’ potential role and their application in immune system modulation. Moreover, the omics have contributed to bioengineering and nanotechnology development by elucidating the mechanisms of cancer and specific biomarkers that could be used as new therapeutic targets. Furthermore, the non-coding microRNA as a target… More >

Sukhbir Shahid^*

Sound & Vibration, Vol.56, No.3, pp. 245-253, 2022, DOI:10.32604/sv.2022.016139

Abstract The potential use of sound and vibration for diagnostic and therapeutic purposes remains largely under-explored and under-estimated. Sound and vibrational energy has great positive impact on the mind and body. It could be particularly useful for psychosomatic diseases as a complementary therapy. Singing bowls, the spiritual ancient therapy has been claimed to aid in mind relaxation and painful and inflammatory conditions. Childhood asthma is an inflammatory airway disease and a psychosomatic disorder. The psychological management in it is often neglected leading to under-treatment or a relapse. Hence, we hypothesized that sound therapy with singing bowls might be useful as complementary… More >

JÉRÔME LALOZE^1,2, ALEXIS DESMOULIÈRE^1,*

BIOCELL, Vol.46, No.12, pp. 2701-2704, 2022, DOI:10.32604/biocell.2022.022229

Abstract Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal cells. The range of therapeutic indications has also expanded over recent years. Numerous recent studies have highlighted the primary importance of paracrine secretion by these cells. Though it is interesting to compare the different types of such secretions, we believe that exosomes (extra-cellular vesicles possessing the same properties as their source cells) will likely be the main key in tomorrow’s cell therapy. Exosomes also have many advantages compared to the direct use of cells, making these particles a major target in fundamental and translational… More >

Hai Long¹, Zhe Wang¹, Yidi Cui^2,3, Junhui Wang⁴, Bo Gao⁵, Chao Chen⁵, Yan Zhu^5,*, Heinrich Herre¹

CMC-Computers, Materials & Continua, Vol.73, No.3, pp. 5197-5217, 2022, DOI:10.32604/cmc.2022.029365

Abstract Psoriasis is a chronic, non-communicable, painful, disfiguring and disabling disease for which there is no cure, with great negative impact on patients’ quality of life (QoL). Diagnosis and treatment with traditional Chinese medical technique based on syndrome differentiation has been used in practice for a long time and proven effective, though, up to now, there are only a few available studies about the use of semantic technologies and the knowledge systems that use Traditional Chinese Medicine (TCM)-syndrome differentiation for information retrieval and automated reasoning. In this paper we use semantic techniques based on ontologies to develop a prototypical system for… More >