Jamie Penno^*, Sarah Hetrick, Grant Christie

International Journal of Mental Health Promotion, Vol.24, No.5, pp. 771-781, 2022, DOI:10.32604/ijmhp.2022.020090

Abstract The mental health of New Zealand’s adolescents is, by global standards, remarkably poor. Addressing such mental health needs is not only pertinent with regards to the quality of life of our young people, but also the health of our society as a whole, with current unmet youth mental health needs becoming future adult population health deficits. While an array of evidence-based psychotherapies are available as treatment, our knowledge of the mechanism of actions underlying each of these is lacking. We propose that the practice of goal setting as a therapeutic technique may represent not only a common element across these… More >

Yang Chen^1,#, Huan Wu^2,#, Annan Jiao³, Jiabing Tong⁴, Jie Zhu⁵, Mei Zhang¹, Zegeng Li^4,*, Ping Li^1,*

Oncologie, Vol.24, No.2, pp. 295-307, 2022, DOI:10.32604/oncologie.2022.022116

Abstract Objectives: Lung cancer is a common and malignant tumor in adults and ranks first in the incidence and mortality of the top five malignant tumors in China. Our previous studies have shown that QYSL prescription can balance lung cancer mice Th1/Th2 and inhibit tumor cell immune escape. Here, we examined the effects of QYSL on lung cancer associated macrophage and the potential associated mechanism. Methods: C57BL/6 mice were injected with Lewis lung cancer cells and treated with QYSL. FACS, RT-PCR, and western blot were used to examined the effect of QYSL on tumor immune microenvironment. Results: We found QYSL inhibited… More >

Pedro Fong^*1, Cheng N. Ao^*†1, Kai I. Tou^*, Ka M. Huang^*, Chi C. Cheong^*, Li R. Meng^*

Oncology Research, Vol.27, No.2, pp. 237-251, 2019, DOI:10.3727/096504018X15235274183790

Abstract The aim of this study was to investigate the inhibition effects of cordycepin and its derivatives on endometrial cancer cell growth. Cytotoxicity MTT assays, clonogenic assays, and flow cytometry were used to observe the effects on apoptosis and regulation of the cell cycle of Ishikawa cells under various concentrations of cordycepin, cisplatin, and combinations of the two. Validated in silico docking simulations were performed on 31 cordycepin derivatives against adenosine deaminase (ADA) to predict their binding affinities and hence their potential tendency to be metabolized by ADA. Cordycepin has a significant dose-dependent inhibitory effect on cell proliferation. The combination of… More >

ISABELLA PANFOLI^1,*, MAURIZIO BRUSCHI², GIOVANNI CANDIANO²

BIOCELL, Vol.46, No.10, pp. 2167-2176, 2022, DOI:10.32604/biocell.2022.020154

Abstract Precision medicine is based on the identification of biomarkers of tumor development and progression. Liquid biopsy is at the forefront of the ability to gather diagnostic and prognostic information on tumors, as it can be noninvasively performed prior or during treatment. Liquid biopsy mostly utilizes circulating tumor cells, or free DNA, but also exosomes. The latter are nanovesicles secreted by most cell types, found in any body fluid that deliver proteins, nucleic acids and lipids to nearby and distant cells with a unique homing ability. Exosomes function in signalling between the tumor microenvironment and the rest of the body, promoting… More >

MARCO INVERNIZZI^1,2,*, NICOLA FUSCO^3,4,*

BIOCELL, Vol.46, No.10, pp. 2221-2223, 2022, DOI:10.32604/biocell.2022.021043

Abstract This article has no abstract. More >

KI-TAEK LIM^#,*, TEJAL V. PATIL^#, DINESH K. PATEL, SAYAN DEB DUTTA, KEYA GANGULY, AAYUSHI RANDHAWA

BIOCELL, Vol.46, No.10, pp. 2201-2208, 2022, DOI:10.32604/biocell.2022.020013

Abstract Mesenchymal stem cells (MSCs) are multipotent cells usually isolated from bone marrow, endometrium, adipose tissues, skin, and dental pulp. MSCs played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material science. Recently, MSCs have been widely explored for their application in regenerative medicine and COVID-19 treatment. Different approaches to evaluate the future of biomaterials and stem cell properties have been developed. However, misconceptions and ethical issues still exist, such as MSCs being non-angiogenic, anti-apoptotic, and immunoregulatory competencies. Embryonic stem cells isolation primarily requires the consent of donors and can include… More >

Lingdi Liu, Chunxiu Wen, Wei Tian, Xiaoliang Xie, Saiqun Wen, Tao Jiang^*

Phyton-International Journal of Experimental Botany, Vol.91, No.10, pp. 2313-2330, 2022, DOI:10.32604/phyton.2022.020295

Abstract Forsythiae Fructus, the fruit of Forsythia suspense is a traditional Chinese hebal medicine that has the antiviral and antioxidant effects in China. Modern analytical chemistry studies showed that the extracts of Forsythiae Fructus contain many bioactive components, such as flavonoids, lignans, phenolic acids, and terpenoids, which can be used to anti-inflammatory and treat toxicity, tonsillitis, ulcers, pharyngitis and acute nephritis. In order to study the types and quantities of metabolites in Forsythiae Fructus, we isolated, identified and analysed metabolites between two varieties of Forsythiae Fructus using UPLC/ESI-Q TRAP-MS/MS. The results showed that a total of 407 metabolites were identified in… More >

Shital Joshi¹, S. Manimurugan^2,3, Ahamed Aljuhani^2,*, Umar Albalawi², Amer Aljaedi²

Computer Systems Science and Engineering, Vol.43, No.3, pp. 1111-1130, 2022, DOI:10.32604/csse.2022.024802

Abstract The Internet of Things (IoT) represents a radical shifting paradigm for technological innovations as it can play critical roles in cyberspace applications in various sectors, such as security, monitoring, medical, and environmental sectors, and also in control and industrial applications. The IoT in E-medicine unleashed the design space for new technologies to give instant treatment to patients while also monitoring and tracking health conditions. This research presents a system-level architecture approach for IoT energy efficiency and security. The proposed architecture includes functional components that provide privacy management and system security. Components in the security function group provide secure communications through… More >

MARCO TATULLO^1,*, LUISA LIMONGELLI², ROSA MARIA MARANO³, ALESSANDRA VALLETTA⁴, ANGELA TEMPESTA², SANDRO RENGO⁴

BIOCELL, Vol.46, No.8, pp. 1837-1842, 2022, DOI:10.32604/biocell.2022.020570

Abstract The scientific community is continuously working to translate the novel biomedical techniques into effective medical treatments. CRISPR-Cas 9 system (Clustered Regularly Interspaced Short Palindromic Repeats-9), commonly known as the “molecular scissor”, represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments, related to several human diseases, such as chronic diseases, neurodegenerative pathologies and, interestingly, oral diseases. Of course, dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches: in this landscape, the use of CRISPR-Cas-9 system may speed and personalize the traditional therapies, ensuring a good predictability of clinical… More >

MASSIMO CONESE^1,*, AURELIO PORTINCASA²

BIOCELL, Vol.46, No.8, pp. 1815-1826, 2022, DOI:10.32604/biocell.2022.019448

Abstract The treatment of nonhealing and chronic cutaneous wounds still needs a clinical advancement to be effective. Both mesenchymal stem cells (MSCs), obtained from different sources, and their secretome derived thereof (especially exosomes) can activate signaling pathways related to promotion of cell migration, vascularization, collagen deposition, and inflammatory response demonstrating prohealing, angiogenetic and anti-scarring capacities. On the other hand, biodegradable biomimetic scaffolds can facilitate endogenous cell attachment and proliferation as well as extracellular matrix production. In this Review, we revise the complex composites made by biomimetic scaffolds, mainly hydrogels, and MSC-derived exosomes constructed for cutaneous wound healing. Studies demonstrate that there… More >