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  • Open Access

    REVIEW

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

    ELYN AMIELA SALLEH1, YEONG YEH LEE2, ANDEE DZULKARNAEN ZAKARIA3, NUR ASYILLA CHE JALIL4, MARAHAINI MUSA1,*

    BIOCELL, Vol.47, No.10, pp. 2233-2244, 2023, DOI:10.32604/biocell.2023.030541 - 08 November 2023

    Abstract Colorectal cancer (CRC) is a major global health concern. Accumulation of cancer-associated fibroblasts (CAFs) in CRC is associated with poor prognosis and disease recurrence. CAFs are the main cellular component of the tumor microenvironment. CAF-tumor cell interplay, which is facilitated by various secretomes, drives colorectal carcinogenesis. The complexity of CAF populations contributes to the heterogeneity of CRC and influences patient survival and treatment response. Due to their significant roles in colorectal carcinogenesis, different clinical applications utilizing or targeting CAFs have been suggested. Circulating CAFs (cCAFs) which can be detected in blood samples, have been proposed… More > Graphic Abstract

    Cancer-associated fibroblasts of colorectal cancer: Translational prospects in liquid biopsy and targeted therapy

  • Open Access

    ARTICLE

    Multi-Criteria Decision-Making for Power Grid Construction Project Investment Ranking Based on the Prospect Theory Improved by Rewarding Good and Punishing Bad Linear Transformation

    Shun Ma1, Na Yu1, Xiuna Wang2, Shiyan Mei1, Mingrui Zhao2,*, Xiaoyu Han2

    Energy Engineering, Vol.120, No.10, pp. 2369-2392, 2023, DOI:10.32604/ee.2023.028727 - 28 September 2023

    Abstract Using the improved prospect theory with the linear transformations of rewarding good and punishing bad (RGPBIT), a new investment ranking model for power grid construction projects (PGCPs) is proposed. Given the uncertainty of each index value under the market environment, fuzzy numbers are used to describe qualitative indicators and interval numbers are used to describe quantitative ones. Taking into account decision-maker’s subjective risk attitudes, a multi-criteria decision-making (MCDM) method based on improved prospect theory is proposed. First, the [−1, 1] RGPBIT operator is proposed to normalize the original data, to obtain the best and worst More >

  • Open Access

    REVIEW

    Cellulose-Based Films for Food Packaging Applications: Review of Preparation, Properties, and Prospects

    Xiaoyan Liu1,2, Zhao Qin1,2,*, Yuxiang Ma1,2, Huamin Liu1,2,*, Xuede Wang1,2

    Journal of Renewable Materials, Vol.11, No.8, pp. 3203-3225, 2023, DOI:10.32604/jrm.2023.027613 - 26 June 2023

    Abstract Packaging is a food preservation technology widely used in the world. Naturally-sourced, biodegradable polymers are becoming increasingly popular in the food packaging sector. Packaging films prepared using cellulose as raw material would contribute to resource sustainability, but the difficulty of cellulose solubilization limits their further development. In view of this, a series of novel solvent systems (LiCl/DMAc, ILs, TBAH/DMSO, NMMO, alkali/urea solutions, metal-complex solutions) were used to prepare high-strength and high-performance cellulose-based films; their characteristics and the mechanisms involved were investigated. Composite films prepared by blending cellulose with various polymers (synthetic polymers, natural polymers, proteins More > Graphic Abstract

    Cellulose-Based Films for Food Packaging Applications: Review of Preparation, Properties, and Prospects

  • Open Access

    REVIEW

    A Review on Intelligent Detection and Classification of Power Quality Disturbances: Trends, Methodologies, and Prospects

    Yanjun Yan, Kai Chen*, Hang Geng, Wenqian Fan, Xinrui Zhou

    CMES-Computer Modeling in Engineering & Sciences, Vol.137, No.2, pp. 1345-1379, 2023, DOI:10.32604/cmes.2023.027252 - 26 June 2023

    Abstract With increasing global concerns about clean energy in smart grids, the detection of power quality disturbances (PQDs) caused by energy instability is becoming more and more prominent. It is well acknowledged that the PQD effects on power grid equipment are destructive and hazardous, which causes irreversible damage to underlying electrical/electronic equipment of the concerned intelligent grids. In order to ensure safe and reliable equipment implementation, appropriate PQD detection technologies must be adopted to avoid such adverse effects. This paper summarizes the newly proposed and traditional PQD detection techniques in order to give a quick start More > Graphic Abstract

    A Review on Intelligent Detection and Classification of Power Quality Disturbances: Trends, Methodologies, and Prospects

  • Open Access

    ARTICLE

    Tissue Culture of Calla Lily (Zantedeschia spreng.): An Updated Review on the Present Scenario and Future Prospects

    Xuan Sun1,2, Xue Wang1, Bijaya Sharma Subedi3, Yin Jiang1,2, Di Wang1,2, Rongxin Gou1,2, Guojun Zhang2, Wenting Xu4,*, Zunzheng Wei1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2413-2428, 2023, DOI:10.32604/phyton.2023.029667 - 25 June 2023

    Abstract The calla lily (Zantedeschia spreng.) is a bulbous flower native to the tropical regions of Africa. Calla lily has gained significant popularity in the international market owing to its intricate morphology and prolonged flowering duration. Despite such advantages, for two sub-groups of calla lily, known as group Zantedeschia and group Aestivae, there are challenges in terms of hybrid production due to the ‘plastome-genome incompatibility’ therebetween. Tissue culture is a fundamental biotechnological tool used in gene editing research, with a focus on disease resistance and flower color in calla lily breeding programs. The present review provides a brief… More >

  • Open Access

    REVIEW

    Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma

    WENFEI GE1,#, SHIYAN SONG1,#, XIAOCHEN QI1,#, FENG CHEN1,#, XIANGYU CHE1, YONGHAO SUN1, JIN WANG1, XIAOWEI LI2, NANA LIU3, QIFEI WANG1,*, GUANGZHEN WU1,*

    Oncology Research, Vol.31, No.3, pp. 255-270, 2023, DOI:10.32604/or.2023.027942 - 22 May 2023

    Abstract As a common tumor of the urinary system, the morbidity and mortality related to renal carcinoma, are increasing annually. Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell carcinoma, accounting for approximately 75% of the total number of patients with renal cell carcinoma. Currently, the clinical treatment of ccRCC involves targeted therapy, immunotherapy, and a combination of the two. In immunotherapy, PD-1/PD-L1 blocking of activated T cells to kill cancer cells is the most common treatment. However, as treatment progresses, some patients gradually develop resistance to immunotherapy. Meanwhile, other patients More > Graphic Abstract

    Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma

  • Open Access

    ARTICLE

    MEC-IoT-Healthcare: Analysis and Prospects

    Hongyuan Wang1, Mohammed Dauwed2, Imran Khan3, Nor Samsiah Sani4,*, Hasmila Amirah Omar4, Hirofumi Amano5, Samih M. Mostafa6

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6219-6250, 2023, DOI:10.32604/cmc.2022.030958 - 29 April 2023

    Abstract Physical sensors, intelligent sensors, and output recommendations are all examples of smart health technology that can be used to monitor patients’ health and change their behavior. Smart health is an Internet-of-Things (IoT)-aware network and sensing infrastructure that provides real-time, intelligent, and ubiquitous healthcare services. Because of the rapid development of cloud computing, as well as related technologies such as fog computing, smart health research is progressively moving in the right direction. Cloud, fog computing, IoT sensors, blockchain, privacy and security, and other related technologies have been the focus of smart health research in recent years.… More >

  • Open Access

    ARTICLE

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

    Jingnan Zhang1, Junyi Wan1, Yihang Li2, Yu Han2, Jiahua Pan3, Fang Fang1, Shiliang Jiang4, Xiangbin Pan1, Gejun Zhang1,*

    Congenital Heart Disease, Vol.18, No.2, pp. 219-234, 2023, DOI:10.32604/chd.2023.027562 - 15 March 2023

    Abstract Background: The Venus-P valve was the first self-expanding valve used world-wide for transcatheter pulmonary valve replacement (TPVR) in patients with severe pulmonary regurgitation (PR). We intended to report the extended follow-up results from the prospective trial (No. NCT02590679). Methods: A total of 38 patients with severe PR (mean age 24.2 ± 13.2) were included. Follow-up data were obtained after implanted at 1, 6, and 12 months and yearly after. The frame geometry was assessed on post-implant computer tomography (CT) scanning by calculating the non-circularity [circularity ratio (minimum diameter/maximum diameter) < 0.9] and under-expansion [expansion ratio (derived external valve… More > Graphic Abstract

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

  • Open Access

    ARTICLE

    RESEARCH PROGRESS AND PROSPECT OF HEAT PIPE CAPILLARY WICKS

    Ningxiang Lu, Jinwang Li*, Yongkang Sun

    Frontiers in Heat and Mass Transfer, Vol.18, pp. 1-15, 2022, DOI:10.5098/hmt.18.24

    Abstract Heat pipe is a kind of high-efficiency heat transfer element which depends on the phase change of its internal working liquid. It has the characteristics of high heat conductivity and excellent average temperature performance. As the core component of heat pipe, capillary wicks play the role of transmitting working fluid and have a crucial impact on the heat transfer performance of heat pipe. In this paper, the research progress of capillary wicks in recent years is introduced from the aspects of structure, fabrication method, performance research, numerical analysis and so on. The current research results More >

  • Open Access

    REVIEW

    Prospects and Challenges of Utilizing Solar Energy for the COVID-19 Vaccine Cold Storage in Remote Clinics of Tropical Countries: Review

    Indra Mamad Gandidi1,*, Apri Wiyono1, Nugroho Agung Pambudi2,*, Rahmat Romadhon3, Alfan Sarifudin2

    Energy Engineering, Vol.119, No.4, pp. 1403-1418, 2022, DOI:10.32604/ee.2022.019200 - 23 May 2022

    Abstract The rapid spread of COVID-19 pandemic has forced several countries in the world to store vaccines in cold storage towards ensuring their protection from being damaged and to maintain their stability. However, most remote clinics, especially those in the equator and islands, are faced with the challenges of hot climates and the inability to afford electricity resources needed to power the cold storage facility. Meanwhile, the hot equatorial region has abundant solar energy to power the vaccine cold storage but previous studies showed that several field workers do not have the ability to maintain the More >

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