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  • Open Access

    REVIEW

    Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma

    WENFEI GE1,#, SHIYAN SONG1,#, XIAOCHEN QI1,#, FENG CHEN1,#, XIANGYU CHE1, YONGHAO SUN1, JIN WANG1, XIAOWEI LI2, NANA LIU3, QIFEI WANG1,*, GUANGZHEN WU1,*

    Oncology Research, Vol.31, No.3, pp. 255-270, 2023, DOI:10.32604/or.2023.027942

    Abstract As a common tumor of the urinary system, the morbidity and mortality related to renal carcinoma, are increasing annually. Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell carcinoma, accounting for approximately 75% of the total number of patients with renal cell carcinoma. Currently, the clinical treatment of ccRCC involves targeted therapy, immunotherapy, and a combination of the two. In immunotherapy, PD-1/PD-L1 blocking of activated T cells to kill cancer cells is the most common treatment. However, as treatment progresses, some patients gradually develop resistance to immunotherapy. Meanwhile, other patients experience great side effects after… More > Graphic Abstract

    Review and prospect of immune checkpoint blockade therapy represented by PD-1/PD-L1 in the treatment of clear cell renal cell carcinoma

  • Open Access

    ARTICLE

    MEC-IoT-Healthcare: Analysis and Prospects

    Hongyuan Wang1, Mohammed Dauwed2, Imran Khan3, Nor Samsiah Sani4,*, Hasmila Amirah Omar4, Hirofumi Amano5, Samih M. Mostafa6

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6219-6250, 2023, DOI:10.32604/cmc.2022.030958

    Abstract Physical sensors, intelligent sensors, and output recommendations are all examples of smart health technology that can be used to monitor patients’ health and change their behavior. Smart health is an Internet-of-Things (IoT)-aware network and sensing infrastructure that provides real-time, intelligent, and ubiquitous healthcare services. Because of the rapid development of cloud computing, as well as related technologies such as fog computing, smart health research is progressively moving in the right direction. Cloud, fog computing, IoT sensors, blockchain, privacy and security, and other related technologies have been the focus of smart health research in recent years. At the moment, the focus… More >

  • Open Access

    ARTICLE

    RESEARCH PROGRESS AND PROSPECT OF HEAT PIPE CAPILLARY WICKS

    Ningxiang Lu, Jinwang Li*, Yongkang Sun

    Frontiers in Heat and Mass Transfer, Vol.18, pp. 1-15, 2022, DOI:10.5098/hmt.18.24

    Abstract Heat pipe is a kind of high-efficiency heat transfer element which depends on the phase change of its internal working liquid. It has the characteristics of high heat conductivity and excellent average temperature performance. As the core component of heat pipe, capillary wicks play the role of transmitting working fluid and have a crucial impact on the heat transfer performance of heat pipe. In this paper, the research progress of capillary wicks in recent years is introduced from the aspects of structure, fabrication method, performance research, numerical analysis and so on. The current research results of capillary wicks are summarized,… More >

  • Open Access

    ARTICLE

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

    Jingnan Zhang1, Junyi Wan1, Yihang Li2, Yu Han2, Jiahua Pan3, Fang Fang1, Shiliang Jiang4, Xiangbin Pan1, Gejun Zhang1,*

    Congenital Heart Disease, Vol.18, No.2, pp. 219-234, 2023, DOI:10.32604/chd.2023.027562

    Abstract Background: The Venus-P valve was the first self-expanding valve used world-wide for transcatheter pulmonary valve replacement (TPVR) in patients with severe pulmonary regurgitation (PR). We intended to report the extended follow-up results from the prospective trial (No. NCT02590679). Methods: A total of 38 patients with severe PR (mean age 24.2 ± 13.2) were included. Follow-up data were obtained after implanted at 1, 6, and 12 months and yearly after. The frame geometry was assessed on post-implant computer tomography (CT) scanning by calculating the non-circularity [circularity ratio (minimum diameter/maximum diameter) < 0.9] and under-expansion [expansion ratio (derived external valve area/nominal external valve area)… More > Graphic Abstract

    Outcomes of Self-Expanding Transcatheter Pulmonary Valves: Extended Follow-Up of a Prospective Trial

  • Open Access

    ARTICLE

    Comparison of Treatment Response and Survival Profiles Between Drug-Eluting Bead Transarterial Chemoembolization and Conventional Transarterial Chemoembolization in Chinese Hepatocellular Carcinoma Patients: A Prospective Cohort Study

    Ping Wen*, Sheng-Duo Chen*, Jia-Rui Wang, Ying-He Zeng*

    Oncology Research, Vol.27, No.5, pp. 583-592, 2019, DOI:10.3727/096504018X15368325811545

    Abstract This study evaluated the difference in treatment response and survival profiles between drug-eluting bead transarterial chemoembolization (DEB-TACE) and conventional transarterial chemoembolization (cTACE) treatments in Chinese hepatocellular carcinoma (HCC) patients. A total of 120 HCC patients were consecutively enrolled in this prospective cohort study, which showed that DEB-TACE achieved higher complete response (CR) (30.8%) compared with cTACE (7.4%) with no difference in overall response rate (ORR) for patients treated with DEB-TACE and cTACE (80.8% vs. 73.5%). In addition, DEB-TACE was associated with a lower rate of progressive disease (PD) compared with cTACE (1.9% vs. 11.8%). With respect to survival, patients in… More >

  • Open Access

    REVIEW

    Prospects and Challenges of Utilizing Solar Energy for the COVID-19 Vaccine Cold Storage in Remote Clinics of Tropical Countries: Review

    Indra Mamad Gandidi1,*, Apri Wiyono1, Nugroho Agung Pambudi2,*, Rahmat Romadhon3, Alfan Sarifudin2

    Energy Engineering, Vol.119, No.4, pp. 1403-1418, 2022, DOI:10.32604/ee.2022.019200

    Abstract The rapid spread of COVID-19 pandemic has forced several countries in the world to store vaccines in cold storage towards ensuring their protection from being damaged and to maintain their stability. However, most remote clinics, especially those in the equator and islands, are faced with the challenges of hot climates and the inability to afford electricity resources needed to power the cold storage facility. Meanwhile, the hot equatorial region has abundant solar energy to power the vaccine cold storage but previous studies showed that several field workers do not have the ability to maintain the vaccine storage temperature as indicated… More >

  • Open Access

    REVIEW

    Milestones of Wireless Communication Networks and Technology Prospect of Next Generation (6G)

    Mohammed H. Alsharif1, Md. Sanwar Hossain2, Abu Jahid3, Muhammad Asghar Khan4, Bong Jun Choi5,*, Samih M. Mostafa6,7

    CMC-Computers, Materials & Continua, Vol.71, No.3, pp. 4803-4818, 2022, DOI:10.32604/cmc.2022.023500

    Abstract Since around 1980, a new generation of wireless technology has arisen approximately every 10 years. First-generation (1G) and second-generation (2G) began with voice and eventually introduced more and more data in third-generation (3G) and became highly popular in the fourth-generation (4G). To increase the data rate along with low latency and mass connectivity the fifth-generation (5G) networks are being installed from 2020. However, the 5G technology will not be able to fulfill the data demand at the end of this decade. Therefore, it is expected that 6G communication networks will rise, providing better services through the implementation of new enabling… More >

  • Open Access

    REVIEW

    Genetic Improvement in Juglans mandshurica and Its Uses in China: Current Status and Future Prospects

    Shikai Zhang1,2, Wang Zhan3, Heng Zhang1,2, Shuanglin Song3, Xibin Qu3, Jiayi Wang3, Mulualem Tigabu4, Xiang Li1,2, Qinhui Zhang1,2, Minghui Zhao1,2, Huanzhen Liu2,*, Xiyang Zhao1,2,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 489-505, 2022, DOI:10.32604/phyton.2022.018321

    Abstract Juglans mandshurica is an economically and ecologically valuable species that is used for various construction purposes, making luxurious furniture, as food and sources of medicinal substances and landscaping because of its excellent wood, edible fruits and rich in various types of chemical compounds. In the past few decades, several genetic improvements of J. mandshurica were made, with a focus on the selection of improved varieties and on breeding technology. Many elite provenances and families were selected based on growth traits or wood properties. In recent years, with the increasing demand for high-quality seedlings in Chinese forestry production, the breeding goals… More >

  • Open Access

    ARTICLE

    Extensive Study of Cloud Computing Technologies, Threats and Solutions Prospective

    Mwaffaq Abu-Alhaija1, Nidal M. Turab1,*, AbdelRahman Hamza2

    Computer Systems Science and Engineering, Vol.41, No.1, pp. 225-240, 2022, DOI:10.32604/csse.2022.019547

    Abstract Infrastructure as a Service (IaaS) provides logical separation between data, network, applications and machines from the physical constrains of real machines. IaaS is one of the basis of cloud virtualization. Recently, security issues are also gradually emerging with virtualization of cloud computing. Different security aspects of cloud virtualization will be explored in this research paper, security recognizing potential threats or attacks that exploit these vulnerabilities, and what security measures are used to alleviate such threats. In addition, a discussion of general security requirements and the existing security schemes is also provided. As shown in this paper, different components of virtualization… More >

  • Open Access

    ARTICLE

    Goal Self-Concordance Model: What Have We Learned and Where are We Going

    Peng Wan1, Ting Wen2,*, Yunfei Zhang3, Hong Gao1, Jigan Wang1

    International Journal of Mental Health Promotion, Vol.23, No.2, pp. 201-219, 2021, DOI:10.32604/IJMHP.2021.015759

    Abstract Goal self-concordance reflects self-generated personal goals aligning with people’s interests and core values in one’s implicit personality as organic components, which is measured by the “perceived locus of causality” PLOC. Pursuing and achieving self-concordant goals both predict diversified outcomes in need-satisfaction, mental and physical well-being, positive attitude and behavior, etc. Based on expounding and sorting out the concept and measurement about goal self-concordance, the author analyzes the differences among a series of goal self-concordance theories. This paper focuses on the latest research trends and summarizes five influencing aspects of goal self-concordance: mental health, cognition, emotion, personal will, and behavioral outcomes.… More >

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