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  • Open Access

    REVIEW

    Male Breast Cancer: Epidemiology, Diagnosis, Molecular Mechanisms, Therapeutics, and Future Prospective

    Ashok Kumar Sah1,*, Ranjay Kumar Choudhary1,2, Velilyaeva Alie Sabrievna3, Karomatov Inomdzhon Dzhuraevich4, Anass M. Abbas5, Manar G. Shalabi5, Nadeem Ahmad Siddique6, Raji Rubayyi Alshammari7, Navjyot Trivedi8, Rabab H. Elshaikh1

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.068238 - 30 December 2025

    Abstract Male breast cancer (MBC) is rare, representing 0.5%–1% of all breast cancers, but its incidence is increasing due to improved diagnostics and awareness. MBC typically presents in older men, is human epidermal growth factor receptor 2 (HER2)-negative and estrogen receptor (ER)-positive, and lacks routine screening, leading to delayed diagnosis and advanced disease. Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations. Clinically, it may resemble gynecomastia but usually appears as a unilateral, painless mass or nipple discharge. Advances in imaging and liquid biopsy have More >

  • Open Access

    ARTICLE

    Prospects of Anthriscus, Chaerophyllum, and Myrrhoides Species Utilization and Biofortification with Selenium

    Nadezhda Golubkina1,*, Viktor Kharchenko1, Ekaterina Krainyuk2, Lubov Riff2, Vladimir Lapchenko3, Helene Lapchenko3, Anastasia Moldovan1, Uliana Plotnoikova4, Otilia Cristina Murariu5, Gianluca Caruso6

    Phyton-International Journal of Experimental Botany, Vol.94, No.12, pp. 4139-4153, 2025, DOI:10.32604/phyton.2025.072328 - 29 December 2025

    Abstract Despite their remarkable content of biologically active compounds, highly valuable for human health, wild relatives of Umbelliferous plants show limited utilization. The aim of the present work was the evaluation of the antioxidant status of Anthriscus, Chaerophyllum, and Myrrhoides species gathered in different climatic zones (from Mediterranean to Arctic) and of their suitability to produce valuable functional food for optimizing the human Se status. Among the Crimean plants, A. sylvestris, C. bulbosis, and M. nososa showed the highest antioxidant status, while the lowest was recorded in A. cerefolium and A. caucalis, displaying a significant correlation between the antioxidant activity (AOA) and polyphenols… More >

  • Open Access

    COMMUNICATION

    A prospective randomized trial comparing dusting and fragmentation techniques using Holmium:YAG laser for pediatric ureteral stones

    Ahmed Ahmed1, Bilal Farhan2, Amr Alam-Eldin1, Maged Amin Helmy1, Mohammed Mostafa Hussein1, Zakieldahshoury Mohamed1, Hassaan A. Gad1, Suraj Nayan Vodnala3,*

    Canadian Journal of Urology, Vol.32, No.5, pp. 483-490, 2025, DOI:10.32604/cju.2025.067228 - 30 October 2025

    Abstract Background: As occurrence rates of pediatric ureteral stones have increased, evaluation of optimal treatment modalities has become imperative. This study’s primary goal is to compare outcomes between dusting and fragmentation techniques using Holmium:YAG (Ho:YAG) laser lithotripsy in children with ureteral stones. Methods: A prospective randomized study was conducted at Aswan University Hospitals from June 2023 to December 2024. One hundred children, under the age of 18, with single, mid- or distal, ureteral stones (5–20 mm) were randomized into two groups. Group A received laser dusting (0.2–0.6 J, 20–40 Hz), while Group B received fragmentation (0.8–1.5… More >

  • Open Access

    ARTICLE

    When friendship meets love: A short-term prospective study of opposite-sex friends need fulfillment effects on romantic relationship quality

    Xiaoyue Zhao1, Ting Wang2, Baoyan Yang3,*, Hongyu Zang1, Qifeng Gao1, Zhongyuan Zhang1, Birong Xing1

    Journal of Psychology in Africa, Vol.35, No.5, pp. 701-711, 2025, DOI:10.32604/jpa.2025.067155 - 24 October 2025

    Abstract This study explored the relationship between need fulfillment given by opposite-sex friends and romantic relationship quality, as well as the potential underlying mechanisms, including perceived quality of opposite-sex friend relationships, need fulfillment given by romantic partners and romantic desire towards opposite-sex friends. A total of 98 unmarried Chinese young adults in romantic relationships were participants (females = 45.9%; M = 22.71, SD = 2.81). The findings from regression, mediation, and moderation analyses indicated need fulfillment given by opposite-sex friends was associated with lower romantic relationship quality. Perceived quality of opposite-sex friend relationships mediated the relationship between… More >

  • Open Access

    REVIEW

    A Comprehensive Study on Application and Prospect of Hydrogel Detection Methods

    Caixia Chen1, Pengyu Liu1, Changhua Wang1, Yanyan Xie1, Wei Wang1,*, Xiaomin Kang2,*

    Journal of Polymer Materials, Vol.42, No.3, pp. 621-660, 2025, DOI:10.32604/jpm.2025.068852 - 30 September 2025

    Abstract Due to their high water content, stimulus responsiveness, and biocompatibility, hydrogels, which are functional materials with a three-dimensional network structure, are widely applied in fields such as biomedicine, environmental monitoring, and flexible electronics. This paper provides a systematic review of hydrogel characterization methods and their applications, focusing on primary evaluation techniques for physical properties (e.g., mechanical strength, swelling behavior, and pore structure), chemical properties (e.g., composition, crosslink density, and degradation behavior), biocompatibility, and functional properties (e.g., drug release, environmental stimulus response, and conductivity). It analyzes the challenges currently faced by characterization methods, such as a More >

  • Open Access

    REVIEW

    The Reductive Amination of Biomass-Based Aldehydes and Alcohols towards 2,5-bis(aminomethyl)furan: Progress, Challenges and Prospects

    Li Ji1,2, Jiawei Mao1,3, Ruixiang Li1,*, Jiaqi Xu1,*

    Journal of Renewable Materials, Vol.13, No.9, pp. 1683-1706, 2025, DOI:10.32604/jrm.2025.02025-0043 - 22 September 2025

    Abstract Primary diamines play an important role in the chemical industry, where they are widely used as raw materials for the manufacture of pharmaceuticals and polymers. Currently, primary diamines are mainly derived from petroleum, while harsh or toxic conditions are often needed. Biomass is abundant and renewable , which serves as a promising alternative raw material to produce primary diamines. This review primarily focuses on the synthesis of 2,5-bis(aminomethyl)furan (BAMF), a bio-based diamine with potential as a biomonomer for polyamides and polyureas. Specifically, this review emphasizes the synthesis of BAMF from three biomass-derived alcohols and aldehydes,… More > Graphic Abstract

    The Reductive Amination of Biomass-Based Aldehydes and Alcohols towards 2,5-bis(aminomethyl)furan: Progress, Challenges and Prospects

  • Open Access

    ARTICLE

    Impact of metabolic syndrome on combination therapy efficacy in LUTS due to BPH: a prospective study

    Iqbal Singh1,*, Himanshu Agrawal2, Vidhi Maurya2, Sanjay Gupta2, Alpana Raizada3

    Canadian Journal of Urology, Vol.32, No.4, pp. 299-308, 2025, DOI:10.32604/cju.2025.064827 - 29 August 2025

    Abstract Objectives: Benign prostatic hyperplasia (BPH) is a common benign tumor in men, with an age-related prevalence of multifactorial etiology. The present study aimed to accurately assess and predict the effect of co-existing metabolic syndrome (MtS) upon treatment outcomes of combination medical therapy in select patients of lower urinary tract symptoms (LUTS) due to BPH. Methods: After obtaining informed consent from the patients, 70 eligible patients with LUTS due to BPH with and without MtS were enrolled in this study from September 2022 to January 2024 from the outpatient clinic at the University College of Medical… More >

  • Open Access

    ARTICLE

    Associations between ureteral stent indwelling time, patient characteristics, and stent pain from an international prospective registry

    Connor M. Forbes1,*, Ben H. Chew1, K.F. Victor Wong1, Runhan Ren1, Yuanyuan Ji2, Alexander P. Glaser3, Kazumi Taguchi4, Amy E. Krambeck5, Marcelino E. Rivera6, Ojas Shah7, Edouard Tariel8, Channa Amarasekera5, Shuzo Hamamoto4, Dirk Lange1, Wilson R. Molina9, John J. Knoedler10, Mitchell R. Humphreys11, Karen L. Stern,11

    Canadian Journal of Urology, Vol.32, No.4, pp. 335-344, 2025, DOI:10.32604/cju.2025.063577 - 29 August 2025

    Abstract Objectives: Previous studies have shown conflicting results concerning the optimal duration of ureteral stenting after endourologic treatment of stone disease, its effect on patient comfort, and the necessity for emergent, unscheduled care. This study assessed the impact of stent duration, sex, and other patient-associated factors on reported pain scores using a large, international prospective registry. Methods: A prospective observational patient registry on ureteral stents from 10 institutions in 4 countries (United States, Canada, France, and Japan) from 2020–2023 was assessed. The primary outcome was Patient-Reported Outcomes Measurement Information System (PROMIS) pain intensity scores administered on… More >

  • Open Access

    REVIEW

    Developments and Prospects in Temperature Control Technique of Loop Heat Pipe for Spacecraft

    Chuxin Wang, Qi Wu, Zenong Fang, Chang Liu, Guoguang Li, Ye Wang, Hongxing Zhang*, Jianyin Miao

    Frontiers in Heat and Mass Transfer, Vol.23, No.4, pp. 1261-1280, 2025, DOI:10.32604/fhmt.2025.066473 - 29 August 2025

    Abstract With the development of space-based remote sensing and deep space exploration technology, higher standards for temperature stability and uniformity of payloads have been proposed to spacecraft thermal control systems. As an efficient two-phase heat transfer device with active temperature control capabilities, the loop heat pipe (LHP) can be widely applied in spacecraft thermal control systems to achieve reliable temperature control under various operating modes and complex space thermal environments. This paper analyzes the fundamental theories of thermal switch-controlled, reservoir temperature-controlled, and bypass valve-controlled LHPs. The focus is on the theories and methods of achieving high-precision… More >

  • Open Access

    REVIEW

    Phytochemicals as Multi-Target Therapeutic Agents for Oxidative Stress-Driven Pathologies: Mechanisms, Synergies, and Clinical Prospects

    Bismillah Mubeen1,2,#, Ammarah Hasnain2,3,#,*, Syed Atif Hasan Naqvi4, Fahad Hakim5, Syed Sheharyar Hassan Naqvi6, Muhammad Zeeshan Hassan4, Muhammad Umer Iqbal7, Mahmoud Moustafa8, Mohammed O. Alshaharni8, Mingzheng Duan1,*

    Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 1941-1971, 2025, DOI:10.32604/phyton.2025.064056 - 31 July 2025

    Abstract Plants have long served as a cornerstone for drug discovery, offering a vast repertoire of bioactive compounds with proven efficacy in combating oxidative stress, a pivotal driver of chronic diseases such as cancer, diabetes, cardiovascular disorders, and neurodegenerative conditions. This review synthesizes current knowledge on plant-derived antioxidants, emphasizing their mechanisms, therapeutic potential, and quantitative efficacy validated through standardized assays. Key phytochemicals, including polyphenols, carotenoids, flavonoids, and terpenoids, neutralize reactive oxygen species (ROS) through radical scavenging, enzyme modulation, and gene regulation. For instance, lutein, a carotenoid found in leafy greens, demonstrates potent antioxidant activity with IC50 values… More >

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