V. Massard, A. Harlé, L. Uwer, J.-L. Merlin

Oncologie, Vol.21, No.1, pp. 29-32, 2019, DOI:10.3166/onco-2019-0027

Abstract Acquired endocrine resistance remains one of the main obstacles in the treatment of estrogen receptor (ER) positive, HER2 negative advanced breast cancer. Recently, activating ESR1 gene mutations affecting the ligand-binding domain have been identified as a key mechanism in aromatase inhibitor (AI) resistance. These mutations can be detected on histological samples or circulating tumour DNA, using PCRbased assays or next-generation sequencing. They induce a constitutive activation of ER, leading to acquired resistance to AI; tamoxifen, fulvestrant and targeted therapies against mTOR or CDK4/6 retain their efficacy. The use of monitoring ESR1 mutations in clinical practice is still to be defined.… More >

Li-an Zhao^1,*, Tieli Wang²

FDMP-Fluid Dynamics & Materials Processing, Vol.17, No.2, pp. 413-426, 2021, DOI:10.32604/fdmp.2021.011205

Abstract The transportation in vertical pipelines of particle slurry of oil shale has important applications in several fields (marine mining, hydraulic mining, dredging of river reservoir, etc.). However, there is still a lack of information about the behavior of coarse particles in comparison to that of fine particles. For this reason, experiments on the fluidization and hydraulic lifting of coarse oil shale particles have been carried out. The experimental data for three kinds of particles with an average size of 5 mm, 15 mm and 25 mm clearly demonstrate that vortices can be formed behind the particles. On this basis, a… More >

Yuan Liu^1,2,#, Yun Jia³, Bing Zhang², Anwen Liu^1,*

Oncologie, Vol.23, No.1, pp. 61-72, 2021, DOI:10.32604/Oncologie.2021.015906

Abstract Gastric cancer (GC) is the most common digestive system malignant tumor and second most common cause of cancer-related death. Even for the early gastric cancer, after radical operation, perioperative and postoperative chemotherapy the recurrence and metastasis are also high. 5-year overall survival of all GC patients is only 10–15%. Chemo-resistance still poses a major obstacle to successful treatment of GC. The aberrant expression of TUG1 (Taurine Upregulated Gene 1) was closely related to chemo-resistance and metastasis in many cancers. Here we over-expressed TUG1 in GC cell line SGC-7901 and MGC-803. We compared the migration ability and sensitivity of cisplatin (CDDP),… More >

Jingying Li¹, Tiejun Zhu¹, Fengming Li¹, Dong Wang¹, Xianbiao Bu², Lingbao Wang^2,*

Energy Engineering, Vol.118, No.3, pp. 517-534, 2021, DOI:10.32604/EE.2021.014464

Abstract The single well geothermal heating (SWGH) technology has attracted extensive attention. To enhance heat extraction from SWGH, a mathematical model describing heat transfer is set up, and the key influence factor and heat transfer enhancement method are discussed by thermal resistance analysis. The numerical results show that the thermal resistance of rock is far greater than that of well wall and fluid. So, reducing rock thermal resistance is the most effective method for enhancing the heat extraction power. For geothermal well planning to drill: rock thermal resistance can be reduced by increasing well diameter and rock thermal conductivity; the temperature… More >

DAN ZHANG¹, HAIJING LIU¹, ZHENNAN YI², YUANYUAN LU³, YANYAN CHEN⁴, WEIQIANG SU², HUIBING LIN², ZHIHUI ZHANG^5,*, WEI LEI^6,*

BIOCELL, Vol.45, No.3, pp. 617-625, 2021, DOI:10.32604/biocell.2021.012504

Abstract Chemotherapy drug resistance is the main cause leading to the relapse and metastasis of non-small cell lung cancer (NSCLC) patients. Our study aimed to investigate the mechanism of pemetrexed resistance in NSCLC. Firstly, the pemetrexed (PEM)-resistant PC-9 and A549 lung adenocarcinoma cell lines (PC-9/PEM and A549/PEM) were established. The expression of thymidylate synthase (TS) in PC-9/PEM, A549/PEM, A549, and PC-9 cells were analyzed by qRT-PCR and western blot. Then, cell viability, colony formation, migration, and invasion were performed on PEM-resistant cells transfected with TS siRNA. The role of EGFR in PEM resistance of PEM-resistant cells was investigated using EGFR siRNA.… More >

JINGRONG SONG^#, JUAN KANG^#, WEI LV, YAN DONG, XIAOYING ZHANG^*

BIOCELL, Vol.45, No.3, pp. 723-731, 2021, DOI:10.32604/biocell.2021.014453

Abstract Bronchial asthma is a common chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammatory cell infiltration, and airway remodeling. F-box/WD repeat-containing protein 7 (FBXW7), an E3 ubiquitin ligase, is required for various endothelial functions, such as cell migration, inflammation, and endothelial integrity. This study aimed to investigate the role of FBXW7 in lipopolysaccharide (LPS)-induced epithelial barrier impairment in bronchial epithelial cells in vitro. By using lentivirus-based technology, FBXW7 was overexpressed or silenced (24 h) in human bronchial epithelial (16HBE) cells, which were treated with LPS or not (24 h). Immunoprecipitation (IP) detection and Western blot analysis were used to evaluate… More >

Jiahao Li, Guolai Yang^*, Quanzhao Sun

CMES-Computer Modeling in Engineering & Sciences, Vol.126, No.3, pp. 1011-1031, 2021, DOI:10.32604/cmes.2021.013982

Abstract In this paper, the subdomain analysis model of the eddy current brake (ECB) is established. By comparing with the finite element method, the accuracies of the subdomain model and the finite element model are verified. Furthermore, the resistance characteristics of radial, axial, and Halbach arrays under impact load are calculated and compared. The axial array has a large braking force coefficient but low critical velocity. The radial array has a low braking force coefficient but high critical velocity. The Halbach array has the advantages of the first two arrays. Not only the braking force coefficient is large, but also the… More >

Zhenzhong Jiang¹, Peng Jiao¹, Zhuo Qi¹, He Zhao², Jing Qu², Siyan Liu¹, Dan Yao¹, Piwu Wang², Shuyan Guan^1,*, Yiyong Ma^2,*

Phyton-International Journal of Experimental Botany, Vol.90, No.2, pp. 449-459, 2021, DOI:10.32604/phyton.2021.013247

Abstract The concept of gene-function-genetic trait was introduced to explore the effects of early flowering on the growth and development of maize at the jointing stage and to obtain early flowering mutants using ethyl methanesulfonate mutagenesis. First, we studied gene expression, phytohormones, and lignin content to explore the physiological peculiarities of the early flowering mutant. Then we analyzed the genetic features of the mutants during the jointing stage by measuring physiological and biochemical indices of drought tolerance. The results showed that the photosynthetic rate of the mutant was significantly higher than that of the control and the rate of accumulation of… More >

ABDUR RAUF^1,*, SAUD BAWAZEER^2,*, MUSLIM RAZA³, EMAN EL-SHARKAWY⁴, MD. HABIBUR RAHMAN^5,6, MOHAMED A. EL-ESAWI⁷, GHIAS UDDIN⁸, BINA S. SIDDIQUI⁹, ANEES AHMED KHALIL¹⁰, JOSEPH MOLNAR¹¹, AKOS CSONKA¹¹, DIÁNA SZABÓ¹², HAROON KHAN¹³, MOHAMMAD S. MUBARAK¹⁴, TAIBI BEN HADDA¹⁵, MUDYAWATI KAMARUDDIN¹⁶, SEEMA PATEL¹⁷

BIOCELL, Vol.45, No.1, pp. 139-147, 2021, DOI:10.32604/biocell.2021.013277

Abstract The bioactive triterpenoid 3-oxo-6-β-hydroxy-β-amyrin (1) has been isolated from multiple plant sources. In this study, chloroform fraction of Pistacia integerrima extract was processed for the isolation of the compound. The compound identity was confirmed by advanced spectroscopy technique. X-ray crystallography was applied for molecular structure confirmation. In addition, compound 1 was screen for its activity on reversal of MDR (multidrug resistance) mediated by P-gp (P-glycoprotein). This was accomplished by using rhodamine123 exclusion on multidrug-resistant human ABCB1 gene transfected mouse T-lymphoma cell line. Outcomes revealed that MDR reversing effect was comparable to verapamil as positive control in vitro. Treatment of TPA-induced… More >

Qing Li¹, Ming Dai¹, Xueren Qian¹, Tian Liu¹, Zhenbo Liu¹, Yu Liu¹, Ming Chen¹, Wang He¹, Suqing Zeng¹, Yu Meng¹, Chenchen Dai¹, Jing Shen¹, Yingtao Liu¹, Wenshuai Chen¹, Wenbo Liu^1,*, Ping Lu^2,*

Journal of Renewable Materials, Vol.9, No.3, pp. 451-461, 2021, DOI:10.32604/jrm.2021.011655

Abstract Nanopaper has attracted considerable interest in the fields of films and paper research. However, the challenge of integrating the many advantages of nanopaper still remains. Herein, we developed a facile strategy to fabricate multifunctional nanocomposite paper (NGCP) composed of wood-derived nanofibrillated cellulose (NFC) and graphene as building blocks. NFC suspension was consisted of long and entangled NFCs (10–30 nm in width) and their aggregates. Before NGCP formation, NFC was chemically modified with a silane coupling agent to ensure that it could interact strongly with graphene in NGCP. The resulting NGCP samples were flexible and could be bent repeatedly without any… More >