Patrick C. Doherty, Heather E. Dillon^† , Justin Roberts

Frontiers in Heat and Mass Transfer, Vol.9, pp. 1-6, 2017, DOI:10.5098/hmt.9.1

Abstract The onset of turbulence in natural convection systems is difficult to predict using traditional computational techniques. The flow patterns that occur before and after the onset of turbulence may be better understood with the help of visual techniques like Schlieren imaging. Schlieren imaging allows visualization of the density gradients of a fluid using collimated light and refractive properties. In this experiment, a device was designed to test the behavior of airflow with non-isothermal boundary conditions within a rectangular cavity. Previous computational fluid modeling suggested a period doubling route to chaos in a cavity with a high aspect ratio and free… More >

Fengxia Shi^1,2, Yucai Tang^1,*, Dedong Ma¹, Xiangyun Shi¹, Guangbiao Zhao¹

FDMP-Fluid Dynamics & Materials Processing, Vol.19, No.10, pp. 2481-2497, 2023, DOI:10.32604/fdmp.2023.028416

Abstract In order to analyze the response of a hydraulic turbine to a variation in the operating conditions, different laws of variation in time of the mass flow rate have been considered. After validating the overall numerical framework through comparison with relevant experiments, the performances of the considered turbine have been analyzed from a fluid-dynamic point of view. The results show that different time profiles of the mass flow rate (in this work, for simplicity, referred to as “transition functions”) have a varying influence on the transient behavior of the turbine. When a quadratic function is considered for the case of… More > Graphic Abstract

GIULIA CHIABOTTO^1,*, STEFANIA BRUNO^2,*

BIOCELL, Vol.47, No.7, pp. 1499-1508, 2023, DOI:10.32604/biocell.2023.028121

Abstract Renal fibrosis and inflammation are common pathological features of chronic kidney disease (CKD). Since currently available treatments can only delay the progression of CKD, the outcome of patients with CKD is still poor. One therapeutic option for the prevention of CKD-related complications could be the use of mesenchymal stromal cells (MSCs), which have shown beneficial effects in tissue fibrosis and regeneration after damage. However, safety issues, such as cellular rejection and carcinogenicity, limit their clinical application. Among the bioactive factors secreted by MSCs, extracellular vesicles (EVs) have shown the same beneficial effect of MSCs, without any notable side effects. This… More > Graphic Abstract

Rongge Xiao^a,*, Dong Wang^a, Shuaishuai Jin^a, Hongping Yu^b, Bo Liu^a

Frontiers in Heat and Mass Transfer, Vol.16, pp. 1-9, 2021, DOI:10.5098/hmt.16.11

Abstract Based on the Viscous Kelvin-Helmholtz theory used by D. Barnea & Y. Taitel (1993), a two-fluid stratified flow model of gas-liquid two-phase flow is established. Using the mathematical derivation, the influence of various influence factors on the stability of liquid level structure is synthesized. Compared with the criteria of D Barnea & Y. Taitel (1993) and Taitel & Dukler(1976) , and the algorithm of flow pattern transition criterion of stratified flow is proposed. According to the data of multiphase flow experimental loop, the influence of liquid viscosity and the instantaneous volume flow rate change of gas-liquid two-phase on the transition… More >

Marwa M. Ibrahim^a,*, Mohamed Mahran Kasem^b,c

Frontiers in Heat and Mass Transfer, Vol.17, pp. 1-11, 2021, DOI:10.5098/hmt.17.20

Abstract Currently electricity generation technologies by thermal energy conversions become strong demand. The objective of this paper is to present a novel thermal study of absorber/receiver circular pipe of parabolic trough solar collector system for laminar and turbulent (k-ɛ model) fluids flow as well as two-dimensional numerical simulation is performed using CFD ANSYS FLUENT software. Significant improvements in heat transfer and velocity were discovered; the pattern of temperature distribution over the pipe absorber was displayed, and velocity vectors, pressure contours, and temperature contours were studied. The impact of increasing the heat flux towards the pipe wall is discussed. Heat transfer coefficient… More >

XIAOYIN LI^1,#, QIAN WANG^2,#, HONGFENG LIANG^3,#, SHISHENG CHEN^4,#, HAIWEN CHEN^1,#, YAOYONG LU^1,*, CHANGFU YANG^1,*

Oncology Research, Vol.30, No.2, pp. 77-87, 2022, DOI:10.32604/or.2022.026511

Abstract In this study, we investigated the functional role of eukaryotic initiation factor 5B (EIF5B) in hepatocellular carcinoma (HCC) and the underlying mechanisms. Bioinformatics analysis demonstrated that the EIF5B transcript and protein levels as well as the EIF5Bcopy number were significantly higher in the HCC tissues compared with the non-cancerous liver tissues. Down-regulation of EIF5B significantly decreased proliferation and invasiveness of the HCC cells. Furthermore, EIF5B knockdown suppressed epithelial-mesenchymal transition (EMT) and the cancer stem cell (CSC) phenotype. Down-regulation of EIF5B also increased the sensitivity of HCC cells to 5-fluorouracil (5-FU). In the HCC cells, activation of the NF-kappa B signaling… More >

A. S. Harish^*, C. Malathy

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 589-600, 2023, DOI:10.32604/iasc.2023.032030

Abstract Retailing is a dynamic business domain where commodities and goods are sold in small quantities directly to the customers. It deals with the end user customers of a supply-chain network and therefore has to accommodate the needs and desires of a large group of customers over varied utilities. The volume and volatility of the business makes it one of the prospective fields for analytical study and data modeling. This is also why customer segmentation drives a key role in multiple retail business decisions such as marketing budgeting, customer targeting, customized offers, value proposition etc. The segmentation could be on various… More >

HUOGEN LIU^#, YUNDI SHI^#, XIN WAN, YING LIU, HAILIN SHU, FENGMING HUANG, ZHENBIN GONG, LING GU^*

BIOCELL, Vol.46, No.12, pp. 2671-2680, 2022, DOI:10.32604/biocell.2022.018054

Abstract Peroxiredoxin 1 (PRDX1) participates in tumor cell proliferation, apoptosis, migration, invasion, and the epithelial-to-mesenchymal transition (EMT). This study aimed to investigate the effect of PRDX1 on the EMT of airway epithelial cells stimulated with lipopolysaccharide (LPS) and transforming growth factor-beta 1 (TGF-β1). PRDX1 overexpression significantly increased the proliferation and migration of human bronchial epithelial (BEAS-2B) cells, reduced cell apoptosis (p < 0.01), and induced EMT and collagen deposition by upregulating the expression of the matrix metallopeptidase (MMP)2, MMP9, α-smooth muscle actin (α-SMA), N-cadherin, vimentin and twist proteins and inhibiting E-cadherin expression (p < 0.05). PRDX1 overexpression promoted TGF-β1-mediated inhibition of… More >

TAMARA FERNÁNDEZ-CALERO^1,2,3,#, IGNACIO LÓPEZ^1,#, MARCOS DAVYT¹, CORA CHALAR¹, RICARDO EHRLICH^1,4, MÓNICA MARÍN^1,*

BIOCELL, Vol.46, No.11, pp. 2353-2356, 2022, DOI:10.32604/biocell.2022.020966

Abstract The epithelial to mesenchymal transition (EMT) is a cellular program that drives de-differentiation of cells in both physiological and pathological processes. One of the characteristics of cells describing an EMT is the (re)acquisition of a motility capacity that allows them to migrate through the original tissue as well as to other sites in the organism. The molecular mechanisms that control the EMT are rapidly emerging and here we add to the idea that the adaptation required for cells to commit to the EMT includes adjustments of the translation machinery and metabolic pathways to cope with a high demand of extracellular… More >

Xingxiang Liu^*†, Lin Cui^†, Dong Hua^*‡

Oncology Research, Vol.27, No.1, pp. 99-106, 2019, DOI:10.3727/096504018X15195193936573

Abstract We aimed to investigate the significant role of long noncoding RNA X inactive specific transcript (XIST) in regulating tumor metastasis in colorectal cancer (CRC), as well as its possible mechanism. Expression of lncRNA XIST in CRC tissues and CRC cells was detected. CRC cells were transfected with pc-XIST, blank control si-XIST, or si-control, and then the effects of lncRNA XIST on CRC cell migration and invasion were investigated, along with the interaction between lncRNA XIST and miR-137. lncRNA XIST was upregulated in CRC tissues. Compared with HT29 cells that had low metastatic potential, XIST was markedly more highly expressed in… More >