Weiliang Gao¹, Shixu Jia², Tingting Zhao^2,3,*, Zhiyong Wang²

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3495-3511, 2024, DOI:10.32604/cmes.2023.046188

Abstract The mechanical properties of interfacial transition zones (ITZs) have traditionally been simplified by reducing the stiffness of cement in previous simulation methods. A novel approach based on the discrete element method (DEM) has been developed for modeling concrete. This new approach efficiently simulates the meso-structure of ITZs, accurately capturing their heterogeneous properties. Validation against established uniaxial compression experiments confirms the precision of this model. The proposed model can model the process of damage evolution containing cracks initiation, propagation and penetration. Under increasing loads, cracks within ITZs progressively accumulate, culminating in macroscopic fractures that traverse the mortar matrix, forming the complex,… More >

Aisa Zulibiya^1,2,#, Jing Wen^3,#, Huiqing Yu^3,#, Xiaoming Chen³, Lei Xu³, Xiao Ma^1,2, Baojian Zhang^1,2,*

Congenital Heart Disease, Vol.18, No.6, pp. 611-625, 2023, DOI:10.32604/chd.2023.047689

Abstract Background: Tetralogy of Fallot (TOF) is a very common cyanotic congenital heart disease. Endothelial-to-mesenchymal transition (EndoMT) is recognized as a physiological mechanism involved in embryonic heart development and endothelial formation. However, there is still a gap in the reports related to the mechanism of EndoMT development in TOF. Methods: First, transcriptomic data of single cell nuclei of TOF and Donor were obtained based on the Gene Expression Omnibus (GEO) database, and the data were normalized and clustered by dimensionality reduction using the Seurat package. Subsequently, differentially expressed genes (DEGs) between TOF and Donor were screened using the “FindMarkers” function, and… More >

JINSONG WU^1,2, ZHENG ZHI¹, WENZHONG XU¹, DIANCGENG LI¹, QIUBO LI¹, YAN HAN¹, JIANMING HE^1,3,*, XI LIANG^1,*

BIOCELL, Vol.47, No.12, pp. 2671-2680, 2023, DOI:10.32604/biocell.2023.043494

Abstract Introduction: Collective cancer cell migration (CCCM) and epithelial-to-mesenchymal transition (EMT) play key roles in metastasis. This study reports that the colorectal carcinoma cell line LIM1863 is useful for the study of CCCM and EMT. Methods: Hematoxylin and eosin staining, scanning electron microscopy, transmission electron microscopy, and western blot analysis were performed. Results: LIM1863 automatically grew as spheroids in suspension and had important typical epithelial properties, including several layers of cells arranged around a central lumen, apical-basal polarity, and types of cell-cell junctions. Treatment with a combination of both TGF beta 1 and TNF alpha induced definite and distinct EMT, a… More >

Cong Liu¹, Mohd Nazri Abdul Rahman^1,*, Nur Eva²

International Journal of Mental Health Promotion, Vol.25, No.11, pp. 1161-1172, 2023, DOI:10.32604/ijmhp.2023.030324

Abstract The implementation of China’s three-child fertility policy has led to a notable increase in multiple-child families. Notably, firstborn children experience a significant transition from being an only child to a non-only child. This transition is associated with problematic behaviors, affecting their social adjustment, sibling relationships, and family harmony. Although several studies have examined the relationship between parent-child attachment and problem behaviors exhibited by firstborn children during family transitions, the findings have been inconsistent. Hence, a meta-analytic study was undertaken to elucidate the inconsistencies in this relationship and explore the moderating factors that may contribute to these discrepancies. Using a systematic… More >

WEILAN LIU, XIAOYAN DUAN, KAIYUN QIN, YAN JIANG, CAIFU ZHAO, CONGWEI DAI^*

BIOCELL, Vol.47, No.11, pp. 2471-2484, 2023, DOI:10.32604/biocell.2023.029617

Abstract Introduction: Structural maintenance of chromosome 1A (SMC1A) is a crucial compound of the cohesin complex. It has been reported to regulate the epithelial-mesenchymal transition (EMT) process in multiple cancers. Objectives: The present study aims to further clarify the role of SMC1A in cervical cancer. Methods: We analyzed data from four datasets and confirmed that SMC1A showed high expression in cervical cancer samples and was related to poor prognosis of patients with cervical cancer. Cell proliferation of SiHa and C-33A with knockdown of SMC1A was assessed using CCK-8 and colony formation assay. The migration and invasion were estimated by wound healing… More > Graphic Abstract

Zhuyou Hu¹, Ping Lin^2,3, He Guo^2,3, Yumei Zhang^2,3, Zhihai Xiang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09475

Abstract In recent years, the vehicle scanning method for bridge inspection has drawn much attention by researchers because of its simple operation and high efficiency [1]. Besides the natural frequency, modal modes and other information of bridges, damage can also be detected in this way [2]. For example, we proposed the passive tap-scan damage detection method [3], which scans the bridge with the tapping force generated by a toothed wheel, mimicking the hunting behavior of woodpeckers. In this talk, we will discuss two critical aspects related to the mechanism of this method. One is the quantitative relationship between the vehicle acceleration… More >

Fengchao Wu^1,*, Xuhai Li¹, Yi Sun¹, Yuanchao Gan¹, Huayun Geng¹, Yuying Yu¹, Jianbo Hu¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09320

Abstract The dynamical response of materials to multiple shock waves is a critical issue in shock physics and engineering applications. In this work, hydrodynamic simulations are used to investigate the shock-induced spall failure and subsequent recompression characteristics of tin, under the implementation of a multiphase equation of state, multi-phase constitutive relations, and a damage model. As within experiments, double shock loadings in simulations are driven by layered impactors with different shock impedances. In general, our numerical calculations agree well with recent tin spall experiments and reproduce the free surface velocity characteristics. Interesting dynamic behaviors such as tin shock compression, dynamic tensile… More >

Zhuyou Hu¹, Ping Lin^2,3, He Guo^2,3, Yumei Zhang^2,3, Zhihai Xiang^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09475

Abstract In recent years, the vehicle scanning method for bridge inspection has drawn much attention by researchers because of its simple operation and high efficiency [1]. Besides the natural frequency, modal modes and other information of bridges, damage can also be detected in this way [2]. For example, we proposed the passive tap-scan damage detection method [3], which scans the bridge with the tapping force generated by a toothed wheel, mimicking the hunting behavior of woodpeckers. In this talk, we will discuss two critical aspects related to the mechanism of this method. One is the quantitative relationship between the vehicle acceleration… More >

LIJUN JIANG¹, WENMIN JI¹, YAJIE GONG², JIAJUN LI², JINCHUN LIU^1,*

BIOCELL, Vol.47, No.8, pp. 1803-1810, 2023, DOI:10.32604/biocell.2023.029516

Abstract Background: Colorectal cancer (CRC) is one of the most common malignancies. Early diagnosis is the key to effective treatment of CRC. Since microRNAs (miRNAs) can be used as biomarkers of CRC, the objective of this work was to examine the effect of miR-520f-3p, which targets YAP1 (Yes-associated protein 1), on the ability of CRC cells to proliferate, invade, migrate, and undergo epithelial-mesenchymal transition (EMT). Methods: A miR-520f-3p mimic was used to overexpress miR-520f-3p in HT29 cells. To establish the tumor-bearing mouse model, transfected HT29 cells were subcutaneously implanted into BALB/c-nu nude mice, and YAP1 and miR-520f-3p levels were determined using… More > Graphic Abstract

FENGXIANG TANG, YANSHI LI, MIN PAN, ZHIHAI WANG, TAO LU, CHUAN LIU, XIN ZHOU, GUOHUA HU^*

Oncology Research, Vol.31, No.5, pp. 787-803, 2023, DOI:10.32604/or.2023.030081

Abstract Background: Lymphatic metastasis (LM) emerges as an independent prognostic marker for hypopharyngeal squamous cell carcinoma (HSPSCC), chiefly contributing to treatment inefficacy. This study aimed to scrutinize the prognostic relevance of HSP90AA1 and its potential regulatory mechanism of concerning LM in HPSCC. Methods: In a preceding investigation, HSP90AA1, a differential gene, was discovered through transcriptome sequencing of HPSCC tissues, considering both the presence and absence of LM. Validation of HSP90AA1 expression was accomplished via qRT-PCR, western-blotting(WB), and immunohistochemistry(IHC), while its prognostic significance was assessed employing Kaplan–Meier survival analysis(KMSA), log-rank test(LR), and Cox’s regression analysis(CRA). Bioinformatics techniques facilitated the prediction and analysis… More > Graphic Abstract