MUHAMMAD BABAR KHAWAR^1,2,3,#, YAJUN WANG^4,#, ANEEQA MAJEED³, ALI AFZAL⁵, KABEER HANEEF⁶, HAIBO SUN^1,2,*

Oncology Research, Vol.31, No.5, pp. 677-688, 2023, DOI:10.32604/or.2023.029718

Abstract Hepatocellular carcinoma, the most common primary liver cancer and a leading cause of death, is a difficult disease to treat due to its heterogeneous nature. Traditional models, such as 2D culture and patient-derived xenografts, have not proven effective. However, the development of 3D culture techniques, such as organoids, which can mimic the tumor microenvironment (TME) and preserve heterogeneity and pathophysiological properties of tumor cells, offers new opportunities for treatment and research. Organoids also have the potential for biomarker detection and personalized medication, as well as genome editing using CRISPR/Cas9 to study the behavior of certain genes and therapeutic interventions. This… More > Graphic Abstract

Sibel Day^*, Nilüfer Koçak-Şahin

Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2461-2471, 2023, DOI:10.32604/phyton.2023.029920

Abstract Aromatic and medicinal plant species having small seeds have field emergence problems due to low nutrient supply. Therefore, Pimpinella anisum seeds were hydro and osmoprimed with 100 mM MgCl₂, CaCl₂, and ZnCl₂, for 2, 4, and 8 h each to compare their growth attributes during germination and seedling establishment stages. Nontreated seeds were used as control. Both hydro and osmo primed seeds were dried for 48 h before, they were sown in plastic trays in growth room conditions to see the impact of treatments on seedling emergence and growth. The maximum root length (12.90 cm), fresh weight (256.30 mg plant⁻¹),… More >

DHANYA K. NAMBIAR¹, DEEPALI MISHRA², RANA P. SINGH^2,3,*

Oncology Research, Vol.31, No.4, pp. 405-421, 2023, DOI:10.32604/or.2023.028310

Abstract Ionizing radiation is frequently used to treat solid tumors, as it causes DNA damage and kill cancer cells. However, damaged DNA is repaired involving poly-(ADP-ribose) polymerase-1 (PARP-1) causing resistance to radiation therapy. Thus, PARP-1 represents an important target in multiple cancer types, including prostate cancer. PARP is a nuclear enzyme essential for single-strand DNA breaks repair. Inhibiting PARP-1 is lethal in a wide range of cancer cells that lack the homologous recombination repair (HR) pathway. This article provides a concise and simplified overview of the development of PARP inhibitors in the laboratory and their clinical applications. We focused on the… More > Graphic Abstract

Haoran Xu¹, Shuai Chen^2,*, Xue Song^1,3, Jingying Wang^1,*

Molecular & Cellular Biomechanics, Vol.20, No.1, pp. 15-22, 2023, DOI:10.32604/mcb.2023.029107

Abstract Clinically, it is common for Class III patients with maxillary skeletal deficiency, which may result in a variety of adverse consequences. Protraction headgear and rapid maxillary expansion (PE) is an effective treatment, but its effect on upper airway hydrodynamics has not been reported. The main purpose of this study was to evaluate the changes of the flow in the upper airway after PE by computational fluid dynamics (CFD). The sample includes fifteen patients (6 males, 9 females, age 11.00 ± 1.00) and the paired T-test was used to analyze the differences between the measured data before and after treatment. The… More > Graphic Abstract

Jialuo Rong^1,2, Shuixiang Xie^3,4, Huijing Geng⁵, Hao Hu^1,2, Shanfa Tang^1,2,*, Yuanpeng Cheng^1,2,*

Energy Engineering, Vol.120, No.8, pp. 1899-1917, 2023, DOI:10.32604/ee.2023.027650

Abstract Due to its extensive use in shale gas exploration and development, oil-based drilling fluids generate large amounts of oil-bearing drill cuttings during the drilling process. The large amount of oil-bearing drill cuttings generated during the drilling process can lead to serious secondary contamination. In this study, a wetting agent FSC-6 with good hydrophobic and oleophobic properties was synthesized to construct an efficient oil removal system. For the first time, the mechanism of this system was analyzed by using the theory of adhesion function, interfacial tension and wettability. At the same time, a combined acoustic-chemical treatment process was applied to the… More >

Qifen Li, Xiaoxiao Yan^*, Yongwen Yang, Liting Zhang, Yuanbo Hou

Journal of Renewable Materials, Vol.11, No.7, pp. 3177-3191, 2023, DOI:10.32604/jrm.2023.027749

Abstract Microbial Electrolytic Cell (MEC) is an electrochemical reaction device that uses electrical energy as an energy input and microorganisms as catalysts to produce fuels and chemicals. The regenerative electrochemical system is a MEC improvement system for methane gas produced by biological carbon sequestration technology using renewable energy sources to provide a voltage environment. In response to the influence of fluctuating disturbances of renewable electricity and the long system start-up time, this paper analyzes the characteristics of two strategies, regulating voltage parameter changes and activated sludge pretreatment, on the methane production efficiency of the renewable gas electrochemical system. In this system,… More >

Shihong Zhang^* , Xu Fan

Frontiers in Heat and Mass Transfer, Vol.14, pp. 1-6, 2020, DOI:10.5098/hmt.14.9

Abstract This article discussed compressive strength, water absorption, thermal conductivity and Frost resistance of building glazed tile of fly ash added in order to solve the problem of shortage of raw materials in the production. According to the technology of catalytic combustion furnace, glazed tiles of fly ash added with pure solid texture and glamorous colors were obtained by radiation heat treatment. It also greatly reduced pollutant emissions. The suitable proportion is about 30% of fly ash from these tests and the molding pressure is 20MPa. The utilization of fly ash not only alleviates the environmental pollution, but also saves raw… More >

Rongge Xiao^a,* , Zheng Dai^a, Yue Zhu^b , Leyuan Sun^a , Hao Li^a , Haiwei Lin^c

Frontiers in Heat and Mass Transfer, Vol.14, pp. 1-5, 2020, DOI:10.5098/hmt.14.2

Abstract In order to select economical and reasonable Boil-off gas (BOG) treatment technology for different types of liquefied natural gas (LNG) stations, this paper introduces the related technologies of BOG treatment without LNG Output. Using the same working fluid and operating parameters to simulate then the six technologies of pulse tube cryocooler recovery, liquid nitrogen recovery, nitrogen expansion recovery, jet refrigeration recovery, mixed refrigerant refrigeration recovery, and direct compression process were compared in terms of power consumption, economy. On the basis of comparative analysis of power consumption, the actual usage of the above process, and with the payback period as the… More >

Minghui Niu^1,#, Heng Zhang^1,#, Xiangyang Li¹, Zhibao Hu¹, Hongjiao Zhang^2,3, Zhiru Xu^2,3, Chunpu Qu^1,4,*, Guanjun Liu^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2001-2015, 2023, DOI:10.32604/phyton.2023.029350

Abstract KANADI (KAN) is a plant-specific gene that controlled the polarity development of lateral organs. It mainly acted on the abaxial characteristics of plants to make the lateral organs asymmetrical. However, it had been less identified in woody plants. In this study, the members of the KAN gene family in Populus trichocarpa were identified and analyzed using the bioinformatics method. The results showed that a total of 8 KAN family members were screened out, and each member contained the unique GARP domain and conserved region of the family proteins. Phylogenetic analysis and their gene structures revealed that all KAN genes from… More >

WENFEI GE^1,#, SHIYAN SONG^1,#, XIAOCHEN QI^1,#, FENG CHEN^1,#, XIANGYU CHE¹, YONGHAO SUN¹, JIN WANG¹, XIAOWEI LI², NANA LIU³, QIFEI WANG^1,*, GUANGZHEN WU^1,*

Oncology Research, Vol.31, No.3, pp. 255-270, 2023, DOI:10.32604/or.2023.027942

Abstract As a common tumor of the urinary system, the morbidity and mortality related to renal carcinoma, are increasing annually. Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal cell carcinoma, accounting for approximately 75% of the total number of patients with renal cell carcinoma. Currently, the clinical treatment of ccRCC involves targeted therapy, immunotherapy, and a combination of the two. In immunotherapy, PD-1/PD-L1 blocking of activated T cells to kill cancer cells is the most common treatment. However, as treatment progresses, some patients gradually develop resistance to immunotherapy. Meanwhile, other patients experience great side effects after… More > Graphic Abstract