CHUYAO WANG^1,2,#, CHUAN LU^2,#, LUXIANG ZOU^2,*, DONGMEI HE^2,*

BIOCELL, Vol.47, No.6, pp. 1293-1306, 2023, DOI:10.32604/biocell.2023.028199

Abstract Background: Temporomandibular joint osteoarthritis (TMJOA) is an end-stage disease that seriously affects the patients’ quality of life. Molecular insights in advancing our understanding of TMJOA are the need of the hour. Methods: We performed RNA high-throughput sequencing and bioinformatics analysis of differentially expressed (DE) long non-coding RNA (lncRNAs), microRNAs (miRNAs), and messenger RNA (mRNAs) in human synovial TMJOA tissues. Firstly, synovium samples of TMJOA patients and non-TMJOA controls were collected for highthroughput sequencing of lncRNAs, miRNAs, and mRNAs. We then performed biological function analysis of the top 100 mRNAs with more than 2-fold differential expression, and their upstream regulated miRNAs… More >

DER-JEU CHEN, CHENG-HUNG LAI^*

BIOCELL, Vol.47, No.6, pp. 1317-1327, 2023, DOI:10.32604/biocell.2023.028883

Abstract Background: Magnolol, a bioactive extract of the Chinese herb Magnolia officinalis has a protective effect against periodontitis. This study is aimed to explore the mechanisms involved in the functioning of magnolol against periodontitis and provide a basis for further research. Methods: Network pharmacology analysis was performed based on the identification of related targets from public databases. The Protein-protein interaction (PPI) network was constructed to visualize the significance between the targets of magnolol and periodontitis. Subsequently, Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to predict the functions and the signal regulatory pathways involved in… More >

QIAN CHEN^1,#, XIN LEI^1,#, GUANHUA HU^1,#, YAN WANG², ZHENGQING FANG¹, GUOQUAN WANG¹, HANG SONG¹, SHU YE^1,*, BIAO CAI^1,*

BIOCELL, Vol.47, No.6, pp. 1265-1277, 2023, DOI:10.32604/biocell.2023.028811

Abstract Background: Huang-Pu-Tong-Qiao formula (HPTQ), a traditional Chinese herbal formula, has a variety of pharmacological effects. It has been used to treat Alzheimer’s disease (AD) for decades. This study aimed to screen differentially expressed proteins in the hippocampus of AD model rats treated with HPTQ. Proteomic studies of the effects of HPTQ on AD are key to understanding the therapeutic mechanisms of HPTQ and identifying potential therapeutic targets. Methods: We hence used the isobaric tags for relative and absolute quantification (ITRAQ) approach to investigate the differentially expressed proteins in the hippocampus of AD model rats before and after HPTQ administration and… More >

Uzma Afzal¹, Tariq Mahmood², Ali Mustafa Qamar^3,*, Ayaz H. Khan^4,5

CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 6251-6267, 2023, DOI:10.32604/cmc.2023.037653

Abstract A complex Laboratory Developed Test (LDT) is a clinical test developed within a single laboratory. It is typically configured from many feature constraints from clinical repositories, which are part of the existing Laboratory Information Management System (LIMS). Although these clinical repositories are automated, support for managing patient information with test results of an LDT is also integrated within the existing LIMS. Still, the support to configure LDTs design needs to be made available even in standard LIMS packages. The manual configuration of LDTs is a complex process and can generate configuration inconsistencies because many constraints between features can remain unsatisfied.… More >

Lina Bashatah^*, Duaa Al-fifi

International Journal of Mental Health Promotion, Vol.25, No.5, pp. 639-653, 2023, DOI:10.32604/ijmhp.2023.025878

Abstract This study identified the methods used by kindergarten teachers to reduce bullying among their students in and out of the classroom and examined differences based on the teachers’ years of experience and the number of courses on bullying they had taken. A descriptive survey using a questionnaire tool collected responses from 208 public kindergarten teachers in Riyadh, Kingdom of Saudi Arabia. The participants agreed with using such methods to reduce bullying among children as responding to parents’ reports and following up on the reasons for a child’s absence. They also agreed that bullying in the classroom could be reduced by… More >

Minting Lai, Guijun Xie^*, Wanju Li, Lamei Li, Yongjian Cao

Journal of Renewable Materials, Vol.11, No.6, pp. 2665-2678, 2023, DOI:10.32604/jrm.2023.027441

Abstract Heat-treated wood has good dimensional stability, durability, and color, but its susceptibility to fungal growth affects its commercial value. In this study, lumber harvested from mature Masson’s pine (Pinus massoniana Lamb.) was vacuum impregnated with a basic copper salt solution (copper hydroxide, diethanolamine, and polyethylene glycol 200) prior to heat-treatment at 220°C for 3 h. Antifungal properties, surface chemistry, crystal structure and sugar contents were tested, compared with heat treatment alone. The results showed that the samples treated by heating without copper salt treatment showed poor suppression of fungal growth, the copper-impregnated heat-treated wood suppressed (100%) the growth of Botryodiplodia theobromae… More >

LIHUA CHEN^1,2,#, HONGTIAN ZHANG^1,2,#, YONG XIA^1,2, KAI SUN¹, WENJIN CHEN¹, RUXIANG XU^1,2,*

BIOCELL, Vol.47, No.5, pp. 1065-1073, 2023, DOI:10.32604/biocell.2023.025924

Abstract Purpose: The present study summarized cases of children (n = 32) with medulloblastoma (MB) who were treated using stratified therapy based on risk grading and also discussed the factors affecting prognosis. Methods: According to the risk stratification criteria, the cases were divided into the following four risk groups: low, standard, high, and very high. The 5-year overall survival (OS) and progression-free survival (PFS) rates were summarized. Further, the effects on the prognosis of tumor size, tumor stage, degree of resection, treatment mode, metastatic recurrence, molecular typing, and risk stratification were analyzed. Results: In the present study, following surgery, 3 cases… More >

Chengxiang Li, Yue Wu, Chunhui Zhang^*, Yao Liu, Qixuan Lin, Junli Ren^*

Journal of Renewable Materials, Vol.11, No.6, pp. 2555-2574, 2023, DOI:10.32604/jrm.2023.026908

Abstract Hemicellulose and lignin are not reasonably utilized during the dissolved pulp preparation process. This work aimed to propose a process for the co-production of dissolving pulp, furfural, and lignin from eucalyptus. High-grade dissolving pulp was prepared from eucalyptus using a combination of extremely low acid (ELA) pretreatment, Kraft cooking, and elementary chlorine-free (ECF) bleaching. The obtained pre-hydrolysate was catalytic conversion into furfural in a biphasic system, and lignin during Kraft cooking and ECF was recovered. The process condition was discussed as well as the mass flow direction. The results showed that ELA pretreatment could effectively remove 80.1% hemicellulose. Compared with… More >

Emad Abd Al Rahman¹, Nur Intan Raihana Ruhaiyem^1,*, Majed Bouchahma², Kamarul Imran Musa³

Intelligent Automation & Soft Computing, Vol.36, No.3, pp. 3007-3028, 2023, DOI:10.32604/iasc.2023.032580

Abstract This study offers a framework for a breast cancer computer-aided treatment prediction (CATP) system. The rising death rate among women due to breast cancer is a worldwide health concern that can only be addressed by early diagnosis and frequent screening. Mammography has been the most utilized breast imaging technique to date. Radiologists have begun to use computer-aided detection and diagnosis (CAD) systems to improve the accuracy of breast cancer diagnosis by minimizing human errors. Despite the progress of artificial intelligence (AI) in the medical field, this study indicates that systems that can anticipate a treatment plan once a patient has… More >

YIFAN XU^1,#, DONGMEI CHENG^1,#, LEI HU¹, XIN DONG², LIYING LV², CHEN ZHANG², JIAN ZHOU^1,3,4,*

BIOCELL, Vol.47, No.4, pp. 825-836, 2023, DOI:10.32604/biocell.2023.026122

Abstract The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation. Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway, yet the function of this pathway in tooth regeneration remains unclear. Here, we found that AZD2858 promotes the accumulation of β-catenin in the nuclei of stem cells from the apical papilla (SCAPs) and enhances cell proliferation. Single-cell sequencing was performed on SCAPs treated with AZD2858. Eight clusters were identified, namely SCAPs-CNTNAP2, SCAPs-DTL, SCAPs-MYH11, SCAPs-MKI67, SCAPs-CXCL8, SCAPs-TPM2, SCAPs-IFIT2 and SCAPs-NEK10. The pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11, SCAPs-CNTNAPs and… More >