GAMALELDIN I. HARISA^1,*, RIYAD F. ALZHRANI¹, ABDULRAHMAN A. ALLUHAIDAN¹, SULTAN M. ALAMRI¹, AHMED H. BAKHEIT², HANADI H. ASIRI², SABRY M. ATTIA³

Oncology Research, Vol.33, No.2, pp. 477-492, 2025, DOI:10.32604/or.2024.053337 - 16 January 2025

Abstract Background: Hepatocellular carcinoma (HCC) is a health problem due to multi-drug resistance (MDR). Codelivery of multiple oncotherapy in one cargo as chimeric cancer therapy (CCT) is suggested as a solution for MDR. This study aims to engineer chitosan-coated nanostructure lipid carriers (NLCs) loaded with gefitinib (GF) and simvastatin (SV) as CCT for HCC. Methods: Both GF and SV-loaded nanostructure lipids carriers (GFSVNLC) and chitosan-capped GF and SV-loaded nanostructure lipids carriers (CGFSVNLC) formulations were assembled by top-down techniques. Moreover, particle size (PS), zeta potential (ZP), and polydispersity index (PDI) were measured by Zetasizer. The biosafety of… More > Graphic Abstract

PIAO YANG¹, MOHSEN SHEYKHHASAN^2,*, REZA HEIDARI³, MOHSEN CHAMANARA^4,5, PAOLA DAMA⁶, AMIRHOSSEIN AHMADIEH-YAZDI⁷, HAMED MANOOCHEHRI⁸, HAMID TANZADEHPANAH⁹, HANIE MAHAKI¹⁰, NASER KALHOR¹¹, ASHKAN DIRBAZIYAN¹², SHARAFALDIN AL-MUSAWI¹³

Oncology Research, Vol.33, No.2, pp. 283-300, 2025, DOI:10.32604/or.2024.052939 - 16 January 2025

Abstract Cancer, a leading cause of global mortality, remains a significant challenge to increasing life expectancy worldwide. Forkhead Box R2 (FOXR2), identified as an oncogene within the FOX gene family, plays a crucial role in developing various endoderm-derived organs. Recent studies have elucidated FOXR2-related pathways and their involvement in both tumor and non-tumor diseases. Dysregulation of FOXR2 has been linked to numerous malignant tumors, spanning the brain, nervous system, thyroid, osteosarcoma, Hodgkin lymphoma, colorectal, liver, pancreatic, lung, breast, ovarian, prostate, female genital tract, endometrial, and uterine cancers. Despite extensive research on FOXR2 dysregulation, its practical applications More >

EDMUND CHEUNG SO^1,2,#, LOUIS W. C. CHOW^3,#, CHIN-MIN CHUANG⁴, CING YU CHEN^5,6, CHENG-HSUN WU⁷, LIAN-RU SHIAO⁸, TING-TSZ OU⁹, KAR-LOK WONG¹⁰, YUK-MAN LEUNG^8,*, YI-PING HUANG^8,*

Oncology Research, Vol.33, No.2, pp. 397-406, 2025, DOI:10.32604/or.2024.052743 - 16 January 2025

Abstract Objectives: Mitochondrial Ca²⁺ uniporter (MCU) provides a Ca²⁺ influx pathway from the cytosol into the mitochondrial matrix and a moderate mitochondrial Ca²⁺ rise stimulates ATP production and cell growth. MCU is highly expressed in various cancer cells including breast cancer cells, thereby increasing the capacity of mitochondrial Ca²⁺ uptake, ATP production, and cancer cell proliferation. The objective of this study was to examine MCU inhibition as an anti-cancer mechanism. Methods: The effects of MCU-i4, a newly developed MCU inhibitor, on cell viability, apoptosis, cytosolic Ca²⁺, mitochondrial Ca²⁺ and potential, glycolytic rate, generation of ATP, and reactive oxygen species,… More >

JUNWEI DU, QIANG ZHANG, JING ZHANG, MAIERDANJIANG MAIHEMUTI, HAIYANG HE, RENBING JIANG^*

Oncology Research, Vol.33, No.2, pp. 357-367, 2025, DOI:10.32604/or.2024.050878 - 16 January 2025

Abstract Objectives: Melanoma is a highly aggressive and metastatic form of cancer, and the role of exosomal microRNAs (miRNAs) in its progression remains largely unexplored. This study aimed to investigate the effects of melanoma cell-derived exosomal miR-424-5p on angiogenesis and its underlying mechanisms. Methods: Exosomes were isolated from melanoma cell lines A375 and A2058, and their effects on the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) were examined. The interaction between miR-424-5p and its target gene, large tumor suppressor kinase 2 (LATS2), was analyzed using luciferase reporter assays and functional experiments. In vivo,… More >

LIANGJIANG XIA¹, GUANGBIN LI², QINGWU ZHOU³, YU FENG^2,*, HAITAO MA^2,*

Oncology Research, Vol.33, No.2, pp. 465-475, 2025, DOI:10.32604/or.2024.050835 - 16 January 2025

Abstract Background: Circular RNAs play an important role in regulating lung adenocarcinoma (LUAD). Bioinformatics analysis identified circ_0015278 as differentially expressed in LUAD. However, the biological mechanism of circ_0015278 in LUAD has not been fully clarified, especially in ferroptosis. Materials and Methods: Bioinformatics analysis was employed to explore the downstream mechanisms of Circ_0015278, subsequently confirmed by luciferase reporter assays. The impact of Circ_0015278 on cell proliferation, migration, invasion, and ferroptosis was investigated through a loss-of-function experiment. A xenotransplantation mouse model elucidated the effect of Circ_0015278 on tumour growth. Results: Circ_0015278 exhibited downregulation in LUAD. It inhibited cell proliferation, More >

ZHENGYANG ZHOU^1,#, LEI QIAO^1,#, TONGTONG WANG¹, WEN PAN¹, JINGJING DUAN¹, HAIYANG ZHANG², TING DENG¹, YI BA^1,*, YI HE^1,*

Oncology Research, Vol.33, No.2, pp. 327-345, 2025, DOI:10.32604/or.2024.050431 - 16 January 2025

Abstract Background: Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC. Nowadays, more and more studies have confirmed that exosomes can participate in tumor lymphangiogenesis. An in-depth exploration of the pathological mechanism in the process of LNM in GC may provide effective targets and improve the diagnosis and treatment effect. Materials and Methods: We used sequencing analysis of collected serum to screen out exo-miRNA related to LNM in GC. ELISA, qRT-PCR, Western Blot, RNA pull-down assay, Transwell assay, animal experiments, and other… More > Graphic Abstract

Ruikun Xu¹, Jiu Li¹, Wenjie Li¹, Wei Zhang^2,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 285-305, 2025, DOI:10.32604/sdhm.2024.057513 - 15 January 2025

Abstract This study investigates the bond performance at the interfacial region shared by Ultra-High Performance Concrete (UHPC) and steel tubes through push-out tests. This study examines how changes in steel fiber volumetric ratio and thickness of steel tube influence the bond strength characteristics. The results show that as the enhancement of the steel tube wall thickness, the ultimate bond strength at the interface improves significantly, whereas the initial bond strength exhibits only slight variations. The influence of steel fiber volumetric ratio presents a nonlinear trend, with initial bond strength decreasing at low fiber content and increasing More >

Yao Jin¹, Yuan Ren¹, Chong-Yuan Guo², Chong Li³, Zhao-Yuan Guo^1,4, Xiang Xu^1,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 307-325, 2025, DOI:10.32604/sdhm.2024.055265 - 15 January 2025

Abstract To improve the accuracy of thermal response estimation and overcome the limitations of the linear regression model and Artificial Neural Network (ANN) model, this study introduces a deep learning estimation method specifically based on the Long Short-Term Memory (LSTM) network, to predict temperature-induced girder end displacements of the Dasha Waterway Bridge, a suspension bridge in China. First, to enhance data quality and select target sensors, preprocessing based on the sigma rule and nearest neighbor interpolation is applied to the raw data. Furthermore, to eliminate the high-frequency components from the displacement signal, the wavelet transform is… More >

Yi Wang¹, Bing Wang², Changwen Li², Feng Zheng¹, Yong Liu², Shaohua He^3,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 385-398, 2025, DOI:10.32604/sdhm.2024.054761 - 15 January 2025

Abstract Complex bridge structures designed and constructed by humans often necessitate extensive on-site execution, which carries inherent risks. Consequently, a variety of engineering practices are employed to monitor bridge construction. This paper presents a case study of a large-span prestressed concrete (PC) variable-section continuous girder bridge in China, proposing a feedback system for construction monitoring and establishing a finite element (FE) analysis model for the entire bridge. The alignment of the completed bridge adheres to the initial design expectations, with maximum displacement and pre-arch differences from the ideal state measuring 6.39 and 17.7 mm, respectively, which More >

Zhao-Jun Zhang¹, Jing-Shui Zhen¹, Bo-Cheng Li¹, De-Cheng Cai¹, Yang-Yang Du¹, Wen-Wei Wang^2,*

Structural Durability & Health Monitoring, Vol.19, No.2, pp. 327-346, 2025, DOI:10.32604/sdhm.2024.054671 - 15 January 2025

Abstract To mitigate the challenges in managing the damage level of reinforced concrete (RC) pier columns subjected to cyclic reverse loading, this study conducted a series of cyclic reverse tests on RC pier columns. By analyzing the outcomes of destructive testing on various specimens and fine-tuning the results with the aid of the IMK (Ibarra Medina Krawinkler) recovery model, the energy dissipation capacity coefficient of the pier columns were able to be determined. Furthermore, utilizing the calibrated damage model parameters, the damage index for each specimen were calculated. Based on the obtained damage levels, three distinct More >