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  • Open Access

    ARTICLE

    Characterization of Malalignment between Atrial and Ventricular Septa in Overriding/Straddling Tricuspid and Mitral Valves

    Mika Saito1,2, Dragulescu Andreea1,2, Shi-Joon Yoo1,2,3,*

    Congenital Heart Disease, Vol.16, No.1, pp. 1-16, 2021, DOI:10.32604/CHD.2021.011694 - 23 December 2020

    Abstract Objective: Overriding/straddling of an atrioventricular valve is a consequence of atrial-ventricular septal malalignment. We sought to characterize the malalignment by analogizing it to a flap-door and using structured approach. Methods: The echocardiograms and magnetic resonance images of 35 patients with overriding/straddling tricuspid or mitral valve were evaluated to assess the following modifiers; the malaligned part of the septum, the reference structure, and the mechanism, direction and severity of malalignment. Results: The pathology included classic overriding tricuspid valve in 15, classic overriding mitral valve in 12, and overriding tricuspid valve with left juxtaposition of atrial appendages in 8.… More >

  • Open Access

    ARTICLE

    Multi Criteria Decision Making System for Parking System

    Manjur Kolhar*, Abdalla Alameen

    Computer Systems Science and Engineering, Vol.36, No.1, pp. 101-116, 2021, DOI:10.32604/csse.2021.014915 - 23 December 2020

    Abstract System supported smart parking can reduce traffic by making it stress free to locate empty parking spaces, hence lowering the risk of unfocussed driving. In this study, we propose a smart parking system using deep learning and an application-based approach. This system has two modules, one module detects and recognizes a license plate (LP), and the other selects a parking space; both modules use deep learning techniques. We used two modules that work independently to detect and recognize an LP by using an image of the vehicle. To detect parking space, only deep learning techniques… More >

  • Open Access

    ARTICLE

    Melt Extrusion of Environmentally Friendly Poly(L-lactic acid)/Sodium Metabisulfite Films for Antimicrobial Packaging Applications

    Norma M. P. Machado1, Gustavo C. Melo1, Matheus F. Camargo1, Giulianna G. Feijó1, Bruna M. S. Putton2, Clarice Steffens2, Rogerio L. Cansian2, Luiz A. Pessan1, Francys K. V. Moreira1,*

    Journal of Renewable Materials, Vol.9, No.2, pp. 337-349, 2021, DOI:10.32604/jrm.2021.011081 - 15 December 2020

    Abstract Food packaging materials compounded with antimicrobial additives can substantially diminish the incidence of foodborne diseases. Here, poly(L-lactic acid) (PLA) films containing sodium metabisulfite (NaM) were produced by melt extrusion as an attempt to develop a new biodegradable material with antimicrobial properties for packaging. Life cycle assessment (LCA) simulations revealed that the environmental footprints of the PLA film did not change upon NaM addition, and that NaM is more eco-friendly than silver nanoparticles. The PLA/NaM films with NaM content varying from 0.5 to 5.0 wt.% were characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and… More >

  • Open Access

    ARTICLE

    Intelligent Decision Support System for COVID-19 Empowered with Deep Learning

    Shahan Yamin Siddiqui1,2, Sagheer Abbas1, Muhammad Adnan Khan3,*, Iftikhar Naseer4, Tehreem Masood4, Khalid Masood Khan3, Mohammed A. Al Ghamdi5, Sultan H. Almotiri5

    CMC-Computers, Materials & Continua, Vol.66, No.2, pp. 1719-1732, 2021, DOI:10.32604/cmc.2020.012585 - 26 November 2020

    Abstract The prompt spread of Coronavirus (COVID-19) subsequently adorns a big threat to the people around the globe. The evolving and the perpetually diagnosis of coronavirus has become a critical challenge for the healthcare sector. Drastically increase of COVID-19 has rendered the necessity to detect the people who are more likely to get infected. Lately, the testing kits for COVID-19 are not available to deal it with required proficiency, along with-it countries have been widely hit by the COVID-19 disruption. To keep in view the need of hour asks for an automatic diagnosis system for early… More >

  • Open Access

    ARTICLE

    AM Fungi and Piriformospora indica Improve Plant Growth of Pinus elliottii Seedlings

    Taoze Sun, Wei Tan, Yujie Yang, Hongna Mu*

    Phyton-International Journal of Experimental Botany, Vol.90, No.1, pp. 171-178, 2021, DOI:10.32604/phyton.2020.013668 - 20 November 2020

    Abstract Pinus elliottii is an exotic afforestation pine extensively distributed in southern parts of China. In order to understand whether endophytic fungi can affect seedling growth of P. elliottii, Piriformospora indica (Pi), Funnelifcrmis mosseae (Fm), and Diversispora tortuosa (Dt) were inoculated respectively, and the non-inoculated group was set as control. The growth indexes, the contents of soluble sugar and soluble protein, and plant endogenous hormone levels in the leaves of P. elliottii, were analyzed. The results showed that Fm, Dt and Pi colonized the P. elliottii roots to form mycorrhizal structure and chlamydospores arranged in beads respectively. Three fungal inoculants exhibited the stimulated… More >

  • Open Access

    ARTICLE

    Allelopathic Potential and Mechanism of Rosebay Willowherb [Chamaenerion angustifolium (L.) Scop.] Demonstrated on Model Plant Lettuce

    Hailin Shi#, Shiwei Sun#, Xiaohong Liu, Jiahe Fan, Jin Wang, Ke Zhao, Wei Wang*

    Phyton-International Journal of Experimental Botany, Vol.90, No.1, pp. 159-170, 2021, DOI:10.32604/phyton.2020.011620 - 20 November 2020

    Abstract Allelopathic plants are important resources for the discovery of bioherbicides. Rosebay willowherb [Chamaenerion angustifolium (L.) Scop. syn. Epilobium angustifolium L.] widely distributes in Western Asia, Europe, and North America, and behaves as a dominant species within the community due to the production of substances that restrict growth of other plants. This study aims at investigating the allelopathic potential of rosebay willowherb by evaluation of the effects of aqueous extracts from different parts on seed germination and seedling growth in lettuce (Lactuca sativa L.), as well as measuring the accumulation of reactive oxygen species and structural analysis of root… More >

  • Open Access

    ARTICLE

    Emergency Prioritized and Congestion Handling Protocol for Medical Internet of Things

    Sabeen Tahir*, Sheikh Tahir Bakhsh, Rayed AlGhamdi

    CMC-Computers, Materials & Continua, Vol.66, No.1, pp. 733-749, 2021, DOI:10.32604/cmc.2020.013261 - 30 October 2020

    Abstract Medical Internet of Things (MIoTs) is a collection of small and energyefficient wireless sensor devices that monitor the patient’s body. The healthcare networks transmit continuous data monitoring for the patients to survive them independently. There are many improvements in MIoTs, but still, there are critical issues that might affect the Quality of Service (QoS) of a network. Congestion handling is one of the critical factors that directly affect the QoS of the network. The congestion in MIoT can cause more energy consumption, delay, and important data loss. If a patient has an emergency, then the… More >

  • Open Access

    ARTICLE

    miR-4792 Inhibits Acute Myeloid Leukemia Cell Proliferation and Invasion and Promotes Cell Apoptosis by Targeting Kindlin-3

    Yun Qin*, Yu Wang†‡§, Dongbo Liu

    Oncology Research, Vol.28, No.4, pp. 357-369, 2020, DOI:10.3727/096504020X15844389264424

    Abstract It has been reported that kindlin-3 expression is closely associated with progression of many cancers and microRNA (miRNA) processing. However, the effects and precise mechanisms of kindlin-3 in acute myeloid leukemia (AML) have not been well clarified. Our study aimed to explore the interaction between kindlin-3 and miR-4792 in AML. In our study, we found that the expression of kindlin-3 was dramatically increased in AML samples and cell lines, and the miR-4792 level was significantly downregulated. Interestingly, the low miR-4792 level was closely associated with upregulated kindlin-3 expression in AML samples. Moreover, introduction of miR-4792 More >

  • Open Access

    ARTICLE

    A Novel BCL-2 Inhibitor APG-2575 Exerts Synthetic Lethality With BTK or MDM2-p53 Inhibitor in Diffuse Large B-Cell Lymphoma

    Qiuyun Luo*†1, Wentao Pan*†‡1, Suna Zhou*†1, Guangfeng Wang, Hanjie Yi, Lin Zhang, Xianglei Yan*†, Luping Yuan*†, Zhenyi Liu#, Jing Wang**, Haibo Chen#, MiaoZhen Qiu*††, DaJun Yang*†‡, Jian Sun*‡‡

    Oncology Research, Vol.28, No.4, pp. 331-344, 2020, DOI:10.3727/096504020X15825405463920

    Abstract Despite therapeutic advances, the effective treatment for relapsed or refractory diffuse large B-cell lymphoma (DLBCL) remains a major clinical challenge. Evasion of apoptosis through upregulating antiapoptotic B-cell lymphoma-2 (BCL-2) family members and p53 inactivation, and abnormal activation of B-cell receptor signaling pathway are two important pathogenic factors for DLBCL. In this study, our aim is to explore a rational combination of BCL-2 inhibitor plus Bruton’s tyrosine kinase (BTK) blockade or p53 activation for treating DLBCL with the above characteristics. We demonstrated that a novel BCL-2 selective inhibitor APG-2575 effectively suppressed DLBCL with BCL-2 high expression… More >

  • Open Access

    ARTICLE

    Between Chronic Diseases and Geriatric Depression: Mediational Effects of Activities of Daily Living (ADLs) Disability Among Older Adults

    Yi Yang1,2,* , Tao Li3

    International Journal of Mental Health Promotion, Vol.22, No.4, pp. 249-259, 2020, DOI:10.32604/IJMHP.2020.014321 - 22 December 2020

    Abstract This study is aimed to explore relations between chronic diseases, activities of daily living (ADLs) disability and depression among older adults, particularly ADLs disability mediational effects on the correlation between chronic diseases and geriatric depression. Records of 5931 participants at age 60 and above from China Health and Retirement Longitudinal Study (CHARLS) in 2015 were used as valid samples for data relating to their chronic diseases index, ADLs scale and Center for Epidemiologic Studies Depression (CES-D) scale. Our findings confirm that among older adults, 75.9% are afflicted with chronic diseases and 52.5% have ADLs difficulty… More >

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