MAKOTO KAWATANI^1,2,*, HARUMI AONO², SAYOKO HIRANUMA³, TAKESHI SHIMIZU³, MAKOTO MUROI^1,2, TOSHIHIKO NOGAWA⁴, TOMOKAZU OHISHI⁵, SHUN-ICHI OHBA⁵, MANABU KAWADA⁵, KANAMI YAMAZAKI⁶, SHINGO DAN⁶, NAOSHI DOHMAE¹, HIROYUKI OSADA^2,7,*

Oncology Research, Vol.31, No.6, pp. 833-844, 2023, DOI:10.32604/or.2023.030241

Abstract Dihydroorotate dehydrogenase (DHODH) is a central enzyme of the de novo pyrimidine biosynthesis pathway and is a promising drug target for the treatment of cancer and autoimmune diseases. This study presents the identification of a potent DHODH inhibitor by proteomic profiling. Cell-based screening revealed that NPD723, which is reduced to H-006 in cells, strongly induces myeloid differentiation and inhibits cell growth in HL-60 cells. H-006 also suppressed the growth of various cancer cells. Proteomic profiling of NPD723-treated cells in ChemProteoBase showed that NPD723 was clustered with DHODH inhibitors. H-006 potently inhibited human DHODH activity in vitro, whereas NPD723 was approximately… More >

Xinsen Wei¹, Ying Guo^1,2,*, Yan Zhao¹

Molecular & Cellular Biomechanics, Vol.20, No.2, pp. 49-61, 2023, DOI:10.32604/mcb.2023.041173

Abstract As one of the most basal avian clades, the Confuciusornithids are ideal in revealing the early evolution of avian flight. Birds’ hindlimbs are functionally diverse and contain a wealth of information about their behavior. The hindlimb of Confuciusornis, however, has only been studied in detail in terms of functional morphology, and quantitative studies that directly assess locomotor ability are relatively lacking. This has led to certain controversies on the behavior of Confuciusornis. This paper reviews the debates over the life habits and take-off ability of Confuciusornis, which are closely related to their hindlimb function. Several methodologies adopted engineering techniques, including… More >

Xin Pan, Ya Gao, Fang Zeng, Chunmei Zheng, Wenxuan Ge, Yan Wan, Yanxia Sun, Xiaoyong Wu^*

Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2921-2936, 2023, DOI:10.32604/phyton.2023.029853

Abstract Pre-harvest sprouting (PHS) will have a serious effect both on the yield and quality of quinoa (Chenopodium quinoa Willd.). It is crucial to select and breed quinoa varieties with PHS resistance and excellent agronomic traits for guidance production and utilization of quinoa. A comprehensive evaluation of the PHS resistance and agronomic traits of 37 species of quinoa resources was conducted in Chengdu Plain. The evaluation used various methods, including grain germination rate (GR), grain germination index (GI), total spike germination rate (SR), total grain germination index (SI), grey correlation analysis (GCA), cluster analysis and correlation analysis. Results showed significant differences… More >

Xiaowei Gao^1,*, Huayu Liu¹, Weilong Fan¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09510

Abstract In this paper, a novel numerical method, Zonal Free Element Method (ZFLM), is proposed and used to solve thermal-mechanical problems composed of multiple and functionally graded materials. ZFLM is a collocation method, in which two or three lines in 2D or 3D problems, called as line-set, are used at each node to establish the solution scheme solving engineering problems governed by partial differential equations. In ZFLM, the Lagrange polynomial is adopted to approximate physical variables varying over each line of the line-set. The first-order partial derivative is derived by using a directional derivative technique along arclength of a line, and… More >

Dongze Yan¹, Jianxiang Wang², Lihua Shao^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-2, 2023, DOI:10.32604/icces.2023.09357

Abstract Non-uniform strains produce a localized break in the microscopic inverse symmetry of materials, which leads to the electromechanical coupling phenomenon known as flexoelectricity in all dielectric materials. However, the size-dependent flexoelectric effect typically only manifests at small scales. Creating a considerable flexoelectric output at the macroscopic scale remains a bottleneck. Micro- and nano-porous materials own a significant number of randomly distributed microscopic pores and ligamentous structures, which can deform non-uniformly under arbitrary forms of macroscopic loading. Moreover, since the small size effect of flexoelectricity, the entire flexoelectricity of the micro- and nano-porous materials will be much more significant than that… More >

Linjuan Wang^1,*, Jianxiang Wang²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.1, pp. 1-1, 2023, DOI:10.32604/icces.2023.09355

Abstract The prediction of overall dynamics of composite materials has been an intriguing research topic more than a century, and numerous approaches have been developed for this topic. One of the most successful representatives is the classical micromechanical models which assume that the behavior of a composite is the same as its constituents except for the difference in mechanical properties, e.g., effective moduli. With the development of advanced composite materials in recent years, especially metamaterials, it is found that the classical micromechanical models cannot describe complex dynamic responses of composites such as the dispersion and bandgaps of elastic waves. Thus, some… More >

Mianmo Meng^1,*, Wenming Ji²

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.4, pp. 1-1, 2023, DOI:10.32604/icces.2023.09159

Abstract Tight reservoirs hold a vast natural gas in Ordos Basin, and efficient development of these resources can offset the energy shortage. Due to the low-porosity and low-permeability, hydraulic fracturing becomes necessary to tap its resources. After fracturing, a large amount of fracturing fluid fills pore space near hydraulic fracture, which will influence the gas production. This study focused on the water occurrence of tight gas reservoirs and its influencing factors. Samples were selected from Upper Paleozoic Taiyuan and Shihezi Formations from Ordos Basin. The main experiments include porosity, permeability, mineral composition, nitrogen adsorption (NA), mercury intrusion porosimetry (MIP), nuclear magnetic… More >

Zipu Yan^1,2, Honghua Dai^1,2,*, Xiaokui Yue^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09138

Abstract As a significant research interest in orbital mechanics, periodic orbits are fundamental for understanding orbital behaviors and space explorations. Although the harmonic balance (HB) method and its variants have been the most widely-used approaches for periodic dynamical systems, they are seldom applied to celestial dynamics. Here we use the reconstruction harmonic balance (RHB) method for solving periodic orbits. Starting from a presupposed Fourier form and an initial guess at the solution, the algorithm uses timedomain collocation points to optimally reconstruct the high-order HB procedure without complicated symbolic operations and non-physical solutions. Following a description of the method, it is applied… More >

Fei Han^1,*, Zhibin Li¹, Jianyu Zhang¹, Zhiying Liu¹, Chen Yao¹, Wenping Han¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09023

Abstract The classical finite element method has been successfully applied to many engineering problems but not to cases with space discontinuity. A peridynamics-based finite element method (PeriFEM) is presented according to the principle of minimum potential energy, which enables discontinuity. First, the integral domain of peridynamics is reconstructed, and a new type of element called peridynamic element (PE) is defined. Although PEs are generated by the continuous elements (CEs) of classical FEM, they do not affect each other. Then, spatial discretization is performed based on PEs and CEs, and the linear equations about nodal displacement are established according to the principle… More >

XIAO-JUN ZHOU^1,*, YU-WEI TIAN¹, RUI-HAN LI²

BIOCELL, Vol.47, No.8, pp. 1907-1913, 2023, DOI:10.32604/biocell.2023.030191

Abstract Background: Acer griseum Pax is an endangered species endemic to China with both ornamental and economic value. However, the lack of information on its genome size and characteristics hinders further work at the genome level. Methods: This paper applied bioinformatics methods to predict the characteristics and patterns of the A. griseum genome, providing an important basis for formulating its whole-genome sequencing scheme. This study also characterized the simple sequence repeats (SSRs) of A. griseum, laying the foundation for the development and application of genome-wide SSR markers. In this study, PE150 sequencing was performed by the BGI MGISEQ platform, and the… More >