ZHONGXIANG TANG^1,2, LILI WANG^1,2, GUOJUN WU^1,2, LING QIN^1,2,*, YURONG TAN^1,2,*

BIOCELL, Vol.47, No.11, pp. 2503-2516, 2023, DOI:10.32604/biocell.2023.031565

Abstract Background: Non-small cell lung cancer (NSCLC) has a poor prognosis with a low 5-year survival rate. Lung adenocarcinoma (LUAD) accounts for 50%. Facio-genital dysplasia-5 (FGD5), a member of a subfamily of Rho GTP-GDP exchange factors, may be a good molecular biomarker for diagnosis and prognosis. Objective: To explore the clinical application of FGD5, the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients. Methods: Through the Wilcoxon signed-rank test and logistic regression, the correlation between clinical characteristics and FGD5 expression was analyzed. Kaplan–Meier plotter analysis, Cox regression, and a… More > Graphic Abstract

LEONARDO GóMEZ ROSSO, BELéN DAVICO, EZEQUIEL LOZANO CHIAPPE, WALTER TETZLAFF, LAURA BOERO, FERNANDO BRITES, MAXIMILIANO MARTíN^*

BIOCELL, Vol.47, No.11, pp. 2361-2383, 2023, DOI:10.32604/biocell.2023.031063

Abstract Cardiovascular diseases (CVDs) are the leading cause of death globally. CVDs are a group of disorders of the heart and blood vessels and include coronary heart disease, cerebrovascular disease and rheumatic heart disease among other conditions. There are multiple independent risk factors for CVD, including hypertension, age, smoking, insulin resistance, elevated low-density lipoprotein cholesterol (LDL-C) levels, and triglyceride levels. LDL-C levels have traditionally been the target for therapies aimed at reducing CVD risk. High density lipoprotein (HDL) constitutes the only lipoprotein fraction with atheroprotective functions. Early HDL-targeted therapies have focused on increasing HDL-C levels. However, clinical trials have shown that… More > Graphic Abstract

QINGPAN BU, PING LI, YUNFEI XIA, XINPEI WEI, KAI SONG^*

BIOCELL, Vol.47, No.11, pp. 2535-2546, 2023, DOI:10.32604/biocell.2023.030781

Abstract Mannose, a different isomer of the hydroxyl group at the C-2 position of glucose, shares the same transport carrier protein with glucose to enter cells and participate in the regulation of glucose metabolism. It affects cell growth, differentiation, and function and plays an active role in tumor immunity and inflammatory processes. This paper provides theoretical support for expanding the clinical applications of mannose by exploring its constitution, metabolic pathways, and role in regulating immune cell function and treating immunology-related diseases. More > Graphic Abstract

Jialing Miao¹, Wei Liao^2,*, Baoguo Xie³

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1147-1157, 2023, DOI:10.32604/ijmhp.2023.030671

Abstract Although employers believe that encouraging and supporting physical exercise activities by purchasing fitness equipment and building sports venues can improve employees’ well-being, the utilization rate is rather low. Since most of the evidence of the well-being promotion in the workplace concentrated on the perspectives of organizational factors and psychosocial factors and focused on the reduction of the negative affect of well-being, it is still an open question whether physical exercise has benefits on both negative and positive affect of wellbeing and who benefits more from physical exercise. Thus, the purpose of this study is to investigate the impact of physical… More >

Cuirong Xu^1,*, Han Yan², Dawei Xu³, Guanjie Chen⁵, Qian Xu², Kunpeng Li⁶, Yehao Rui⁷, Zanmin Song³, Neeraj Gill³, Jing Sun^3,4,*

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1089-1102, 2023, DOI:10.32604/ijmhp.2023.030526

Abstract Objective: The purpose of this study was to evaluate the effectiveness of post-traumatic growth (PTG) model-based intervention to improve positive psychological traits in Chinese breast cancer patients. Design: A randomized control trial of a psychological group intervention based on PTG model. Methods: The Clinical Trial was registered on 17 August 2019 at Chinese Clinical Trials.gov with Registration number ChiCTR1900025264. A total of 92 patients with breast cancer were recruited. The participants were randomly assigned to the experimental group (n = 46) and the control group (n = 46). A six-session psychological group intervention based on PTG model was implemented in… More >

Namyun Kil^1,*, Jin Gun Kim², Emily Thornton¹, Amy Jeranek³

International Journal of Mental Health Promotion, Vol.25, No.10, pp. 1117-1125, 2023, DOI:10.32604/ijmhp.2023.022981

Abstract

Mental health conditions in children and adolescents can be improved by slow mindful nature connection known as forest therapy or bathing. Forest therapy has recently received growing attention as an enabler of relaxation and preventive health care with demonstrated clinical efficacy. However, it is not well-known that forest therapy also decreases mental health issues among individuals with mental health disorders. This study explored the psychological and physiological health benefits of structured forest therapy programs for children and adolescents with mental health disorders. A one-group pre-test-posttest design was employed for our study participants. Twelve participants (aged 9–14 years) engaged in two… More >

Ain Raal^1,*, Linda Rusalepp², Tatiana Chiru³, Nicolae Ciobanu³, Kelly Talvistu¹, Michelle Shusta¹, Oleh Koshovyi^1,4, Tõnu Püssa²

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2965-2979, 2023, DOI:10.32604/phyton.2023.042723

Abstract The fruits of the Sea buckthorn (Hippophae rhamnoides L.) are a popular plant food and a valuable health product. Cultivating plants produces a lot of leaves with fine branches as an unnecessary residue, which needs valorization. The aim of the study was to estimate (by HPLC-MS/MS) the qualitative and quantitative content of polyphenolic compounds in different parts of H. rhamnoides (HR), and to determine the level of antioxidant activity of leaves and fruits (by DPPH, ABTS methods and ferrozine test). Up to 19 compounds were identified in different parts of HR. The fruits are rich in flavonoids, including various glycosides… More >

LINGYAN LV^1,2,#, JING ZHAO^1,2,#, XUAN WANG^1,2, LIUYAN XU^1,2, YINGYI FAN², CHUNHUI WANG³, HONGQIAO FAN^4,5,*, XIAOHUA PEI^5,*

BIOCELL, Vol.47, No.9, pp. 1977-1994, 2023, DOI:10.32604/biocell.2023.030742

Abstract Background: The development and prognosis of breast cancer are intricately linked to psychological stress. In addition, depression is the most common psychological comorbidity among breast cancer survivors, and reportedly, Fang-Xia-Dihuang decoction (FXDH) can effectively manage depression in such patients. However, its pharmacological and molecular mechanisms remain obscure. Methods: Public databases were used for obtaining active components and related targets. Main active components were further verified by ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UPLC-HRMS). Protein–protein interaction and enrichment analyses were taken to predict potential hub targets and related pathways. Molecule docking was used to understand the interactions between main compounds and hub… More >

XIANBAO FANG^1,#, MINGYAN TANG^1,#, ZIYANG YU^1,#, JIAQI DING¹, CHONG CUI², HONG ZHANG^1,*

BIOCELL, Vol.47, No.9, pp. 2059-2068, 2023, DOI:10.32604/biocell.2023.030565

Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were determined by enrichment analysis. The SWISS-MODE website was used in homology modeling with EML4… More > Graphic Abstract

EUN SOOK KIM¹, SANGHEE KIM², AREE MOON^1,*

Oncology Research, Vol.31, No.6, pp. 867-875, 2023, DOI:10.32604/or.2023.030411

Abstract Invasion and metastasis are important hallmarks of breast cancer and are the leading cause of patient mortality. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer characterized by a poor prognosis and a lack of effective targeted therapies. The present study investigated the inhibitory effect of a novel FTY720 derivative on the invasive phenotype of TNBC cells. Here, we showed that a novel compound with an isoxazole ring, 4-(3-Decylisoxazol-5-yl)-1-hydroxy-2-(hydroxymethyl)butan-2-aminium chloride (CM2-II-173), significantly inhibited invasiveness of MDA-MB-231 TNBC cells. Expression of matrix metalloproteinase (MMP)-9 and invasiveness of MCF10A normal breast cells induced by sphingosine-1-phosphate (S1P) were reduced by CM2-II-173… More >