Shijie Tang^1,2, Yong Ding^1,3,4,*, Huiyong Wang⁵

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 1129-1150, 2025, DOI:10.32604/cmc.2024.059143 - 03 January 2025

Abstract As more and more devices in Cyber-Physical Systems (CPS) are connected to the Internet, physical components such as programmable logic controller (PLC), sensors, and actuators are facing greater risks of network attacks, and fast and accurate attack detection techniques are crucial. The key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time series. To address this issue, we propose an anomaly detection method based on distributed deep learning. Our method uses a bilateral filtering algorithm for sequential sequences to remove noise in the More >

Jing Guo^*, Ziying Wang, Yajuan Guo, Haitao Jiang

CMC-Computers, Materials & Continua, Vol.82, No.1, pp. 427-442, 2025, DOI:10.32604/cmc.2024.057045 - 03 January 2025

Abstract The rapid proliferation of electric vehicle (EV) charging infrastructure introduces critical cybersecurity vulnerabilities to power grids system. This study presents an innovative anomaly detection framework for EV charging stations, addressing the unique challenges posed by third-party aggregation platforms. Our approach integrates node equations-based on the parameter identification with a novel deep learning model, xDeepCIN, to detect abnormal data reporting indicative of aggregation attacks. We employ a graph-theoretic approach to model EV charging networks and utilize Markov Chain Monte Carlo techniques for accurate parameter estimation. The xDeepCIN model, incorporating a Compressed Interaction Network, has the ability… More >

YUEZHOU ZHANG^1,#, ZHAO ZHANG^2,#, JINXIN DONG¹, CHANGAN LIU^1,*

Oncology Research, Vol.33, No.1, pp. 83-102, 2025, DOI:10.32604/or.2024.055866 - 20 December 2024

Abstract Background: Aberrant expression of RNA-binding proteins (RBPs) has been linked to a variety of diseases, including hematological disorders, cardiovascular diseases, and multiple types of cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a member belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) family, plays a pivotal role in nucleic acid metabolism. Previous studies have underscored the significance of HNRNPC in tumorigenesis; however, its specific role in malignant tumor progression remains inadequately characterized. Methods: We leveraged publicly available databases, including The Cancer Genome Atlas (TCGA), to explore the potential involvement of HNRNPC across various cancers. Additionally, we performed experimental… More > Graphic Abstract

NASSER MULLA^1,*, YOUSEF KATIB², ASIM M. ALMUGHAMSI³, DUAA S. ALKHAYAT¹, MOHAMED MOSAAD^1,4, SAMIR T. ALFOTIH⁵, RAWAN ALAOFI⁶

Oncology Research, Vol.33, No.1, pp. 149-160, 2025, DOI:10.32604/or.2024.050903 - 20 December 2024

Abstract Background: Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients’ overall survival (OS). Methods: A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis. Results: The mean patient age of all… More >

LEI WANG¹, XIANJIN XIE^2,*

Oncology Research, Vol.33, No.1, pp. 123-132, 2025, DOI:10.32604/or.2024.048562 - 20 December 2024

Abstract Background: To investigate SCL/TAL 1 interrupting locus (STIL)’s role and prognostic significance in lung adenocarcinoma (LUAD) progression, we examined STIL and E2 promoter binding factor 1 (E2F1) expression and their impacts on LUAD prognosis using Gene Expression Profiling Interactive Analysis (GEPIA). Methods: Functional assays including CCK-8, wound-healing, 5-ethynyl-2-deoxyuridine (EdU), Transwell assays, and flow cytometry, elucidated STIL and E2F1’s effects on cell viability, proliferation, apoptosis, and migration. Gene set enrichment analysis (GSEA) identified potential pathways, while metabolic assays assessed glucose metabolism. Results: Our findings reveal that STIL and E2F1 are overexpressed in LUAD, correlating with adverse outcomes. It enhances More >

GENGYUN SUN^1,*, YIPING ZHENG^1,2, JIANFENG CAI², JIE GAO², LIE DONG², XIANGBIN ZHANG², YINGHUI HUANG^2,*

Oncology Research, Vol.33, No.1, pp. 171-184, 2025, DOI:10.32604/or.2024.047626 - 20 December 2024

Abstract Background: Long noncoding RNA, LINC01106 exhibits high expression in lung adenocarcinoma (LUAD) tumor tissues, but its functional role and regulatory mechanism in LUAD cells remain unclear. Methods: LINC01106 expression was analyzed in LUAD tissues and its functional impact on LUAD cells was assessed. LUAD cells were silenced with sh-LINC01106 and injected into nude mice to investigate tumor growth. The downstream transcription factors and molecular mechanism were determined using the Human transcription factor database (TFDB) database and Gene Expression Profiling Interactive Analysis (GEPIA) database. Additionally, the impact of linc01106 on autophagy was analyzed by determining the… More > Graphic Abstract

Zhan Wu, Mystie Chen, Ryan Mori

Canadian Journal of Urology, Vol.31, No.2, pp. 11858-11860, 2024

Abstract Urethral cancer after urethral reconstruction is an under-recognized, uncommon disease associated with significant morbidity and mortality. The survival rates of patients with carcinoma of the bulbar urethra are as low as 20%-30%. Stricture recurrence and unrecognized malignant changes present prior to reconstruction are major risk factors for urethral cancer. Skin substitution urethroplasty is subjected to higher rates of recurrence, which lends to the potential for carcinogenesis. We present a case of a 59-year-old male who underwent multi-stage skin substitution urethroplasty who developed urethral carcinoma 20 years later. More >

Andrew S. Iskandar, Kevin K. Zarrabi, William J. Tester

Canadian Journal of Urology, Vol.31, No.4, pp. 11921-11930, 2024

Abstract Introduction: Renal cell carcinoma is as the most prevalent form of kidney cancer, with the clear cell subtype comprising approximately 75% of cases. The identification of predictive and prognostic biomarkers has emerged as a crucial area of research within the field. Despite advancements in treatment, metastatic renal cell carcinoma presents formidable challenges, with survival rates heavily dependent upon the optimal choice of treatment.
Materials and methods: This review summarizes the current literature regarding the prognostic and predictive value of biomarkers in patients with renal cell carcinoma. We conducted a comprehensive literature search to identify studies that reference… More >

Jacob Grassauer¹, Wesley H. Chou², Anna Geduldig¹, Jackson Schmidt², Nicholas H. Chakiryan^1,2,3,4

Canadian Journal of Urology, Vol.31, No.6, pp. 12060-12071, 2024

Abstract Introduction: It is unclear whether laterality has prognostic implications for patients with renal cell carcinoma (RCC). Some suggest that left sided tumors may have worse survival outcomes. The purpose of this study is to associate tumor characteristics and clinical outcomes with laterality in patients with RCC.
Materials and methods: Patients with RCC were identified in the National Cancer Database between 2004-2020. Patients were categorized as having either localized, regional or metastatic disease. Time-series charts were generated to demonstrate laterality differences and variance over time. Multivariable Cox proportional hazards regression was utilized to associate laterality with overall survival, stratified… More >

ARMAND N. YAZDANI¹, MICHAELA PLETSCH¹, ABRAHAM CHORBAJIAN¹, DAVID ZITSER¹, VIKRANT RAI^1,2,*

BIOCELL, Vol.48, No.12, pp. 1683-1702, 2024, DOI:10.32604/biocell.2024.056252 - 30 December 2024

Abstract Mixed cholangiocarcinoma is a rare and aggressive neoplastic proliferation of biliary tract epithelial cells, accounting for up to 20% of primary liver cancers. It is the second most common primary liver malignancy with a 5-year survivability of less than 10% at diagnosis and is associated with various inflammatory diseases. Current management involves systemic chemotherapy, targeted radiation, and surgical resection, but long-term survival remains low, especially for surgically unresectable cases. Novel discoveries and understandings of the tumor microenvironment reveal new opportunities for targeted therapies for cholangiocarcinoma. Specifically, new pharmaceuticals including cell-based vaccines, tumor-associated neutrophils, and hepatic… More >