SHIDA HOU^1,#, TIANJUN LAN^2,#, YAOCHENG YANG^3,#, PEISHENG LIANG¹, XIN LIU^4,5, JUNJIE WANG⁶, ZHIFENG CHEN⁷, RONGSHENG ZENG^1,*, ZIJING HUANG^8,*

BIOCELL, Vol.47, No.12, pp. 2641-2660, 2023, DOI:10.32604/biocell.2023.043291

Abstract Background: 5-Methylcytosine (m5C) methylation contributes to the development and progression of various malignant tumors. This study aimed to explore the potential role of m5C methylation regulators (m5CMRs) in head and neck squamous cell carcinoma (HNSCC). Methods: The transcription data of HNSCC samples were obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) databases. Subsequently, the m5C patterns in HNSCC were evaluated based on 14 m5CMRs. Then, the m5Cscore was developed to quantify m5C patterns by using principal component analysis (PCA) algorithms. Two single-cell RNA sequencing datasets and various methods were employed to assess the prognostic value… More >

JIE DUAN, AIDONG GU^*, WEI CHEN, CHANGHAO CHEN, FANGNAN SONG, FAXI CHEN, FANGFANG JIANG, HUIWEN XING

BIOCELL, Vol.47, No.12, pp. 2609-2615, 2023, DOI:10.32604/biocell.2023.042472

Abstract Objective: This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2 (NRF2) and glutathione peroxidase 4 (GPX4) in primary hepatic carcinoma (PHC). Methods: The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC. The prognostic significance of NRF2 and GPX4 was evaluated by 3-year follow-up. Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased, and the expression of NRF2 and GPX4 in the cells was determined. NRF2 and GPX4 aberrant expression vectors were… More > Graphic Abstract

Keunhan Park^a,∗, Zhuomin Zhang^b

Frontiers in Heat and Mass Transfer, Vol.4, No.1, pp. 1-26, 2013, DOI:10.5098/hmt.v4.1.3001

Abstract This article reviews the recent advances in near-field radiative energy transfer, particularly in its fundamentals and applications. When the geometrical features of radiating objects or their separating distances fall into the sub-wavelength range, near-field phenomena such as photon tunneling and surface polaritons begin to play a key role in energy transfer. The resulting heat transfer rate can greatly exceed the blackbody radiation limit by several orders magnitude. This astonishing feature cannot be conveyed by the conventional theory of thermal radiation, generating strong demands in fundamental research that can address thermal radiation in the near field. Important breakthroughs of near-field thermal… More >

Wei Zhang¹, Ping He^2,*, Ting Li², Fan Yang¹, Ying Liu³

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 1893-1910, 2023, DOI:10.32604/cmc.2023.044253

Abstract Some reconstruction-based anomaly detection models in multivariate time series have brought impressive performance advancements but suffer from weak generalization ability and a lack of anomaly identification. These limitations can result in the misjudgment of models, leading to a degradation in overall detection performance. This paper proposes a novel transformer-like anomaly detection model adopting a contrastive learning module and a memory block (CLME) to overcome the above limitations. The contrastive learning module tailored for time series data can learn the contextual relationships to generate temporal fine-grained representations. The memory block can record normal patterns of these representations through the utilization of… More >

Adel Alkhalil^1,*, Abdulaziz Aljaloud¹, Diaa Uliyan¹, Mohammed Altameemi¹, Magdy Abdelrhman^2,3, Yaser Altameemi⁴, Aakash Ahmad⁵, Romany Fouad Mansour⁶

CMC-Computers, Materials & Continua, Vol.77, No.2, pp. 2049-2078, 2023, DOI:10.32604/cmc.2023.044506

Abstract Supervisory control and data acquisition (SCADA) systems are computer systems that gather and analyze real-time data, distributed control systems are specially designed automated control system that consists of geographically distributed control elements, and other smaller control systems such as programmable logic controllers are industrial solid-state computers that monitor inputs and outputs and make logic-based decisions. In recent years, there has been a lot of focus on the security of industrial control systems. Due to the advancement in information technologies, the risk of cyberattacks on industrial control system has been drastically increased. Because they are so inextricably tied to human life,… More >

Majid Ahmed Mohammed¹, Abdullah Talab Derea², Mohammed Yaseen Lafta³, Obed Majeed Ali¹, Omar Rafae Alomar^4,*

Frontiers in Heat and Mass Transfer, Vol.21, pp. 215-226, 2023, DOI:10.32604/fhmt.2023.041668

Abstract It is common knowledge that phase-change materials are used for the purpose of thermal storage because of the characteristics that are exclusive to these materials and not found in others. These characteristics include a large capacity for absorbing heat and a large capacity for releasing heat when the phase changes; however, these materials have a low thermal conductivity. This paper presents the results of an experimental study that investigated the impact that nanoparticles of copper oxide had on reducing the temperature of solar panels. The phase change substance that was used was determined to be beeswax. The impact of adding… More >

HAIYING YUE, CHUNHUI WANG, HUIJUN ZHU, QINGHUA DU, JIAN LI, XUE OU, XIANGDE LI, QIULU ZHONG, YITING XIE, DANJING LUO, YIHE LI, CHUNXIAO LIANG, XUEMEI XU, SONGNAN DU, WENQI LIU^*

BIOCELL, Vol.47, No.11, pp. 2445-2452, 2023, DOI:10.32604/biocell.2023.042512

Abstract Background: Nasopharyngeal carcinoma (NPC) is one of the most prevalent cancers in Southeast Asia. Sirtuin 2 (SIRT2) is a member of the NAD+-dependent deacetylase family and has been shown to play important roles in numerous biological processes. However, Its function in NPC remains uncertain. The primary aim of this study is to clarify the role of SIRT2 in NPC. Methods: In this research, we examined the effect of SIRT2 silencing on NPC cell proliferation and colony formation using vitro NPC cell lines. Co-immunoprecipitation and mass spectrometry was applied to identify SIRT2-interacting proteins in NPC cells. Results: In comparison to nasopharyngeal… More > Graphic Abstract

ZHONGXIANG TANG^1,2, LILI WANG^1,2, GUOJUN WU^1,2, LING QIN^1,2,*, YURONG TAN^1,2,*

BIOCELL, Vol.47, No.11, pp. 2503-2516, 2023, DOI:10.32604/biocell.2023.031565

Abstract Background: Non-small cell lung cancer (NSCLC) has a poor prognosis with a low 5-year survival rate. Lung adenocarcinoma (LUAD) accounts for 50%. Facio-genital dysplasia-5 (FGD5), a member of a subfamily of Rho GTP-GDP exchange factors, may be a good molecular biomarker for diagnosis and prognosis. Objective: To explore the clinical application of FGD5, the study was designed to investigate the prognosis value of FGD5 expression and its correlation with immune infiltrates in LUAD patients. Methods: Through the Wilcoxon signed-rank test and logistic regression, the correlation between clinical characteristics and FGD5 expression was analyzed. Kaplan–Meier plotter analysis, Cox regression, and a… More > Graphic Abstract

ZHIWANG LI, HAN YU, YUPING LIU, WEISHENG WU, HAIJING ZENG, EN LI^*

BIOCELL, Vol.47, No.11, pp. 2409-2422, 2023, DOI:10.32604/biocell.2023.031186

Abstract Familial adenomatous polyposis (FAP) is an autosomal dominant disease with a high probability of becoming cancerous. Many RNAs potentially associated with FAP have not been identified. In this study, a circRNA (circular RNA) expression profile of FAP was established using a circRNA microarray, and differentially expressed circRNAs were verified by RT-qPCR. The effects of hsa_circ_0036740 on the malignant behavior of tumor cells (proliferation, apoptosis, and epithelial mesenchymal transition) and the levels of C3A complement protein expression were evaluated. Moreover, neutrophils were isolated and co-cultured with colorectal cancer cells (CRCs), followed by measurements of MPO-DNA, citrullinated histone H3, interleukin (IL)-1β, IL-6,… More > Graphic Abstract

RENLONG ZHOU^1,2,#, SHUANG LI^3,#, XILIN XIAO^1,*

BIOCELL, Vol.47, No.11, pp. 2397-2408, 2023, DOI:10.32604/biocell.2023.030281

Abstract Background: In many cancer types, aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) has been found to be associated with tumor cell proliferation and prognosis. However, the role of ARNT2 in clear cell renal cell carcinoma (ccRCC) has not been completely elucidated. In this study, the potential role of ARNT2 in ccRCC development was characterized. Methods: A pan-cancer dataset (TCGA-TARGET-GTEx) was accessed from UCSC Xena Data Browser. ARNT2 expression in normal and tumor samples was compared. Univariate Cox regression was performed to evaluate the prognostic value of ARNT2. Single sample gene set enrichment analysis (ssGSEA) was used to estimate the enrichment… More >