LAURA MARRONE¹, MASSIMO D’AGOSTINO¹, CAROLINA GIORDANO², VALERIA DI GIACOMO¹, SIMONA URZINI¹, CHIARA MALASOMMA¹, MARIA PAOLA GAMMELLA¹, MARTINA TUFANO¹, SIMONA ROMANO^1,*, MARIA FIAMMETTA ROMANO^1,*

Oncology Research, Vol.31, No.4, pp. 423-436, 2023, DOI:10.32604/or.2023.028392 - 25 June 2023

Abstract Scaffold proteins are crucial regulators of signaling networks, and their abnormal expression may favor the development of tumors. Among the scaffold proteins, immunophilin covers a unique role as ‘protein-philin’ (Greek ‘philin’ = friend) that interacts with proteins to guide their proper assembly. The growing list of human syndromes associated with the immunophilin defect underscores the biological relevance of these proteins that are largely opportunistically exploited by cancer cells to support and enable the tumor’s intrinsic properties. Among the members of the immunophilin family, the FKBP5 gene was the only one identified to have a splicing variant. More > Graphic Abstract

XINGBO WU, DAN PAN, SHOUYI TANG, YINGQIANG SHEN^*

BIOCELL, Vol.47, No.7, pp. 1459-1472, 2023, DOI:10.32604/biocell.2023.028790 - 21 June 2023

Abstract The term “undruggable” is to describe molecules that are not targetable or at least hard to target pharmacologically. Unfortunately, some targets with potent oncogenic activity fall into this category, and currently little is known about how to solve this problem, which largely hampered drug research on human cancers. Ras, as one of the most common oncogenes, was previously considered “undruggable”, but in recent years, a few small molecules like Sotorasib (AMG-510) have emerged and proved their targeted anti-cancer effects. Further, myc, as one of the most studied oncogenes, and tp53, being the most common tumor suppressor genes,… More >

Xiaotian Liang^1,#, Qi Wen^1,#, Rui Luo¹, Yanxin Zhang¹, Mingda Yin¹, Yanpeng Wen¹, Xuemei Hu¹, Zhiyan Wang¹, Yumiao Huo¹, Fenglan Huang^{1,2,3,4,5,6,*}

Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1765-1792, 2023, DOI:10.32604/phyton.2023.026935 - 11 April 2023

Abstract Castor bean (Ricinus communis L.), is one of the top 10 oilseed crops in the world and, therefore, of high economic value. Hybridization is one of the most effective ways to breed new varieties with high yield, high oil content, and better stress resistance. Therefore, prediction of desired traits in castor hybrid offspring is particularly important. In this study, proteomic analysis was performed to identify differentially expressed proteins (DEPs) in seeds between castor hybrid offspring and their female (Lm female line aLmAB₂) and male parents (CSR·181). Among the DEPs upregulated in the seeds of hybrid offspring, the… More >

JULIANA A. PORTES¹, ROSSIANE C. VOMMARO¹, LUCIO AYRES CALDAS², ERICA S. MARTINS-DUARTE^3,*

BIOCELL, Vol.47, No.4, pp. 929-950, 2023, DOI:10.32604/biocell.2023.026629 - 08 March 2023

Abstract Toxoplasma gondii is a protozoan of worldwide distribution and the agent of toxoplasmosis. It is estimated that 30%–50% of the world population could be infected with this parasite. Although the infection in immunocompetent individuals is mostly asymptomatic, the disease in immunosuppressed and pregnant is a risk condition. As a member of the phylum Apicomplexa, T. gondii has an obligatory intracellular lifestyle; therefore, invading a host cell and establishing it inside a parasitophorous vacuole (PV) are mandatories for the survival of this parasite. The construction of a perfect intracellular niche for T. gondii requires the secretion of an arsenal More >

Liang Chai^1,2, Cheng Cui¹, Benchuan Zheng¹, Jinfang Zhang¹, Jun Jiang¹, Haojie Li^1,2,*, Liangcai Jiang^1,*

Phyton-International Journal of Experimental Botany, Vol.92, No.3, pp. 645-663, 2023, DOI:10.32604/phyton.2023.024717 - 29 November 2022

Abstract Nitrogen (N) is one of the basic nutrients and signals for plant development and deficiency of it would always limit the productions of crops in the field. Quantitative research on expression of N-stress responsive proteins on a proteome level remains elusive. In order to gain a deep insight into the proteins responding to nitrogen stress in rapeseed (Brassica napus L.), comparative proteomic analysis was performed to investigate changes of protein expression profiles from the root, stem and leaf under different N concentrations, respectively. More than 200 differential abundance proteins (DAPs) were detected and categorized into groups More >

Lunzeng Huang^1,2,#, Hongsheng Gao^1,#, Ning Jiang^1,2, Yunhong Xu^1,2, Zijian Gong^1,2, Lele Chen^1,2, Shijie Xue^1,2, Xiaoyan Li¹, Ruichao Liu^1,2, Bei Li¹, Hongxia Zhang¹, Chunyan Yu^1,*, Xiaotong Guo^1,2,*

Phyton-International Journal of Experimental Botany, Vol.92, No.2, pp. 349-368, 2023, DOI:10.32604/phyton.2022.025467 - 12 October 2022

Abstract Calcium (Ca²⁺) plays a pivotal role in various signal transduction pathways. Calcineurin B-like proteins (CBLs) are a unique group of Ca²⁺ sensors that decode Ca²⁺ signals by activating the plant specific protein kinase known as the CBL-interacting protein kinase (CIPK). In plants, the CBL-CIPK signaling network regulates multiple signals in response to different extracellular cues including abiotic stress. However, the genome wide annotation and expression patterns of CBLs and CIPKs in woody cutting flower plants are still unclear. In this study, a total number of 7 CBLs (RcCBLs) and 17 CIPKs (RcCIPKs) genes, divided into four and five subfamilies,… More >

T. Edwin Ponraj^1,*, J. Charles²

Intelligent Automation & Soft Computing, Vol.36, No.1, pp. 1189-1203, 2023, DOI:10.32604/iasc.2023.033383 - 29 September 2022

Abstract The mutation is a critical element in determining the proteins’ stability, becoming a core element in portraying the effects of a drug in the pharmaceutical industry. Doing wet laboratory tests to provide a better perspective on protein mutations is expensive and time-intensive since there are so many potential mutations, computational approaches that can reliably anticipate the consequences of amino acid mutations are critical. This work presents a robust methodology to analyze and identify the effects of mutation on a single protein structure. Initially, the context in a collection of words is determined using a knowledge More >

Munir Ozturk^1,*, Mert Metin², Volkan Altay³, Tomonori Kawano², Alvina Gul⁴, Bengu Turkyilmaz Unal^5,*, Dilek Unal⁶, Rouf Ahmad Bhat⁷, Moonisa Aslam Dervash⁸, Kristina Toderich⁹, Esra Koc¹⁰, Pedro Garcia Caparros¹¹, Andleeb Shahzadi¹²

Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 165-192, 2023, DOI:10.32604/phyton.2022.022038 - 06 September 2022

Abstract Aluminum is an abundant metal in the earth’s crust that turns out to be toxic in acidic environments. Many plants are affected by the presence of aluminum at the whole plant level, at the organ level, and at the cellular level. Tobacco as a cash crop (Nicotiana tabacum L.) is a widely cultivated plant worldwide and is also a good model organism for research. Although there are many articles on Al-phytotoxicity in the literature, reviews on a single species that are economically and scientifically important are limited. In this article, we not only provide the biology… More >

Minjie Liu^*, Na Gao, Yaqiong Zhao, Yingpeng Wu, Zongying Yuan

Phyton-International Journal of Experimental Botany, Vol.91, No.11, pp. 2367-2382, 2022, DOI:10.32604/phyton.2022.021406 - 12 July 2022

Abstract Lysin motif (LysM)-containing proteins (LYPs) are important pattern recognition receptors in plants. However, the evolutionary history and characteristics of LYP genes remain largely unclear in wheat. In this study, 62 LYPs were identified at genome wide in wheat. Based on phylogenetic and domain analysis, wheat LYPs were classified into 6 subgroups (group LysMe, LysMn, LYP, LYK, LysMFbox). Syntenic analysis showed the evolution of LYP genes in wheat. RNA-seq data showed that 22 genes were not expressed at any tissue or stress stimulation period. Some LYP and LYK genes were tissue- or stage- specific. The majority of TaLYK5s, More >

Robabeh Faghani Baladehi^1,2, Mohammad Yousef Memar¹, Abolfazl Jafari Sales³, Ahad Bazmani^1,4, Javid Sadri Nahand^1,5,6, Parisa Shiri Aghbash^2,7, Hossein Bannazadeh Baghi^1,2,7,*

Oncologie, Vol.24, No.2, pp. 227-245, 2022, DOI:10.32604/oncologie.2022.020648 - 29 June 2022

Abstract The ability of host cells to activate apoptosis is perhaps the most potent weapon for helping cells eliminate viruses. Human papillomaviruses (HPV) activate several pathways, enabling the infected cells to avoid extrinsic and intrinsic apoptosis pathways. The incapacity of prostatic epithelial cells to induce apoptosis leads to the invasive development of prostate cancer. For the pathogenesis of prostate cancer, several risk factors have been reported; for example, some viruses and infectious diseases have been proposed as causative agents for their relation to prostate diseases. According to several studies, high-risk human papillomaviruses cause malignancy by interfering More >